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*  Tumor necrosis factor superfamily
They include: Tumor necrosis factor (TNF) (also known as cachectin or TNF alpha) is a cytokine that has a wide variety of ... Tumor Necrosis Factors at the US National Library of Medicine Medical Subject Headings (MeSH) pex1 tumor necrosis factor gene. ... Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10. ... Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte- ...
*  Tumor necrosis factor alpha
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ... Tumor Necrosis Factor-alpha at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal Medicine ... reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). Both factors were described ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ...
*  ADAM17
"Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF ... ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and ... Zheng Y, Schlondorff J, Blobel CP (November 2002). "Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE ... Black RA (January 2002). "Tumor necrosis factor-alpha converting enzyme". The International Journal of Biochemistry & Cell ...
*  Sarcoidosis
"Tumor necrosis factor-alpha inhibitor treatment for sarcoidosis". Therapeutics and Clinical Risk Management. 4 (6): 1305-13. ... Cathcart S, Sami N, Elewski B; Sami; Elewski (May 2012). "Sarcoidosis as an adverse effect of tumor necrosis factor inhibitors ... and anti-tumor necrosis factor treatment (such as infliximab, etanercept, golimumab, and adalimumab). In a clinical trial ... "Relationship between tumor necrosis factor-α (TNFA) gene polymorphisms and cardiac sarcoidosis". In Vivo. Athens, Greece. 28 (6 ...
*  LRRFIP1
"GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073-81. doi:10.1128/MCB.25.20.9073- ... "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury". Circ ... "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34 ...
*  Nitric oxide synthase
Tumor necrosis factor alpha and Interferon gamma). Induction of the high-output iNOS usually occurs in an oxidative environment ... It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack ... These properties may define the roles of iNOS in host immunity, enabling its participation in anti-microbial and anti-tumor ... NO produced by eNOS has been shown to be a vasodilator identical to the endothelium-derived relaxing factor produced in ...
*  Testicular immunology
Lysiak JJ (2004). "The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in ... Hutson JC (1993). "Secretion of tumor necrosis factor alpha by testicular macrophages". J Reprod Immunol. 23 (1): 63-72. doi: ... Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and ... Other immune factors found in the testis include the enzyme inducible nitric oxide synthase (iNOS), and its product nitric ...
*  Howel-Evans syndrome
Mutations in RHBDF2 inhibit tumour necrosis factor alpha. RHBDL2 also acts on Epidermal growth factor and EphrinB3. ... RHBDF2 is involved in the regulation of the secretion of several ligands of the epidermal growth factor receptor. The rhomboid ... Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer. Fam Cancer ...
*  Proteases in angiogenesis
ADAM17 is able to release active tumor necrosis factor-alpha (TNFα) and heparin-binding EGF-like growth factor (HB-EGF) from ... Black, R (2002). "Tumor necrosis factor-alpha converting enzyme". Int. J. Biochem. Cell Biol. 34 (1): 1-5. doi:10.1016/S1357- ... Abounader, R; Laterra, J (2005). "Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis". Neuro-oncol ... Several growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are trapped ...
*  SERPINB10
Schleef RR, Chuang TL (August 2000). "Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence ... Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices. A ... "Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins". Biochemistry. 28 ...
*  P2RX7
"Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia". J. Neurochem. 75 (3): 965-72. doi:10.1046/j ... "Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT". J. Neurochem. 108 ...
*  Risk factors for tuberculosis
Mutlu G, Mutlu E, Bellmeyer A, Rubinstein I (2006). "Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody ... Some drugs, including rheumatoid arthritis drugs that work by blocking tumor necrosis factor-alpha (an inflammation- ... HIV is a major risk factor for tuberculosis. The risk of developing TB is estimated to be between 20-37 times greater in people ... There are a number risk factors for tuberculosis infection; worldwide the most important of these is HIV. Co-infection with HIV ...
*  Yersinia pseudotuberculosis
Boland A, Cornelis GR (1998). "Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during ... Correlation with its inhibitory effect on tumor necrosis factor-alpha production". J. Biol. Chem. 272 (25): 15920-7. doi: ... Structurally, it is unlike any other superantigen, but is remarkably similar to the tumour necrosis factor and viral capsid ... Since this pathway gives secretion selectivity, it is a virulence factor. In contrast to the ysc and yop genes listed above, ...
*  ZFP36
Carballo E, Lai WS, Blackshear PJ (August 1998). "Feedback inhibition of macrophage tumor necrosis factor-alpha production by ... It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2. TTP binds to AU-rich ... For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA ... "A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence". J Biol Chem. 265 (31): 19185-91 ...
