"Transcriptional activation by Myc is under negative control by the transcription factor AP-2". The EMBO Journal. 14 (7): 1508- ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... activating transcription factor binding. Cellular component. • cytosol. • nucleoplasm. • protein complex. • nucleolus. • ... Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, ...
2006). "GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation". Nucleic Acids Res ... Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene. AP-2 beta is a ... "Entrez Gene: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)". Tsukada S, Tanaka Y, Maegawa H, et ... 2009). "Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology ...
... general transcription factor IIIA". Murphy JE, Keen JH (May 1992). "Recognition sites for clathrin-associated proteins AP ... Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene. GRCh38: Ensembl release 89: ENSG00000122034 ... Oettel S, Härtel F, Kober I, Iben S, Seifart KH (Jun 1997). "Human transcription factors IIIC2 , IIIC1 and a novel component ... Seifart KH, Wang L, Waldschmidt R, Jahn D, Wingender E (Jan 1989). "Purification of human transcription factor IIIA and its ...
Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is ... 2005). "Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors". Int. J. Cancer. 115 (3 ... Transcription factor AP-2 gamma is involved in early development, specifically morphogenesis - the formation of shape. AP2- ... "Transcription Factor AP-2gamma Is Essential in the Extra-embryonic Lineages for Early Postimplantation Development." National ...
Werling U, Schorle H (May 2002). "Transcription factor gene AP-2 gamma essential for early murine development". Molecular and ... The induction of Transcription Factor T was seen 12 hours after BMP/WNT signaling, as opposed to the 24 to 36 hours it took for ... Transcription factor T acts upstream of BLIMP1 and PRDM4 in PGC specification by binding to the genes respective enhancer ... A central role of Blimp 1 is the induction of Tcfap2c, a helix-span helix transcription factor. Tcfap2c mutants exhibited an ...
Transcription factor AP-2 delta (activating enhancer binding protein 2 delta), also known as TFAP2D, is a human gene. The ... "Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1)". Int. J. Biochem. Cell Biol ... protein encoded by this gene is a transcription factor. Activating protein 2 Cheng C, Ying K, Xu M, Zhao W, Zhou Z, Huang Y, ...
Transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon), also known as TFAP2E, is a human gene. The ... protein encoded by this gene is a transcription factor. Activating protein 2 Tummala R, Romano RA, Fuchs E, Sinha S (December ... "Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family". Gene. 321: 93-102. doi:10.1016/ ...
"Transcriptional activation by Myc is under negative control by the transcription factor AP-2". The EMBO Journal. 14 (7): 1508- ... Myc family of transcription factors contain a bHLH (basic helix-loop-helix) structural and LZ (leucine zipper) motifs. Through ... Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, ... By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. In ...
... functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559-65. doi:10.1074 ... functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559-65. doi:10.1074 ... is a cytokine-inducible transcription factor with transformation activity". Proceedings of the National Academy of Sciences of ... Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S (Dec 2003). "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation ...
... functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559-65. doi:10.1074/jbc.M110850200. PMID ... Pastorcic M, Das HK (November 2000). "Regulation of transcription of the human presenilin-1 gene by ets transcription factors ... The p300 protein carries out its function of activating transcription by binding to transcription factors, and the ... The p300 interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor interaction ...
"Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor ... Transcription factor AP-2 alpha is expressed in ectoderm and in neural-crest cells migrating from the cranial folds during ... Analysis of transcription factor binding site analysis showed that the risk allele disrupt a binding site for AP-2 alpha. ... Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in ...
... has also been identified as a target gene of the transcription factor AP-2 gamma (TFAP2C). TFAP2C has been shown to be ... including binding sites for zinc fingers and Kruppel-like transcription factors. The top 20 transcription binding sites as ... "Identification of target genes of transcription factor activator protein 2 gamma in breast cancer cells". BMC Cancer. 9 (1): ... There are several transcription factor binding sites located in this promoter, ...
AP-1). Apart from being regulated by different transcription factors, FHL2 is itself involved extensively in regulating the ... The name LIM was derived from the first letter of the transcription factors LIN-11, ISL-1 and MEC-3, from which the domain was ... Different transcription factors that have been reported responsible for the regulation of fhl2 expression include the well- ... Such discrepancies are most likely due to the existence of the wide variety of transcription factors governing FHL2 expression ...
