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*  Safinamide
An interaction with tyramine, a substance found in various foods, could be expected by the same reasoning but has been excluded ...
*  Monoamine oxidase B
MAO-A is involved in the metabolism of tyramine; inhibition, in particular irreversible inhibition of MAO-A can result in a ... Nonspecific (i.e. MAOA/B combined) inhibitors can pose problems when taken concomitantly with tyramine-containing foods such as ... generally metabolizes tyramine, norepinephrine (NE), serotonin (5-HT), and dopamine (DA) (and other less clinically relevant ... dangerous pressor effect when foods high in tyramine are consumed such as cheeses (informally known as the "cheese effect"). ...
*  Norepinephrine
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ... CYP2D4 (433 μm) > CYP2D2 ≈ CYP2D6 > CYP2D18 (688 μm) for p-tyramine Musacchio JM (2013). "Chapter 1: Enzymes involved in the ...
*  Substituted phenethylamine
... tyramine, thyronamine, and iodothyronamine) - are substituted phenethylamines. Several notable recreational drugs, such as MDMA ...
*  Tyramine
A large dietary intake of tyramine (or a dietary intake of tyramine while taking MAO inhibitors) can cause the tyramine pressor ... Tyramine is not scheduled at the federal level in the United States and is therefore legal to buy, sell, or possess. Tyramine ... Tyramine binds to both TAAR1 and TAAR2 as an agonist in humans. Tyramine is physiologically metabolized by monoamine oxidases ( ... Tyramine-restricted Diet 1998, W.B. Saunders Company. Ghose, K.; Coppen, A.; Carrol, D. (1977-05-07). "Intravenous tyramine ...
*  Meta-Tyramine
... , also known as m-tyramine and 3-tyramine, is an endogenous trace amine neuromodulator and a structural analog of ... meta-Tyramine is produced in humans via aromatic amino acid decarboxylase-mediated metabolism of meta-tyrosine. meta-Tyramine ... Dyck LE, Juorio AV, Boulton AA (June 1982). "The in vitro release of endogenous m-tyramine, p-tyramine and dopamine from rat ... McQuade PS, Wood PL (1984). "The effects of administration of meta-tyramine and para-tyramine on dopamine and its metabolites ...
*  Tyramine N-methyltransferase
In enzymology, a tyramine N-methyltransferase (EC 2.1.1.27) is an enzyme that catalyzes the chemical reaction S-adenosyl-L- ... The tyramine methylpherase of barley roots". J. Biol. Chem. 238: 381-385. Molecular and Cellular Biology portal. ... The systematic name of this enzyme class is S-adenosyl-L-methionine:tyramine N-methyltransferase. Other names in common use ... and tyramine methylpherase. This enzyme participates in tyrosine metabolism. Mann JD; Mudd SH (1963). "Alkaloids and plant ...
*  Tyramine N-feruloyltransferase
Other names in common use include tyramine N-feruloyl-CoA transferase, feruloyltyramine synthase, feruloyl-CoA tyramine N- ... In enzymology, a tyramine N-feruloyltransferase (EC 2.3.1.110) is an enzyme that catalyzes the chemical reaction feruloyl-CoA ... The systematic name of this enzyme class is feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase. ... the two substrates of this enzyme are feruloyl-CoA and tyramine, whereas its two products are CoA and N-feruloyltyramine. This ...
*  History of catecholamine research
An enzyme tyramine oxidase described in 1928 also oxidized dopamine, noradrenaline and adrenaline. It was later named monoamine ... Mary Lilias Christian Hare (1928). "Tyramine oxidase. I. A new enzyme system in liver". Biochemical Journal. 22: 968-979. ...
*  List of dopaminergic drugs
Tyramine (TRA) • Xylopropamine • Zylofuramine Piperazines: 2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP) • Benzylpiperazine ...
*  Vittorio Erspamer
2. Tyramine and octopamine (oxyoctopamine) (1948). "Active Substances in the Posterior Salivary Glands of Octopoda. II. ... Tyramine and Octopamine (Oxyoctopamine)". Acta Pharmacologica et Toxicologica. 4 (3-4): 224-247. doi:10.1111/j.1600-0773.1948. ...
