Tyrosine aminotransferase
... (or tyrosine transaminase) is an enzyme present in the liver and catalyzes the conversion of tyrosine ... Dietrich JB (April 1992). "Tyrosine aminotransferase: a transaminase among others?". Cellular and Molecular Biology. 38 (2): 95 ... L-tyrosine + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 4-hydroxyphenylpyruvate + L-glutamate In humans, the tyrosine ... and elevated blood tyrosine levels. Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals ...
Diiodotyrosine transaminase
Nakano M (January 1967). "Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney ... and halogenated tyrosine transaminase. It employs one cofactor, pyridoxal phosphate. ... The systematic name of this enzyme class is 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase. Other names in common use ... In enzymology, a diiodotyrosine transaminase (EC 2.6.1.24) is an enzyme that catalyzes the chemical reaction 3,5-diiodo-L- ...
Tyrosine
para-hydroxyphenylalanine) begins with an α-ketoglutarate dependent transamination through the tyrosine transaminase to para- ... It transforms L-tyrosine into p-coumaric acid.Tyrosine is also the precursor to the pigment melanin. Tyrosine (or its precursor ... Tyrosine residues may also be modified by the addition of a sulfate group, a process known as tyrosine sulfation. Tyrosine ... Tyrosine MS Spectrum Tyrosine metabolism Archived 2019-07-26 at the Wayback Machine Phenylalanine and tyrosine biosynthesis ...
Corneal dystrophy
... tyrosine transaminase deficiency, systemic lysosomal storage diseases, and several skin diseases (X-linked ichthyosis, ...
List of EC numbers (EC 2)
... alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC 2.6.1.5: tyrosine transaminase EC ... D-amino-acid transaminase EC 2.6.1.11: acetylornithine transaminase EC 2.6.1.12: alanine-oxo-acid transaminase EC 2.6.1.13: ... neamine transaminase EC 2.6.1.94: 2′-deamino-2′-hydroxyneamine transaminase EC 2.6.1.95: neomycin C transaminase EC 2.6.1.96: 4 ... UDP-N-acetylbacillosamine transaminase EC 2.6.1.35: glycine-oxaloacetate transaminase EC 2.6.1.36: L-lysine 6-transaminase EC ...
Transferase
In the case of aspartate transaminase, which can act on tyrosine, phenylalanine, and tryptophan, it reversibly transfers an ... This includes enzymes like transaminase (also known as "aminotransferase"), and a very small number of oximinotransferases and ... "transaminase"), was first noted in 1930 by Dorothy M. Needham, after observing the disappearance of glutamic acid added to ...
Dihydroxyphenylalanine transaminase
... phenylalanine-DOPP transaminase (PDT), DOPA 2-oxoglutarate aminotransferase, and DOPAATS. This enzyme participates in tyrosine ... aspartate-DOPP transaminase (ADT), L-dopa transaminase, dopa aminotransferase, glutamate-DOPP transaminase (GDT), ... In enzymology, a dihydroxyphenylalanine transaminase (EC 2.6.1.49) is an enzyme that catalyzes the chemical reaction 3,4- ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ...
Methionine transaminase
Heilbronn J, Wilson J, Berger BJ (March 1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in ... Methionine transaminase (EC 2.6.1.88, methionine-oxo-acid transaminase) is an enzyme with systematic name L-methionine:2-oxo- ... Methionine+transaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 2.6.1). ...
Histidinol-phosphate transaminase
This enzyme participates in 5 metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, ... Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, ... imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. ... In enzymology, a histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the chemical reaction L-histidinol ...
Aromatic-amino-acid transaminase
This enzyme participates in 6 metabolic pathways: methionine metabolism, tyrosine metabolism, phenylalanine metabolism, ... In enzymology, an aromatic-amino-acid transaminase (EC 2.6.1.57) is an enzyme that catalyzes the chemical reaction an aromatic ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... phenylalanine, tyrosine and tryptophan biosynthesis, novobiocin biosynthesis, and alkaloid biosynthesis i. It employs one ...
