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*  Diiodotyrosine transaminase
Nakano M (1967). "Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney ... and halogenated tyrosine transaminase. It employs one cofactor, pyridoxal phosphate. ... The systematic name of this enzyme class is 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase. Other names in common use ... In enzymology, a diiodotyrosine transaminase (EC 2.6.1.24) is an enzyme that catalyzes the chemical reaction 3,5-diiodo-L- ...
*  Tyrosine aminotransferase
... (or tyrosine transaminase) is an enzyme present in the liver and catalyzes the conversion of tyrosine ... L-tyrosine + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 4-hydroxyphenylpyruvate + L-glutamate In humans, the tyrosine ... "Tyrosine aminotransferase: a transaminase among others?". Cellular and molecular biology. 38 (2): 95-114. PMID 1349265. ... and elevated blood tyrosine levels. Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals ...
*  Tyrosine
para-hydroxyphenylalanine) begins with an α-ketoglutarate dependent transamination through the tyrosine transaminase to para- ... Tyrosine MS Spectrum Tyrosine metabolism Phenylalanine and tyrosine biosynthesis Phenylalanine, Tyrosine, and tryptophan ... Tyrosine residues may also be modified by the addition of a sulfate group, a process known as tyrosine sulfation. Tyrosine ... It transforms L-tyrosine into p-coumaric acid. Tyrosine is also the precursor to the pigment melanin. Tyrosine (or its ...
*  Corneal dystrophy
... tyrosine transaminase deficiency, systemic lysosomal storage diseases, and several skin diseases (X-linked ichthyosis, ...
*  List of EC numbers (EC 2)
... alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC 2.6.1.5: tyrosine transaminase EC ... neamine transaminase EC 2.6.1.94: 2'-deamino-2'-hydroxyneamine transaminase EC 2.6.1.95: neomycin C transaminase EC 2.6.1.96: 4 ... 6-trideoxyglucose transaminase EC 2.6.1.35: glycine-oxaloacetate transaminase EC 2.6.1.36: L-lysine 6-transaminase EC 2.6.1.37 ... glutamine-phenylpyruvate transaminase EC 2.6.1.65: N6-acetyl-b-lysine transaminase EC 2.6.1.66: valine-pyruvate transaminase EC ...
*  Transferase
In the case of aspartate transaminase, which can act on tyrosine, phenylalanine, and tryptophan, it reversibly transfers an ... This includes enzymes like transaminase (also known as "aminotransferase"), and a very small number of oximinotransferases and ... "transaminase"), was first noted in 1930 by D. M. Needham, after observing the disappearance of glutamic acid added to pigeon ...
*  Dihydroxyphenylalanine transaminase
... phenylalanine-DOPP transaminase (PDT), DOPA 2-oxoglutarate aminotransferase, and DOPAATS. This enzyme participates in tyrosine ... aspartate-DOPP transaminase (ADT), L-dopa transaminase, dopa aminotransferase, glutamate-DOPP transaminase (GDT), ... In enzymology, a dihydroxyphenylalanine transaminase (EC 2.6.1.49) is an enzyme that catalyzes the chemical reaction 3,4- ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ...
*  Methionine transaminase
Heilbronn, J.; Wilson, J.; Berger, B.J. (1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in ... Methionine transaminase (EC 2.6.1.88, methionine-oxo-acid transaminase) is an enzyme with systematic name L-methionine:2-oxo- ... Methionine transaminase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ...
*  Histidinol-phosphate transaminase
This enzyme participates in 5 metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, ... Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, ... imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. ... In enzymology, a histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the chemical reaction L-histidinol ...
*  List of MeSH codes (D08)
... tryptophan transaminase MeSH D08.811.913.477.700.900 --- tyrosine transaminase MeSH D08.811.913.555.150 --- amidinotransferases ... receptor protein-tyrosine kinases MeSH D08.811.913.696.620.682.725.400.020 --- fms-like tyrosine kinase 3 MeSH D08.811.913.696. ... protein-tyrosine kinase MeSH D08.811.913.696.620.682.725.049 --- focal adhesion protein-tyrosine kinases MeSH D08.811.913.696. ... leucine transaminase MeSH D08.811.913.477.700.550 --- l-lysine 6-transaminase MeSH D08.811.913.477.700.700 --- ornithine-oxo- ...
*  Aromatic-amino-acid transaminase
This enzyme participates in 6 metabolic pathways: methionine metabolism, tyrosine metabolism, phenylalanine metabolism, ... In enzymology, an aromatic-amino-acid transaminase (EC 2.6.1.57) is an enzyme that catalyzes the chemical reaction an aromatic ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... phenylalanine, tyrosine and tryptophan biosynthesis, novobiocin biosynthesis, and alkaloid biosynthesis i. It employs one ...
*  Glutamate-prephenate aminotransferase
In these animals, tyrosine is synthesized from phenylalanine via the enzyme phenylalanine hydroxylase, whereas plants have ... In enzymology, glutamate-prephenate aminotransferase (EC 2.6.1.79, also known as prephenate transaminase, PAT, and L-glutamate: ... This is a necessary process for any organism which needs to convert arogenate into phenylalanine or tyrosine, as arogenate is ... It operates in the phenylalanine and tyrosine biosynthesis pathway. The gene which encodes this enzyme has recently been ...
*  ETV6
... adds and removes tyrosine residues on α-tubulin), GOT1 (an Aspartate transaminase), and ACSL6 (a Long-chain-fatty-acid-CoA ... It is proposed that tyrosine kinase inhibitors with specificity for NTRK3's tyrosine kinase activity in ETV6-NTRK3 gene- ... The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), ... the ETV6 gene fusion to receptor tyrosine kinases and non-receptor tyrosine kinases may be sensitive to therapy with tyrosine ...