The Jun dimerization protein is a member of the AP-1 family of transcription factors. JDP 2 was found by a Sos-recruitment ... a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL". The Journal of ... "The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and ... It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF- ...
AP-1 is a dimer and is composed of c-Jun and c-Fos proteins. It cooperates with other transcription factors including NFkB and ... PLC activates 3 major transcription factors and their pathways: NFAT, NFkB and AP-1. After costimulation from CD28 the optimal ... The key factor was isolated from cultured mouse cells in 1979 and from cultured human cells in 1980. The gene for human IL-2 ... analogous to the growth factors being studied by endocrinologists and biochemists". In the mid-1960s, studies reported " ...
AP-1 transcription factor, Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a ... CREB (cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP ... homeodomain proteins are transcription factors sharing a characteristic protein fold structure that binds DNA ... CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose ...
Transcription Factor AP-2 at the US National Library of Medicine Medical Subject Headings (MeSH). ... Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". ... is a family of closely related transcription factors which plays a critical role in regulating gene expression during early ... Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding ...
... is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development ... 1999). "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger ... 2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional ... Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene. Activator protein-2 alpha (AP-2 alpha) ...
... cDNA indicate a number of transcription factor binding site consensus sequences, including those for AP-2, c-Myb, NF-1, sox-5, ... RE1-silencing transcription factor) (REST) is a transcription repressor that binds to REST DNA recognition element (RE-1) in ... where it needs to localize to function as a transcription factor. PTPrho also dephosphorylates paxillin on tyrosine 88. Higher ... Dephosphorylation by PTPrho in colorectal cancer cells results in a reduction in the total level of transcription of the STAT3 ...
ZNF41: Zinc finger protein 41 is a likely zinc finger family transcription factor. DLG3: Disks large homolog 3, also named ... AP1S2: AP-1 complex subunit sigma-2. Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the ... IQSEC2: encodes an exchange factor for the Arf family of small GTP binding proteins, involved in the formation of secretory ... The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. PHF8: PHD ...
... or transcription factor AP-2 gamma (TFAP2C), was repressed significantly. The team then tried to assess whether the luciferase ... This is due to chromosomes being highly condensed, preventing RNA polymerase and other transcription factors from recognizing ... "Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor ... However, in an altered methylation of the CpG islands (generally where the methylation pattern is inverted), transcription can ...
The proximal promoter region contains multiple binding sites for transcription factors, including specific-1 (Sp1), activator ... The SOD2 gene has been shown to bind: Sp1, NF-κB, AP-1, AP-2, Egr-1, CREB, p53, and NFE2L2. The SOD2 protein has been shown to ... AP-2), and early growth response 1 (Egr-1). This gene is a mitochondrial member of the iron/manganese superoxide dismutase ... 116 (2): 205-19. doi:10.1016/s0092-8674(04)00046-7. PMID 14744432. Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a ...
... it provides the blueprint for the arrangement of 437 amino acids that make up the protein transcription factor known as AP-2 ... This protein transcription factor binds to a carboxy terminus helix-span-helix motifand an amino terminus portion of DNA that ... AP-2 alpha is especially important during the embyros development principally in the development of the branchial arches. ...
Transcription factors such as TRAF6, JNK, Erk1/2, p38, AP-1 and NF-κB have been implicated in IL-17 mediated signaling in a ... IL-17F also dimerizes in a fashion similar to nerve growth factor (NGF) and other neurotrophins. Recent work suggests the IL-23 ... Promoting the inflammation, IL-17 acts in concert with tumor necrosis factor and interleukin-1 Moreover, an activation of IL-17 ... "Transforming growth factor-beta induces development of the T(H)17 lineage". Nature. 441 (7090): 231-4. doi:10.1038/nature04754 ...
Sp1 transcription factor, Sp3 transcription factor, TOP2B, and YY1. Histone deacetylase GRCh38: Ensembl release 89: ... Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999). "Mi-2 complex couples DNA methylation to chromatin ... Yao YL, Yang WM, Seto E. "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell. Biol. 21 (17): ... "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". ...
transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ... "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339-47. PMC ...