Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes ... Pickart CM (2001). "Mechanisms underlying ubiquitination". Annu. Rev. Biochem. 70: 503-33. doi:10.1146/annurev.biochem.70.1.503 ... mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725-32. doi:10.1046/j.1432- ...
Ben-Neriah Y (Jan 2002). "Regulatory functions of ubiquitination in the immune system". Nature Immunology. 3 (1): 20-6. doi: ... Pickart CM (2001). "Mechanisms underlying ubiquitination". Annual Review of Biochemistry. 70: 503-33. doi:10.1146/annurev. ... Protein ubiquitination and subsequent proteolysis and degradation by the proteasome are important mechanisms in the regulation ...
Phosphorylation and ubiquitination of Bim dependent on ERK caused Bim to be degraded in proteasomes. However, presence of ... Pickart, Cecile M. (June 2001). "Mechanisms Underlying Ubiquitination". Annual Review of Biochemistry. 70 (1): 503-533. doi: ... due to its previous ubiquitination. However, in cancer cells and CAFs, Snail1 degradation is prevented. One of the mechanisms ... the reversal process of ubiquitination, regulating the fate of ubiquitin-conjugated proteins. Based on its conserved catalytic ...
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Either by autoubiquitination or by ubiquitination of a cofactor, it is then responsible for directing the virions to the ... Fukuda-Kamitani T, Kamitani T (July 2002). "Ubiquitination of Ro52 autoantigen". Biochemical and Biophysical Research ...
Additionally, histone ubiquitination is related to genomic maintenance, as ubiquitination of histone H2AX is involved in DNA ... Ubiquitination of the H2A core histone typically represses gene expression as it prevents methylation at H3K4, while H2B ... Ubiquitination is a post-translational modification involving the addition of ubiquitin proteins onto target proteins. Histones ... "Histone Ubiquitination - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2021-12-02. Ikura T, Tashiro S, ...
Ubiquitination plays a central role in cell signaling that regulates processes including protein degradation and immunological ... Ubiquitination is a component of several immune responses. Without ubiquitin's proper functioning, the invasion of pathogens ... Trujillo, Marco; Shirasu, Ken (1 August 2010). "Ubiquitination in plant immunity". Current Opinion in Plant Biology. 13 (4): ... "Role of Ubiquitination in Plant Innate Immunity and Pathogen Virulence". Journal of Plant Biology. 53 (1): 10-18. doi:10.1007/ ...
STUB1 mediates the ubiquitination of the chaperone-bound client, which induces the recruitment of the autophagic ubiquitin ... Shaid S, Brandts CH, Serve H, Dikic I (January 2013). "Ubiquitination and selective autophagy". Cell Death Differ. 20 (1): 21- ...
... ubiquitination, triggered by K411-m1. Effects on biological progress - cell growth, inhibited, triggered by K411-m1. The effect ...
Ubiquitination occurs via the BRCA1 fusion protein and is abolished by zinc chelation. The enzyme activity of the fusion ... BARD1 is thought to be involved in the recognition and binding of protein targets for ubiquitination. It attaches to proteins ... Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (July 2003). "BRCA1-independent ubiquitination of FANCD2 ... The ring domain is an important element of ubiquitin E3 ligases, which catalyze protein ubiquitination. Ubiquitin is a small ...
Mono-ubiquitination is also required for interaction with the nuclease FAN1. FAN1 recruitment and its consequent activity ... Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (July 2003). "BRCA1-independent ubiquitination of FANCD2 ... Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (July 2003). "BRCA1-independent ubiquitination of FANCD2 ...
Ubiquitination has been observed to be most involved in the final stages of the connexin protein's lifecycle, regulating both ... The distinct effects of ubiquitination tend to vary widely, depending on the tissues and subcellular location where it occurs ... Leithe, Edward; Rivedal, Edgar (2007-11-14). "Ubiquitination of Gap Junction Proteins". Journal of Membrane Biology. 217 (1-3 ... Ubiquitination of Cx43 that is at the plasma membrane and organized into gap junctions will result in internalization, or ...
Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes ... Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (July 2003). "BRCA1-independent ubiquitination of FANCD2 ... Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000). "Activation of HIF1α ubiquitination by a ... It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor ...
It is responsible for the mono-ubiquitination of histone H2A at lysine 119, a modification commonly associated with ... Weake VM, Workman JL (March 2008). "Histone ubiquitination: triggering gene activity". Molecular Cell. 29 (6): 653-63. doi: ...
Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (Jul 2003). "BRCA1-independent ubiquitination of FANCD2 ...
