Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the ... "Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein". Cell. 55 (6 ... Tat acts by binding to an RNA stem-loop structure, the trans-activating response element (TAR), found at the 5′ ends of nascent ... The basic region is involved in RNA (TAR, trans-activation response element) binding and Tat proteins thus belong to the family ...
Sodroski, JG; Goh WC; Rosen CA; Dayton AI; Terwilliger E; Haseltine WA (1986). "A Second post-Transcriptional Trans-activator ... region of bovine leukemia virus genome encodes a trans-activator protein" (PDF). The EMBO Journal. 5 (10): 2585-2589. doi: ... They named the transactivator tat and the second protein art; the latter was renamed rev. He predicted that drugs that target ... Sodroski, JG; Patarca R; Rosen CR; Wong-Staal F; Haseltine WA (1985). "Location of the Trans-activating Region on the Genome of ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... "Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator". J. Biol. Chem. 283 (14): 9031-9. doi:10.1074/ ... interacts with signal transducer and activator of transcription (STAT) 5a". Mol. Endocrinol. 13 (4): 555-65. doi:10.1210/mend. ...
SREBP1c is a basic helix-loop-helix zipper (bHLHZ) transactivator. This class of transactivators bind to the "E box" sequence ... Filipski KJ, Pfefferkorn JA (August 2014). "A patent review of glucokinase activators and disruptors of the glucokinase-- ... The latter may operate via the FOXO1 transactivator. However, as would be expected given its antagonistic effect on glycogen ... Upstream stimulatory factor 1 (USF1) is another basic helix-loop-helix zipper (bHLHZ) transactivator. Hepatic nuclear factor 6 ...
"The trans-activator gene of HTLV-III is essential for virus replication". Nature. 320 (6060): 367-371. Bibcode:1986Natur.320.. ... that at the time was presumed to be a transcriptional activator.[citation needed] Fisher's group showed that Ikaros proteins ... Fisher showed that the transactivator gene tat was essential for virus replication, that truncation of the 3' open reading ...
CIITA is a non-DNA-binding co-activator whose expression is tightly controlled by a regulatory region containing three ... "Regulation of MHC class II gene expression by the class II transactivator". Nature Reviews. Immunology. 5 (10): 793-806. doi: ... profile exhibited by MHC class II molecules is a single master regulatory factor known as the class II transactivator (CIITA). ...
"Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the subtype.[3] Tat ... "Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein". Cell. 55 (6 ... Selby MJ, Peterlin BM (August 1990). "Trans-activation by HIV-1 Tat via a heterologous RNA binding protein". Cell. 62 (4): 769- ... The basic region is involved in RNA (TAR, trans-activation response element) binding and Tat proteins thus belong to the family ...
"Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa". Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (Apr 1997). "The human immunodeficiency virus transactivator Tat ... Chen M, Pan ZQ, Hurwitz J (Apr 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 ( ... Pan ZQ, Chen M, Hurwitz J (Jan 1993). "The subunits of activator 1 (replication factor C) carry out multiple functions ...
"Entrez Gene: RFC3 replication factor C (activator 1) 3, 38kDa". Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (Apr 1997). "The human immunodeficiency virus transactivator Tat ... also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene ...
The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (April 1997). "The human immunodeficiency virus transactivator ... "Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa". Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, ...
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat ... Liang G, Hai T (1997). "Characterization of human activating transcription factor 4, a transcriptional activator that interacts ... Rowlands JC, McEwan IJ, Gustafsson JA (1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon ...
"Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa". Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (Apr 1997). "The human immunodeficiency virus transactivator Tat ... also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene ...
Tat acts as a trans-activator during transcription to enhance initiation and elongation. The Rev responsive element acts post- ... Gene regulatory proteins: Tat: main trans-activator Rev: important for synthesis of major viral proteins Accessory proteins: ...
"The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of ... "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator". Science. 248 (4963): 1650-3. ...
