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*  Tryptophan 2,3-dioxygenase
... oxygenases). This family includes tryptophan 2,3-dioxygenase (TDO, also sometimes referred to as tryptophan oxygenase and L- ... In enzymology, tryptophan 2,3-dioxygenase (EC 1.13.11.11) is a heme enzyme that catalyzes the oxidation of L-tryptophan (L-Trp ... Comings DE, Muhleman D, Dietz GW, Donlon T (February 1991). "Human tryptophan oxygenase localized to 4q31: possible ... A tryptophan 2,3-dioxygenase inhibitor developed by the group restored the ability of these mice to reject tryptophan 2,3- ...
*  List of MeSH codes (D08)
... tryptophan oxygenase MeSH D08.811.682.690.562 --- inositol oxygenase MeSH D08.811.682.690.708 --- mixed function oxygenases ... heme oxygenase (decyclizing) MeSH D08.811.682.690.708.410.500 --- heme oxygenase-1 MeSH D08.811.682.690.708.425 --- 4- ... tryptophan-tRNA ligase MeSH D08.811.464.263.200.900 --- tyrosine-tRNA ligase MeSH D08.811.464.263.200.950 --- valine-tRNA ... tryptophan synthase MeSH D08.811.520.241.300.900 --- urocanate hydratase MeSH D08.811.520.241.300.950 --- uroporphyrinogen iii ...
*  Catechol 1,2-dioxygenase
Hayaishi, O; Katagiri, M; Rothberg, S (1957). "Pioneering the Field of Oxygenases through the Study of Tryptophan Metabolism: ... Hayaishi, O.; Lardy, H.; Myrbäck, K. (1963). "Direct oxygenation by O2, oxygenases". In Boyer, P.D. The Enzymes. 8 (2nd ed.). ... Itoh, M (1981). "Characteristics of a new catechol-1,2-oxygenase from Trichosporon cutaneum WY2-2". Agric. Bio. I. Chem. 45 (1 ... Hayaishi, O.; Katagiri, M.; Rothberg, S. (1957). "Studies on oxygenases: pyrocatechase". J. Biol. Chem. 229 (2): 905-920. PMID ...
*  7,8-dihydroxykynurenate 8,8a-dioxygenase
8-dihydroxykynurenate oxygenase, and 7,8-dihydroxykynurenate 8,8alpha-dioxygenase. This enzyme participates in tryptophan ... oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 7,8- ...
*  3-hydroxyanthranilate 3,4-dioxygenase
3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase, and 3HAO. This enzyme participates in tryptophan metabolism ... Other names in common use include 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, ... oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 3- ...
*  Ergotamine
... the prenylation of L-tryptophan. Further reactions, involving methyltransferase and oxygenase enzymes, yield the ergoline, ... Its biosynthesis in these fungi requires the amino acid L-tryptophan and dimethylallyl diphosphate. These precursor compounds ... are the substrates for the enzyme, tryptophan dimethylallyltransferase, catalyzing the first step in ergot alkaloid ...
*  Tryptophan 2-monooxygenase
... oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal ... In enzymology, a tryptophan 2-monooxygenase (EC 1.13.12.3) is an enzyme that catalyzes the chemical reaction L-tryptophan + O2 ... I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi". J. Biol. Chem. 241 ( ... the two substrates of this enzyme are L-tryptophan and O2, and its 3 products are (indol-3-yl)acetamide, CO2, and H2O. This ...
*  Roland Stocker
... the understanding of how antioxidants and heme oxygenase-1 protect against atherosclerosis, and the contribution of tryptophan ... Stocker R, Perrella MA (2006). "BHeme oxygenase-1: a novel drug target for atherosclerotic diseases?". Circulation. 114 (20): ... "Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging". J Exp ...
*  Tryptophan 2'-dioxygenase
... oxygenases). The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is L- ... tryptophan side chain oxidase type I, TSO I, TSO II, and tryptophan side chain oxidase. This enzyme participates in tryptophan ... tryptophan side-chain alpha,beta-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan ... In enzymology, a tryptophan 2'-dioxygenase (EC 1.13.99.3) is an enzyme that catalyzes the chemical reaction L-tryptophan + O 2 ...
*  Peptide-tryptophan 2,3-dioxygenase
... oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is peptide- ... and tryptophan pyrrolooxygenase. Frydman RB, Tomaro ML, Frydman B (1972). "Pyrrolooxygenase: its action on tryptophan- ... In enzymology, a peptide-tryptophan 2,3-dioxygenase (EC 1.13.11.26) is an enzyme that catalyzes the chemical reaction peptide ... the two substrates of this enzyme are peptide tryptophan and O2, whereas its product is peptide formylkynurenine. This enzyme ...
*  List of EC numbers (EC 1)
... inositol oxygenase EC 1.13.99.2: now EC 1.14.12.10 EC 1.13.99.3: tryptophan 2'-dioxygenase EC 1.13.99.4: now EC 1.14.12.9 EC ... premnaspirodiene oxygenase EC 1.14.13.122: chlorophyllide-a oxygenase EC 1.14.13.123: germacrene A hydroxylase EC 1.14.13.124: ... diapolycopene oxygenase EC 1.14.99.45: carotene epsilon-monooxygenase EC 1.14.99.46: pyrimidine oxygenase EC 1.14.99.47: (+)- ... heme oxygenase (decyclizing) EC 1.14.99.4: progesterone monooxygenase EC 1.14.99.5: now EC 1.14.19.1 EC 1.14.99.6: now EC 1.14. ...
