"Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase". The Journal of Biological ... Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells ... "Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol ... of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion ...

... growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin ... of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... Calalb MB, Polte TR, Hanks SK (February 1995). "Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic ...

Notably the phosphorylation of specific tyrosine residues on the focal adhesion adapter protein-paxillin by specific tyrosine ... also called focal adhesions) in the cell membrane of the smooth muscle cell, called the sarcolemma. The adherens junctions ... The phosphorylation of hsp20 appears to alter actin and focal adhesion dynamics and actin-myosin interaction, and recent ... Other cell signaling pathways and protein kinases (Protein kinase C, Rho kinase, Zip kinase, Focal adhesion kinases) have been ...

"Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol ... "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". J. Biol. Chem. ... "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". J. Cell Sci. 112 (2): 181- ... "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to ...

His research on focal adhesions includes the discovery of many adhesion proteins including vinculin, talin and paxillin, and ... "Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal ... where he continued to work on focal adhesions. He discovered talin (protein) as another focal adhesion protein and then, in ... He then discovered other focal adhesion components including paxillin and contributed to the discovery of zyxin and palladin. ...

... binding to paxillin LD1 motif regulates ILK localization to focal adhesions". The Journal of Biological Chemistry. 276 (26): ... "Regulation of Akt/PKB activation by tyrosine phosphorylation". The Journal of Biological Chemistry. 276 (34): 31858-62. doi: ... "A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". The Journal ... Zhang Y, Chen K, Guo L, Wu C (October 2002). "Characterization of PINCH-2, a new focal adhesion protein that regulates the ...

January 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". ... April 2002). "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and ... Ohanian J, Pieri M, Ohanian V (September 2015). "Non-receptor tyrosine kinases and the actin cytoskeleton in contractile ... May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 ...

... of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion ... consists of a globular head domain that contains binding sites for talin and α-actinin as well as a tyrosine phosphorylation ... The complex at the focal adhesions consists of several proteins such as vinculin, α-actinin, paxillin, and talin, at the ... Based on research, it has been postulated that the lack of vinculin may decrease cell adhesion by inhibiting focal adhesion ...

"The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin". Nat. Struct. ... "Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in ... and sufficient for localizing focal adhesion kinase (FAK) to focal adhesions. It forms a four-helix bundle structure and ... Focal adhesion targeting (FAT) domain The FAT-like C-terminal domain is highly conserved in focal adhesion proteins, ...

"Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep ... "Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion". J. Biol. Chem. 278 (52): 52116-23. doi ... Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA (1999). "A tyrosine-phosphorylated protein ... and its localization in focal adhesion". Biochemical and Biophysical Research Communications. 235 (3): 794-798. doi:10.1006/ ...

This protein is localized in the cytoplasm at focal adhesion sites. It functions as a central protein for fatty acids and ... focal adhesions and adherens junctions. LIM domains are named after their initial discovery in the three homeobox proteins that ... The LIM domain at the c-terminal bind protein tyrosine phosphatase-PEST. PTP-PEST binds at c-termini LIM 3 and 4 to disassemble ... The extent of binding will depend on LIM 2 and 4. This will occur upon dephosphorylation of p130 and paxillin. This protein is ...

In muscle, CAP/Ponsin plays a role in the formation of mature costameres from focal adhesion-like contacts during assembly of ... Liu J, Kimura A, Baumann CA, Saltiel AR (Jun 2002). "APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in ... multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions". The Journal ... "Paxillin and ponsin interact in nascent costameres of muscle cells". Journal of Molecular Biology. 369 (3): 665-82. doi:10.1016 ...

... and the focal adhesion proteins paxillin and p130. Since FAK phosphorylation is involved in uptake of yersiniae as well as T ... tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions". ... YopH acts on host focal adhesion sites by dephosphorylating several phosphotyrosine residues on focal adhesion kinase (FAK) ... Alrutz MA, Isberg RR (1998). "Involvement of focal adhesion kinase in invasin-mediated uptake". Proc. Natl. Acad. Sci. U.S.A. ...

In a reverse direction, when a receptor tyrosine kinase is activated, integrins co-localise at focal adhesion with the receptor ... paxillin, and alpha-actinin. These act by regulating kinases such as FAK (focal adhesion kinase) and Src kinase family members ... Focal adhesions are large molecular complexes, which are generated following interaction of integrins with ECM, then their ... "Control of osteopontin signaling and function by post-translational phosphorylation and protein folding". Journal of Cellular ...