... and characterization of a PA700-dependent activator of the proteasome". J. Biol. Chem. 271 (6): 3112-8. doi:10.1074/jbc.271.6. ... "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator". Science. 248 (4963): 1650-3. ... "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of ...
It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ... "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF". Curr. Biol. 12 ( ...
This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ... This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EP300 is closely related to ... "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, ...
This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is ... Rowlands JC, McEwan IJ, Gustafsson JA (September 1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ... "Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators". Science. 267 (5197): 531- ...
Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R (Feb 2002). "Structure, function, and activator-induced conformations of the ... "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Molecular and Cellular ... "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 ... transcriptional activator". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2339-44. ...
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. ... "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175-81. 2002. doi:10.1080/ ... "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular ...
1997). „Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S ... 2008). „Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator". J. Biol. Chem. United States. 283 (14 ... 1999). „Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a ...
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. • ربط بروتيني. • RNA binding. ... "Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells". The Journal of ... transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. • sequence- ... "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. 15 (8): 1933- ...
... alternative splicing of pre-mRNA transcripts is regulated by a system of trans-acting proteins (activators and repressors) that ... Trans-splicing is a form of splicing that joins two exons that are not within the same RNA transcript.[17] ... For example, a splicing factor that serves as a splicing activator when bound to an intronic enhancer element may serve as a ... "Cis- and trans-splicing of mRNAs mediated by tRNA sequences in eukaryotic cells". Proceedings of the National Academy of ...
... when it was found that the trans-activating transcriptional activator (TAT) from human immunodeficiency virus 1 (HIV-1) could ...
a b c US patent 6,060,511, Gainer J, "Trans-sodium crocetinate, methods of making and methods of use thereof", issued 2000-05- ... A combination therapy study with tissue plasminogen activator". Brain Research. 1309: 136-145. doi:10.1016/j.brainres.2009.10. ... 2006). "Trans sodium crocetinate and diffusion enhancement". The Journal of Physical Chemistry B. 110 (37): 18078-18080. doi: ... Trans-crocetin has been found to act as an NMDA receptor antagonist with high affinity, and has been implicated in the ...
8 nm nanocrystalline silver particles were modified by the addition of trans-activating transcriptional activator (TAT), ...
Six half transporters with ATP binding sites on the N terminus and trans-membrane domains at the C terminus make up the ABCG ... SUR is also the binding site for drugs such as sulfonylureas and potassium-channel openers activators such as diazoxide. The ... but these genes do not encode for trans-membrane domains. ABCE consists of only one member, OABP or ABCE1, which is known to ... These domains consist of two trans-membrane (T) domains and two cytosolic (A) domains. The two T domains alternate between an ...
This reagent has led to the development of immobilised catalyst/activator species; where the catalyst/activator is immobilised ... Dalton Trans. 2009, 3129.doi:10.1039/B819621D ... boron is used as an activator or cocatalyst: (C6F5)3B + (C5H5)2 ...
Trans. 22 (2): 427-31. doi:10.1042/bst0220427. PMID 7958339.. *. Zhao Y, Meng XM, Wei YJ, et al. (2003). "Cloning and ...
Kamp, J. V. D.; Mosettig, E. (1936). "Trans- and Cis-As-Octahydrophenanthrene". Journal of the American Chemical Society. 58 (6 ... suffers from the disadvantage that the product is more nucleophilic than the reactant because alkyl groups are activators for ...
"Tissue plasminogen activator for acute ischemic stroke". The National Institute of Neurological Disorders and Stroke rt-PA ... "Penggunaan Trans Cranial Doppler untuk Deteksi Perubahan Hemodinamik Serebral pada Pasien Kritis". Diakses tanggal 3 April 2015 ... Pendarahan yang terjadi kemudian direspon tubuh dengan memproduksi urokinase-type plasminogen activator (uPA). Ekspresi MMP-9 ... "Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain". Department of ...