*  Tyrosine hydroxylase
Tryptophan is a poor substrate for tyrosine hydroxylase, however it can hydroxylate L-phenylalanine to form L-tyrosine and ... The enzyme is an oxygenase which means it uses molecular oxygen to hydroxylate its substrates. One of the oxygen atoms in O2 is ... Grenett HE, Ledley FD, Reed LL, Woo SL (Aug 1987). "Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and ... This has shown how its structure is very similar to that of phenylalanine hydroxylase and tryptophan hydroxylase; together the ...
*  Dioxygenase
... tryptophan to N-formylkynurenine is catalyzed by either tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO), ... Sono, M; Roach, MP; Coulter, ED; Dawson, JH (Nov 7, 1996). "Heme-Containing Oxygenases". Chemical Reviews. 96 (7): 2841-2888. ... Due to the degree of diversity in the dioxygenase family, dioxygenases have a wide range of influences in biology: Tryptophan 2 ... Since it affects levels of both tryptophan and kynurenine, IDO has also been implicated in influencing systems related to ...
*  2,3-dihydroxyindole 2,3-dioxygenase
... oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,3- ... dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing). This enzyme participates in tryptophan metabolism. Fujioka M, Wada H ( ...
*  Antimycin A
Synthesis begins with tryptophan, an amino acid. 1. The indole ring of tryptophan, an amino acid, is opened by a pathway- ... 4. Anthranilate is converted to 3-aminosalicylate by a multicomponent oxygenase, AntHIJKL. 5. 3-Aminosalicylate is presented to ...
*  Indole 2,3-dioxygenase
IDO is a peripheral enzyme, in contrast to tryptophan oxidase, an enzyme of similar amino acid sequence, which is active only ... Divakar NG, Subramanian V, Sugumaran M, Vaidyanathan CS (1979). "Indole oxygenase from the leaves of Jasminum grandiflorum". ... oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is indole:oxygen 2,3 ... "Purification and characterization of a new indole oxygenase from the leaves of Tecoma stans L". Plant Physiol. 71 (1): 19-23. ...
*  Kynurenine 3-monooxygenase
"Recent advances in tryptophan research : tryptophan and serotonin pathways". Advances in Experimental Medicine and Biology. 398 ... SAITO Y, HAYAISHI O, ROTHBERG S (1957). "Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine ... It participates in tryptophan metabolism through the kynurenine catabolic pathway. This enzyme belongs to the family of ... The kynurenine pathway is responsible for >95% of tryptophan oxidative degradation. L-Kynurenine is an important branch point ...
*  Hemopexin
The 18 tryptophan residues are arranged in four clusters, and 12 of the tryptophans are conserved in homologous positions. ... Ma B, Day JP, Phillips H, Slootsky B, Tolosano E, Doré S (2016). "Deletion of the hemopexin or heme oxygenase-2 gene aggravates ... Role for hemopexin in hepatic uptake of Sn-protoporphyrin IX and induction of mRNA for heme oxygenase". The Journal of ... Smith A, Alam J, Escriba PV, Morgan WT (April 1993). "Regulation of heme oxygenase and metallothionein gene expression by the ...
*  Kynurenine
L-Kynurenine (/kaɪˈnjʊərɪniːn/) is a metabolite of the amino acid L-tryptophan used in the production of niacin. Kynurenine is ... Kynureninase, European Bioinformatics Institute Saito Y, Hayaishi O, Rothberg S (1957-12-01). "Studies on Oxygenases". The ... KMO deficiency leads to an accumulation of kynurenine and to a shift within the tryptophan metabolic pathway towards kynurenine ... Hirata Y, Kawachi T, Sugimura T (1967). "Fatty liver induced by injection of L-tryptophan". Biochim. Biophys. Acta. 144 (2): ...
*  Alkylglycerol monooxygenase
Other names in use are glyceryl-ether monooxygenase, glyceryl-ether cleaving enzyme, glyceryl ether oxygenase, glyceryl ... tryptophan hydroxylase and nitric oxide synthase, alkylglycerol monooxygenase critically depends on the cofactor ...
*  Ciliate, dasycladacean and hexamita nuclear code
Tryptophan (Trp, W), Tyrosine (Tyr, Y), Valine (Val, V) Bases: adenine (A), cytosine (C), guanine (G) and thymine (T) or uracil ... 5-bisphosphate carboxylase/oxygenase of two species of Acetabularia and the occurrence of unusual codon usage". Molecular & ... Tryptophan (Trp, W), Tyrosine (Tyr, Y), Valine (Val, V) Ciliata: Oxytricha and Stylonychia, Paramecium, Tetrahymena, ...
*  Chaetomium cupreum
... tyrosine and tryptophan biosynthesis. Proteases produced by C. cupreum are involved in pathogen cell wall breakdown and ... "Degradation of catechin and purification and partial characterization of catechin oxygenase from Chaetomium cupreum". World ... methionine and tryptophan metabolism; phenylalanine, valine, leucine and isoleucine degradation; valine, leucine, isoleucine, ...