Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene. GRCh38: Ensembl release 89: ... "Entrez Gene: UBE3C ubiquitin protein ligase E3C". Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and ... 2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369- ...
Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 ... "Entrez Gene: Listerin E3 ubiquitin protein ligase 1". Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, ... Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase. Listerin is a component of the ribosome quality ... "A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration". Proceedings of ...
... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... Fang N, Fang D, Wang HY, Altman A, Liu YC (2002). "Regulation of immune responses by E3 ubiquitin-protein ligases". Curr. Dir. ... RING domain function in ubiquitin-protein ligases". Cell. 102 (4): 533-9. doi:10.1016/S0092-8674(00)00057-X. PMID 10966114. ... Cbl functions as an E3 ligase, and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's ...
E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 ( ... Harvey KF, Kumar S (1999). "Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular ... 3-4 WW protein-protein interaction domains, and a carboxyl-terminal catalytic HECT ubiquitin ligase domain. The C2 domain ... "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating ...
HECT domain E3 ubiquitin protein ligase 4 is a protein that in humans is encoded by the HECTD4 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: HECT domain E3 ubiquitin protein ligase 4". Retrieved 2016-10-24. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR ( ...
NFX1 is also a probable E3 ubiquitin-protein ligase. These enzymes are of interest as they have been shown to participate in 3 ... "Eyelid protein is key to allergy". BBC News. January 16, 2005. Retrieved April 1, 2010. CS1 maint: discouraged parameter (link ... This factor can bind DNA, RNA and protein via a reiterated RING finger motifs in the central domain of the polypeptide. The ... Ono SJ; Liou HC; Davidon R; Strominger JL; Glimcher LH (May 1991). "Human X-box-binding protein 1 is required for the ...
Chuang TH, Ulevitch RJ (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nature Immunology ... The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay ... After ligand binding, all TLRs apart from TLR3, interact with adaptor protein MyD88. Another adaptor protein, which is ... In that species it is a universal adapter protein as it is used by almost all TLRs (except TLR 3) to activate the transcription ...
... a gene encoding an E3 ubiquitin-protein ligase, was identified as the most likely candidate gene, with two protein-truncating ... "Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2". Nature Cell Biology. 5 (4): 336-40. doi:10.1038/ ... "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins". FEBS Letters. 580 ... The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at ...
E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene. In a study identifying genes in rat ... Araki T, Milbrandt J (2003). "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases". J. Neurosci. 23 (28): ... indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family. ... 2002). "Regulation of immune responses by E3 ubiquitin-protein ligases". In Altman A (ed.). Signal Transduction Pathways in ... 2001). "Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells". J. Biol. ... 1997). "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation". Oncogene ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases ... F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. Members of the F-box protein ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene. Members of the F-box protein family, such as ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene. Members of the F-box protein family, such as ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... the F-box protein FBXO31, a candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various ...
E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene. The protein encoded by this gene ... This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of ... This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in ... 2007). "Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce ...
Joazeiro CA, Weissman AM (2000). "RING finger proteins: mediators of ubiquitin ligase activity". Cell. 102 (5): 549-52. doi: ... This protein domain contains from 40 to 60 amino acids. Many proteins containing a RING finger play a key role in the ... They bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger ... Brown RS (2005). "Zinc finger proteins: getting a grip on RNA". Curr. Opin. Struct. Biol. 15 (1): 94-8. doi:10.1016/j.sbi. ...
2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene. GRCh38: Ensembl release 89: ENSG00000037042 - ...
Cullin-7 acts as scaffold protein in the E3 ubiquitin ligase complex. The role of this complex is to tag damaged and excess ... in the CUL7 gene blocks the ability of the cullin-7 protein to bring together the components of this E3 ubiquitin ligase ... This ubiquitin-proteasome system acts as the cell's quality control system by breaking down unwanted proteins. Additionally, ... Once attached to the protein, ubiquitin serves as a signaling molecule to the proteasomes, which then bind to the ubiquinated ...
2004). "Np95 is a histone-binding protein endowed with ubiquitin ligase activity". Mol. Cell. Biol. 24 (6): 2526-35. doi: ... Histone H2B type 1-B is a protein that in humans is encoded by the HIST1H2BB gene. Histones are basic nuclear proteins that are ...
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating ... The human protein Mitochondrial E3 ubiquitin protein ligase 1 is ~40 kDa in size and composed of 352 amino acids. The ... Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. ... "Entrez Gene: MUL1 mitochondrial E3 ubiquitin protein ligase 1". Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, ...
