Transferrin is a serum transport protein that transports iron to the reticuloendothelial system for utilization and ... Transferrin RESERVED, INSERM US14 -- ALL RIGHTS. "Orphanet: Congenital atransferrinemia". www.orpha.net. Retrieved 2017-02-20. ... "OMIM Entry - * 190000 - TRANSFERRIN; TF". omim.org. Retrieved 20 February 2017. Marks, Vincent; Mesko, Dusan (2002). ... Bartnikas, Thomas Benedict (1 August 2012). "Known and potential roles of transferrin in iron biology". BioMetals. 25 (4): 677- ...
Bacterioferritin Transferrin Ferritin Ilari, A.; Stefanini, S.; Chiancone, E.; Tsernoglou, D. (2000). "The dodecameric ferritin ...
possibly involving the transferrin receptor. IGFBP-3 enters the cell nucleus by a mechanism that is incompletely understood, ... Storch S, Kübler B, Höning S, Ackmann M, Zapf J, Blum W, Braulke T (2001). "Transferrin binds insulin-like growth factors and ... Weinzimer SA, Gibson TB, Collett-Solberg PF, Khare A, Liu B, Cohen P (2001). "Transferrin is an insulin-like growth factor- ... The serum proteins transferrin, fibronectin, and plasminogen are also known to bind IGFBP-3. In the cell and tissue environment ...
Iron in the bloodstream is then bound by transferrin, which carries the iron to target cells. Iron is stored in cells and blood ... Blood tests may show high levels of ferritin and low, normal, or high levels of transferrin saturation, depending on the form ... The accumulation of iron in tissues due to impaired iron export can lead to increasing transferrin iron saturation and liver ... Goodsell, D.S. "Ferritin and transferrin". PDB Molecule of the Month. doi:10.2210/rcsb_pdb/mom_2002_11. Retrieved 9 November ...
And more transferrin receptors make it easier for the cell to bring in more iron from transferrin-iron complexes circulating ... The transferrin receptor mRNA is rapidly degraded without the IRE-BP attached to it. The cell stops producing transferrin ... Since iron is tightly bound to transferrin, cells throughout the body have receptors for transferrin-iron complexes on their ... On its own, the IRE-BP binds to the IREs of ferritin and transferrin receptor mRNA. But, when iron binds to the IRE-BP, the IRE ...
He researched and published studies on transferrin in the blood such as intact transferrin receptors in human plasma, human ... deferric transferrin's interaction with reticulocytes, the uptake and release of iron in human transferrin, rat transferrin and ... and Intact Transferrin Receptors in Human Plasma and Their Relation to Erythropoisis in blood (1990). Transferrin, a blood ... The significance of transferrin for intestinal iron absorption HA Huebers, E Huebers, E Csiba, W Rummel, and CA Finch Blood, ...
Implications for non-transferrin-bound iron speciation". Biochim. Biophys. Acta. 1794 (10): 1449-58. doi:10.1016/j.bbapap. ...
1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor". Am. J. ... This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in ... The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance ... Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, ...
... the ability for transferrin to bind iron is exceeded and non-transferrin bound iron is formed. It represents a potentially ... During normal iron homeostasis the circulating iron is bound to transferrin, but with an iron overload, ... These tests include complete blood count; hemoglobin electrophoresis; serum transferrin, ferritin, total iron-binding capacity ...
Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Letters. 518 ...
Wiley, Devin (2013). "Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin ... However, vectors targeting BBB transporters, such as the transferrin receptor, have been found to remain entrapped in brain ... It was reported that those natural substances such as albumin, α-1-fetoprotein or transferrin with elevated plasma ... receptor-mediated transcytosis for insulin or transferrin; and the blocking of active efflux transporters such as p- ...
Serum transferrin and transferrin saturation are commonly used as screening for haemochromatosis. Transferrin binds iron and is ... Measuring transferrin provides a crude measure of iron stores in the body. Fasting transferrin saturation values in excess of ... Transferrin levels are typically elevated at times of iron depletion (low ferritin stimulates the release of transferrin from ... Transferrin saturation greater than 62% is suggestive of homozygosity for mutations in the HFE gene. Serum Ferritin: Ferritin, ...