Figure 3. The main mechanism of IL-15 signaling is trans-presentation which is mediated by membrane-bound complex IL-15/IL-15Rα ... which leads to phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5.[16] Due ... The main mechanism of IL-15 signaling is trans-presentation which is mediated by membrane-bound complex IL-15/IL-15Rα (Figure 3 ... Schluns KS, Stoklasek T, Lefrançois L (August 2005). "The roles of interleukin-15 receptor alpha: trans-presentation, receptor ...
Activators: 3-Methyl-GABA. See also. Receptor/signaling modulators GABA receptor modulators GABAA receptor positive modulators ...
Trans. 31 (Pt 6): 1095-105. doi:10.1042/BST0311095. PMID 14641005.. *^ a b c Lodish, H, Berk A, Matsudaira P, Kaiser CA, ... "Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator". BMC ...
Signaling pathways and trans-autophosphorylation[edit]. Among a number of various molecules, Receptor Tyrosine Kinases (RTKs ) ... Mutations in the genes encoding them or their potential activators or repressors can affect any number of functions within an ... 3 Signaling pathways and trans-autophosphorylation *3.1 Examples of RTKs which undergo autophosphorylation *3.1.1 Epidermal ... trans autophosphorylation). The latter often occurs when kinase molecules dimerize.[3] In general, the phosphate groups ...
Penemuan penislin selalu dikaitkan dengan ilmuwan Skotlandia, Alexander Fleming pada 1929, walaupun sebenarnya banyak ilmuwan lain yang telah mencatat efek antibakteri sebelum Fleming.[2]. Fleming, dalam laboratoriumnya di Rumah Sakit Santa Maria (kini merupakan salah satu rumah sakit pendidikan di London), mencatat adanya lingkaran hambatan (zona bening) pada pertumbuhan bakteri di piringan kultur Staphylococcus. Fleming menyimpulkan bahwa hambatan itu dikarenakan sebuah subtansi penghambat pertumbuhan dan menghancurkan bakteri. Ia kemudian menumbuhkan sebuah kultur murni dan menemukan Penicillium yang kemudian dikenal sebagai Penicillium chrysogenum. Fleming memberikan istilah "penisilin" untuk menggambarkan hasil filtrasi dari kultur mikrobiologis Penicillium.[2]. Walaupun di tahapan awal ini, penisilin ditemukan efektif melawan bakteri Gram positif dan tidak efektif pada Gram negatif dan jamur. Fleming optimis bahwa penisilin akan menjadi disinfektan yang sangat berguna, berpotensi tinggi ...
The values given in the nutritional labels for total fat, saturated fat, and trans fat do not include those present in mono- ... IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of ... an activator of a subfamily of transient receptor potential canonical (TRPC) cation channels, TRPC3/6/7. ...
Trans-cycloalkenes (usually cyclooctenes) and other strained alkenes such as oxanorbornadiene react in click reactions with a ... "Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator". Proc. ... A Tetrazine-Alkene reaction between a generalized tetrazine and a strained, trans-cyclooctene ... Like the other reactions of the trans-cyclooctene, ring strain release is a driving force for this reaction. Thus, three- ...
Cytokines produced during innate immune responses are among the activators of adaptive immune responses.[26] Antibodies exert ... "Trans-generational immune priming in honeybees". Proceedings. Biological Sciences. 281 (1785): 20140454. doi:10.1098/rspb. ...
trans-Golgi network. • extracellular region. • perinuclear region of cytoplasm. • cortical actin cytoskeleton. • Golgi ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ...
Guzey M, Takayama S, Reed JC (December 2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. ... between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators ... O receptor pertence á familia dos factores reguladores transcricionais que actúan en trans e mostran unha similitude de ...
