*Triosephosphate isomerase

Triose Phosphate Isomerase deficiency TPI1 Triosephosphate isomerase in interactive 3D at Proteopedia Triosephosphate isomerase ... severe neurological disorder called triose phosphate isomerase deficiency. Triose phosphate isomerase deficiency is ... Triose-phosphate isomerase (TPI or TIM) is an enzyme (EC 5.3.1.1) that catalyzes the reversible interconversion of the triose ... The sequence around the active site residues is conserved in all known triose phosphate isomerases. The structure of triose ...

*Triosephosphate isomerase deficiency

"Triose Phosphate Isomerase Deficiency Is Caused by Altered Dimerization-Not Catalytic Inactivity-of the Mutant Enzymes". PLoS ... Triosephosphate isomerase deficiency is a rare autosomal recessive metabolic disorder which was initially described in 1965. It ... 1996). "The 1591C mutation in triosephosphate isomerase (TPI) deficiency. Tightly linked polymorphisms and a common haplotype ... Schneider, Arthur S. (Mar 2000). "Triosephosphate isomerase deficiency: historical perspectives and molecular aspects". Best ...

*Isomerase

"Triosephosphate Isomerase Deficiency". NORD. Retrieved 14 December 2013. "Triose phosphate isomerase deficiency -TPI" (PDF). ... Phosphohexose Isomerase Dificiency (PHI) is also known as phosphoglucose isomerase deficiency or Glucose-6-phosphate isomerase ... The conversion of D-glucose-6-phosphate to D-fructose-6-phosphate is catalyzed by glucose-6-phosphate isomerase, an ... "Triose phosphate-isomerase deficiency". Orphanet. Retrieved 14 November 2013. Celotto AM, Frank AC, Seigle JL, Palladino MJ ( ...

*Pyrobaculum asR3 small RNA

"On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase". Philosophical Transactions of the ... asR3 binds to the 3'-end of the tpi gene (triose-phosphate-isomerse). The tpi mRNA has a conserved structural element located ...

*Michael Sternberg

"An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase". Journal of Molecular ... "An analysis of the three-dimensional structure of chicken triose phosphate isomerase". Biochemical Society Transactions. 5 (3 ...

*Glyceraldehyde 3-phosphate

Dihydroxyacetone phosphate (DHAP), catalyzed by triose phosphate isomerase. Compound C00111 at KEGG Pathway Database.Enzyme 5.3 ... Glyceraldehyde 3-phosphate, also known as triose phosphate or 3-phosphoglyceraldehyde and abbreviated as G3P, GA3P, GADP, GAP, ... The CAS number of glyceraldehyde 3-phosphate is 591-59-3 and that of D-glyceraldehyde 3-phosphate (one of the two optical ... D-glyceraldehyde 3-phosphate is also of some importance since this is how glycerol (as DHAP) enters the glycolytic and ...

*List of hematologic conditions

Michael; Lehrach, Hans; Krobitsch, Sylvia (December 20, 2006). "Triose Phosphate Isomerase Deficiency Is Caused by Altered ...

*Phenylarsine oxide

"An improved phenylarsine oxide-affinity method identifies triose phosphate isomerase as a candidate redox receptor protein". ...

*TPI1

Triose Phosphate Isomerase is a member of the alpha and beta (α/β) class of proteins; it is a homodimer, and each subunit ... "Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man". The ... "Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human ... Daar IO, Artymiuk PJ, Phillips DC, Maquat LE (Oct 1986). "Human triose-phosphate isomerase deficiency: a single amino acid ...

*Protein domain

The α/β-barrel is commonly called the TIM barrel named after triose phosphate isomerase, which was the first such structure to ... 1975). "Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5 angstrom resolution using ...

*Leslie D. Gottlieb

"Evidence for duplication of the structural genes coding plastid and cytosolic isozymes of triose phosphate isomerase in diploid ... and triosephosphate isomerase (TPI). In that review he reported that PGI in Clarkia was produced in both the cytosol and ... Froman, B. F.; Tait, R. C.; Gottlieb, L. D. (1989). "Isolation and characterization of the phosphoglucose isomerase gene from ... In C. similis a gene producing phosphoglucose isomerase (called PgiC2) was silenced after the polyploidization event, while in ...

*Fatty acid metabolism

The glycolytic enzyme triose phosphate isomerase converts this compound to glyceraldehyde 3-phosphate, which is oxidized via ... converted into glyceraldehyde 3-phosphate by the enzyme triose phosphate isomerase. From here the three carbon atoms of the ... Glycerol 3-phosphate is then oxidized to dihydroxyacetone phosphate, which is, in turn, ... and the resulting glycerol 3-phosphate is oxidized to dihydroxyacetone phosphate. ...

*Inborn errors of carbohydrate metabolism

Glucose-6-phosphate isomerase deficiency affects step 2 of glycolysis. Triosephosphate isomerase deficiency affects step 5 of ... Glucose-6-phosphate dehydrogenase deficiency affects the degradation of glucose in the pentose phosphate pathway, which is ... to galactose-1-phosphate (Gal-1-P), which in turn is converted by the enzyme galactose-1-phosphate uridylyltransferase (GALT) ... The Pentose phosphate pathway (PPP) (See also bioenergetic systems.) An alternative to glycolysis is the Pentose phosphate ...

