Richman, DD; Wrin, T; Little, SJ; Petropoulos, CJ (2003). "Rapid evolution of the neutralizing antibody response to HIV type 1 ... He is a member of the board of directors of the human vaccine program. He has published over 730 papers and edited several ... His laboratory elucidated the remarkable evolution of neutralizing antibody responses in HIV infection, providing important ... insights for the development of an effective HIV vaccine. Dr. Richman's current research activities are now focused on the ...

Subbarao K, McAuliffe J... Murphy B (2004). Prior infection and passive transfer of neutralizing antibody prevent replication ... Murphy's research has focused on vaccine development for various viruses. In particular, his group is known for working on ... 1761-1764 Clements ML, Betts RF... Murphy BR (1986). Serum and nasal wash antibodies associated with resistance to experimental ... "The Influenza Viruses and their Vaccines - Seminar Notice". NIH Clinical Center. Retrieved 18 July 2019. Alexander C. Schmidt, ...

The vaccine induced antibodies in participants. Antibodies against gp120 surface antigen and P24 capsid antigen increased up to ... Broadly neutralizing antibodies were found in some blood samples of the participants. Phase II clinical trial The Phase II ... 2] New HIV Vaccine Proves Successful In Phase 1 Human Trial Canadian HIV Vaccine Pushes Through Trials Promising vaccine ... A Killed-Virus Vaccine for HIV/AIDS DID SCIENCE MISS ITS BEST SHOT AT AN AIDS VACCINE? IAVI Report on Whole Killed AIDS ...

Neutralizing Antibody Levels Against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron BA.1 and BA.2 After UB-612 Vaccine ... Taiwanese COVID-19 vaccines, Peptide vaccines, All stub articles, Vaccine stubs, COVID-19 vaccine stubs). ... UB-612 is a COVID-19 vaccine candidate developed by United Biomedical Asia [zh], and Vaxxinity, Inc. It is a peptide vaccine. ... "Platform Trial to Compare Homologous Boost of Authorized COVID-19 Vaccines and Heterologous Boost With UB-612 Vaccine" at ...

In 2016 and 2018, he demonstrated the potential of combining therapeutic vaccines or broadly neutralizing antibodies with ... "HIV Vaccine Takes Big Step , Harvard Medical School". hms.harvard.edu. "Monoclonal antibodies show promise as effective HIV ... In 2000, Barouch began researching the development of an HIV vaccine. In 2002, he published that a candidate HIV vaccine can ... Dan Barouch to lead Beth Israel Deaconess center for vaccine research - The Boston Globe". BostonGlobe.com. "Novel HIV vaccine ...

... usually the immunodominant antigen of the pathogen or a surface protein that enables the formation of neutralizing antibodies ... Genetic vaccines thus include DNA vaccines, RNA vaccines and viral vector vaccines. Most vaccines other than live attenuated ... A genetic vaccine (also gene-based vaccine) is a vaccine that contains nucleic acids such as DNA or RNA that lead to protein ... As a result, genetic vaccines and live vaccines generate cytotoxic T-cells in addition to antibodies in the vaccinated ...

"Efficacy of SARS-CoV-2 vaccines and the dose-response relationship with three major antibodies: a systematic review and meta- ... immunosuppressed individuals found that people with a weakened immune system are less able to produce neutralizing antibodies. ... The other vaccine requires only one shot. Booster doses are recommended too. Evidence from vaccine use during the pandemic ... The Moderna vaccine was granted emergency use authorization on December 17, 2020, and the Janssen (Johnson & Johnson) vaccine ...

... vaccinated with the Pfizer-BioNTech vaccine are likely to have more than five times lower levels of neutralizing antibodies ... June 2021). "Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination". The Lancet ... The rate was higher in 20-39 age group (98.9%) but slightly lower in the over 60 age group (93.3%). Neutralising antibodies ... "Over 95% individuals developed antibodies against the Sinopharm vaccine - USJ Researchers". USJ - University of Sri ...

