Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene. Cellular calcium ... signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals ... Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase". J. Biol. Chem. 270 (16): 9370-7 ... This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with ...

"The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity". ... Phospholipase A Phospholipase C Triglyceride lipase Phospholipase A2 Outer membrane phospholipase A1 Patatin-like phospholipase ... 2003). "Phospholipase A(2)". Prostaglandins Leukot Essent Fatty Acids. 69 (2-3): 87-97. doi:10.1016/S0952-3278(03)00069-3. PMID ... A diverse array of genetically distinct lipase enzymes are found in nature, and they represent several types of protein folds ...

Alpha-1 receptor is a Gq type G-protein coupled receptor. When it is activated, it will lead to activation of phospholipase C, ... increase of phospholipase C, IP3 and DAG hence increase of Ca Concentration). As a result, the contraction of smooth muscle is ...

Petit A, Geoffroy P, Bélisle S (1997). "Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 ... G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C- ...

"The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity". ... "Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection ... Wild-type AAV has attracted considerable interest from gene therapy researchers due to a number of features. Chief amongst ... Some of these steps may look different in various types of cells, which, in part, contributes to the defined and quite limited ...

... is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded ... The G-proteins activate the phospholipase C PLCB4, which causes the TRP-channels TRPC6 and TRPC7 mediate to open so that the ... This shows promise for the use of melanopsin as an optogenetic tool for the treatment of Type II diabetes. Light effects on ... In comparison to wild-type mice that expressed melanopsin normally, deficits in light-induced phase shifts in locomotion ...

Textilotoxin is a type of phospholipase A2, a group of enzymes with diverse effects that are commonly found in snake venoms. At ... least two further phospholipase A2 enzymes have been found in eastern brown snake venom. Two postsynaptic neurotoxins have been ...

PKR2 is a Gq-coupled protein, so when the ligand binds, beta-type phospholipase C is activated which creates inositol ...

The researchers hypothesized that co-regulation of Cx26 and Cx30 is dependent on phospholipase C signaling and the NF-κB ... Connexin genes are expressed in a cell type-specific manner with overlapping specificity. The gap junction channels have unique ... The cochlea contains two cell types, auditory hair cells for mechanotransduction and supporting cells. Gap junction channels ... properties depending on the type of connexins constituting the channel.[supplied by OMIM] Connexin 30 is prevalent in the two ...

"Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective ... reported that Phospholipase A2-the major allergen in bee venom -- "is sensed by the innate immune system" and induces an immune ... People with allergies are at much lower risk for some types of cancers, most notably the brain tumor glioma. While research has ...

It can enhance the activity of proteins for viruses that cause cancer such as human T-cell lymphotropic virus type-1 (HTLV), ... interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production". Molecular ... Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (Apr 2001). "Tip60 is a cell-type-specific transcriptional ... Nordentoft I, Jørgensen P (Aug 2003). "The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting ...

More than one type of G protein co-exist in the same tissue. For example, in adipose tissues, two different G-proteins with ... For example, the Gβγ complex, when bound to histamine receptors, can activate phospholipase A2. Gβγ complexes bound to ... The last function is activating L-type calcium channels, as in H3 receptor pharmacology. Heterotrimeric G-protein signaling in ...

"Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by ... "Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages ... Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene. GRCh38: Ensembl release 89: ... "Entrez Gene: PLA2G2D phospholipase A2, group IID". Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and ...

Phospholipase A2 is an enzyme to catalyze the release of arachidonic acid in our body. After arachidonic acid is released, it ... There are various types of prostaglandins responsible for different physiological reactions such as maintaining the blood flow ... Cyclooxygenase (COX) and Phospholipase A2 are the major enzymes involved in prostaglandin production, and they are the drug ... Glucocorticoids work by inhibiting phospholipase A2, hence indirectly inhibiting prostaglandin synthesis. Yazid, Samia; Norling ...

The effects of certain general anesthetics are less pronounced in K2P knock-out mice, as compared to their wild-type ... activation was shown through an anesthetic perturbation to membrane lipid clusters and activation of phospholipase D2; direct ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCD3 phospholipase C, delta 3". Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (Dec 1990). "Human ... Lin FG, Cheng HF, Lee IF, Kao HJ, Loh SH, Lee WH (Aug 2001). "Downregulation of phospholipase C delta3 by cAMP and calcium". ... Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W (Feb 2002). "Membrane targeting of C2 domains of phospholipase C-delta ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... Gross BS, Melford SK, Watson SP (1999). "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc ... The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic ... From OMIM as of March 24, 2020: Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)". Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 ... Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000). "Association of mammalian trp4 and phospholipase C ... Hwang SC, Park KH, Ha MJ, Noh IS, Park TB, Lee YH (1996). "Distribution of phospholipase C isozymes in normal human lung tissue ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)". Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, ... Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (2000). "Regulation of phospholipase C-beta 3 activity by Na+/ ... Xia C, Bao Z, Yue C, Sanborn BM, Liu M (2001). "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by ...

