Uromodulin
... may act as a constitutive inhibitor of calcium crystallization in renal fluids. The excretion of uromodulin in urine ... Uromodulin consists of an EGF domain (EGF I); two calcium-binding EGF domains (EGF II, III); a cysteine-rich decoy module ... Uromodulin is the most abundant protein excreted in ordinary urine. The human UMOD gene is located on chromosome 16. While ... Uromodulin (UMOD), also known as Tamm-Horsfall protein (THP), is a Zona pellucida-like domain-containing glycoprotein that in ...
Medullary cystic kidney disease
In uromodulin kidney disease (UKD), individuals have one normal and one abnormal UMOD gene. The abnormal (mutated) gene ... "uromodulin-associated kidney disease". Genetics Home Reference. Retrieved 2016-06-15. Kirby, A. (Mar 2013). "Mutations causing ... The genes produce the protein mucin-1 and uromodulin, respectively. These proteins are expressed only in certain cells in the ... uromodulin kidney disease (UKD). The diagnosis of medullary cystic kidney disease can be done via a physical exam. Further ...
Zona pellucida-like domain
The first 3D structure of a ZP module protein filament, native human uromodulin (UMOD), was determined by cryo-EM. Additional ... "Cryo-EM structure of native human uromodulin, a zona pellucida module polymer". EMBO J. 39 (24): e106807. doi:10.15252/embj. ... "A structured interdomain linker directs self-polymerization of human uromodulin". Proc. Natl. Acad. Sci. U.S.A. 113 (6): 1552- ... "Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH". Nat. ...
Cryopyrin-associated periodic syndrome
"Uromodulin Triggers IL-1β-Dependent Innate Immunity via the NLRP3 Inflammasome". Journal of the American Society of Nephrology ...
Urine test strip
Uromodulin is routinely produced in the distal convoluted tube, and forms the matrix of casts. Traditional reagent strip ... Uromodulin produced by the renal tubular epithelial cells and proteins from prostatic, seminal, and vaginal secretions. ...
GP2 (gene)
"Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH". Nat. ...
Kidney
The highest expressed kidney specific protein is uromodulin, the most abundant protein in urine with functions that prevent ...
THP
... may refer to: Tamm-Horsfall protein (also known as uromodulin), a glycoprotein found in urine Tetrahydropalmatine, a plant ...
Crystallopathy
Paraproteins Amyloid beta peptides Amylin Transthyretin Alpha-synuclein Prions Uromodulin ASC speck complex Myoglobin Heme ...