RCN vaccine-laden baits increased antibodies against plague in both antigens. In contrast to known members of the poxvirus ... Promoting rabies virus neutralizing antibodies in raccoons, dogs, cotton rats, rabbits, bobcats, and foxes; sometimes at lethal ... Fortunately, the rRCN vaccine did relatively little harm to sheep when ingested orally, suggesting that rRCN vaccines used for ... rRCN vaccines have been successful too in treating rabies virus in mice. These vaccines functioned by either expressing the ...

Like VP4, VP1 also occasionally "pokes" out of the viral particle, making it available to neutralizing antibodies. Both ... along with an adjuvanted polyvalent Rhinovirus vaccine, shows potential for future development in vaccine treatment. Human ... There are no vaccines against these viruses as there is little-to-no cross-protection between serotypes. At least 99 serotypes ... Antibodies are a major defense against infection with the epitopes lying on the exterior regions of VP1-VP3. Interferon-alpha ...

EMEA Approval of Vaccine Gambel JM, DeFraites R, Hoke C, et al. (1995). "Japanese encephalitis vaccine: persistence of antibody ... For patients with JE virus IgM antibodies, confirmatory neutralizing antibody testing should be performed. Confirmatory testing ... The neutralizing antibody persists in the circulation for at least two to three years, and perhaps longer. The total duration ... Jelinek T (July 2008). "Japanese encephalitis vaccine in travelers". Expert Rev Vaccines. 7 (5): 689-93. doi:10.1586/14760584.7 ...

... using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody ... The HIU and the Pirbright Institute studied the Oxford RBD-SpyVLP vaccine, a virus-like particle (VLP)-based vaccine targeting ... "Studies show promising results for new Oxford COVID-19 vaccine". Open Access Government. 25 January 2021. Tan, T.K.; Rijal, P ... Hoch, Werner; McConville, John; Helms, Sigrun; Newsom-Davis, John; Melms, Arthur; Vincent, Angela (2001). "Auto-antibodies to ...

... that elicits antibodies with neutralizing activity. V3 loop Human Immunodeficiency Virus National Institutes of Health (NIH), ... National Institute of Allergy and Infectious Diseases (NIAID) (May 1, 2000). "HIV Vaccine Glossary". NIAID Fact Sheet. AIDSinfo ... Neutralizing domain in the external envelope glycoprotein of SIVmac251, NLM Gateway Principal neutralizing domain of the human ... The neutralizing domain is a specific site or section of the Human Immunodeficiency Virus(HIV) (most commonly on the envelope ...

A vaccine candidate that can elicit or boost anti-gp46 neutralizing antibody response may have a potential for prevention and ... Tanaka Y, Takahashi Y, Kodama A, Tanaka R, Saito M (2014). "Neutralizing antibodies against human T cell leukemia virus type-I ... While there is no present licensed vaccine, there are many factors which make a vaccine against HTLV-1 feasible. The virus ... Plasmid DNA vaccines elicit potent and protective immune responses in numerous small-animal models of infectious diseases. ...

May 2011). "A West Nile virus DNA vaccine utilizing a modified promoter induces neutralizing antibody in younger and older ... "Prime-boost" strategies with recombinant protein have successfully increased both neutralising antibody titre, and antibody ... DNA vaccines can polarise T-cell help towards TH1 or TH2 profiles and generate CTL and/or antibody when required. This can be ... A DNA vaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a ...

Neutralizing antibody Blocking+Antibodies at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Hook LM, ... The blocking of MSP-1 has been proposed to be a method of creating a vaccine against malaria by preventing its invasion and ... A blocking antibody is an antibody that does not have a reaction when combined with an antigen, but prevents other antibodies ... Blocking antibodies have been described as a mechanism for HSV-1 to evade the immune system. Blocking antibodies can be used in ...

After showing that antibodies are gamma globulins, he used oligosaccharides of different lengths to interfere with antibodies ... During World War II, Kabat worked for the National Defense Research Committee on developing a meningitis vaccine, accurate ... syphilis test, and detectors for neutralizing the plant toxin ricin. Kabat is best known for discovering the structural and ... He designed the eponymous Kabat numbering scheme for numbering amino acid residues in antibodies based on their variable ...

