Other oncofetal antigens are trophoblast glycoprotein precursor and immature laminin receptor protein (also known as oncofetal ... Another example is carcinoembryonic antigen, which is elevated in people with colon cancer and other tumors. ... protein entry for trophoblast glycoprotein precursor 37 kiloDalton oncofetal antigen protein and immature laminin receptor ... which is produced by hepatocellular carcinoma and some germ cell tumors. ...
Rao, NC; Barsky, SH; Terranova, VP; Liotta, LA (1983). "Isolation of a tumor cell laminin receptor". Biochem. Biophys. Res. ... 37 kDa Laminin Receptor Precursor; 37LRP; 67 kDa Laminin Receptor; 67LR; 37/67 kDa Laminin Receptor; LRP/LR; LBP/p40; and p40 ... "Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein". ... Wang, KS; Kuhn, RJ; Strauss, EG; Ou, S; Strauss, JH (1992). "High-affinity laminin receptor is a receptor for Sindbis virus in ...
Laminin receptor is also a target for PEDF, and the interaction occurs between residues 24-57 of PEDF, a region known to ... PEDF induces PPAR-gamma expression which in turn induces p53, a tumor suppressor gene involved in cell cycle regulation and ... Bernard A, Gao-Li J, Franco CA, Bouceba T, Huet A, Li Z (Apr 2009). "Laminin receptor involvement in the anti-angiogenic ... Secreted PEDF binds a receptor on the cell surface termed PEDF-R. PEDF-R has phospholipase A2 activity which liberates fatty ...
Arch RH, Thompson CB (January 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor ... Loo DT, Chalupny NJ, Bajorath J, Shuford WW, Mittler RS, Aruffo A (March 1997). "Analysis of 4-1BBL and laminin binding to ... Schwarz H, Arden K, Lotz M (June 1997). "CD137, a member of the tumor necrosis factor receptor family, is located on chromosome ... Arch RH, Thompson CB (January 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor ...
... laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin ... "Entrez Gene: RPL10 ribosomal protein L10". Oh HS, Kwon H, Sun SK, Yang CH (September 2002). "QM, a putative tumor suppressor, ... receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants ... This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this ...
Moreover, CAR expression is not found in normal or tumor cell lines. Expression of CAR in endothelial cells can be regulated by ... laminin-1 and tenascin-R. In addition, it is thought to regulate the cytoskeleton through interactions with actin and ... Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. The protein encoded by ... CAR is a receptor for both Coxsackie B virus and adenovirus 2 and 5, which are structurally distinct. In patients with ...
... tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was ... 2006). "Changes in laminin isoforms associated with brain tumor invasion and angiogenesis". Front. Biosci. 11 (1): 81-8. doi: ... Laminin subunit beta-1 is a protein that in humans is encoded by the LAMB1 gene. Laminins, a family of extracellular matrix ... Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they ...
Altered syndecan-2 expression has been detected in several different tumor types. SDC2 has been shown to interact with: CASK, ... The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for ... "A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4". J. ... trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271-83. doi:10.1016/s1044-7431(02)00027-1. ...
Tumor-associated exon 3 of GPC2 shows the lowest expression in normal tissues compared with other exons. Cerebroglycan is a ... Chimeric antigen receptor (CAR) T cells and Immunotoxins (antibody-cytotoxin fusion proteins) targeting GPC2 inhibit ... Cerebroglycan has especially high affinity for laminin-1. GPC2 has been identified as a therapeutic target in neuroblastoma in ... The CT3 antibody has been shown to recognize a tumor-associated isoform (isoform 201) of GPC2 with high affinity. ...
In addition, the tumor cells may also express adenosine A1 and A3 receptors associated with Gαi proteins, promoting both the ... and signaling molecule and can regulate cellular signaling with extracellular matrix components such as fibronectin and laminin ... Subsequently, cAMP signaling is triggered in T cell that express the adenosine A2A receptor. Adenosine receptor are also ... In tumor cells the miRNA expression pattern often change and therefore affect the surface NT5E, which as result interfere the ...
It may improve cancer treatment by enabling doctors to prevent tumors from spreading and forming new tumors. The environment of ... Different ECM proteins (such as collagen, elastin, fibronectin, laminin, and others) allow cells to adhere and migrate, while ... that stimulates other cells in the group that have the receptors to that chemo-attractant. Cells sense the secreted substrate ... Spreading of cancer (metastasis): common complication of cancer involve formation of new tumors (secondary tumors), as a result ...