... which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It ... E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene. The protein encoded by this gene ... is a membrane-bound ubiquitin ligase". Journal of Cell Science. 114 (Pt 10): 1949-57. PMID 11329381. Pouly S, Prat A, Blain M, ... "Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1". The Journal of ...
identical protein binding. • ubiquitin protein ligase binding. • p53 binding. • SUMO transferase activity. • ubiquitin-protein ... protein N-terminus binding. • ubiquitin protein ligase activity. • NEDD8 ligase activity. • disordered domain specific binding ... Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by ... E3 ligase activity[edit]. The E3 ubiquitin ligase MDM2 is a negative regulator of the p53 tumor suppressor protein. MDM2 binds ...
E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene. PJA1 has been shown to interact ... Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase ... "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx- ... "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx- ...
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HACE1 ... This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific ... "Entrez Gene: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1". Retrieved 2018-07-11. Anglesio MS, ... "Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus ...
Yogosawa S, Miyauchi Y, Honda R, Tanaka H, Yasuda H (March 2003). "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase ... 2003). "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase". Biochem. Biophys. Res. Commun. 302 (4): 869-72. doi: ... Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in ... 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent ...
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin- ... "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". ... "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". ... a newly identified ubiquitin protein ligase, in lung cancer". Journal of the National Cancer Institute. 96 (22): 1718-21. doi: ...
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. SMURF2 has been shown to interact ... "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2". Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K ... Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in ... an E3 ubiquitin ligase". Proceedings of the National Academy of Sciences of the United States of America. 98 (3): 974-9. doi: ...
The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating ... E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene. This gene encodes a cytoplasmic ... Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): ... an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495-502. doi:10.1038/ni1066. ISSN 1529- ...
E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. This gene encodes a ubiquitin ... "Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1". Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 ... Overview of all the structural information available in the PDB for UniProt: Q9HCE7 (E3 ubiquitin-protein ligase SMURF1) at the ... ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein ...
... ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin- ... Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene. The modification of proteins with ... Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): ... "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins ...
... specificity is gained by coupling targeted proteins to an "E3 ubiquitin ligase". Each E3 ubiquitin ligase binds to a particular ... Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others - ... The protein balance at time of dormancy is also maintained by lower levels of protein breakdown during the winter time. At ... Furthermore, 1 gram of nitrogen is roughly equivalent to 6 gram of protein, and 1 gram of protein is roughly equivalent to 4 ...
"Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated ... Caltagarone J، Rhodes J، Honer WG، Bowser R (August 1998). "Localization of a novel septin protein, hCDCrel-1, in neurons of ... Hsu SC، Hazuka CD، Roth R، Foletti DL، Heuser J، Scheller RH (June 1998). "Subunit composition, protein interactions, and ... v2 is a parkin-binding protein". Brain Research. Molecular Brain Research. 117 (2): 179-89. PMID 14559152. doi:10.1016/S0169- ...
Wnt-protein binding. • protein binding. • protein kinase binding. • ubiquitin protein ligase binding. • transmembrane signaling ... gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed ... G-protein coupled receptor activity. Cellular component. • clathrin-coated endocytic vesicle membrane. • Golgi apparatus. • ... Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[5][6][7] ...
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. „Genes Dev.". 22 (18 ... Towards a proteome-scale map of the human protein-protein interaction network. „Nature". 437 (7062), s. 1173-8, 2005. DOI: ... a b Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H. TOK-1, a novel p21Cip1-binding protein that ... Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. „Mol. Cell. Biol.". 19 (1), s. 635-45, 1999. PMID: ...
ubiquitin protein ligase binding. • ‏GO:1904264، ‏GO:1904822، ‏GO:0090622، ‏GO:0090302 ubiquitin protein ligase activity. ... protein transport. • positive regulation of protein binding. • positive regulation of protein phosphorylation. • lysosome ... ubiquitin-like protein transferase activity. • ‏GO:0001948 ربط بروتيني. • ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ...
Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin ... ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase". Nature. 428 (6979): 190-3. doi:10.1038/nature02330. PMID 15014502.. ... Ubiquitin-receptor proteins have an N-terminal ubiquitin-like (UBL) domain and one or more ubiquitin-associated (UBA) domains. ... The protein degradation processEdit. Ribbon diagram of ubiquitin, the highly conserved protein that serves as a molecular tag ...
Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... a b Proto-Oncogene+Proteins+c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) ... Hannink M, Donoghue DJ (1989). "Structure and function of platelet-derived growth factor (PDGF) and related proteins". Biochim ... The first engineered dominant negative protein was designed to inhibit PDGF [29] ...
