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*  Adapter molecule crk
Ohashi Y, Tachibana K, Kamiguchi K, Fujita H, Morimoto C (1998). "T cell receptor-mediated tyrosine phosphorylation of Cas-L, a ... Angers-Loustau A, Côté JF, Charest A, Dowbenko D, Spencer S, Lasky LA, Tremblay ML (1999). "Protein tyrosine phosphatase-PEST ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ... Qiu W, Cobb RR, Scholz W (1998). "Inhibition of p130cas tyrosine phosphorylation by calyculin A". J. Leukoc. Biol. 63 (5): 631- ...
*  INPP5D
Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, Matsuda Y, Takai T (January 1998). "Association of tyrosine ... Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H (October 1997). "Tyrosine ... is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous ... and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells". Biochemical and Biophysical ...
*  CLEC4A
... a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol. 163 (4): 1973- ...
*  Lymphocyte cytosolic protein 2
Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T ... SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation ... The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated ... Wunderlich L, Faragó A, Downward J, Buday L (April 1999). "Association of Nck with tyrosine-phosphorylated SLP-76 in activated ...
*  Protein phosphatase
They contain the well-known classical receptor (a) and non-receptor PTPs (b), which are strictly tyrosine-specific, and the ... The CC1 fold is the most common, and includes tyrosine-specific (PTP), dual-specific (DSP) and even lipid-specific (PTEN) ... Ladbury JE (January 2007). "Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction". Acta ... Mendrola JM, Shi F, Park JH, Lemmon MA (2013). "Receptor tyrosine kinases with intracellular pseudokinase domains". Biochemical ...
*  CD20
"Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence ...
*  XB130
When tyrosine phosphorylated, XB130 has the ability to interact with the p85ɑ subunit of PI3K through its SH2 domains. This ... Several tyrosine phosphorylation sites and a proline rich sequence are included in the N-terminal region of XB130, which allows ... XB130 is a substrate and regulator of multiple tyrosine kinase-mediated signaling. XB130 is highly expressed in the thyroid and ...
*  Protein primary structure
Similar to phosphorylated tyrosines, sulfated tyrosines are used for specific recognition, e.g., in chemokine receptors on the ... The phosphorylated tyrosines are often used as "handles" by which proteins can bind to one another, whereas phosphorylation of ... sulfation Tyrosines may become sulfated on their O η {\displaystyle \mathrm {O^{\eta }} } atom. Somewhat unusually, this ... A phosphate group can be attached to the sidechain hydroxyl group of serine, threonine and tyrosine residues, adding a negative ...
*  Leukocyte receptor tyrosine kinase
... spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine ... Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene. The protein encoded by this gene is ... Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and ... "Entrez Gene: LTK leukocyte tyrosine kinase". Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, ...
*  GSK-3
Phosphorylation at tyrosine-216 in GSK-3β or tyrosine-279 in GSK-3α enhances the enzymatic activity of GSK-3, while ...
*  TNK2
ACK1 has been shown to directly phosphorylate AKT at tyrosine 176, AR at Tyrosine 267 and 363, and WWOX at tyrosine 287 ... TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL ... "Entrez Gene: TNK2 tyrosine kinase, non-receptor, 2". Mahajan NP, Liu Y, Majumder S, Warren MR, Parker CE, Mohler JL, Earp HS, ... 2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. ...
*  List of OMIM disorder codes
... response to tyrosine kinase inhibitor in; 211980; EGFR Nonsmall cell lung cancer, somatic; 211980; IRF1 Nonsmall cell lung ... response to tyrosine kinase inhibitor in; 211980; EGFR Adenocarcinoma of lung, somatic; 211980; BRAF Adenocarcinoma of lung, ... GALNT3 Tyrosine kinase 2 deficiency; 611521; TYK2 Tyrosinemia type II; 277660; TAT Tyrosinemia type III; 276710; HPD Ullrich ...
*  PTPRF
Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene. The protein encoded by ... "Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F". Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de ... Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine ... Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine- ...
*  Reactive nitrogen species
Another reaction is tyrosine nitration; however peroxynitrite does not react directly with tyrosine. Tyrosine reacts with other ...
*  Immunoglobulin V-set domain
... in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1). Immunoglobulin V-set, subgroup InterPro ...
*  Neurotransmitter
It is synthesized from tyrosine. Epinephrine which is also synthesized from tyrosine takes part in controlling the adrenal ... A few studies suggest potential antidepressant effects of L-phenylalanine and L-tyrosine, but there is much room for further ... AMPT prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine; reserpine prevents dopamine storage within ... L-phenylalanine and L-tyrosine are both precursors for dopamine, norepinephrine, and epinephrine. These conversions require ...
*  IL2RB
Torigoe T, Saragovi HU, Reed JC (1992). "Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell ... Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H, Taniguchi T (1995). "Protein tyrosine kinase Syk is ... Mills GB, May C, McGill M, Fung M, Baker M, Sutherland R, Greene WC (1990). "Interleukin 2-induced tyrosine phosphorylation. ... Kirken RA, Rui H, Evans GA, Farrar WL (1993). "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116- ...
*  Bioconjugation
Joshi, N.S.; Whitaker, L.R.; Francis, M.B. (2004). "A Three-Component Mannich-Type Reaction for Selective Tyrosine ... Specifically, diazonium effectively couples with tyrosine residues (diazonium salt shown as reagent in the first reaction in ... Ban, H.; Nagano, M.; Gavrilyuk, J.; Barbas, C.F. (2015). "Facile and Stabile Linkages through Tyrosine: Bioconjugation ... Recent development has shown that the tyrosine can be modified through electrophilic aromatic substitutions (EAS) reactions, ...
*  STAT5A
Phosphorylation of tyrosine 694 and glycosylation of threonine 92 are important for STAT5a activity. Mutation of serine 710 to ... Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 ... "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. 274 (24): ...
*  Targeted therapy
Many are tyrosine-kinase inhibitors. Imatinib mesylate (Gleevec, also known as STI-571) is approved for chronic myelogenous ... Gefitinib (Iressa, also known as ZD1839), targets the epidermal growth factor receptor (EGFR) tyrosine kinase and is approved ...
*  Protein kinase
Tyrosine-specific protein kinases (EC 2.7.10.1 and EC 2.7.10.2) phosphorylate tyrosine amino acid residues, and like serine/ ... Tyrosine kinases recruited to a receptor following hormone binding are receptor-associated tyrosine kinases and are involved in ... TK - containing the tyrosine kinases. TKL - containing the tyrosine-kinase like group of kinases. Serine/threonine protein ... Most kinases act on both serine and threonine (serine/threonine kinases), others act on tyrosine (tyrosine kinases), and a ...
*  STAT5B
Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 ...
*  Angiopoietin receptor
They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because ... pathway TIE Receptor Tyrosine Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) Jeltsch M, ... Leppanen VM, Saharinen P, Alitalo K (2013). "Receptor Tyrosine Kinase-Mediated Angiogenesis". Cold Spring Harbor Perspectives ... they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling. It is somewhat ...
*  ITPR1
Structure, localization, and tyrosine phosphorylation". The Journal of Biological Chemistry. 270 (6): 2833-40. doi:10.1074/jbc. ...
*  Angiogenesis
These receptors are tyrosine kinases. Thus, they can initiate cell signaling when ligand binding causes a dimerization that ... The FGF-receptor family is composed of seven members, and all the receptor proteins are single-chain receptor tyrosine kinases ... Binding to VEGF receptor-2 (VEGFR-2) starts a tyrosine kinase signaling cascade that stimulates the production of factors that ... Thurston G (October 2003). "Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis". ...