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*  MACPF
Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82-90. doi: ... Perforin is stored in granules within cytotoxic T-cells and is responsible for killing virally infected and transformed cells. ... Perforin is released by cytotoxic T cells and lyses virally infected and transformed cells. In addition, perforin permits ... Cell. 121 (2): 247-56. doi:10.1016/j.cell.2005.02.033. PMID 15851031. Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S (2006 ...
*  DBC1
Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82-90. doi: ... Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor ... 2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 ... "Entrez Gene: DBC1 deleted in bladder cancer 1". Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour ...
*  Omega-6 fatty acid
Tokar, Steve (2005-09-02). "Omega-6 fatty acids cause prostate tumor cell growth in culture". Medical News Today. MediLexicon ... after the cell damage has been repaired. The conversion of cell membrane arachidonic acid (20:4n-6) to omega-6 prostaglandin ... Mammalian cells lack the enzyme omega-3 desaturase and therefore cannot convert omega-6 fatty acids to omega-3 fatty acids. ... A ratio of 2.5:1 reduced rectal cell proliferation in patients with colorectal cancer, whereas a ratio of 4:1 had no effect. ...
*  Saos-2 cells
Fogh J, Fogh JM, Orfeo T (1977). "One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice". ... Gundle R, Beresford JN (1995). "The isolation and culture of cells from explants of human trabecular bone". Calcif. Tissue Int ... Hausser HJ, Brenner RE (2005). "Phenotypic instability of Saos-2 cells in long-term culture". Biochem. Biophys. Res. Commun. ... the possibility to obtain large amounts of cells in short time, and the fact that Saos-2 cells can be fully differentiated in a ...
*  Protease inhibitor (pharmacology)
For example, nelfinavir and atazanavir are able to kill tumor cells in culture (in a Petri dish). This effect has not yet been ... examined in humans; but studies in laboratory mice have shown that nelfinavir is able to suppress the growth of tumors in these ...
*  Panobinostat
In the study, investigators found that this combination destroyed up to 65 percent of cultured pancreatic tumor cells. The ... Comparison of HDAC inhibitors in clinical development: Effect on HIV production in latently infected cells and T-cell ... Panobinostat was able to selectively target triple negative breast cancer (TNBC) cells by inducing hyperacetylation and cell ... These resting cells are not recognized by the immune system as harboring the virus and do not respond to antiretroviral drugs. ...
*  Morphogenesis
... can take place also in a mature organism, in cell culture or inside tumor cell masses. Morphogenesis also ... In cell culture cells that have the strongest adhesion move to the center of a mixed aggregates of cells. Moreover, cell-cell ... One of the ways this can occur is when cells share the same cell-to-cell adhesion molecules. For instance, homotypic cell ... such as cell adhesion or cell contractility. For example, during gastrulation, clumps of stem cells switch off their cell-to- ...
*  INH1
Oct 15, 2008). "Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal". ... Experiments show that INH1 potently inhibits the proliferation of multiple human breast cancer cell lines, cervical HeLa cells ... INH1, a thiazolyl benzamide compound, is a cell-permeable Hec1/Nek2 mitotic pathway inhibitor I. INH1 controls the biological ... and colon cancer cells in vitro. "biological activity of INH1 by selleckchemicals". selleck. Wu G, et al. ( ...
*  Vusamazulu Credo Mutwa
"In vitro culture studies of Sutherlandia frutescens on human tumor cell lines". Journal of Ethnopharmacology. 93 (1): 9-19. doi ... The village was primary designed for tourism to promote African culture and was generally ignored by the Sowetan locals, partly ... each representing the traditional cultures of the main South African tribal peoples. The Kwa-Khaya Lendaba cultural village in ...
*  Temozolomide
In the laboratory, this combination indeed showed increased temozolomide activity in tumor-cell culture in vitro and in animal ... This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type ... Because tumor cells that express the MGMT gene are more resistant to the effects of temozolomide, researchers investigated ... In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors ...
*  Pancreatic stellate cell
For example, culture supernatants from human pancreatic tumour cell lines induce PaSC proliferation and the production of ECM ... Pancreatic tumour cells stimulate the proliferation of PaSCs through the secretion of PDGF, and induce PaSC production of ECM ... Watari likened these cells to hepatic stellate cells. The publication of two seminal research papers in 1998 outlining the ... Pancreatic stellate cells (PaSCs) are classified as myofibroblast-like cells that are located in exocrine regions of the ...
*  Formazan
... of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines ... These formazan dyes are commonly used in cell proliferation and toxicity assays like the EpiDerm and EpiSkin tests since they ... When reduced in a cell, either enzymatically or through direct reaction with NADH or NADPH, the classical tetrazolium salt, MTT ... "A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function". Growth Regul. 5 (2): ...
*  Isothermal microcalorimetry
2008). Analogous successful use of IMC to determine the effects of antitumor drugs on tumor cells in culture within a few hours ... the size of the donor animal has no effect on the metabolic rate of the cell when cultured in vitro. Mammalian cells in culture ... Degradation of a culture medium in which metabolism and growth of living cells is being studied. Thus great care must be taken ... 33,000 cells is detectable. Based on this sensitivity, IMC was used to perform a large number of pioneering studies of cultured ...
*  Secreted frizzled-related protein 1
... but also markedly inhibited tumor cell growth in culture, soft agar and xenografts in athymic nude mice. Growth in culture and ... showed that SFRP1 expression in UMRC3 cells (clear cell renal cell carcinoma cell line) resulted in a growth-inhibited ... There are 3 types of tumor suppressor genes: Genes that affect cell growth Genes that limit the cell cycle and induce apoptosis ... should be simultaneously expressed in myeloma cells and growth of tumour cells should be inhibited upon addition of SFRP1. Chim ...