Glutamate-prephenate aminotransferase
In these animals, tyrosine is synthesized from phenylalanine via the enzyme phenylalanine hydroxylase, whereas plants have ... In enzymology, glutamate-prephenate aminotransferase (EC 2.6.1.79, also known as prephenate transaminase, PAT, and L-glutamate: ... This is a necessary process for any organism which needs to convert arogenate into phenylalanine or tyrosine, as arogenate is ... It operates in the phenylalanine and tyrosine biosynthesis pathway. The gene which encodes this enzyme has recently been ...
Phenylketonuria
... in particular tyrosine. Tyrosine is a conditionally essential amino acid for PKU patients because without PAH it cannot be ... Excessive phenylalanine can be metabolized into phenylketones through the minor route, a transaminase pathway with glutamate. ... Tyrosine, which is normally derived from phenylalanine and which is necessary for normal brain function, is usually ... Tetrahydrobiopterin is required to convert Phe to Tyr and is required to convert Tyr to L-DOPA via the enzyme tyrosine ...
ETV6
... adds and removes tyrosine residues on α-tubulin), GOT1 (an Aspartate transaminase), and ACSL6 (a Long-chain-fatty-acid-CoA ... It is proposed that tyrosine kinase inhibitors with specificity for NTRK3's tyrosine kinase activity in ETV6-NTRK3 gene- ... The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), ... the ETV6 gene fusion to receptor tyrosine kinases and non-receptor tyrosine kinases may be sensitive to therapy with tyrosine ...
4-Hydroxyphenylglycine
Tyrosine, a similar amino acid, differs by a methylene group (CH2) between the aromatic ring and the alpha carbon. HPG is ... Finally, 4-hydroxyphenylglycine transaminase (HpgT) transfers an ammonia moiety from a donor to 4-hydroxylbenzoylformate to ... Several different molecules can serve as the nitrogen donor for the transamination, however, Hubbard et al suspect L-tyrosine ... synthesized from prephenate, an intermediate in the shikimic acid pathway and also a precursor to tyrosine. Prephenate is ...
Angiokinase inhibitors
BIBW 2992 is a next-generation tyrosine kinase inhibitor developed by Boehringer Ingelheim which irreversibly blocks both ... BIBW 2992 was well tolerated, with reversible adverse events including rash, diarrhoea, elevations in transaminases. BIBW 2992 ... tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours". British Journal of Cancer. 98 (1 ... by targeting receptor tyrosine kinases. Examples include nintedanib (BIBF 1120), afatinib (BIBW 2992) and motesanib (AMG 706). ...
List of MeSH codes (D08)
... tryptophan transaminase MeSH D08.811.913.477.700.900 - tyrosine transaminase MeSH D08.811.913.555.150 - amidinotransferases ... glycine transaminase MeSH D08.811.913.477.700.535 - leucine transaminase MeSH D08.811.913.477.700.550 - l-lysine 6-transaminase ... transaminases MeSH D08.811.913.477.700.100 - alanine transaminase MeSH D08.811.913.477.700.120 - 2-aminoadipate transaminase ... receptor protein-tyrosine kinases MeSH D08.811.913.696.620.682.725.400.020 - fms-like tyrosine kinase 3 MeSH D08.811.913.696. ...
International Working Group on Neurotransmitter Related Disorders
The group studies deficiencies in aromatic amino acid decarboxylase, tyrosine hydroxylase, dopamine beta-hydroxylase, monoamine ... GABA-transaminase, and succinate-semialdehyde dehydroxylase. Opladen, T.; Cortes-Saladelafont, E.; Mastrangelo, M.; Horvath, G ...
Amino acid
Likewise, lysine, tyrosine and cysteine will typically act as a Brønsted acid. Histidine under these conditions can act both as ... This process involves transaminases, often the same as those used in amination during synthesis. In many vertebrates, the amino ... The oxidation pathway starts with the removal of the amino group by a transaminase; the amino group is then fed into the urea ... None of these amino acids' side chains ionize easily, and therefore do not have pKas, with the exception of tyrosine (Tyr, Y). ...
Biochemistry
Enzymes called transaminases can easily transfer the amino group from one amino acid (making it an α-keto acid) to another α- ... and tyrosine, the nonessential amino acids. While they can synthesize arginine and histidine, they cannot produce it in ...
