Loading...
*  FOXC2
... is a member of the fork head box (FOX) family of transcription factors. The protein is 501 amino acids in length. The ... Monaghan AP, Schlöndorff J, Mincheva A, Lichter P, Schütz G (June 1996). "Clustered arrangement of winged helix genes fkh-6 and ... FOX transcription factors are expressed during development and are associated with a number of cellular and developmental ... 2010). "The Foxc2 transcription factor regulates tumor angiogenesis". Biochem. Biophys. Res. Commun. 392 (2): 201-6. doi: ...
*  AP-1 transcription factor
Lee W, Mitchell P, Tjian R (June 1987). "Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements". ... Activator protein Transcription factor Hess, J; Angel, P; Schorpp-Kistner, M (1 December 2004). "AP-1 subunits: quarrel and ... June 2001). "Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 ... Lee, W; Haslinger, A; Karin, M; Tjian, R (January 1987). "Activation of transcription by two factors that bind promoter and ...
*  Trypanosoma cruzi
"Activation of Transcription Factors AP-1 and NF- B in Murine Chagasic Myocarditis". Infection and Immunity. 71 (5): 2859-67. ... It was found that within seven days the concentration of AP-1 was significantly higher in T. cruzi-infected mice when compared ... Huang, Huan; Petkova, Stefka B.; Cohen, Alex W.; Bouzahzah, Boumediene; Chan, John; Zhou, Jian-nian; Factor, Stephen M.; Weiss ... AP-1, and NF-κB. Also, the mitotic regulator for G1 progression, cyclin D1 was found to be activated. Although there was no ...
*  Arsenic poisoning
Hu Y, Jin X, Snow ET (July 2002). "Effect of arsenic on transcription factor AP-1 and NF-κB DNA binding activity and related ... hydroxylation of fatty acids and the inhibition of pro-inflammatory transcription factors (NF-κB and AP-1), pro-inflammatory ... Increased AP-1 and NF-κB obviously also result in an up-regulation of mdm2 protein, which decreases p53 protein levels. Thus, ... Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M (November 1996). "The tumor promoter arsenite stimulates AP-1 activity by ...
*  IFI16
2003). "Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16". J. ... Johnstone RW, Kerry JA, Trapani JA (1998). "The human interferon-inducible protein, IFI 16, is a repressor of transcription". J ... localization sequence of the interferon-induced nuclear factor IFI 16". Biochem. J. 353 (Pt 1): 69-77. doi:10.1042/0264-6021: ... 89 (1): 80-93. doi:10.1002/jcb.10475. PMID 12682910. Xin H, Curry J, Johnstone RW, et al. (2003). "Role of IFI 16, a member of ...
*  C-Met
Hypoxia also activates transcription factor AP-1, which is involved in MET transcription. MET pathway plays an important role ... "Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway". ... ETS1 activates MET transcription in vitro. MET transcription is activated by hypoxia-inducible factor 1 (HIF1), which is ... MET transcription is activated by HGF and several growth factors. MET promoter has four putative binding sites for Ets, a ...
*  C-jun
"Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 ... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 ... The c-jun transcription is autoregulated by its own product, Jun. The binding of Jun (AP-1) to a high-affinity AP-1 binding ...
*  Arylsulfatase B
Galectin-3 then acts on transcription factors AP-1 to increase expression of chondroitin sulfate proteoglycan versican and SP-1 ... Bhattacharyya S, Feferman L, Tobacman JK (2014). "Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated ... Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor ... 380 (1-2): 122-7. doi:10.1016/j.cca.2007.01.021. PMID 17324393. Bhattacharyya S, Feferman L, Tobacman JK (2016). "Effect of ...
*  TLR4
... while activation of MAPK cascades lead to the activation of another transcription factor AP-1. Both of them have a role in the ... TRAM-TRIF signals activate the transcription factor Interferon Regulatory Factor-3 (IRF3) via TRAF3. IRF3 activation induces ... signaling pathway leads to the induction of the transcription factor NF-κB, ... Transforming growth factor-β-Activated Kinase 1) that leads to the activation of MAPK cascades (Mitogen-Activated Protein ...
*  Sequence motif
An example of a PFM from the TRANSFAC database for the transcription factor AP-1: The first column specifies the position, the ... 2013). "Evaluation of methods for modeling transcription factor sequence specificity". Nature Biotechnology. 31 (2): 126-134. ... an algorithm for identifying motifs to which transcription factors bind Multiple EM for Motif Elicitation Nucleic acid sequence ... 16 (1): 16-23. doi:10.1093/bioinformatics/16.1.16. PMID 10812473. Balla S; Thapar V; Verma S; Luong T; Faghri T; Huang CH; ...
*  Silvia Bulfone-Paus
... and transcription factors AP-1 and NF-kB- Journal of Biological Chemistry Retraction Notice 11) Natural Soluble Interleukin-15R ... 1) ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells ... α Is Generated by Cleavage That Involves the Tumor Necrosis Factor-α-converting Enzyme (TACE/ADAM17)- Journal of Biological ... Smear Campaign'.." (PDF). Lab Times (1): 3-3. February 2011. Retrieved 17 January 2012. "Response to Open Letter" (PDF). ...