These types of cytolysin are also known as pore-forming toxins (PFTs) and comprise the largest portion of all cytolysins. ... Representative cytolysins include C. perfringens α-toxin (phospholipase C), S. aureus β-toxin (sphingomyelinase C) and Vibrio ... This type of structure is shown in staphylococcal α-hemolysin. A pore can also be formed through membrane fusions. Controlled ... Targets of this type of cytolysins range from general cell membranes to more specific microorganisms, such as cholesterols and ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase ... "Entrez Gene: PLCE1 phospholipase C, epsilon 1". This article incorporates text from this source, which is in the public domain ... vom Dorp F, Sari AY, Sanders H, Keiper M, Oude Weernink PA, Jakobs KH, Schmidt M (August 2004). "Inhibition of phospholipase C- ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCB2 phospholipase C, beta 2". Barr AJ, Marjoram R, Xu J, Snyderman R (Apr 2002). "Phospholipase C-beta 2 ... Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000). "Association of mammalian trp4 and phospholipase C ... The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and ...

In NAPE-phospholipase D (NAPEPLD)-knockout mice, cleavage of NAPE is reduced in low calcium concentrations, but not abolished, ... When the CB1 receptor is knocked out in mice, these animals tend to be leaner and less hungry than wild-type mice. A related ... 2-AG was found to act on presynaptic CB1 receptors to mediate retrograde STD following activation of L-type calcium channeles, ... Expression appears to be exclusive, so that both types of endocannabinoids are not co-synthesized. This exclusion is based on ...

The formation of ionic bridges is seen in the protein-lipid interaction between both protein C2 type domains and annexins.. Any ... "Pfam entry: Phospholipase A2". Archived from the original on 2007-09-29. Retrieved 2007-01-25. "Pfam entry: ... ISBN 3-527-31151-3. Ghosh M, Tucker DE, Burchett SA, Leslie CC (November 2006). "Properties of the Group IV phospholipase A2 ... Some cytosolic proteins are recruited to different cellular membranes by recognizing certain types of lipid found within a ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCB4 phospholipase C, beta 4". Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 ... Lyu MS, Park DJ, Rhee SG, Kozak CA (1996). "Genetic mapping of the human and mouse phospholipase C genes". Mamm. Genome. 7 (7 ... "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)". Genomics. 29 (1): ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCD1 phospholipase C, delta 1". Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link ... 1998). "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector". Biochem. J. 331 (1): 283 ... Ishikawa S, Takahashi T, Ogawa M, Nakamura Y (Nov 1997). "Genomic structure of the human PLCD1 (phospholipase C delta 1) locus ...

85 kDa calcium-independent phospholipase A2, also known as 85/88 kDa calcium-independent phospholipase A2, Group VI ... This type of enzyme is responsible for breaking down (metabolizing) phospholipids. Phospholipid metabolism is essential for ... phospholipase A2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, or Patatin-like phospholipase ... Specifically, the A2 phospholipase produced from the PLA2G6 gene, sometimes called PLA2 group VI, helps to regulate the levels ...

"Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ... "Entrez Gene: PLCD4 phospholipase C, delta 4". Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 ... 2004). "Phospholipase C δ-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 ... Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High- ...

Azurophils may contain myeloperoxidase, phospholipase A2, acid hydrolases, elastase, defensins, neutral serine proteases, ... may refer to a unique type of cells, identified only in reptiles. These cells are similar in size to so-called heterophils with ...

... s are a type of cellular compartment that form as a result of macropinocytosis. Macropinosomes have been described ... PI3K and phosphoinositide phospholipase C activation have been shown to be necessary for macropinosome formation in fibroblasts ... in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C ...

However these methods do not provide the layer of information needed in order to determine what type of interaction is present ... Growth factor receptor binding proteins and phospholipase Cγ are examples of proteins that have SH2 domains. Src homology 3 ( ... When characterizing PPI interfaces it is important to take into account the type of complex. Parameters evaluated include size ... protein-protein relationships are often the result of multiple types of interactions or are deduced from different approaches, ...

categorize these reactions into nine basic types of indole syntheses: Fischer, Mori, Hemetsberger, Buchwald, Sundberg, Madelung ... an inhibitor of secretory phospholipase. Currently, one of the most interesting applications of the Nenitzescu synthesis is its ...