Ubiquitination--more than two to tango". Science. 289 (5487): 2061-2. doi:10.1126/science.289.5487.2061. PMID 11032556. S2CID ... Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes ... 1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade". Science. 286 (5443): ...
Their activity is modified by many post translational activities, such as phosphorylation, ubiquitination, and acetylation. ... "Mdm2 induces mono-ubiquitination of FOXO4". PLOS ONE. 3 (7): e2819. Bibcode:2008PLoSO...3.2819B. doi:10.1371/journal.pone. ...
2003). "BRCA1-independent ubiquitination of FANCD2". Mol. Cell. 12 (1): 247-254. doi:10.1016/S1097-2765(03)00281-8. PMID ... "Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA". EMBO Reports. 21 (7): e50133. doi: ... "Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination". The EMBO Journal. 42 (3): e111898. doi: ...
2009). Ubiquitination and Death-receptor signaling. Death Receptors and Cognate Ligands in Cancer. Results Probl Cell Differ, ...
Song MS, Song SJ, Kim SY, Oh HJ, Lim DS (July 2008). "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by ... Brenkman AB, de Keizer PL, van den Broek NJ, Jochemsen AG, Burgering BM (2008). "Mdm2 induces mono-ubiquitination of FOXO4". ... and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes. Removing MDM2 simultaneously with the H2AK119 ... Several lysine residues in p53 C-terminus have been identified as the sites of ubiquitination, and it has been shown that p53 ...
Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquin-conjugating enzymes, ... Ubiquitination--more than two to tango". Science. 289 (5487): 2061-2. doi:10.1126/science.289.5487.2061. PMID 11032556. S2CID ... 1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade". Science. 286 (5443): ... Webster JM, Tiwari S, Weissman AM, Wojcikiewicz RJ (2003). "Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by ...
Ubiquitination of histone H2B in response to DNA damage is important for timely initiation of DNA repair. Ubiquitinase RNF20/ ... Histone ubiquitination in the DNA damage response. DNA Repair (Amst). 2017 Aug;56:92-101. doi: 10.1016/j.dnarep.2017.06.011. ... Acetylation and ubiquitination are examples of two post-translational modifications that affect the function of histone H2B in ... Acetylation, phosphorylation, and ubiquitination are the most common and most studied modifications of histone H2B. Histone H2B ...
2002). "Histone ubiquitination: a tagging tail unfolds?". BioEssays. 24 (2): 166-74. doi:10.1002/bies.10038. PMID 11835281. ...
Site specific ubiquitination of histone H2A has a role in the recruitment of DNA repair proteins to DNA double strand breaks ... Histone ubiquitination in the DNA damage response. DNA Repair (Amst). 2017 Aug;56:92-101. doi: 10.1016/j.dnarep.2017.06.011. ... In the DNA damage response, it is thought that ubiquitination of H2A by the BRCA1/BARD1 heterodimer promotes homologous ... recombination, and that ubiquitination of H2A by RNF168 protein promotes non-homologous end joining. H2A is coded by many genes ...
Yang WL, Zhang X, Lin HK (August 2010). "Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation ... The regulation could be related to ubiquitin function; proteins with ubiquitination type function were found to interact with ... Furthermore, multiple proteins were involved in ubiquitination. Some of the interacting yeast proteins with the higher ... ubiquitination, and ribosomes in the cytoplasm. The basis of these arguments is on the interaction data of human CXorf26 as ...
... promotes the skipping of exon 9 of the NUMB transcript, producing a NUMB isoform that causes ubiquitination followed by ... June 2014). "A COFRADIC protocol to study protein ubiquitination". Journal of Proteome Research. 13 (6): 3107-13. doi:10.1021/ ... July 2018). "UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites". Nature Structural & ...
In COS-1 monkey kidney cells transfected with mouse HAS2 and HAS3 plasmids, one site of ubiquitination is seen on the lysine at ... "The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination". Journal of Biological Chemistry. 285 ( ... HAS2 is regulated by dimerization and ubiquitination. ...
"Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI)". MBL International. Retrieved 2019-12-12. ScienceDirect - Cell ...
Song MS, Song SJ, Kim SY, Oh HJ, Lim DS (July 2008). "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by ... Carpentier I, Coornaert B, Beyaert R (October 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and ... Ott DE, Coren LV, Chertova EN, Gagliardi TD, Schubert U (December 2000). "Ubiquitination of HIV-1 and MuLV Gag". Virology. 278 ... "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Molecular Cell ...
HO-1 enzymes are degraded via ubiquitination. The enzyme has been the subject of extensive investigation into its regulatory ...