The tumor microenvironment is often hypoxic. As the tumor mass increases, the interior of the tumor becomes farther away from ... The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, ... Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing ... This immune response did not however affect the primary tumor. The primary tumor instead established a microenvironment that is ...
Research foci: drug resistance; cancer genomics; tumor microenvironment; cancer metabolism; growth control in mammalian cells; ... Upon taking charge in 1968, he focused the Laboratory on cancer research, creating a tumor virus group and successfully ...
... cell and tumor biology; tumor microenvironment; systems biology and other emerging technologies. The AACR launched Cancer ...
CAFs are a complex and abundant cell type within the tumour microenvironment; the number cannot decrease, as they are unable to ... If the tumour is unable to develop the blood supply it requires, cells within the tumour will begin to die and further growth ... July 2017). "A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment". ... FSP1, which is secreted by CAFs, promotes tumours through another method - by altering the tumour microenvironment (TME). Some ...
"Tumor-Microenvironment Interactions". Tumor-microenvironment interactions: the selectin-selectin ligand axis in tumor- ... Tumor cells exploit the selectin-dependent mechanisms mediating cell tethering and rolling interactions through recognition of ... In fact, the extravasation of circulating tumor cells in the host organ requires successive adhesive interactions between ... enhanced E-selectin expression on the surface of endothelial vessels at the site at tumor metastasis, and the capacity of ...
"Analyzing the Tumor Microenvironment by Flow Cytometry". The Tumor Microenvironment. Methods in Molecular Biology. Vol. 1458. ... An example is the detection of tumor markers, such as in the diagnosis of leukemia. It involves the labelling of white blood ...
... tumor biology and microenvironment; and tumor metastasis. "Special Research Programs" falling under the aegis of the DCB ... In the Molecular Target Program thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines ... The third phase of the study is the human tumor xenograft evaluation. Active compounds are selected for testing based on ... A second phase screen establishes the maximum tolerable dosage and involves in vivo examination of tumor regression using the ...
Biomarkers of the Tumor Microenvironment. Cham: Springer. pp. 31-52. doi:10.1007/978-3-030-98950-7_3. ISBN 978-3-030-98949-1. ... which gives an opportunity for implementation of new biomarkers of tumour angiogenesis and could provide new anti-angiogenic ... It has been recognised that endothelial cells building tumour vasculature have distinct morphological characteristics, ... "Molecular Phenotypes of Endothelial Cells in Malignant Tumors.". In Akslen LA, Watnick RS (eds.). ...
Mukherjee's primary area of research revolves around tumor and tumor microenvironments. His research also deals with protein- ... "Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth". ACS Nano. 10 (12): 10636-10651. doi: ... "Reprogramming Tumor Microenvironment by Nanoparticle". (Articles with short description, Short description is different from ... Some of Mukherjee's research focuses on reprogramming tumor microenvironments. In this area, he has worked on disrupting CC-CAF ...
Biomarkers of the Tumor Microenvironment. Springer, Cham. pp. 351-376. Oien DB, Garay T, Eckstein S, Chien J (2018). "Cisplatin ... Increase in AXL function has been linked to key mechanisms of drug resistance and immune escape by tumor cells, leading to ... Davidsen KT, Haaland GS, Lie MK, Lorens JB, Engelsen AS (2017). "The role of Axl receptor tyrosine kinase in tumor cell ... from Rigel Pharmaceuticals by BerGenBio and currently undergoing six Phase II trials in various solid and hematological tumors ...
The microenvironment of a tumor is different compared to normal healthy tissues in the body. One distinct difference is the pH ... and the release of acidic metabolites by the tumor cells. Tumor hypoxia occurs when a tumor's environment has low or severely ... As a result, targeting the acidic microenvironment of tumors has emerged as a promising strategy for cancer therapy. One ... The heterogeneity of the tumor pH is one of the reasons for this cause. The pH of the tumor tends to become more acidic as you ...
"Endogenous Myc maintains the tumor microenvironment". Genes & Development. 25 (9): 907-916. doi:10.1101/gad.2038411. PMC ... "Validation of MdmX as a therapeutic target for reactivating p53 in tumors". Genes & Development. 25 (16): 1746-1757. doi: ... "The pathological response to DNA damage does not contribute to p53-mediated tumour suppression". Nature. 443 (7108): 214-217. ... "Selective activation of p53-mediated tumour suppression in high-grade tumours". Nature. 468 (7323): 567-571. Bibcode:2010Natur. ...