The neurotoxic component of the type A venom is referred to as canebrake toxin, and is a phospholipase A2. It is analogous to ... Type B is hemorrhagic and proteolytic, and is found consistently in the north and in parts of the southeast. Type A + B is ... Four venom patterns have been described for this species: Type A is largely neurotoxic, and is found in various parts of the ... Type C venom has none of the above components and is relatively weak. ...

"Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth ... "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". J ... Pei Z, Maloney JA, Yang L, Williamson JR (September 1997). "A new function for phospholipase C-gamma1: coupling to the adaptor ... Tvorogov D, Carpenter G (July 2002). "EGF-dependent association of phospholipase C-gamma1 with c-Cbl". Exp. Cell Res. 277 (1): ...

Antibodies to an M-type phospholipase A2 receptor are responsible around 60% of cases of membranous nephropathy. Testing for ... In 2014, a second autoantigen was discovered, the thrombospondin type 1 domain-containing 7A (THSD7A) system that might account ...

Thy-1, like many other GPI anchored proteins can be shed by special types of Phospholipase C e.g. PI-PLC (phosphatidyl-Inositol ... Crosslinking anti-Thy-1 Ab can promote neurite outgrowth which is dependent on G{alpha}i and L- and N-type calcium channel ... In this regard it has yet another historic association: Thy-1 happens to be the first glycoprotein in which cell type ... learning from other mice which foods are safe to eat as compared to wild-type mice). This failure can be rescued by the ...

January 1997). "Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the ... Occurence [sic] of phospholipase A1 and A2 in human decidua". Prostaglandins. 9 (5): 667-673. doi:10.1016/0090-6980(75)90106-9 ... Yeats DA, Bakhle YS (June 1989). "Phospholipases A2 and C of human lung; subcellular distribution and substrate selectivity". ... November 2002). "A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and ...

Young MB, Thomas SA (January 2014). "M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M- ... mediates M-type currents". The Journal of Biological Chemistry. 275 (31): 24089-24095. doi:10.1074/jbc.M003245200. PMID ... D5 receptors and beta-2 adrenergic receptors to redundantly activate phospholipase C, which inhibits the activity of KCNQ ...

2001). "A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells". J. Biol. Chem. 276 (21): 18321-6 ... Group XIIA secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G12A gene. GRCh38: Ensembl release 89: ... "Entrez Gene: PLA2G12A phospholipase A2, group XIIA". Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- ... 2003). "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)". J. Biol ...

cells Type II NKT cells recognize CD1d but lack the highly conserved TCRα chain and reactivity to α-GalCer that classify type I ... lysophosphatidylethanolamine generated through the cleavage of phosphatidylethanolamine by virus-induced phospholipases. Even ... are antigenic for some type II NKT cells. Thus, type II NKT cells seem to recognize diverse antigens presented by CD1d and ... Type I NKT cells are less frequent in humans than in mice (1-3% of T cells in most mouse tissues, 50% in mouse liver and bone ...

Corticosteroids inhibit phospholipase A2 production by boosting production of lipocortin, an inhibitor protein. Relatively new ... a subclass of eicosanoid compounds which function as signaling molecules in numerous types of animal tissues. NSAIDs are ...

The composition of venom from a sting can even affect the types of treatment a patient should be given. Differences have been ... P. gallicus venom was found to be a combination of four major allergens: Ag5 (antigen 5), hyaluronidase, phospholipase, and ... Response to different epitope spectrums depends on the type of Polistes that did the stinging. ...

It is suggested that type C may be type B that forms spores more readily so does not go through the toxin-production stage. ... "Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins". The Journal of ... The toxins normally produced by the various types are shown in table 1 The alpha-toxin of Clostridium botulinum types C and D, ... forming a separate type D in the genus. More recent 16S-rDNA studies however have suggested, that C. haemolyticus and types B ...

"Entrez Gene: Phospholipase D family, member 3". Universal protein resource accession number Q8IV08 for "PLD3 - Phospholipase D3 ... PLD3 is a 490 amino acid-long type 2 transmembrane protein, unlike PLD1 and PLD2 which do not contain a transmembrane protein ... PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D ... PLD3 is a member of the phospholipase D protein family, however, unlike phospholipase PLD1 and PLD2, it serves as a 5' ...

Eto M, Karginov A, Brautigan DL (Jan 2000). "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes". ... "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on ...