*  Phenylketonuria
... in particular tyrosine. Tyrosine is a conditionally essential Amino acid for PKU patients because without PAH it cannot be ... Excessive phenylalanine can be metabolized into phenylketones through the minor route, a transaminase pathway with glutamate. ... Tyrosine, which is normally derived from phenylalanine and which is necessary for normal brain function, is usually ... Tetrahydrobiopterin is required to convert Phe to Tyr and is required to convert Tyr to L-DOPA via the enzyme tyrosine ...
*  Angiokinase inhibitors
BIBW 2992 is a next-generation tyrosine kinase inhibitor developed by Boehringer Ingelheim which irreversibly blocks both ... BIBW 2992 was well tolerated, with reversible adverse events including rash, diarrhoea, elevations in transaminases. BIBW 2992 ... tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours". British Journal of Cancer. 98 (1 ... by targeting receptor tyrosine kinases. Examples include nintedanib (BIBF 1120), afatinib (BIBW 2992) and motesanib (AMG 706). ...
*  Biochemistry
Enzymes called transaminases can easily transfer the amino group from one amino acid (making it an α-keto acid) to another α- ... and tyrosine, the nonessential amino acids. While they can synthesize arginine and histidine, they cannot produce it in ...
*  Amino acid
This process involves transaminases, often the same as those used in amination during synthesis. In many vertebrates, the amino ... This compound is an analogue of tyrosine and can poison animals that graze on these plants. Amino acids are used for a variety ... The oxidation pathway starts with the removal of the amino group by a transaminase; the amino group is then fed into the urea ... In order to form other amino acids, the plant uses transaminases to move the amino group to another alpha-keto carboxylic acid ...
*  Rosmarinic acid
... is a potential anxiolytic as it acts as a GABA transaminase inhibitor, more specifically on 4-aminobutyrate ... 4-dihydroxyphenyllactic acid derived from L-tyrosine. Thus, chemically, rosmarinic acid is an ester of caffeic acid with 3,4- ... using an in vitro measure of GABA transaminase activity. Awad R, Muhammad A, Durst T, Trudeau VL and Arnason JT, Phytother Res ... transaminase. Rosmarinic acid also inhibits the expression of indoleamine 2,3-dioxygenase via its cyclooxygenase-inhibiting ...
*  Cabozantinib
It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. It was discovered and ... elevated transaminases, higher cholesterol levels, and loss of red and white blood cells. Common adverse effects (between 1% ... It inhibits the following receptor tyrosine kinases: MET (hepatocyte growth factor receptor protein) and VEGFR, RET, GAS6 ... receptor (AXL), KIT), and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib (previously XL184) was granted orphan drug status by ...
*  Enzyme promiscuity
An example of a commonly evolved enzyme is ω-transaminase which can replace a ketone with a chiral amine and consequently ... whereas the next most catalysed native amino acid was the structurally similar tyrosine, but at a thousandth as much as ... Shin JS, Kim BG (August 2001). "Comparison of the omega-transaminases from different microorganisms and application to ... Distinct multiple chemistries catalyzed by phosphatase domain of receptor protein tyrosine phosphatase". Biochemical Journal. ...
*  Sorafenib
... is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases (more avidly C- ... Fever Influenza-like illness Transient increase in transaminase Uncommon (0.1-1% frequency) Folliculitis Infection ... a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling". Mol. Cancer Ther. 7 (10): ...
*  Amino acid synthesis
Finally, a transamination catalyzed either by an alanine-valine transaminase or a glutamate-valine transaminase results in ... Tyrosine can also be inhibited at the transcriptional level by the TyrR repressor. TyrR binds to the TyrR boxes on the operon ... Phenylalanine, tyrosine, and tryptophan are known as the aromatic amino acids. The synthesis of all three share a common ... Tyrosine is synthesized by the hydroxylation of phenylalanine, an essential amino acid. The pathways for the biosynthesis of ...
*  Glucagon
... see alanine transaminase reaction). Acetylcholine Cholecystokinin Secretion of glucagon is inhibited by: Somatostatin Insulin ( ... Diabetes mellitus Glucagon-like peptide-1 Glucagon-like peptide-2 Insulin Islets of Langerhans Pancreas Proglucagon Tyrosine ...
*  Chromosome 12 (human)
... protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) PUS1: encoding enzyme tRNA pseudouridine synthase A ... encoding protein Branched chain amino acid transaminase 1 C12orf42: encoding protein uncharacterised chromosome 12 open reading ...
*  Index of oncology articles
... serum glutamate pyruvate transaminase - Serum glutamic oxaloacetic transaminase - serum tumor marker test - sesquiterpene ... tyrosine kinase inhibitor - TZT-1027 ubiquinone - UCN-01 - UGT1A1 - ultrasonogram - ultrasonography - ultrasound-guided biopsy- ... aspartate transaminase - aspergillosis - Aspergillus - asthenia - astrocyte - astrocytoma - asymptomatic - atamestane - ataxia ...
*  List of OMIM disorder codes
... response to tyrosine kinase inhibitor in; 211980; EGFR Nonsmall cell lung cancer, somatic; 211980; IRF1 Nonsmall cell lung ... ABCA4 GABA-transaminase deficiency; 613163; ABAT Galactokinase deficiency with cataracts; 230200; GALK1 Galactose epimerase ... response to tyrosine kinase inhibitor in; 211980; EGFR Adenocarcinoma of lung, somatic; 211980; BRAF Adenocarcinoma of lung, ... GALNT3 Tyrosine kinase 2 deficiency; 611521; TYK2 Tyrosinemia type II; 277660; TAT Tyrosinemia type III; 276710; HPD Ullrich ...