Two other naturally occurring 13-HODEs that may accompany the production of 13(S)-HODE are its cis-trans (i.e., 9E,11E) isomers ... far weaker GPR132 activators than 9(S)-HpODE or 9(S)-HODE.[42][43] GPR132 was initially described as a pH sensing receptor; the ... Michael reaction or a glutathione transferase-dependent reaction to form 13-oxo-ODE products containing an 11 trans double ...
trans-Golgi network. • جهاز غولجي. • موصل خلوي. • نظام غشائي داخلي. • peroxisomal membrane. • cell leading edge. • إسقاط عصبون ... phospholipase D activator activity. • nucleotide binding. • GTP binding. • ربط أيون المغنسيوم. • GTPase activity. • GDP binding ... "Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin ... two guanine nucleotide-dependent activators of cholera toxin". Proc. Natl. Acad. Sci. U.S.A. 86 (16): 6101-5. 1989. doi:10.1073 ...
Activators of soluble guanylate cyclase[edit]. Soluble guanylate cyclase (sGC) is the intracellular receptor for NO. As of ... April 2009[update], the sGC activators cinaciguat and riociguat were undergoing clinical trials for the treatment of PAH.[81] ...
Trans. 34 (Pt 5): 633-45. doi:10.1042/BST0340633. PMID 17052168.. *^ a b c d e f Wang Q, Zhang H, Guerrette S, Chen J, Mazurek ... "Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma ... Trans. R. Soc. Lond. B Biol. Sci. 359 (1441): 123-8. doi:10.1098/rstb.2003.1371. PMC 1693294. PMID 15065664.. ...
Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.. ... transmembrane receptor protein tyrosine kinase activator activity. • neurotrophin TRKA receptor binding. • ephrin receptor ...
Trans. 32 (Pt 2): 326-9. doi:10.1042/BST0320326. PMID 15046600.. *. Hendriks RW, Kersseboom R (2006). "Involvement of SLP-65 ...
Activators. *BKCa-specific: Flufenamic acid. *Meclofenamic acid. *Niflumic acid. *Nimesulide. *Rottlerin (mallotoxin) ... trans-3-ACPBPA. *ZAPA. *Negative modulators: 5α-Dihydroprogesterone. *Bilobalide. *Loreclezole. *Picrotoxin (picrotin, ...
Isomerization of 11-cis-retinal into all-trans-retinal by light induces a conformational change in the protein that activates ...
Transcranial ultrasound is being tested for use in aiding tissue plasminogen activator treatment in stroke sufferers in the ... This includes HIFU, lithotripsy, targeted ultrasound drug delivery, trans-dermal ultrasound drug delivery, ultrasound ...
Regulation of GS only occurs in prokaryotes.[24] GS is subject to reversible covalent modification. Tyr397 of all 12 subunits can undergo adenylylation or deadenylylation by adenylyl transferase (AT), a bifunctional regulatory enzyme.[24] Adenylylation is a post-translational modification involving the covalent attachment of AMP to a protein side chain. Each adenylylation requires an ATP and complete inhibition of GS requires 12 ATP. Deadenylylation by AT involves phosphorolytic removal of the Tyr-linked adenylyl groups as ADP. AT activity is influenced by the regulatory protein that is associated with it: PII, a 44-kD trimer.[24] PII also undergoes post-translational modification by uridylyl transferase, thus PII has two forms. The state of PII dictates the activity of adenylyl transferase. If PII is not uridylylated, then it will take on the PIIA form. The AT:PIIA complex will deactivate GS by adenylylation. If PII is uridylylated, then it will take on the PIID form. The AT:PIID complex will ...
Rhodopsin, for example, uses the conversion of 11-cis-retinal to all-trans-retinal for this purpose. ... The cAMP produced is a second messenger in cellular metabolism and is an allosteric activator of protein kinase A. ... termed activators of G-protein signalling (AGS). Both the ubiquity of these interactions and the importance of Gα vs. Gβγ ...
Sirtuin activators mimic caloric restriction and delay ageing in metazoans». Nature, 430, 7000, 2004, pàg. 686-9. DOI: 10.1038/ ... Trans., 31, Pt 6, 2003, pàg. 1095-105. DOI: 10.1042/BST0311095. PMID: 14641005. ... Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan». Nature, 425, 6954, 2003, pàg. 191-6. DOI: ...