3. What receptor hormone the tumour has. Observation of metastases provides direct feedback on the effectiveness of the ... MMP-19 cleaves components of the basal lamina such as collagen type IV, laminin 5, nidogen (entactin) and other ECM proteins ... Apart from the breast tumor cells, the resident stromal cells also contribute to tumor survival. Growth factors such as ... It is highly expressed in tumor stroma and stimulates tumor-cell proliferation. It is hypothesised that TNC stimulates invasion ...
The binding of netrin-1 to its receptors inhibits the tumor suppressor p53 dependent apoptosis. Such receptors share the ... The basement membrane assembly across species, Vertebrate laminin-1 (α1β1γ1) and laminin-10 (α5β1γ1), like the two ... The function of UNC-5 is to repel axons while the other receptor UNC-40 (or Deleted in Colorectal Cancer) attracts axons to the ... UNC-5 is a receptor for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses ...
The binding of netrin-1 to its receptors inhibits the tumor suppressor p53 dependent apoptosis. Such receptors share the ... The basement membrane assembly across species, Vertebrate laminin-1 (α1β1γ1) and laminin-10 (α5β1γ1), like the two ... Such proteins include UNC-5, a receptor for UNC-6 which is one of the netrins. Netrins are a class of proteins involved in axon ... The function of UNC-5 is to repel axons while the other receptor UNC-40 (or DCC:Deleted in Colorectal Cancer) attracts axons to ...
So the spread of the tumor is halted. Scientists have just announced that this enzyme predicts death, as it has been shown to ... For instance, cleavage of laminin-5 by cathepsin S leads to generation of proangiogenic peptides. The expression of cathepsin S ... as a signaling molecule via activation of protease-activated receptors 2 and 4 members of the G-protein coupled receptor family ... In tumorogenesis, cathepsin S promotes a tumor growth. Cathepsin S expression and activity has also been shown to be ...
For example, folate receptors are overexpressed in tumor cells and are therefore promising targets for localized drug delivery ... This is performed via selective interaction of the dendrimer with laminin receptors. Peptide dendrimers may be employed in the ... As epidermal growth factor receptors (EGFRs) are often overexpressed in brain tumors, EGFRs are a convenient target for site- ... "Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor" (PDF). ...
Finally, the tumor-targeting properties of MMP inhibitors offer a potential strategy for identifying small tumors. Researchers ... MMP-2 has also been shown to cleave other non-ECM substrates including growth factors such as TGF-β, FGF receptor-1, proTNF, IL ... As another example, cleavage of laminin-5, a component of the basement membrane, by MMP-2 has been shown to reveal a cryptic ... This process is essential for tumor progression, because as tumors grow they need increasing supplies of oxygen and nutrients. ...
... G domain: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5), cadherin EGF LAG seven-pass G-type receptors ( ... A crucial event in tumor progression referred to as epithelial to mesenchymal transition (EMT) allows carcinoma cells to ... The laminin N-terminal domain is found in all laminin and netrin subunits except laminin alpha 3A, alpha 4 and gamma 2. Laminin ... Laminin domain II: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) Laminin B (domain IV): all laminin alpha chains ...
... a receptor for VegfC and VegfD), and also the presence of Lyve1, which is a lymphatic specific hyluronan receptor. However, ... These markers include CD34 and Laminin. This experiment proves that Prox1 is necessary for lymphatic cells to specify. It is ... ISBN 978-0443-06811-9. Dieter Marmé; Norbert Fusenig (6 December 2007). Tumor angiogenesis: basic mechanisms and cancer therapy ... This potential is indicated by the presence of some known lymphatic markers such as Vascular endothelial growth factor receptor ...
... L degrades fibronectin, insulin receptor (IR), and insulin-like growth factor 1 receptor (IGF-1R). Cathepsin L- ... High levels of this enzyme in tumor cells seems to be associated with greater invasiveness. Cathepsin K is the most potent ... Cathepsin D (an aspartyl protease) appears to cleave a variety of substrates such as fibronectin and laminin. Unlike some of ... Cancer, Cathepsin D is a mitogen and "it attenuates the anti-tumor immune response of decaying chemokines to inhibit the ...