Diiodotyrosine
... transaminase Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein ... Iodinated tyrosine derivatives, All stub articles, Organohalide stubs). ...
Cabozantinib
It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. It was discovered and ... elevated transaminases, higher cholesterol levels, and loss of red and white blood cells. Common adverse effects (between 1% ... Cabozantinib inhibits the following receptor tyrosine kinases: MET (hepatocyte growth factor receptor protein) and VEGFR, RET, ... GAS6 receptor (AXL), KIT), and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib was granted orphan drug status by the US Food ...
Colony stimulating factor 1 receptor
Many proteins become tyrosine phosphorylated in response to CSF1R signaling (Table 1) including p85, Cbl, and Gab3 which are ... alanine transaminase), edema, nausea, lacrimation, and reduced appetite, but no signs of liver toxicity were found. There are ... CSF1R, the protein encoded by the CSF1R gene is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor ... The cytoplasmic domain has a juxtamembrane domain and tyrosine kinase domain that is interrupted by a kinase insert domain. At ...
Amino acid synthesis
Tyrosine can also be inhibited at the transcriptional level by the TyrR repressor. TyrR binds to the TyrR boxes on the operon ... The genes that encode both the dihydroxy acid dehydrase used in the creation of α-ketoisovalerate and Transaminase E, as well ... Tyrosine and phenylalanine are biosynthesized from prephenate, which is converted to an amino acid-specific intermediate. This ... Phenylalanine, tyrosine, and tryptophan, the aromatic amino acids, arise from chorismate. The first step, condensation of 3- ...
Enzyme promiscuity
An example of a commonly evolved enzyme is ω-transaminase which can replace a ketone with a chiral amine and consequently ... Protein tyrosine phospatase(PTP) and human carbonic anhydrase II (CAII)) has shown the main activity is "robust" towards change ... Shin JS, Kim BG (August 2001). "Comparison of the omega-transaminases from different microorganisms and application to ... whereas the next most catalysed native amino acid was the structurally similar tyrosine, but at a thousandth as much as ...
Ruxolitinib
Laboratory abnormalities have included alanine transaminase (ALT) abnormalities, aspartate transaminase (AST) abnormalities, ... Clinical trial number NCT03610971 for "Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase ... Non-receptor tyrosine kinase inhibitors, Pyrrolopyrimidines, Pyrazoles, Nitriles, Cyclopentanes, Novartis brands, Orphan drugs) ... "Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors".[full citation needed][ ...
Chromosome 12
... protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) PUS1: encoding enzyme tRNA pseudouridine synthase A ... encoding protein Branched chain amino acid transaminase 1 C12orf24: encoding protein FAM216A C12orf42: encoding protein ...
Index of oncology articles
... serum glutamate pyruvate transaminase - Serum glutamic oxaloacetic transaminase - serum tumor marker test - sesquiterpene ... tyrosine kinase inhibitor - TZT-1027 ubiquinone - UCN-01 - UGT1A1 - ultrasonogram - ultrasonography - ultrasound-guided biopsy- ... aspartate transaminase - aspergillosis - Aspergillus - asthenia - astrocyte - astrocytoma - asymptomatic - atamestane - ataxia ...
Enzyme catalysis
Enzymes utilizing such cofactors include the PLP-dependent enzyme aspartate transaminase and the TPP-dependent enzyme pyruvate ... tyrosine, lysine and arginine, as well as serine and threonine. In addition, the peptide backbone, with carbonyl and amide N ...
List of EC numbers (EC 5)
... tyrosine 2,3-aminomutase EC 5.4.3.7: leucine 2,3-aminomutase EC 5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase EC 5.4.3.9: ... glutamine-fructose-6-phosphate transaminase (isomerizing) EC 5.3.1.20: ribose isomerase EC 5.3.1.21: corticosteroid side-chain- ...
Pyridoxal phosphate
In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine ... generally tyrosine (which may also partake in the acid-base catalysis). Despite the limited requirements for a PLP binding ... liver cysteine desulfhydrase activity disappears and serine and threonine dehydrase and alanine glutamate transaminase ...