*Methylglyoxal pathway

The enzyme triose phosphate isomerase affects the levels of DHAP by converting glyceraldehyde 3-phosphate (GAP) into DHAP. The ... Low phosphate levels inhibit GAP dehydrogenase; GAP is instead converted into DHAP by triosephosphate isomerase. Again, ... Methylglyoxal is formed from dihydroxyacetone phosphate (DHAP) by the enzyme methylglyoxal synthase, giving off a phosphate ... an inorganic phosphate is given off which can be used to replenish a low concentration of needed inorganic phosphate. The ...

*Enzyme catalysis

Triose phosphate isomerase (EC 5.3.1.1) catalyses the reversible interconvertion of the two triose phosphates isomers ... into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). The advent of single-molecule studies led in the 2010s ... Notably, the final steps of ATP hydrolysis include the fast release of phosphate and the slow release of ADP. The release of a ... Thus, we arrive at the conclusion that the primary release of the inorganic phosphate H2PO4− leads to transformation of a ...

*Omega loop

... such as in the enzyme triose phosphate isomerase, and can directly affect protein function in other enzymes. A heritable ... the reaction catalyzed by triosephosphate isomerase". Biochemistry. 43 (36): 11436-45. doi:10.1021/bi049208d. PMID 15350130. ...

*Phosphoinositide phospholipase C

... all family members possess homologous X and Y catalytic domains in the form of a distorted Triose Phosphate Isomerase (TIM) ... However, PLC-β binds to the lipid surface independent of PIP2 with all isozymes preferring phosphoinositol-3-phosphate or ... position on the inositol ring and the adjacent phosphate group resulting in a cyclic IP3 intermediate. At this point, DAG is ... tether the enzyme tightly to the plasma membrane in order to access substrate through ionic interactions between the phosphate ...

*Glycoside hydrolase family 6

... reveals an alpha-beta protein with a fold similar to the ubiquitous barrel topology first seen in triose phosphate isomerase. ...

*Chromosome 12 (human)

Stuttering Triose Phosphate Isomerase deficiency tyrosinemia Von Willebrand Disease G-banding ideograms of human chromosome 12 ... encoding protein Glycerol-3-phosphate dehydrogenase 1 GOLT1B: Golgi transport 1B GPN3: encoding enzyme GPN-loop GTPase 3 HNF1A- ... encoding protein Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma PIWIL1: encoding protein Piwi-like protein 1 POP5: ...

*ICD-10 Chapter III: Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism -...

Anaemia due to disorders of glycolytic enzymes hexokinase deficiency pyruvate kinase deficiency triose-phosphate isomerase ... Anaemia due to glucose-6-phosphate dehydrogenase (G6PD) deficiency Favism G6PD deficiency anaemia (D55.1) Anaemia due to other ...

*List of biophysically important macromolecular crystal structures

Triose phosphate isomerase 1976 - Rhizopuspepsin 1976 - Endothiapepsin 1976 - Penicillopepsin 1978 - Icosahedral virus 1981 - ...

*Phosphopentose epimerase

... erythrose-4-phosphate isomerase, phosphoketopentose 3-epimerase, xylulose phosphate 3-epimerase, phosphoketopentose wpimerase, ... Furthermore, Phosphopentose epimerase folds into a (β/α)8 triosephosphate isomerase (TIM) barrel that includes loops. The core ... D-ribulose 5-phosphate wpimerase, D-ribulose-5-P 3-epimerase, D-xylulose-5-phosphate 3-epimerase, and pentose-5-phosphate 3- ... Phosphopentose Isomerase Phosphoribulose Kinase Pentose Phosphate Pathway TIM barrel RPE (human gene encoding Ribulose- ...

*Glycolysis

Glyceraldehyde 3-phosphate Triosephosphate isomerase 2 × Glyceraldehyde 3-phosphate 2 × Glyceraldehyde-3-phosphate ... Triosephosphate isomerase rapidly interconverts dihydroxyacetone phosphate with glyceraldehyde 3-phosphate (GADP) that proceeds ... Glucose Hexokinase ATP ADP Glucose 6-phosphate Glucose-6-phosphate isomerase Fructose 6-phosphate phosphofructokinase-1 ATP ADP ... Cofactors: Mg2+ G6P is then rearranged into fructose 6-phosphate (F6P) by glucose phosphate isomerase. Fructose can also enter ...

*Methylglyoxal synthase

Triose phosphate catabolism switches over to MGS when phosphate concentrations are too low for glyceraldehyde-3-phosphate ... "Liberation of the triosephosphate isomerase reaction intermediate and its trapping by isomerase, yeast aldolase, and ... Methylglyoxal synthase provides an alternative catabolic pathway for triose phosphates created in glycolysis. It has activity ... Although mechanistically similar to triosephosphate isomerase (TIM), MGS contains widely dissimilar protein folding that ...

*2-dehydro-3-deoxy-phosphogluconate aldolase

The molecule has tertiary folding similar to triosephosphate isomerase and the A-domain of pyruvate kinase, forming an eight ... aldolase 2-keto-3-deoxygluconate-6-phosphate aldolase 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate- ... The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase ( ... triosephosphate isomerase, and the A-domain of pyruvate kinase. Convergent evolution can lead to geometrically similar active ...

*Fructolysis

... to glyceraldehyde 3-phosphate by triosephosphate isomerase or undergo reduction to glycerol 3-phosphate by glycerol 3-phosphate ... Thus, fructose can provide trioses for both the glycerol 3-phosphate backbone, as well as the free fatty acids in TG synthesis ... Fructose-1-phosphate then undergoes hydrolysis by fructose-1-phosphate aldolase (aldolase B) to form dihydroxyacetone phosphate ... The absence of fructose-1-phosphate aldolase (aldolase B) results in the accumulation of fructose 1 phosphate in hepatocytes, ...