1998). "Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine ... 1991). "Evidence that the B2 chain of laminin is responsible for the neurite outgrowth-promoting activity of astrocyte ... 2000). "LDL receptor-related protein as a component of the midkine receptor". Biochem. Biophys. Res. Commun. 270 (3): 936-41. ... A molecular complex containing receptor-type tyrosine phosphatase zeta (PTPζ), low density lipoprotein receptor-related protein ...
The ephrins EPH receptor A2 and A3 are shed by ADAM10, creating cleaved soluble Eph receptors, which inhibit tumor angiogenesis ... The vascular basement membrane is composed of type IV collagen, type XV collagen, type XVIII collagen, laminins, entactin, ... or cleavage and release of receptors. Release of the receptor may also generate soluble receptors which act as decoys by ... 2000). "Aminopeptidase N is a receptor for tumor homing peptides and a target for inhibiting angiogenesis". Cancer Res. 60 (3 ...
Other receptor interactions include the VEGF-R2/KDR/Flk-1 receptor on human umbilical vein endothelial cells. Endostatin may ... 42 patients with pancreatic endocrine tumors or carcinoid tumors were treated. Of the 40 patients which could be evaluated for ... Javaherian, K.; Park, S.Y.; Pickl, W.F.; LaMontagne, K.R.; Sjin, R.T.T.; Gillies, S.; Lo, K. (2002). "Laminin modulates ... "Treatment with Endostatin did not result in significant tumor regression in patients with advanced neuroendocrine tumors." A ...
... which mediates ligand binding by the LDL receptor. Domain III has homology to the domain IVa and IVb of laminin. Domain IV ... More research into GAG chain or core protein modification by invasive tumor cells as compared to benign tumor cells and normal ... Thus in this system it does appear that tumor cell expression of perlecan is necessary for tumor aggregation. ... reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule". ...
Cancer can result from disruption of normal morphogenesis, including both tumor formation and tumor metastasis. Mitochondrial ... Collagen, laminin, and fibronectin are major ECM molecules that are secreted and assembled into sheets, fibers, and gels. ... Multisubunit transmembrane receptors called integrins are used to bind to the ECM. Integrins bind extracellularly to ... Integrins also serve as receptors to trigger signal transduction cascades when binding to the ECM. A well-studied example of ...
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; ... Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine ... and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35-42. PMID 9950216. "Entrez Gene: NTN1 netrin ... Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis". Nat. Rev. Cancer. 4 (12): 978-87. doi:10.1038/nrc1504. PMID ...
Lymphocytes have receptors for such chemokines. For example, Naive T cells express the CCR7 receptor for the chemokine CCL21. ... MRCs express the molecule TRANCE (also known as RANKL), a type of tumor necrosis factor. They are one of organizer cells ... Most also express common markers such as desmin, laminin, various subunits of integrins, vascular cell adhesion molecule 1 ( ... They also express the Fc receptors, CD16, CD23 and CD32; the complement receptors CD21 and CD35 and complement components. The ...
This protein can bind to fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein ... It has been suggested that activating the CD36 receptor causes an increase in ECs sensitivity to apoptotic signals. Type I ... Taraboletti G, Roberts DD, Liotta LA (Nov 1987). "Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are ... However, CD36 is generally considered to be the dominant inhibitory signaling receptor for TSP1, and EC expression of CD36 is ...
... such as laminin and types IV and V collagen. The final step is the adhesion of the metastatic tumor cell to connective tissue ... thus enabling tumor cell invasion and intravasation. A newly identified metastasis suppressor, p75 neurotrophin receptor ( ... collectively known as tumor microenvironment of metastasis (TMEM) can allow tumor cells to enter blood vessels. Tumors can use ... Tumor-associated macrophages (TAMs) have been shown to be abundantly present in the microenvironments of metastasizing tumors. ...
MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium ... 1991). "Integrins in human cells and tumors". Cell Differ. Dev. 32 (3): 215-27. doi:10.1016/0922-3371(90)90034-T. PMID 2099238 ... 1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 ( ... "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a ...
This actin regulatory protein binds to fibronectin receptors and aids in the haptotactic and chemotactic processes of tumor ... "Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin". J Cell Biol. 97 (3): 772-7 ... Fibronectin and laminin both play a role in adrenocyte mutation into distinctive distribution in the adrenal gland. The ... Basara, M. L.; McCarthy, J. B.; Barnes, D. W.; Furcht, L. T. (1985). "Stimulation of haptotaxis and migration of tumor cells by ...