Transferrins can bind aluminium. Periodic table highlighting dietary elements The composition of the human body is expressed in ...
Transferrin is found in blood and tissue fluids. Lactoferrin is found in milk, blood, tears and saliva. Ferritin is found in ... Four iron-binding proteins are Haemoglobin, Ferritin, lactoferrin and transferrin. Haemoglobin is located in red blood cells. ...
"Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of ... Especially transferrin and albumin are good binding partners. The overall method of action for KP1019 needs to be supported ... Tumor cells have a high requirement of iron, which results in a large concentration of transferrin. Ru(III) complexes bind to ... As rapidly dividing cells have an increased demand for iron, the levels of transferrin receptors found on these cancerous cells ...
Schmidt, J. A.; Marshall, J.; Hayman, M. J. (1985-12-15). "Identification and characterization of the chicken transferrin ...
Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol ... ISBN 0-07-470436-2. [page needed] Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule ... Transferrin Last reviewed on October 28, 2009. Pietrangelo, Antonello (2010). "Hereditary Hemochromatosis: Pathogenesis, ...
Transferrin does not belong to either of these classes. The ability of sea mussels to maintain their grip on rocks in the ocean ... Transferrin contains Fe3+ in the middle of a distorted octahedron, bonded to one nitrogen, three oxygens and a chelating ... At the bone marrow, transferrin is reduced from Fe3+ and Fe2+ and stored as ferritin to be incorporated into hemoglobin. The ... A major component of this regulation is the protein transferrin, which binds iron ions absorbed from the duodenum and carries ...
Transferrin and beta-lipoprotein (LDL) comprises the beta-1. Increased beta-1 protein due to the increased level of free ... transferrin is typical of iron deficiency anemia, pregnancy, and oestrogen therapy. Increased beta-1 protein due to LDL ...
Vincent, John (2012). "The binding and transport of alternative metals by transferrin". Biochimica et Biophysica Acta (BBA) - ... the roles of transferrin and chromodulin". J. Biol. Inorg. Chem. 6 (5-6): 608-17. doi:10.1007/s007750100238. PMID 11472024. ...
Transferrin is present in the serum at approximately 30 μM, and contains two iron-binding sites, each with an extremely high ... Ferritin is a much larger protein than transferrin and is capable of binding several thousand iron atoms in a nontoxic form. ... In mammalian hosts, iron is tightly bound to proteins such as hemoglobin, transferrin, lactoferrin and ferritin. The strict ... Mammals also produce lactoferrin, which is similar to serum transferrin but possesses an even higher affinity for iron. ...
One arm had a low-affinity anti-transferrin receptor binding site that induces transcytosis. A high-affinity binding site would ... Monoclonal antibody Trojan horses that target the BBB insulin or transferrin receptor have been in drug development for over 10 ... ArmaGen has developed genetically engineered antibodies against both the insulin and transferrin receptors, and has fused to ... Examples of macromolecules transported include IgA, transferrin, and insulin. While transcytosis is most commonly observed in ...
"Selection at the transferrin locus in cropped vole populations1". Heredity. 30: 53-62. doi:10.1038/hdy.1973.6. Retrieved 6 ...
The iron appears to be present as a hydrolysis product such as FeO(OH). Iron is transported by transferrin whose binding site ... therefore assisting in its transport in the blood plasma in association with transferrin, which can carry iron only in the Fe( ... ". "Iron absorption and biliary excretion of transferrin in rats". "Biliary excretion of waste products". Lindskog, S. (1997 ...
Transferrin, on the other hand, has a pI of 5.9, so it cannot be easily separated by this method. A difference in pI of at ... Transferrin can instead be removed by size exclusion chromatography. This method is one of the more reliable chromatography ... Cell culture sample contaminants consist primarily of media components such as growth factors, hormones and transferrins. In ...