*  Role of microglia in disease
"Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia". Journal of Neurochemistry. 75 (3): 965-72. ... Crosstalk between tumor cells and TAMs is characterized by the release of growth factors and cytokines by TAMs in response to ... Tumor-associated macrophages/microglia (TAMs) are the main infiltrate in gliomas, comprising up to 40% of the tumor mass. TAMs ... Not only tumor cells, but also non-tumor cells of the microenvironment contribute to cancer progression and response to ...
*  Laminin, gamma 1
Davis JM, Narachi MA, Alton NK, Arakawa T (1987). "Structure of human tumor necrosis factor alpha derived from recombinant DNA ... 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are ... Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they ...
*  IL1A
It is on the pathway that activates tumor necrosis factor-alpha. Interleukin 1 was discovered by Gery in 1972. He named it ... IL-1α is also known as fibroblast-activating factor (FAF), lymphocyte-activating factor (LAF), B-cell-activating factor (BAF), ... Constine LS, Harwell S, Keng P, Lee F, Rubin P, Siemann D (Mar 1991). "Interleukin 1 alpha stimulates hemopoiesis but not tumor ... Interleukin 1 alpha (IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded ...
*  SH3BGRL3
2001). "A novel tumor necrosis factor-alpha inhibitory protein, TIP-B1". Int. J. Immunopharmacol. 22 (12): 1137-42. doi:10.1016 ... reported SH3BGRPL3 protein as a post-translational modification of the 27kDa tumor necrosis factor alpha (TNF-α) inhibitory ... 1999). "Identification, characterization, and cloning of TIP-B1, a novel protein inhibitor of tumor necrosis factor-induced ... Conversely, the related protein SH3BGRL is reported to be downregulated in fibroblasts, lymphoid cells, and splenic tumor cells ...
*  Gaucher's disease
... and tumor necrosis factor alpha in splenic Gaucher cells (engorged macrophages). The three types of Gaucher's disease are ... Prenatal diagnosis is available and is useful when a known genetic risk factor is present. A diagnosis can also be implied by ... A deformity of the distal femur in the shape of an Erlenmeyer flask is commonly described (aseptic necrosis of the femur joint ... making this the most common known genetic risk factor for Parkinson's. Cancer risk may be increased, particularly myeloma. This ...
*  TNF inhibitor
... www.drugs.com/fda/tumor-necrosis-factor-alpha-tnf-alpha-blockers-label-change-boxed-warning-updated-risk-infection-13023.html ... October 1994). "Randomized double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus ... a tumor necrosis factor alpha-neutralizing agent". N. Engl. J. Med. 345 (15): 1098-104. doi:10.1056/NEJMoa011110. PMID 11596589 ... receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency". J. Pharmacol. Exp ...
*  Lymphotoxin
... beta receptor Tumor necrosis factor-alpha#Discovery Parham, Peter (2005). "Chapter 6: T-cell mediated immunity". ... Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 ... Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts ... The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. ...
*  Alpha-enolase
Rus HG, Niculescu F, Vlaicu R (August 1991). "Tumor necrosis factor-alpha in human arterial wall with atherosclerosis". ... Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha- ... ENO1 overexpression has been associated with multiple tumors, including glioma, neuroendocrine tumors, neuroblastoma, ... Alpha-enolase has been shown to interact with TRAPPC2. Enolase ENO2 ENO3 Alpha-Enolase Linked to Severe Asthma - medscape news ...
*  PLCB4
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications ... 1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". ... "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174-80. doi:10.1006/viro. ... 5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 ( ...
*  PRKACB
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications ... PRKACB has been shown to interact with Ryanodine receptor 2 and Low affinity nerve growth factor receptor. GRCh38: Ensembl ... 1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". ...
*  PLCD3
Chen P, Mayne M, Power C, Nath A (Sep 1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ... "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174-80. doi:10.1006/viro. ... 5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of ...
*  Childbirth
"Fetal distress increases interleukin-6 and interleukin-8 and decreases tumour necrosis factor-alpha cord blood levels in ... These factors form the Bishop score. The Bishop score can also be used as a means to predict the success of an induction of ... Risk factors for significant vaginal birth injury include: A baby weighing more than 9 pounds (4.1 kg). The use of forceps or ... Risk factors for GBS infection include: prematurity (birth before 37 weeks gestation) a sibling who has had a GBS infection ...
*  Sphingosine kinase 1
"Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological ... "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological ... including platelet-derived growth factor and serum. SPHK1 has been shown to interact with TRAF2. GRCh38: Ensembl release 89: ... inhibitors of SPHK block formation of S1P and selectively inhibit cellular proliferation induced by a variety of factors, ...