... inhibiting the activity of the E3 ubiquitin ligase, resulting in accumulation of the ligase substrates and downregulation of ... Cereblon is a 51 kDa protein localized in the cytoplasm, nucleus and peripheral membrane of cells in numerous parts of the body ... It acts as a component of the E3 ubiquitin ligase, regulating various developmental processes, including embryogenesis, ... Further anti-tumor activity is mediated through the inhibition of apoptosis protein-2 and pro-survival effects of IGF-1, ...
Long-chain-fatty-acid-CoA ligase. 6.3: Carbon-Nitrogen. *Glutamine synthetase. *Ubiquitin ligase *Cullin ... McClain WH (November 1993). "Rules that govern tRNA identity in protein synthesis". Journal of Molecular Biology. 234 (2): 257- ... An aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto ... For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ...
protein binding. • cyclin-dependent protein serine/threonine kinase inhibitor activity. • ubiquitin protein ligase binding. • ... cyclin-dependent protein serine/threonine kinase activity. • protein kinase inhibitor activity. • protein kinase binding. • ... This article is about the p21Cip1 protein. For the p21/ras protein, see Ras (protein). For other uses, see P21 (disambiguation) ... p21 is negatively regulated by ubiquitin ligases both over the course of the cell cycle and in response to DNA damage. ...
Stage two involves four key Mur ubiquitin ligase enzymes: MurC (EC),[1] MurD (EC),[2] MurE (EC) [3] and MurF (EC).[4] These ... "Protein Sci. 14 (12): 3039-47. doi:10.1110/ps.051604805. PMC 2253247. PMID 16322581.. ... 6-diaminopimelate ligase (MurE), and UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF). This entry also includes ... All four Mur ligases are topologically similar to one another, even though they display low sequence identity. They are each ...
... ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin- ... ligase activity. • protein binding. • protein heterodimerization activity. • acid-amino acid ligase activity. • NEDD8 ... The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins ... ubiquitin-like modifier activating enzyme activity. • ATP binding. • identical protein binding. • NEDD8 transferase activity. • ...
"Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis". The Plant Journal. 34 (6): 753-67. doi: ... a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin ... Ubiquitin ligase. References[edit]. *^ Nandi D, Tahiliani P, Kumar A, Chandu D (2006). "The ubiquitin-proteasome system". ... Once conjugated to ubiquitin, the E2 molecule binds one of several ubiquitin ligases or E3s via a structurally conserved ...
protein binding. • cyclin-dependent protein kinase activating kinase activity. • cyclin binding. • ubiquitin protein ligase ... protein complex binding. • metal ion binding. Cellular component. • cyclin-dependent protein kinase holoenzyme complex. • ... regulation of protein import into nucleus, translocation. • cellular response to heat. • Fc-epsilon receptor signaling pathway ... Ras protein signal transduction. • negative regulation of cell proliferation. • fibroblast growth factor receptor signaling ...
Interaction with CHIP (Carboxyl-terminus of Hsp70 Interacting Protein)-an E3 ubiquitin ligase-allows Hsp70 to pass proteins to ... Binding immunoglobulin protein (BiP or Grp78) is a protein localized to the endoplasmic reticulum. It is involved in protein ... The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. ... The Hsp70 superfamily also includes a family of Hsp110/Grp170 (Sse) proteins, which are larger proteins related to Hsp70.[22] ...
protein binding. • ankyrin binding. • gamma-catenin binding. • beta-catenin binding. • GTPase activating protein binding. • ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ... Several proteins such as SNAI1/SNAIL,[58][59] ZFHX1B/SIP1,[60] SNAI2/SLUG,[61][62] TWIST1[63] and DeltaEF1[64] have been found ... identical protein binding. Cellular component. • cell-cell adherens junction. • apical junction complex. • trans-Golgi network ...
Ubiquitin ligases transfer ubiquitin to its pendant, proteins, and caspases, which engage in proteolysis in the apoptotic cycle ... Cysteine residues play a valuable role by crosslinking proteins, which increases the rigidity of proteins and also functions to ... which play an important role in the folding and stability of some proteins, usually proteins secreted to the extracellular ... Roles in protein structure[edit]. In the translation of messenger RNA molecules to produce polypeptides, cysteine is coded for ...
ubiquitin protein ligase activity. • apolipoprotein A-I receptor binding. • GTP-dependent protein binding. • GTPase activity. • ... protein binding. • thioesterase binding. • protein kinase binding. • nucleotide binding. • GTP binding. • identical protein ... "Protein Data Bank in Europe. EMBL-EBI. Retrieved 2016-04-22.. *^ "CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))" ... Cell division control protein 42 homolog, also known as Cdc42, is a protein involved in regulation of the cell cycle. It was ...