Ungefroren H, Sebens S, Seidl D, Lehnert H, Hass R (September 2011). "Interaction of tumor cells with the microenvironment". ... The dispersed tumors are called metastatic tumors, while the original is called the primary tumor. Almost all cancers can ... The dispersed tumors are called metastatic tumors, while the original is called the primary tumor. Almost all cancers can ... All tumor cells show the six hallmarks of cancer. These characteristics are required to produce a malignant tumor. They include ...
Kessenbrock K, Plaks V, Werb Z (2010). "Matrix metalloproteinases: regulators of the tumor microenvironment". Cell. 141 (1): 52 ... Tumor-suppressor through Tumor metastasis-inhibiting peptide KISS1 Another study, led by Zhang B, created a L. lactis strain ... In addition, it was demonstrated that tumor growth can be inhibited by the LAB strain itself, due to the ability of LAB to ... lactis requires much lower doses than systemic treatments like antibodies to tumor necrosis factor (TNF) or recombinant IL-10. ...
These cells and their interactions all contribute to the changing tumor microenvironment, which the tumor largely manipulates ... In addition, inducing peripheral tolerance in the local microenvironment is a common survival strategy for a number of tumors ... In addition to promoting immune tolerance, other aspects of the microenvironment aid in immune evasion and induction of tumor- ... Becker, JC; Andersen MH; Schrama D; Straten P (Jul 2013). "Immune-suppressive properties of the tumor microenvironment". Cancer ...
2010). Cancer genome and tumor microenvironment (Online-Ausg. ed.). New York: Springer. p. 203. ISBN 978-1-4419-0711-0. ... This low risk is thought to be due to an increase in the expression of tumor suppressor genes present on chromosome 21. One ...
Whatcott CJ, Han H, Posner RG, Hostetter G, Von Hoff DD (September 2011). "Targeting the tumor microenvironment in cancer: why ... Chanmee T, Ontong P, Itano N (May 2016). "Hyaluronan: A modulator of the tumor microenvironment". Cancer Letters. 375 (1): 20- ... However, studies show that removal of hyaluronan from tumors prevents tumor invasion.[citation needed] Hyaluronidases are also ... Limited data support a role of lysosomal hyaluronidases in metastasis, while other data support a role in tumor suppression. ...
IL-17F may also be involved in tumorigenesis and associated with the tumor microenvironment (TME), as pro-tumor and anti-tumor ... Gorczynski RM (2020). Birbrair A (ed.). "IL-17 Signaling in the Tumor Microenvironment". Advances in Experimental Medicine and ... However, a role for IL-17F in tumor development has not been well described. GRCh38: Ensembl release 89: ENSG00000112116 - ... such as tumor necrosis factor, interleukin 1, interleukin 6 and some members of the colony-stimulating factor family. IL-17F ...
September 2012). "Opposing roles for complement component C5a in tumor progression and the tumor microenvironment". Journal of ... Ungefroren H, Sebens S, Seidl D, Lehnert H, Hass R (September 2011). "Interaction of tumor cells with the microenvironment". ... Such an approach may limit side effects that are unrelated to the tumor of interest, and may help preserve vital homeostatic ... The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin calor, dolor, rubor, tumor, and functio ...
Kessenbrock, K; Plaks, V; Werb, Z (2 April 2010). "Matrix metalloproteinases: regulators of the tumor microenvironment". Cell. ... However, double knockout mice with mutated Nbs1 which were also null of the p53 tumor suppressor gene displayed tumor onset ... In this same study, Nbs1 levels were significantly higher in secondary tumor samples than in samples from the primary tumor, ... Since tumor cells have increased mitotic rates compared to non-malignant cells this is not entirely unexpected, as it is ...
Weinstein AM, Storkus WJ (2015). "Therapeutic Lymphoid Organogenesis in the Tumor Microenvironment". Advances in Cancer ... Lymphotoxin beta receptor Tumor necrosis factor-alpha#Discovery Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, ... Studies using mice with an LT-α knockout found increased tumor growth in the absence of LT-αβ. However, some studies using ... Lymphotoxin has cytotoxic properties that can aid in the destruction of tumor cells and promote the death of cancerous cells. ...