*  Robert Huebner
Wallace Rowe first tried to use adenoid and tonsil tissue, before using a culture based on tumor cells. From that culture they ... After culturing and isolating the organism in laboratory mice, the pathogen they named Rickettsia akari was identified as the ... could cause normal cells to mutate and become cancerous. A specific gene matching the theorized description was discovered and ... which was discovered to be a trigger for normal cells turning cancerous. Huebner was born in Cheviot, Ohio, a western suburb of ...
*  Histone deacetylase inhibitor
... are a new class of cytostatic agents that inhibit the proliferation of tumor cells in culture and in vivo by inducing cell ... Histone deacetylase inhibitors exert their anti-tumour effects via the induction of expression changes of oncogenes or tumour ... "Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells". ... The goal is for HDAC inhibitors to flush HIV from the reservoirs it builds within the DNA of infected cells, followed by a ...
*  Neutron capture therapy of cancer
... of brain tumors and have shown high uptake by brain tumor cells in tissue culture (in vitro). Third, gamma rays and internal ... The selective destruction of brain tumor (glioma) cells in the presence of normal cells represents an even greater challenge ... "Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: ... In principle, NCT is a radiation therapy that could selectively deliver lethal doses of radiation to tumor cells while sparing ...
*  Celecoxib
However, when the ability of all these compounds to kill tumor cells in cell culture was investigated, the antitumor potency ... For example, a recent study with malignant tumor cells showed celecoxib could inhibit the growth of these cells in vitro, but ... "COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in ... Different from cancer prevention, cancer treatment is focused on the therapy of tumors that have already formed and have ...
*  Ganglioside
... and very low concentrations of a specific ganglioside can induce differentiation of cultured neuronal tumor cells. One NANA ("M ... It is a component of the cell plasma membrane that modulates cell signal transduction events, and appears to concentrate in ... and act as distinguishing surface markers that can serve as specific determinants in cellular recognition and cell-to-cell ... Ultimately the ganglion cells in the nervous system swell enormously, disturbing the normal functions of neurons. Gangliosides ...
*  COX-2 inhibitor
However, when the ability of all these compounds to kill tumor cells in cell culture was investigated, it turned out that the ... a recent study with various malignant tumor cells showed that celecoxib could inhibit the growth of these cells, even though ... Functional p53 allows DNA damaged neuroblastoma cells to commit suicide through apoptosis, halting tumor growth. COX-2 up- ... itself and this anticancer effect could also be verified in highly drug-resistant tumor cells and in various animal tumor ...
*  Lipoplatin
... by endocytosis by tumor cells as shown from Lipoplatin containing fluorescent lipids and imaging of the tumor cells in culture ... Lipoplatin nanoparticles once inside the tumor cell mass can fuse with the cell membrane because of the presence of the ... inside the cytoplasm to kill the tumor cell. The cell membrane is considered a significant barrier to transportation of the ... toxic molecules of cisplatin across and inside the tumor cell. The results of a Phase III trial were published in October 2011 ...
*  Oncolytic herpes virus
... which may be the reason why HSV1716 effectively kills a wide range of tumour cell lines in tissue culture. An HSV1716 variant, ... while still allowing replication in tumor cells), although it also reduces replication in tumor cells as compared to wild type ... The study assessed tumour response by CT scan and FDG-PET scans, showing 67% of patients had an initial increase in tumour size ... However, tumour cells have much weaker PKR-linked defences, ... largely overcomes the reduction in replication in tumor cells ...
*  H295R
The initial polyclonal populations of tumor cells obtained from the patients' tumor were cultured and the resultant cell line ... All three strains grow as adherent monolayer cultures. Wang T, Rainey WE (2012). "Human Adrenocortical Carcinoma Cell Lines". ... Rainey WE, Saner K, Schimmer BP (2004). "Adrenocortical cell lines". Mol. Cell. Endocrinol. 228 (1-2): 23-38. doi:10.1016/j.mce ... Cell. Endocrinol. 351 (1): 58-65. doi:10.1016/j.mce.2011.08.041. PMC 3288152 . PMID 21924324. Gazdar AF, Oie HK, Shackleton CH ...
*  MTOR inhibitors
Thus, this data is based on preclinical assays, based on in vitro cultured tumor cell lines, which suggest that the effects of ... Another reason for the limited success is that there is a feedback loop between mTORC1 and AKT in certain tumor cells. It seems ... It appears that genetic determinants predispose cancer cells to be sensitive or resistant to these compounds. Tumors that ... A G0-G1 cell-cycle blockage can be the consequence of inactivation of mTOR in hypoxia-activated pericytes and endothelial cells ...
*  ATP-binding cassette transporter
Discovery of the first eukaryotic ABC transporter protein came from studies on tumor cells and cultured cells that exhibited ... In addition to conferring MDR in tumor cells, ABC transporters are also expressed in the membranes of healthy cells, where they ... For example, the ABCB1 protein (P-glycoprotein) functions in pumping tumor suppression drugs out of the cell. Pgp also called ... ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood ...
*  Scarring hair loss
... tumors, or traction. Primary cicatricial alopecias are further classified by the type of inflammatory cells that destroy the ... In addition, if pustules are present, cultures are taken to identify which microbes, if any, may be contributing to the ... If the stem cells and sebaceous gland are destroyed, there is then no possibility for regeneration of the hair follicle, and ... The goal of treatment is to decrease or eliminate the lymphocytic inflammatory cells that are attacking and destroying the hair ...