Induction of broadly neutralizing antibodies in healthy individuals is a potential strategy for a preventive HIV vaccine, as is ... Antibody production: All individuals with HIV make antibodies against the virus. In most patients, broadly neutralizing ... At this point, the latent reservoir has already been established and the presence of broadly neutralizing antibodies is not ... In some rare patients, these antibodies emerge earlier and can result in a delayed disease course. These patients, however, are ...

... of protein resurfacing was the design of the RSC3 probe to select broadly neutralizing HIV antibodies at the NIH Vaccine ... RSC3 was later used to discover the broadly neutralizing antibody VRC01 in the serum of a long-term HIV-infected non-progressor ... For example, the composition of the surface of the RSC3 probe to select HIV-broadly neutralizing antibodies was restricted ... In 2010, one of the most powerful broadly neutralizing antibodies was isolated from patient serum using a computationally ...

Neutralizing antibodies are important in protecting against the virus, and it has been noted that people who have antibodies ... In other words, the vaccine for human mumps appears to reduce the risk of infection from the bat mumps virus. Tropism in bats ... These proteins are the targets of the neutralizing antibodies, and due to the similarities between the two viruses, there is ... from a vaccine or infection of human mumps virus are able to neutralize the bat-borne mumps virus in an efficient manner. ...

Milk of Cow and Goat, Immunized by Recombinant Protein Vaccine ZF-UZ-VAC2001(Zifivax), Contains Neutralizing Antibodies Against ... The edible tomato COVID-19 vaccine, TOMAVAC, induces neutralizing IgGs. doi:10.21203/rs.3.rs-2447951/v1. PPR:PPR593613. ... Efficacy and Safety of the RBD-Dimer-Based Covid-19 Vaccine ZF2001 in Adults. N Engl J Med. 386(22):2097-2111. DOI: 10.1056/ ... VCANBIO International Cooperation Award in Biosciences and Medicine for his innovative achievements on joint COVID-19 vaccine ...

Implications for Cross-Reactivity of Neutralizing Antibodies". Frontiers in Immunology. 5 (38): 38. doi:10.3389/fimmu. ... March 2005). "HIV vaccine development by computer assisted design: the GAIA vaccine". Vaccine. 23 (17-18): 2136-48. doi:10.1016 ... "Vaccine Design from the Ensemble of Surface Glycoprotein Epitopes of SARS-CoV-2: An Immunoinformatics Approach". Vaccines. 8 (3 ... donovani candidate peptide vaccines". Human Vaccines & Immunotherapeutics. 8 (12): 1769-74. doi:10.4161/hv.21881. PMC 3656064. ...

The 15 μg group induced the highest titre of neutralising antibodies, which was about twofold more than the antibody titre of ... Drugs that are a vaccine, Chinese COVID-19 vaccines, RNA vaccines, Science and technology in China). ... The trial measured anti-SARS-CoV-2 RBD IgG using a standardised ELISA, and neutralising antibodies using pseudovirus-based and ... AWcorna, originally termed ARCoV and also known as the Walvax COVID-19 vaccine, is an mRNA COVID-19 vaccine developed by Walvax ...

... of L1 are the basis of a successful group of prophylactic HPV vaccines designed to elicit virus-neutralizing antibodies that ... This probably reflects a mechanism for evasion of neutralizing antibody responses elicited by previous papillomavirus ... but if these infections do not cause disease they can be used as a vaccine. PDB entry 6bt3 shows how antibodies surfaces attack ... doi:10.1016/j.vaccine.2006.05.115. PMID 16949995. Mistry N, Wibom C, Evander M (October 2008). "Cutaneous and mucosal human ...

May 2021). "Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection". ... Vaccine" at ClinicalTrials.gov "Combination of the first component of Sputnik V vaccine (Sputnik Light vaccine) with vaccines ... Russian COVID-19 vaccines, Science and technology in Russia, Viral vector vaccines, Gamaleya Research Institute of Epidemiology ... It consists of the first dose of the Sputnik V vaccine, which is based on the Ad26 vector, and it can be stored at a normal ...