*  Collateralization
... are the transcription factors AP-1, egr-1, carp, ets, by the Rho pathway and by the mitogen activated kinases ERK-1 and -2. In ... Most observers agree that a 90% occlusion is necessary to bring about transformation in the absence of other factors, though a ... Mononuclear cells produce proteases and growth factors to digest the extra-cellular scaffold and allow motility and provide ... followed by vascular endothelial growth factor (VEGF) secretion, which induces monocyte chemoattractant protein-1 (MCP-1) ...
*  Cocaine
"Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine". Nature. 401 (6750): 272-6. doi: ... Hope BT (May 1998). "Cocaine and the AP-1 transcription factor complex". Annals of the New York Academy of Sciences. 844: 1-6. ... The color of "crack" cocaine depends upon several factors including the origin of the cocaine used, the method of preparation ... The efficiency of absorption of orally administered cocaine is limited by two additional factors. First, the drug is partly ...
*  BATF (gene)
Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF ... The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of ... "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon ... Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor ...
*  FOSL2
... thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell ... transcription factor) GRCh38: Ensembl release 89: ENSG00000075426 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Ng DC, Shafaee S, Lee D, Bikle DD (August 2000). "Requirement of an AP-1 site in the calcium response region of the involucrin ... Udalova IA, Kwiatkowski D (November 2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF ...
*  FOSL1
... thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell ... Herdegen T, Leah JD (Dec 1998). "Inducible and constitutive transcription factors in the mammalian nervous system: control of ... transcription factor) GRCh38: Ensembl release 89: ENSG00000175592 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Involvement of AP-1/ARE and Fra-1". The Journal of Biological Chemistry. 277 (24): 21158-66. doi:10.1074/jbc.M112145200. PMID ...
*  Gennadij Raivich
"The AP-1 transcription factor c-Jun is required for efficient axonal regeneration." Neuron 43.1 (2004): 57-67. Raivich, ... "Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in ...
*  Visna virus
20 position and a recognition site for the AP-4 transcription factor at the -60 position. There are several AP-1 transcription ... Most studies have indicated that Tat is a transcription factor necessary for viral transcription from the LTRs. Tat contains ... Carruth LM, Hardwick JM, Morse BA, Clements JE (Oct 1994). "Visna virus Tat protein: a potent transcription factor with both ... "Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 ...
*  ITGA10
"Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1". Biochem. Biophys ... 345 (1): 495-501. doi:10.1016/j.bbrc.2006.04.123. PMID 16684505. ITGA10 Info with links in the Cell Migration Gateway This ... The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding ...
*  JUNB
Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor ... "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 ... Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. ... Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper ...
*  JunD
"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Transcription factor JunD is a protein that in humans is encoded by the JUND gene. The protein encoded by this intronless gene ...
*  COP9 constitutive photomorphogenic homolog subunit 5
It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors. COP9 constitutive ... Claret FX, Hibi M, Dhut S, Toda T, Karin M (1996). "A new group of conserved coactivators that increase the specificity of AP-1 ... transcription factors". Nature. 383 (6599): 453-7. doi:10.1038/383453a0. PMID 8837781. Asano K, Vornlocher HP, Richter-Cook NJ ... Dai YS, Cserjesi P (2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E- ...
*  FOSB
... thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell ... The transcription factor delta FosB is increased in the NAc, PFC, dorsal striatum, and VTA following repeated sexual behavior ( ... ΔJunD, a transcription factor, and G9a, a histone methyltransferase, both oppose the function of ΔFosB and inhibit increases in ... In addition, transcription factors expressed with chronic events such as ΔFosB (a truncated splice variant of FosB) are ...
*  WDR90
The promoter for WDR90 in humans has been predicted to have domains for the transcription factors: ARNT, AP-1, MYB, and ... or transcription regulation. Database, GeneCards. "WDR90 Gene - GeneCards , WDR90 Protein , WDR90 Antibody". www.genecards.org ... repeating domains have been found to play a role in a variety of functions ranging from signal transduction and transcription ...
*  Photoaging
The nuclear transcription factor activator protein, AP-1, which controls the transcription of matrix metalloproteinases (MMP), ... Another transcription factor NF-κB, which is also activated by UV light, also increases the expression of MMP-9. The up- ... UV radiation activates the transcription factor, NF-κB, which is the first step in inflammation. NF-κB activation results in ... IL-6 vascular endothelial growth factor, and tumor necrosis factor (TNF-α). This then attract neutrophils which lead to an ...
*  NFIX
"Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, ... NFIX has been shown to interact with SKI protein and it is also known to interact with AP-1. NFI-X3 has been shown to interact ... for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66-73. doi:10.1006/geno.1995.1107. PMID 7590749 ... "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of ...
*  Histone acetylation and deacetylation
... the myogenic transcription factor MEF2 which an essential role in muscle differentiation as a DNA binding transcription factor ... Inflammatory lung diseases are characterized by expression of specific inflammatory genes such as NF-κB and AP-1 transcription ... and transcription factors that process and "read" the modification codes. The outcome can be activation of transcription or ... Structural analysis of transcription factors has shown that highly conserved bromodomains are essential for protein to bind to ...