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. . In: J. Biol. Chem.. . 277, Nr. 24, 2002, S. 22085-92. doi: ... Das Histon H2AX ist ein Protein aus der Gruppe der Histone, das im Zellkern aller Eukaryoten vorkommt. Es stabilisiert die ... Residue-specific mass signatures for the efficient detection of protein modifications by mass spectrometry. . In: Anal. Chem. ...
K3 and K5 - ubiquitin E3 ligases - regulate antigen presentation K4 - vCCL2 - chemokine ... ORF36 - vPK - viral protein kinase with multiple roles in replication cycle ORF37 - SOX - dual function protein - DNase ... a G protein-coupled receptor, interferon regulatory factor and Flice inhibitory protein (FLIP), as well as DNA synthesis ... ORF45 - tegument protein, interacts with p90 ribosomal S6 kinases (RSKs) to modulate the ERK/RSK MAPK signaling pathway ...
... ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin- ... ubiquitin conjugating enzyme activity. • ubiquitin-protein transferase activity. • transferase activity. • protein binding. ... The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins ... protein K48-linked ubiquitination. • protein K11-linked ubiquitination. • regulation of growth. • protein ubiquitination. ...
ubiquitin protein ligase binding. • transcription regulatory region DNA binding. • ubiquitin-protein transferase activity. • ... The ring domain is an important element of ubiquitin E3 ligases, which catalyze protein ubiquitination. Ubiquitin is a small ... Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 (/ˌbrækəˈwʌn/) gene.[5] ... ubiquitin ligase complex. • plasma membrane. • nucleoplasm. • condensed chromosome. • cytoplasm. • chromosome. • cell nucleus. ...
Palmitoyl protein thioesterase. *Ubiquitin carboxy-terminal hydrolase L1. *4-hydroxybenzoyl-CoA thioesterase ... Glucose is then exported from the cell via glucose transporter membrane proteins.[1] This catalysis completes the final step in ... The transfer of the glucose 6-phosphate is carried out by a transporter protein (T1) and the endoplasmic reticulum (ER) ... Glucose 6-phosphatase is a complex of multiple component proteins, including transporters for G6P, glucose, and phosphate. The ...
Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986). „The protein substrate binding site of the ubiquitin-protein ligase ... Mechanism and role in protein-ubiquitin conjugation". J. Biol. Chem. 257: 2543-2548. PMID 6277905.. CS1 одржавање: Вишеструка ... ATP + ubikvitin + protein lizin ⇌. {\displaystyle \rightleftharpoons }. AMP + difosfat + protein N-ubikvitilizin. Ubikvitin je ... Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley- ...
... ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin- ... protein binding. • ATP binding. • ubiquitin conjugating enzyme activity. Cellular component. • cytosol. • ubiquitin ligase ... protein complex. • extracellular exosome. Biological process. • ubiquitin-dependent protein catabolic process. • protein ... "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157- ...
RCSB Protein Data Bank. Retrieved 2010-05-08.. *^ a b c d e Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T ... Long-chain-fatty-acid-CoA ligase. 6.3: Carbon-Nitrogen. *Glutamine synthetase. *Ubiquitin ligase *Cullin ... "Glutamine synthetase inactivation by protein-protein interaction". Proceedings of the National Academy of Sciences of the ... glutamate-ammonia ligase. Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding ...
protein kinase activity. • kinase activity. • protein binding. • protein tyrosine kinase activity. • ATP binding. • Ras guanyl- ... membrane protein proteolysis. • phosphorylation. • transmembrane receptor protein tyrosine kinase signaling pathway. • positive ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ...
... of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau E3 ubiquitin ligase ... In protein catabolism, proteins are broken down by proteases into their constituent amino acids. Their carbon skeletons (i.e. ... Evan M.W.Duo Click on genes, proteins and metabolites below to link to respective articles. [§ 1] ... Most organisms utilize EC 6.2.1.5, succinate-CoA ligase (ADP-forming) (despite its name, the enzyme operates in the pathway in ...
... more specifically ubiquitin protein ligases called E3, bind to the misfolded protein. Next they align the protein and E2, thus ... Parkin is a protein that functions in complex with CHIP as a ubiquitin ligase and overcomes the accumulation and aggregation of ... Most evidence suggest that the Hrd1 E3 ubiquitin-protein ligase can function as a retrotranslocon or dislocon to transport ... What is the channel for the retrotranslocation of luminal ER proteins?. *Which E3 ligase finally tags the proteins for the ...
COX-2 up-regulation has also been linked to the phosphorylation and activation of the E3 ubiquitin ligase HDM2, a protein that ...