Tumor Microenvironment: Tissue cytometry is heavily used in research to characterize the tumor microenvironment including e.g. ... "Next-Generation Digital Histopathology of the Tumor Microenvironment". Genes. 12 (4): 538. doi:10.3390/genes12040538. ISSN 2073 ... published a method to quantify prostate-specific acid phosphatase (PSAP) in histologic sections of prostate tumor with the ... or tumor foci). Fluorescence Activated Cell Sorting (FACS) is a method of analysis that measures fluorescence signals on single ...
... and cell migration in the brain tumor microenvironment. In 2021, she was elected a fellow of the American Association for the ...
It promotes tumor cell death and normalizes the tumor microenvironment. Active transcription is the process by which there are ... Lurbinectedin also has important role in tumor microenvironment. The tumor cells act upon macrophages to avoid them from ... Macrophages can contribute to tumor growth and progression by promoting tumor cell proliferation and invasion, fostering tumor ... inhibiting the production of tumor growth factors. In this way, lurbinectedin normalizes the tumor microenvironment. ...
"A Novel Organotypic Model Mimics the Tumor Microenvironment". The American Journal of Pathology. 175 (3): 1281-1291. doi: ... myogel is extracted from a human benign tumor tissue called leiomyoma. Myogel was developed in Tuula Salo's lab at the ...
... is highly expressed by macrophages and monocytes in the tumor microenvironment (TME), including tumor-associated ... Higher infiltration of tumor tissues by macrophages was seen in tumors expressing PD-L1; macrophages within tumor cell nests co ... Jahchan NS, Mujal AM, Pollack JL, Binnewies M, Sriram V, Reyno L, Krummel MF (2019). "Tuning the Tumor Myeloid Microenvironment ... December 2020). "Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer ...
Iyengar NM, Gucalp A, Dannenberg AJ, Hudis CA (December 2016). "Obesity and Cancer Mechanisms: Tumor Microenvironment and ... The DDP human homologs are over-represented in known cancer drivers, and their RNAs in tumors predict heavy mutagenesis and a ... These treatments are ineffective in cancer tumor that have mutated p53 since they do not have a functioning p53 to either ... also known as a tumor suppressor gene, is a major regulatory protein in the DNA damage response system which binds directly to ...
"Transcriptome analysis reveals tumor microenvironment changes in glioblastoma". Cancer Cell. 41 (4): 678-692.e7. doi:10.1016/j. ... "Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens". Nature Biotechnology. 40 ... an algorithm for gene fusion discovery in tumor RNA-Seq data". PLOS Computational Biology. 7 (5): e1001138. Bibcode:2011PLSCB ...
Tang D, Park S, Zhao H (March 2020). "NITUMID: Nonnegative matrix factorization-based Immune-TUmor MIcroenvironment ... For example, cancer tumors consist of heterogeneous mixtures of various healthy cells of different types such as immune cells ... Qin Y, Zhang W, Sun X, Nan S, Wei N, Wu HJ, Zheng X (November 2020). "Deconvolution of heterogeneous tumor samples using ... Hao Y, Yan M, Heath BR, Lei YL, Xie Y (May 2019). "Fast and robust deconvolution of tumor infiltrating lymphocyte from ...
"Spatial CRISPR Genomics of Tumor Microenvironments". 16 March 2022. "Cell Papers on Viruses in Chinese Game Animals, Perturb- ... developed a new CRISPR imaging technology called Perturb-map capable of identifying regulators in tumor microenvironments. The ... "Spatial CRISPR genomics identifies regulators of the tumor microenvironment". Cell. 185 (7): 1223-1239.e20. doi:10.1016/j.cell. ... "Spatial CRISPR genomics identifies regulators of the tumor microenvironment". Cell. 185 (7): 1223-1239.e20. doi:10.1016/j.cell. ...
"Molecular Phenotypes of Endothelial Cells in Malignant Tumors", Biomarkers of the Tumor Microenvironment, Cham: Springer ... The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as "hot ... The combined blockade of VEGF and Dll4 results in the inhibition of tumor progression and angiogenesis throughout the tumor. ... Biomarkers of the Tumor Microenvironment. pp. 31-52. doi:10.1007/978-3-030-98950-7_3. ISBN 978-3-030-98949-1. S2CID 250460190. ...