Uridine phosphorylase
In enzymology, an uridine phosphorylase (EC 2.4.2.3) is an enzyme that catalyzes the chemical reaction uridine + phosphate ⇌ {\ ... Pontis H, Degerstedt G, Reichard P (1961). "Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor". Biochim. ... The systematic name of this enzyme class is uridine:phosphate alpha-D-ribosyltransferase. Other names in common use include ... PAEGE LM, SCHLENK F (1952). "Bacterial uracil riboside phosphorylase". Arch. Biochem. Biophys. 40 (1): 42-9. doi:10.1016/0003- ...
UPP1
Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene. It belongs to the uridine phosphorylase enzyme ... "Entrez Gene: UPP1 uridine phosphorylase 1". Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine ... 2002). "Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update". Biochim. ... 2006). "The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood ...
Vimentin
Russell RL, Cao D, Zhang D, Handschumacher RE, Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. ...
Deoxyuridine phosphorylase
The reaction is catalysed by EC 2.4.2.2, pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4 ... Yamada EW (1964). "The effect of cortisol administration on the activities of uridine and deoxyuridine phosphorylases of normal ... In enzymology, a deoxyuridine phosphorylase is an enzyme that catalyzes the chemical reaction 2'-deoxyuridine + phosphate ⇌ {\ ... thymidine phosphorylase. These enzymes belong to the family of glycosyltransferases, specifically the pentosyltransferases. ...
Pyrimidine phosphorylase
... may refer to: Thymidine phosphorylase Uridine phosphorylase This article includes a list of related ...
UDP-N-acetylglucosamine diphosphorylase
... uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and ... Strominger JL, Smith MS (1959). "Uridine diphosphoacetylglucosamine pyrophosphorylase". J. Biol. Chem. 234 (7): 1822-1827. doi: ... Pattabiraman TN, Bachhawat BK (June 1961). "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep ... Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine ...
UPH
... may refer to: Unpenthexium, an unsynthesized chemical element with atomic number 156 and symbol Uph Uridine phosphorylase, ...
Nucleotide salvage
The nucleotide salvage pathway requires distinct substrates: Uridine phosphorylase or pyrimidine-nucleoside phosphorylase ... Uridine kinase (aka uridine-cytidine kinase) can then phosphorylate the 5'-carbon of this nucleoside into uridine monophosphate ... Thymidine phosphorylase or pyrimidine-nucleoside phosphorylase adds 2-deoxy-alpha-D-ribose 1-phosphate to thymine, with thymine ... which converts them to uridine and deoxyuridine, respectively. Alternatively, uridine-cytidine kinase can phosphorylate them ...
Purine nucleoside phosphorylase
Thymidine can be phosphorylated by thymidine kinase (TK). Uridine can be phosphorylated by uridine kinase (UK). Cytidine can be ... Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase (EC 2.4.2.1) is an enzyme that in humans is encoded by ... Other names in common use include: inosine phosphorylase PNPase PUNPI PUNPII inosine-guanosine phosphorylase nucleotide ... phosphatase purine deoxynucleoside phosphorylase purine deoxyribonucleoside phosphorylase purine nucleoside phosphorylase ...
Uridine monophosphate synthase
... thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer". Prostate Cancer and Prostatic Diseases. 8 ... These two sites catalyze the last two steps of the de novo uridine monophosphate (UMP) biosynthetic pathway. After addition of ... The enzyme Uridine monophosphate synthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'- ... Traut TW, Jones ME (1996). Uracil metabolism--UMP synthesis from orotic acid or uridine and conversion of uracil to beta- ...
List of EC numbers (EC 2)
... purine-nucleoside phosphorylase EC 2.4.2.2: pyrimidine-nucleoside phosphorylase EC 2.4.2.3: uridine phosphorylase EC 2.4.2.4: ... pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase. EC 2.4.2.24: 1 ... 2-α-glucosylglycerol phosphorylase EC 2.4.1.333: 1,2-β-oligoglucan phosphorylase EC 2.4.1.334: 1,3-α-oligoglucan phosphorylase ... diacetylchitobiose phosphorylase EC 2.4.1.281: 4-O-β-D-mannosyl-D-glucose phosphorylase EC 2.4.1.282: 3-O-α-D-glucosyl-L- ...
Glycogen synthase
... catalyzes the conversion of the glucosyl (Glc) moiety of uridine diphosphate glucose (UDP-Glc) into glucose ... This structural property, among others, is shared with related enzymes, such as glycogen phosphorylase and other ... Buchbinder JL, Rath VL, Fletterick RJ (2001). "Structural relationships among regulated and unregulated phosphorylases". Annu ... Much research has been done on glycogen degradation through studying the structure and function of glycogen phosphorylase, the ...
List of MeSH codes (D08)
... purine-nucleoside phosphorylase MeSH D08.811.913.400.725.900 - thymidine phosphorylase MeSH D08.811.913.400.725.950 - uridine ... glycogen phosphorylase, brain form MeSH D08.811.913.400.450.460.400.186.124 - glycogen phosphorylase, liver form MeSH D08.811. ... phosphorylase b MeSH D08.811.913.400.450.460.400.374 - starch phosphorylase MeSH D08.811.913.400.450.460.750 - starch synthase ... phosphorylases MeSH D08.811.913.400.450.460.400.186 - glycogen phosphorylase MeSH D08.811.913.400.450.460.400.186.061 - ...
