... (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily ... Rifkin DB (March 2005). "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta ... "Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin ... Left-Right Determination Factor 2; LEFTYA; Left-Right Determination Factor A; Transforming Growth Factor Beta-4; Protein Lefty- ...
TGFB3 transforming growth factor, beta 3". Herpin A, Lelong C, Favrel P (May 2004). "Transforming growth factor-beta-related ... "Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression in nontumorous and ... "Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor ... "Transforming growth factor-beta 1, -beta 2 and -beta 3 mRNA expression in human cornea". Current Eye Research. 14 (3): 235-41. ...
Burt DW, Law AS (1994). "Evolution of the transforming growth factor-beta superfamily" (PDF). Prog. Growth Factor Res. 5 (1): ... The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that ... ISBN 3-540-51184-9. Daopin S, Piez KA, Ogawa Y, Davies DR (July 1992). "Crystal structure of transforming growth factor-beta 2 ... Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB (June 1983). "Transforming growth factor-beta in human platelets. ...
Isoforms of transforming growth factor-beta (TGF-β1) are also thought to be involved in the pathogenesis of pre-eclampsia.[ ... Transforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα ... "Circulating transforming growth factor-{beta} in Marfan syndrome". Circulation. 120 (6): 526-32. doi:10.1161/CIRCULATIONAHA. ... citation needed] They belong to the transforming growth factor beta family. TGFβ receptors are single pass serine/threonine ...
1989). "Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta ... 1999). "Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A ... 1992). "Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter". Growth Factors. 4 (4): ... "Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2- ...
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of ... TGFB1 transforming growth factor, beta 1". Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB (1983). "Transforming growth ... "Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells". Nature. 316 ( ... "The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta ...
... epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Decorin has been shown to either ... "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth". ... Lysiak JJ, Hunt J, Pringle GA, Lala PK (April 1995). "Localization of transforming growth factor beta and its natural inhibitor ... Takeuchi Y, Kodama Y, Matsumoto T (December 1994). "Bone matrix decorin binds transforming growth factor-beta and enhances its ...
Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB (June 1983). "Transforming growth factor-beta in human platelets. ... "Role of Ras signaling in the induction of snail by transforming growth factor-beta". The Journal of Biological Chemistry. 284 ( ... When platelets are recruited to a site in the blood vessel they can release a variety of growth factors (PDGF, VEGF, ... Kepner N, Lipton A (February 1981). "A mitogenic factor for transformed fibroblasts from human platelets". Cancer Research. 41 ...
"Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated ... Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006). "Transforming growth factor-beta regulation of immune responses". ... The principal function of αvβ6 is the activation of cytokine transforming growth factor-b1 (TGF-β1). Latent-TGF-β1 is bound to ... Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, Steadman R (May 2013). "Transforming growth factor-β1 (TGF- ...
Transforming growth factor beta regulator 1 is a protein that in humans is encoded by the TBRG1 gene. GRCh38: Ensembl release ... "Entrez Gene: TBRG1 transforming growth factor beta regulator 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method ... "Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta". Mol Reprod Dev. 41 (2): 133-9. ...
... and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may ... interact with growth factors implicated in motor neuron differentiation and survival. Loss of Crim1 function as demonstrated by ... Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) ...
"Entrez Gene: TBRG4 transforming growth factor beta regulator 4". Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant ... Transforming growth factor beta regulator 4 (TBRG4), also known as cell cycle progression restoration protein 2 (CPR2) and FAST ... downregulation of its expression may contribute to reducing tumor growth by arresting cell cycle progression. GRCh38: Ensembl ...
The transforming growth factor βs. In: Sporn, M.B. and Roberts, A.B., Editors, 1990. Peptides, Growth Factors and Their ... "Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein". J ... "Latent transforming growth factor-beta binding proteins (LTBPs) structural extracellular matrix proteins for targeting TGF-beta ... "Interactions between growth factors and integrins: latent forms of transforming growth factor-β are ligands for the integrin ...
1995). "Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and ... 1994). "beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment ... Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in ... "Entrez Gene: TGFBI transforming growth factor, beta-induced, 68kDa". Munier FL, Korvatska E, Djemaï A, Le Paslier D, Zografos L ...
... belongs to the transforming growth factor beta superfamily. GDF2 contains an N-terminal TGF-beta-like pro-peptide ( ... and a C-terminal transforming growth factor beta superfamily domain (325-428). GDF2 (BMP9) is secreted as a pro-complex ... 9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes". International Journal of Molecular ... Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded ...