*  Octopamine (neurotransmitter)
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... Tyramine and Octopamine (Oxyoctopamine)". Acta Pharmacologica et Toxicologica. 4 (3-4): 224-47. doi:10.1111/j.1600-0773.1948. ... Receptors in the TyrR class, however, are generally more strongly activated by tyramine than by octopamine. In vertebrates no ...
*  Trace amine
Phenylethanolamine m-Tyramine p-Tyramine 3-Methoxytyramine N-Methyltyramine m-Octopamine p-Octopamine Synephrine Thyronamine ... Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... Rank order of potency tyramine > β-phenylethylamine > octopamine = dopamine "Dopamine: Biological activity". IUPHAR/BPS guide ...
*  3-Methoxytyramine
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... Tyramine 3,4-Dimethoxyphenethylamine Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ...
*  Candicine
It is the N,N,N-trimethyl derivative of the well-known biogenic amine tyramine, and, being a natural product with a positively ... Tyramine N-Methyltyramine Hordenine T. A. Smith (1977). "Phenethylamines and related compounds in plants." Phytochemistry 16 9- ... candicine iodide was about twice as potent as its structural analog tyramine, and much more potent than its even-closer analog ... "N-Methylated Derivatives of Tyramine in Citrus Genus Plants: Identification of N,N,N-Trimethyltyramine (Candicine)". Journal of ...
*  Monoamine oxidase
Hare ML (1928). "Tyramine oxidase: A new enzyme system in liver". The Biochemical Journal. 22 (4): 968-79. doi:10.1042/ ... The enzyme was originally discovered by Mary Bernheim in the liver and was named tyramine oxidase. They belong to the protein ... tyramine, and tryptamine equally. Specific reactions catalyzed by MAO include: Adrenaline or noradrenaline to 3,4- ...
*  Mary Bernheim
Following her discovery, Bernheim predicted that tyramine oxidase was important for the oxidative deamination of tyramine, thus ... Following this, crude tyramine was procured by heating tyrosine in the presence of the catalyst diphenylamine. The extracted ... As a doctoral student, Bernheim was aware of the limited research which had been conducted on the catabolism of tyramine, a ... She discovered that the oxidation of tyramine did take place, with the observation that one atom of oxygen was absorbed per ...
*  Phenethylamine
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... The biogenic amines, phenethylamine and tyramine, are N-oxygenated by FMO to produce the N-hydroxy metabolite, followed by a ... The preferred in vitro substrates of AOC2 were found to be 2-phenylethylamine, tryptamine and p-tyramine instead of methylamine ...
*  Neurotransmitter
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... tyramine, 3-iodothyronamine, octopamine, tryptamine, etc. Peptides: somatostatin, substance P, cocaine and amphetamine ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ...
*  Dopamine
... p-Tyramine → Dopamine Minor: L-Phenylalanine → m-Tyrosine → m-Tyramine → Dopamine The direct precursor of dopamine, L-DOPA, can ... Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... Substrate: m-tyrosine Product: m-tyramine + CO2 Organism: Homo sapiens Reaction diagram Musacchio JM (2013). "Chapter 1: ...
*  Dopamine beta-hydroxylase
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ... CYP2D4 (433 μm) > CYP2D2 ≈ CYP2D6 > CYP2D18 (688 μm) for p-tyramine Glennon RA (2013). "Phenylisopropylamine stimulants: ...
*  Adrenergic storm
MAOIs that irreversibly inhibit MAO-A will permit high levels of circulating tyramine able to cause tyramine-induced ... While both MAO-A and MAO-B metabolize tyramine, only MAO-A is present in the gastrointestinal tract and singularly metabolizes ... An important substrate of the enzyme MAO is tyramine. MAOIs inhibit the enzyme either reversibly, in which MAO is inhibited ... It is usually caused by overdose of stimulants, especially cocaine or methamphetamine, or eating foods high in tyramine while ...
*  CYP2D6
... and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver. Considerable variation exists ... Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ...
*  N-Methylphenethylamine
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ... CYP2D4 (433 μm) > CYP2D2 ≈ CYP2D6 > CYP2D18 (688 μm) for p-tyramine Miller GM (January 2011). "The emerging role of trace amine ...
*  Phenylalanine
Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual ... The Km values of the CYP2D isoforms are as follows: CYP2D6 (87-121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and ... are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. ... CYP2D4 (433 μm) > CYP2D2 ≈ CYP2D6 > CYP2D18 (688 μm) for p-tyramine Nelson DL, Cox MM (2000). Lehninger, Principles of ...