So, while some of the antibodies and T cell clones made against earlier versions of the virus, or against the vaccines may not ... As of December 2021, most monoclonal antibodies had lost in vitro neutralizing activity against Omicron, with only 3 out of 29 ... June 2022). "Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney ... December 2021). "Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift". bioRxiv. 602 (7898). doi:10.1038 ...

... therefore this vaccine is a DNA based vaccine. This results in the production of antibodies against the ZP, which stop the ... The anti-hCG antibodies generated were capable of neutralizing the biological activity of hCG. Without active hCG, maintenance ... One approach is a vaccine designed to inhibit the fusing of spermatozoa to the zona pellucida. This vaccine has been tested in ... an experimental vaccine consisting of a dimer of β-hCG, with the tetanus toxoid (TT) as an adjuvant, produced antibodies ...

This monoclonal antibody binds to all of six well characterized broadly neutralizing anti-HIV antibodies. A vaccine concept ... A suitable anti-anti-HIV antibody envisaged for use in this vaccine is the monoclonal antibody 1F7, which was discovered by ... The vaccine concept comprised complexes of an anti-anti-HIV antibody and an HIV antigen, and was designed to induce the ... A hypothetical HIV vaccine concept based on immune network theory has been described. The vaccine concept was based on a ...

HA head-based methods such as computationally optimized broadly neutralizing antigens, anti-idiotypic antibodies, and vaccines ... neutralizing the virus. In humans, a sizeable antibody response occurs ~1 week after viral exposure. This antibody response is ... Two types of vaccines are in use: inactivated vaccines that contain "killed" (i.e. inactivated) viruses and live attenuated ... In general, influenza vaccines are only effective if there is an antigenic match between vaccine strains and circulating ...

Frontiers in Immunology A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective ... the preprint server for Biology A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and ... In 2020 he co-founded Phylex BioSciences, Inc., a company based in San Diego developing a universal vaccine against the severe ... In 2022 he published positive results of a protection study with the vaccine. In 1999, Brandys was awarded Outstanding Service ...

... derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates". ... He is known for developing various therapeutics and vaccines, such as saRNA COVID-19 vaccine, influenza vaccine, and ... An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman ... The vaccine recently was shown to be the first new TB vaccine with significant efficacy. While working with GSK, he was also ...

... is naturally attenuated and induces neutralizing antibodies to tick-borne encephalitis virus (TBEV) and protection against ... At the same time, another vaccine was tested, but the group vaccinated with the LGTV-based vaccine had the lowest level of ... In the 1970s a live attenuate LGTV-based vaccine against tick-borne encephalitis was made. ... "Study of the distant consequences of immunizing people with a live vaccine against tick-borne encephalitis". Tr Inst Im Pastera ...

In a phase 1/2 clinical trial in Japan, the developers concluded reactions to the vaccine were mild, and neutralizing ... although neutralizing antibodies against the Omicron variant were reduced. ... Japanese COVID-19 vaccines, Protein subunit vaccines, All stub articles, COVID-19 vaccine stubs, Vaccine stubs). ... "Safety and Immunogenicity of an Intranasal RSV Vaccine Expressing SARS-CoV-2 Spike Protein (COVID-19 Vaccine) in Adults". jrct. ...

Unless a gp120-based vaccine can be designed to elicit antibodies with strongly neutralizing antiviral properties, there is ... "Global Shape and Ligand Binding Efficiency of the HIV-1-neutralizing Antibodies Differ from Those of Antibodies That Cannot ... Many neutralizing antibodies bind to sites located in variable regions of gp120, so mutations in these regions will be selected ... While the transmitting host has developed a neutralizing antibody response to gp120, the newly infected host lacks immune ...

The antibody has been refined in order to remove any excess, unstable mutations that could negatively affect its neutralising ... Universal flu vaccine Gallagher, James (29 July 2011). "'Super antibody' fights off flu". BBC. "Scientists hail the prospect of ... Science Magazine: A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A ... Chan AL (28 July 2011). "Universal Flu Vaccine On The Horizon: Researchers Find 'Super Antibody'". Huff Post. Corti, D; Voss, J ...