Cyclic nucleotide
... primarily focusing on the activity of glycogen phosphorylase in dog liver. Glycogen phosphorylase catalyzes the first step in ... The role of cyclic uridine monophosphate (cUMP) is even less well known. Discovery of cyclic nucleotides has contributed ... is required for the conversion of glycogen phosphorylase b to glycogen phosphorylase a. While investigating the action of ... Earl Sutherland investigated the effect of the hormones adrenaline and glucagon on glycogen phosphorylase, earning him the ...
Galactose epimerase deficiency
Walter JH, Roberts RE, Besley GT, Wraith JE, Cleary MA, Holton JB, MacFaul R (April 1999). "Generalised uridine diphosphate ... Maddaiah VT, Madsen NB (September 1966). "Kinetics of purified liver phosphorylase". J. Biol. Chem. 241 (17): 3873-81. doi: ... High galactose-1-phosphate levels have been shown to interfere with phosphoglucomutase, glycogen phosphorylase, UDP- ...
Glycogen branching enzyme
Baum H, Gilbert GA (May 1953). "A simple method for the preparation of crystalline potato phosphorylase and Q-enzyme". Nature. ... More specifically, during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become ... such as glycogen phosphorylase, with many terminal residues for rapid degradation. Branching also importantly increases the ...
Glycosidic bond
investigated use of cellobiose phosphorylase (CP) toward synthesis of alpha-glycosides in ionic liquids. The best condition for ... by being joined via a glycosidic bond to the phosphate group of a nucleotide such as uridine diphosphate (UDP), guanosine ... "Chemoenzymatic Synthesis of β-D Glucosides using Cellobiose Phosphorylase from Clostridium thermocellum". Advanced Synthesis & ...
Glucose 6-phosphate
Glucose 1-phosphate can then be combined with uridine triphosphate (UTP) to form UDP-glucose, driven by the hydrolysis of UTP, ... When the body needs glucose for energy, glycogen phosphorylase, with the help of an orthophosphate, can cleave away a molecule ...
Vidarabine
... deoxyribonucleoside phosphorylase, methyltransferase, or nucleoside phosphorylase, affording the corresponding 5'-phosphate, ... transesterification from ethylene carbonate to uridine accompanied by spontaneous intramolecular elimination of carbon dioxide ...
Glycogen
... phosphorylase is the primary enzyme of glycogen breakdown. For the next 8-12 hours, glucose derived from liver ... Energy for glycogen synthesis comes from uridine triphosphate (UTP), which reacts with glucose-1-phosphate, forming UDP-glucose ... Glycogen is cleaved from the nonreducing ends of the chain by the enzyme glycogen phosphorylase to produce monomers of glucose- ...
Regulatory enzyme
The most important groups that work as modifiers are phosphate, methyl, uridine, adenine and adenosine diphosphate ribosyl. ... regulation of glycogen phosphorylase). Each phosphate group contains two negative charges, so the addition of this group can ...
Tipiracil
... has been shown to inhibit SARS-CoV-2 Nsp15 and interacts with the uridine binding pocket of the enzyme's active site ... Tipiracil is a thymidine phosphorylase (TPase) inhibitor and inhibits degradation of trifluridine by inhibiting TPase, thus ... Tipiracil helps maintain the blood concentration of trifluridine by inhibiting the enzyme thymidine phosphorylase which ... "Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2" (PDF). bioRxiv. doi:10.1101/2020.06 ...
List of biomolecules
C5H4N4O3 Uridine Valine Valinomycin Vanabins Vasopressin Verruculogen Vitamins (in general) Vitamin A (retinol) Vitamin B ... Glycine Glycogen Glycogenin Glycogen synthase Glycogen phosphorylase Glycolic acid Glycolipid Glycoprotein Gonadotropin- ...
Floxuridine
Metabolism
The metabolism of glycogen is controlled by activity of phosphorylase, the enzyme that breaks down glycogen, and glycogen ... made by the sequential addition of monosaccharides by glycosyltransferase from a reactive sugar-phosphate donor such as uridine ... but activating phosphorylase. Insulin causes glycogen synthesis by activating protein phosphatases and producing a decrease in ...
Inborn errors of carbohydrate metabolism
... muscle glycogen phosphorylase) comes in two forms: form 'a' is phosphorylated by phosphorylase kinase, form 'b' is not ... is caused a lack of the enzyme uridine diphosphate galactose-4-epimerase which breaks down a byproduct of galactose. This type ... See Glycogen phosphorylase§Regulation). Mutations in the PRKAG2 gene have been traced to fatal congenital nonlysosomal cardiac ... GeneReviews: Phosphorylase Kinase Deficiency OMIM:GSD 9d OMIM:PRKAG2 Media related to Disorders of carbohydrate metabolism at ...
List of EC numbers (EC 3)
... uridine nucleosidase EC 3.2.2.4: AMP nucleosidase EC 3.2.2.5: NAD+ glycohydrolase EC 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP- ... phosphorylase) phosphatase EC 3.1.3.18: phosphoglycolate phosphatase EC 3.1.3.19: glycerol-2-phosphatase EC 3.1.3.20: ... phosphorylase EC 3.1.4.16: 2′,3′-cyclic-nucleotide 2′-phosphodiesterase EC 3.1.4.17: 3′,5′-cyclic-nucleotide phosphodiesterase ...