... and epidermal growth factor. The activity is decreased by transforming growth factor beta. Epidermis McGrath, J.A.; Eady, R.A ...
Regulation by transforming growth factor-beta.J Clin Invest. 1994, 93, 1709-1715 Varga J, Rudnicka L, Uitto J.: Connective ... Majewski S, Hunzelmann N, Nischt R, Eckes B, Rudnicka L, Orth G, Krieg T, Jablonska S.:TGF beta-1 and TNF alpha expression in ... 1992, 35, 771-775 Mauviel A, Chen YQ, Kähäri VM, Ledo I, Wu M, Rudnicka L, Uitto J: Human recombinant interleukin -1 beta up= ... She was one of the co-initiators to transform the Task Force into a Work Group (in 2017) to include a higher number of experts ...
"Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor ... "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine & Growth ... It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which ... Dai F, Chang C, Lin X, Dai P, Mei L, Feng XH (September 2007). "Erbin inhibits transforming growth factor beta signaling ...
... transforming growth factor beta (TGFβ), the enzyme cyclooxygenase-2 (COX-2) and its product prostaglandin E2, and many others. ... "Role of transforming growth factor beta in testicular immunosuppression". Journal of Reproductive Immunology. 24 (2): 1213-137 ... effects of activin and transforming growth factor beta on lymphocyte subsets in vitro". Biology of Reproduction. 58 (4): 943- ... and impaired growth and development of the embryo. Risk factors for the formation of antisperm antibodies in men include the ...
Chou YT, Yang YC (Jul 2006). "Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads ... "CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor". The Journal of ... functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559-65. doi:10.1074 ... functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559-65. doi:10.1074 ...
Transforming growth factor beta family proteins bind to these receptors. There are four bone morphogenetic protein receptors: ...
Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene. GRCh38: ... Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3 (Pt ... "Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3". Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J ... 1998). "Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and ...
Transforming growth factor beta (TGF-β) plays an important role in MFS. Fibrillin-1 directly binds a latent form of TGF-β, ... Entrez Gene (2007). "TGFBR2 transforming growth factor, beta receptor II" (Entrez gene entry). NCBI. Archived from the original ... but also serves as a reservoir for growth factors. Elastic fibers are found throughout the body, but are particularly abundant ... Beta blockers are used to reduce the stress exerted on the aorta and to decrease aortic dilation. If the dilation of the aorta ...
"Regulation of TG-interacting factor by transforming growth factor-beta". Biochem. J. 371 (Pt 2): 257-63. doi:10.1042/BJ20030095 ... Lo RS, Wotton D, Massagué J (2001). "Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor ... Cell Growth Differ. 12 (9): 457-63. PMID 11571228. Sharma M, Sun Z (2002). "5'TG3' interacting factor interacts with Sin3A and ... Lam DS, Lee WS, Leung YF, Tam PO, Fan DS, Fan BJ, Pang CP (2003). "TGFbeta-induced factor: a candidate gene for high myopia". ...
"DACH1 inhibits transforming growth factor-beta signaling through binding Smad4". J. Biol. Chem. 278 (51): 51673-51684. doi: ... "DACH1 inhibits transforming growth factor-beta signaling through binding Smad4". The Journal of Biological Chemistry. 278 (51 ... "Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth". Molecular Biology of the Cell. 18 (3 ... "DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth". Mol. Cell. Biol. 26 (19): 7116-7129 ...
Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion. pp. 87-134. doi: ... Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene. The protein ... 1996). "Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical ... 1997). "Latent transforming growth factor-beta: structural features and mechanisms of activation". Kidney Int. 51 (5): 1376-82 ...
"Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase". J. Biol. Chem. 278 ( ... 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". ...
1991). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine ... BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of ... Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all ... Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: ...
"Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior- ... GDF11 is a member of the Transforming growth factor beta family. GDF11 acts as a cytokine and its molecular structure is ... GDF11 belongs to the transforming growth factor beta superfamily that controls anterior-posterior patterning by regulating the ... May 2013). "Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy". Cell. 153 ...
This gene encodes a protein - transducer mediating transforming growth factor beta. Some researchers believe that the SMAD4 ... Myhre SA, Ruvalcaba RHA, Graham CB (1981) A new growth deficiency syndrome. Clin Genet 20: 1-5 "Myhre syndrome , Genetic and ... The clinical presentation is variable but includes[citation needed] developmental and growth delay athletic muscular build ...