In the case of aspartate transaminase, which can act on tyrosine, phenylalanine, and tryptophan, it reversibly transfers an ... This includes enzymes like transaminase (also known as "aminotransferase"), and a very small number of oximinotransferases and ... "transaminase"), was first noted in 1930 by D. M. Needham, after observing the disappearance of glutamic acid added to pigeon ...
... or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L- ... Tyrosine hydroxylase catalyzes the reaction in which L-tyrosine is hydroxylated in the meta position to obtain L-3,4- ... Tyrosine hydroxylase can be inhibited by the drug α-methyl-para-tyrosine (metirosine). This inhibition can lead to a depletion ... Tyrosine hydroxylase catalyzes conversion of tyrosine to L-DOPA using Fe2+, O2 and BH4 ...
2.6 GABA transaminase. *2.7 Nucleotidyltransferase *Integrase. *Reverse transcriptase. *Protein kinase *Tyrosine kinase *Janus ... A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes ... Levitzki A, Mishani E (2006). "Tyrphostins and other tyrosine kinase inhibitors". Annu Rev Biochem. 75: 93-109. doi:10.1146/ ... Crystal structure of the second generation Bcr-Abl tyrosine-kinase inhibitor nilotinib (red) in complex with an Abl kinase ...
... tyrosine transaminase deficiency, systemic lysosomal storage diseases, and several skin diseases (X-linked ichthyosis, ...
... alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC 2.6.1.5: tyrosine transaminase EC ... neamine transaminase EC 2.6.1.94: 2'-deamino-2'-hydroxyneamine transaminase EC 2.6.1.95: neomycin C transaminase EC 2.6.1.96: 4 ... 6-trideoxyglucose transaminase EC 2.6.1.35: glycine-oxaloacetate transaminase EC 2.6.1.36: L-lysine 6-transaminase EC 2.6.1.37 ... glutamine-phenylpyruvate transaminase EC 2.6.1.65: N6-acetyl-b-lysine transaminase EC 2.6.1.66: valine-pyruvate transaminase EC ...
para-hydroxyphenylalanine) begins with an α-ketoglutarate dependent transamination through the tyrosine transaminase to para- ... Tyrosine MS Spectrum Tyrosine metabolism Phenylalanine and tyrosine biosynthesis Phenylalanine, Tyrosine, and tryptophan ... Tyrosine residues may also be modified by the addition of a sulfate group, a process known as tyrosine sulfation. Tyrosine ... It transforms L-tyrosine into p-coumaric acid. Tyrosine is also the precursor to the pigment melanin. Tyrosine (or its ...
... (or tyrosine transaminase) is an enzyme present in the liver and catalyzes the conversion of tyrosine ... L-tyrosine + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 4-hydroxyphenylpyruvate + L-glutamate In humans, the tyrosine ... "Tyrosine aminotransferase: a transaminase among others?". Cellular and molecular biology. 38 (2): 95-114. PMID 1349265. ... and elevated blood tyrosine levels. Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals ...
... phenylalanine-DOPP transaminase (PDT), DOPA 2-oxoglutarate aminotransferase, and DOPAATS. This enzyme participates in tyrosine ... aspartate-DOPP transaminase (ADT), L-dopa transaminase, dopa aminotransferase, glutamate-DOPP transaminase (GDT), ... In enzymology, a dihydroxyphenylalanine transaminase (EC 2.6.1.49) is an enzyme that catalyzes the chemical reaction 3,4- ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ...
Heilbronn, J.; Wilson, J.; Berger, B.J. (1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in ... Methionine transaminase (EC 2.6.1.88, methionine-oxo-acid transaminase) is an enzyme with systematic name L-methionine:2-oxo- ... Methionine transaminase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ...
Nakano M (1967). "Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney ... and halogenated tyrosine transaminase. It employs one cofactor, pyridoxal phosphate. ... The systematic name of this enzyme class is 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase. Other names in common use ... In enzymology, a diiodotyrosine transaminase (EC 2.6.1.24) is an enzyme that catalyzes the chemical reaction 3,5-diiodo-L- ...
This enzyme participates in 5 metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, ... Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, ... imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. ... In enzymology, a histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the chemical reaction L-histidinol ...
This enzyme participates in 6 metabolic pathways: methionine metabolism, tyrosine metabolism, phenylalanine metabolism, ... In enzymology, an aromatic-amino-acid transaminase (EC 2.6.1.57) is an enzyme that catalyzes the chemical reaction an aromatic ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... phenylalanine, tyrosine and tryptophan biosynthesis, novobiocin biosynthesis, and alkaloid biosynthesis i. It employs one ...
