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*  Urokinase
The most important inhibitors of urokinase are the serpins plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator ... Trans. 30 (2): 177-83. doi:10.1042/BST0300177. PMID 12023847. Alfano M, Sidenius N, Blasi F, Poli G (2004). "The role of ... "Entrez Gene: PLAU plasminogen activator, urokinase". Geiger M, Huber K, Wojta J, Stingl L, Espana F, Griffin JH, Binder BR (Aug ... Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, Schmitt M (2004). "Urokinase-type plasminogen activator (uPA) ...
*  Tat (HIV)
Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the ... "Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein". Cell. 55 (6 ... Tat acts by binding to an RNA stem-loop structure, the trans-activating response element (TAR), found at the 5′ ends of nascent ... The basic region is involved in RNA (TAR, trans-activation response element) binding and Tat proteins thus belong to the family ...
*  Glucokinase
SREBP1c is a basic helix-loop-helix zipper (bHLHZ) transactivator. This class of transactivators bind to the "E box" sequence ... Potential glucokinase activator MK-0941 led to unsustained glycemic improvements, as well as increased blood pressure and ... Jain, A. Glucokinase Activators in Diabetes Management Matschinsky FM (May 2009). "Assessing the potential of glucokinase ... The latter may operate via the FOXO1 transactivator. However, as would be expected given its antagonistic effect on glycogen ...
*  Amanda Fisher
"The trans-activator gene of HTLV-III is essential for virus replication". Nature. 320 (6060): 367-371. doi:10.1038/320367a0. ... In the following 4 years, Fisher showed that the transactivator gene tat was essential for virus replication, that truncation ... that at the time was presumed to be a transcriptional activator. Fisher's group showed that Ikaros proteins unexpectedly ...
*  William A. Haseltine
Sodroski, JG; Goh WC; Rosen CA; Dayton AI; Terwilliger E; Haseltine WA (1986). "A Second post-Transcriptional Trans-activator ... region of bovine leukemia virus genome encodes a trans-activator protein. EMBO Journal". The EMBO Journal. 10: 2585-2589. ... Sodroski, JG; Patarca R; Rosen CR; Wong-Staal F; Haseltine WA (1985). "Location of the Trans-activating Region on the Genome of ... Haseltine and his laboratory discovered that HTLV carried a novel gene, called the transactivator X (now called tax). Over the ...
*  POLR2I
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
*  POLR2C
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
*  EP300
This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ... This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EP300 is closely related to ... "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, ...
*  MAPK1
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... "Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator". J. Biol. Chem. 283 (14): 9031-9. doi:10.1074/ ... interacts with signal transducer and activator of transcription (STAT) 5a". Mol. Endocrinol. 13 (4): 555-65. doi:10.1210/mend. ...
*  RFC5
"Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa". Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (Apr 1997). "The human immunodeficiency virus transactivator Tat ... also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene ...
*  Lentivirus
Tat acts as a trans-activator during transcription to enhance initiation and elongation. The Rev responsive element acts post- ...
*  TAF8
1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. ... "Positive and Negative TAFII Functions That Suggest a Dynamic TFIID Structure and Elicit Synergy with TRAPs in Activator-Induced ...
*  Rev (HIV)
"A second post-transcriptional trans-activator gene required for HLTV-III replication". Nature. 321 (6068): 412-417. Bibcode: ... anti-repression transactivator). Later studies suggested that the protein was involved in regulation of the RNA splicing ...
*  PSMC4
"The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of ... "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator". Science. 248 (4963): 1650-3. ...
*  ATF4
Reddy TR, Tang H, Li X, Wong-Staal F (1997). "Functional interaction of the HTLV-1 transactivator Tax with activating ... Liang G, Hai T (1997). "Characterization of human activating transcription factor 4, a transcriptional activator that interacts ...
*  TAF1
It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ... "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF". Curr. Biol. 12 ( ...
*  TAF7
This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is ... Rowlands JC, McEwan IJ, Gustafsson JA (September 1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ... "Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators". Science. 267 (5197): 531- ...
*  TAF12
These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis- ... Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and ... Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ...
*  TAF4
... functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription". Mol. Cell. ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ... "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators". Mol. Cell ...
*  TAF9
The 17-amino-acid-long trans-activating domains (TAD) of several transcription factors were reported to bind directly to TAF9: ... smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. doi:10.1038/367295a0. PMID ...
*  CREB-binding protein
Marcello A, Zoppé M, Giacca M (March 2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". ... Goldman PS, Tran VK, Goodman RH (1997). "The multifunctional role of the co-activator CBP in transcriptional regulation". ... a model for activator:coactivator interactions". Cell. 91 (6): 741-52. doi:10.1016/S0092-8674(00)80463-8. PMID 9413984. Zor T, ... activators". The Journal of Biological Chemistry. 277 (44): 42241-8. doi:10.1074/jbc.M207361200. PMID 12196545. Giebler HA, ...
*  Cyclin-dependent kinase 9
Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
*  POLR2J
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat ...
*  POLR2A
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ... with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators ...
*  PCAF
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator ... "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175-81. doi:10.1080/ ...
*  AP-1 transcription factor
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, ... "Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor". Cell. 49 (6): ... May 2004). "HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth ... Activator protein Transcription factor Hess, J; Angel, P; Schorpp-Kistner, M (1 December 2004). "AP-1 subunits: quarrel and ...
*  Cyclin T1
Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection ... Marcello A, Zoppé M, Giacca M (2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...