Artificial cells have been successful for transplanting a number of cells including islets of Langerhans for diabetes treatment ... Advances in cell-free transcription and translation reactions allow the expression of many genes, but these efforts are far ... this prodrug into the active drug can be tailored to accumulate in the pancreatic carcinoma or implanting the artificial cells ... An artificial cell, synthetic cell or minimal cell is an engineered particle that mimics one or many functions of a biological ...
... bone marrow cells, islet cells and endothelial cells. However, the derivation of such cell types from ESCs is not without ... Retinoblastoma proteins that inhibit the transcription factor E2F until the cell is ready to enter S phase are ... Kleinsmith LJ, Pierce GB Jr (1964). "Multipotentiality of Single Embryoncal Carcinoma Cells". Cancer Res. 24: 1544-1551. PMID ... The resulting inner cell mass cells are plated onto cells that will supply support. The inner cell mass cells attach and expand ...
... in the angiogenic blood vessels and invasive fronts of carcinoma in the RIP-Tag2 transgenic mouse model of pancreatic islet ... Activated c-kit is then able to recruit hematopoietic, endothelial and mast cell progenitor cells, these cells are then ... MMP activity is regulated at the level of transcription, post-translationally by proteolytic cleavage, and by endogenous ... Cathepsins also can be secreted by cells, associate with the cell surface, and degrade the ECM. A study of all 11 members of ...
"Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells". The Journal of Cell Biology. ... usually transcription factors, introduced in the cells. The starting material can be either pluripotent stem cells (PSCs), or ... cell type affected in diseases are a major focus of research, this includes hepatocytes, Langerhans islet beta-cells, ... Historically, embryonic carcinoma (EC) cells have also been used. Fibroblasts or other differentiated cell types have been used ...
... produced by antigen-presenting cells (APCs). M1-activated macrophages express transcription factors such as interferon ... Stephen TF, Pavel NZ, Xiaoxiao W, Boris C, Maxim NA, Emil RU, and Javier AC (2017). "The islet-resident macrophage is in an ... February 2017). "Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ ... for example apoptotic cells, symbiont cells, gametes and cells of the embryo in the uterus). M2 macrophages hence govern ...
Strong and diffuse cytoplasmic and nuclear expression of p16 in squamous cell carcinomas (SCC) of the female genital tract is ... methylation can lead to the recruitment of transcription factors that repress transcription. Both mechanisms cause the same end ... "p16INK4a induces an age-dependent decline in islet regenerative potential". Nature. 443 (7110): 453-457. Bibcode:2006Natur.443 ... Tissue samples of primary oral squamous cell carcinoma (OSCC) often display hypermethylation in the promoter regions of p16. ...
Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription ... TCF7L2 modulates pancreatic islet β-cell function strongly implicating its significant association with GDM risk. T alleles of ... March 1997). "Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma". Science. 275 ( ... Duval A, Rolland S, Tubacher E, Bui H, Thomas G, Hamelin R (July 2000). "The human T-cell transcription factor-4 gene: ...
... in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77-85. doi: ... receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". ... The difference in ratios of the isoforms imply a tissue-specific control of transcription. Somatostatin receptor 2b is not ... A cell line is grown as a culture under controlled conditions, so the first discovery was found by culturing these cells in ...
Hepatocellular carcinoma cell proliferation may arise from miR-21 interaction with MAP2K3, a tumor repressor gene. Optimal ... through its direct target hedgehog pathway transcription factor, Gli3. Many miRNAs can directly target and inhibit cell cycle ... "A pancreatic islet-specific microRNA regulates insulin secretion". Nature. 432 (7014): 226-30. Bibcode:2004Natur.432..226P. doi ... and cell cycle in mice lacking miRNA-1-2". Cell. 129 (2): 303-17. doi:10.1016/j.cell.2007.03.030. PMID 17397913. Thum T, ...
Other exocrine cancers include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, colloid carcinomas, ... PanNETs are sometimes called "islet cell cancers", though they are now known to not actually arise from islet cells as ... for example the transcription factor PELP1. In 2015, pancreatic cancers of all types resulted in 411,600 deaths globally. In ... The next-most common type, acinar cell carcinoma of the pancreas, arises in the clusters of cells that produce these enzymes, ...
... they cannot penetrate cell membranes. Thus, GH exerts some of its effects by binding to receptors on target cells, where it ... a 53-year-old female with carcinoma of the breast and widespread skeletal metastases; a 68-year-old female with advanced ... an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review". ... liver uptake of glucose Promotes gluconeogenesis in the liver Contributes to the maintenance and function of pancreatic islets ...
CD47 knockdown acutely increases mRNA levels of c-Myc and other stem cell transcription factors in cells in vitro and in vivo. ... March 2014). "De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts". Cell Reports. 6 (6): 1046- ... teratoma-initiating embryonic-like carcinoma cells during differentiation. The survival of these teratoma-initiating cells is ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ...
Kowluru A (January 2008). "Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a ... The sterol response elements then facilitate increased transcription of various other proteins, most notably, LDL receptor. The ... Specifically, statins may reduce the risk of esophageal cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, ... In rabbits, liver cells sense the reduced levels of liver cholesterol and seek to compensate by synthesizing LDL receptors to ...