In these animals, tyrosine is synthesized from phenylalanine via the enzyme phenylalanine hydroxylase, whereas plants have ... In enzymology, glutamate-prephenate aminotransferase (EC 2.6.1.79, also known as prephenate transaminase, PAT, and L-glutamate: ... This is a necessary process for any organism which needs to convert arogenate into phenylalanine or tyrosine, as arogenate is ... It operates in the phenylalanine and tyrosine biosynthesis pathway. The gene which encodes this enzyme has recently been ...
Tyrosine aminotransferase. *Kynurenine-oxoglutarate transaminase. *Ornithine aminotransferase. *Branched-chain amino acid ... In enzymology, a beta-alanine-pyruvate transaminase (EC 2.6.1.18) is an enzyme that catalyzes the chemical reaction ... Other names in common use include beta-alanine-pyruvate aminotransferase, and beta-alanine-alpha-alanine transaminase. This ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ...
... adds and removes tyrosine residues on α-tubulin), GOT1 (an Aspartate transaminase), and ACSL6 (a Long-chain-fatty-acid-CoA ... It is proposed that tyrosine kinase inhibitors with specificity for NTRK3's tyrosine kinase activity in ETV6-NTRK3 gene- ... The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), ... the ETV6 gene fusion to receptor tyrosine kinases and non-receptor tyrosine kinases may be sensitive to therapy with tyrosine ...
... in particular tyrosine. Tyrosine is a conditionally essential Amino acid for PKU patients because without PAH it cannot be ... Excessive phenylalanine can be metabolized into phenylketones through the minor route, a transaminase pathway with glutamate. ... Tyrosine, which is normally derived from phenylalanine and which is necessary for normal brain function, is usually ... Tetrahydrobiopterin is required to convert Phe to Tyr and is required to convert Tyr to L-DOPA via the enzyme tyrosine ...
para-hydroxyphenylalanine) begins with an α-ketoglutarate dependent transamination through the tyrosine transaminase to para- ... Tyrosine residues may also be modified by the addition of a sulfate group, a process known as tyrosine sulfation.[7] Tyrosine ... namely meta-tyrosine (also known as 3-hydroxyphenylalanine, L-m-tyrosine, and m-tyr) and ortho-tyrosine (o-tyr or 2- ... It transforms L-tyrosine into p-coumaric acid. Precursor to pigmentsEdit. Tyrosine is also the precursor to the pigment melanin ...
2.6 GABA transaminase. *2.7 Nucleotidyltransferase *Integrase. *Reverse transcriptase. *Protein kinase *Tyrosine-kinase *Janus ...
2.6 GABA transaminase. *2.7 Nucleotidyltransferase *Integrase. *Reverse transcriptase. *Protein kinase *Tyrosine-kinase *Janus ...
2.6 GABA transaminase. *2.7 Nucleotidyltransferase *Integrase. *Reverse transcriptase. *Protein kinase *Tyrosine kinase *Janus ...
2.6 GABA transaminase. *2.7 Nucleotidyltransferase *Integrase. *Reverse transcriptase. *Protein kinase *Tyrosine-kinase *Janus ...
2.6 GABA transaminase. *2.7 Nucleotidyltransferase *Integrase. *Reverse transcriptase. *Protein kinase *Tyrosine-kinase *Janus ...
BIBW 2992 is a next-generation tyrosine kinase inhibitor developed by Boehringer Ingelheim which irreversibly blocks both ... BIBW 2992 was well tolerated, with reversible adverse events including rash, diarrhoea, elevations in transaminases. BIBW 2992 ... tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours". British Journal of Cancer. 98 (1 ... by targeting receptor tyrosine kinases. Examples include nintedanib (BIBF 1120), afatinib (BIBW 2992) and motesanib (AMG 706). ...
Enzymes called transaminases can easily transfer the amino group from one amino acid (making it an α-keto acid) to another α- ... and tyrosine, the nonessential amino acids. While they can synthesize arginine and histidine, they cannot produce it in ...
... tryptophan transaminase MeSH D08.811.913.477.700.900 --- tyrosine transaminase MeSH D08.811.913.555.150 --- amidinotransferases ... receptor protein-tyrosine kinases MeSH D08.811.913.696.620.682.725.400.020 --- fms-like tyrosine kinase 3 MeSH D08.811.913.696. ... protein-tyrosine kinase MeSH D08.811.913.696.620.682.725.049 --- focal adhesion protein-tyrosine kinases MeSH D08.811.913.696. ... leucine transaminase MeSH D08.811.913.477.700.550 --- l-lysine 6-transaminase MeSH D08.811.913.477.700.700 --- ornithine-oxo- ...
... tyrosine transaminase deficiency, systemic lysosomal storage diseases, and several skin diseases (X-linked ichthyosis, ...