Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the ... "Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein". Cell. 55 (6 ... Tat acts by binding to an RNA stem-loop structure, the trans-activation response element (TAR), found at the 5′ ends of nascent ... The basic region is involved in RNA (TAR, trans-activation response element) binding and Tat proteins thus belong to the family ...
SREBP1c is a basic helix-loop-helix zipper (bHLHZ) transactivator. This class of transactivators bind to the "E box" sequence ... Filipski KJ, Pfefferkorn JA (August 2014). "A patent review of glucokinase activators and disruptors of the glucokinase-- ... The latter may operate via the FOXO1 transactivator. However, as would be expected given its antagonistic effect on glycogen ... Upstream stimulatory factor 1 (USF1) is another basic helix-loop-helix zipper (bHLHZ) transactivator. Hepatic nuclear factor 6 ...
Sodroski, JG; Goh WC; Rosen CA; Dayton AI; Terwilliger E; Haseltine WA (1986). "A Second post-Transcriptional Trans-activator ... region of bovine leukemia virus genome encodes a trans-activator protein" (PDF). The EMBO Journal. 5 (10): 2585-2589. doi: ... They named the transactivator tat and the second protein art; the latter was renamed rev. He predicted that drugs that target ... Sodroski, JG; Patarca R; Rosen CR; Wong-Staal F; Haseltine WA (1985). "Location of the Trans-activating Region on the Genome of ...
... (CAP; also known as cAMP receptor protein, CRP) is a trans-acting transcriptional activator that ... p. 193 Catabolite+Activator+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles ... Lawson CL, Swigon D, Murakami KS, Darst SA, Berman HM, Ebright RH (2004). "Catabolite activator protein: DNA binding and ... Busby S, Ebright RH (2001). "Transcription activation by catabolite activator protein (CAP)". J. Mol. Biol. 293 (2): 199-213. ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367..295K. ... "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF". Curr. Biol. 12 ( ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
p300 HAT contains a bromodomain which is involved in IL6 signaling.: 3.1 This gene has also been identified as a co-activator ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ... This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EP300 is closely related to ... "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, ...
This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is ... Rowlands JC, McEwan IJ, Gustafsson JA (September 1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367..295K. ... "Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators". Science. 267 (5197): 531- ...
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis- ... Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and ... Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367..295K. ...
... functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription". Mol. Cell. ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367..295K. ... "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators". Mol. Cell ...
The 17-amino-acid-long trans-activating domains (TAD) of several transcription factors were reported to bind directly to TAF9: ... smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators ... "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367..295K. ...
Waddell AR, Huang H, Liao D (June 2021). "CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging ... Marcello A, Zoppé M, Giacca M (March 2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". ... Goldman PS, Tran VK, Goodman RH (1997). "The multifunctional role of the co-activator CBP in transcriptional regulation". ... emerging evidence suggests that these two co-activators may promote transcription of genes with different biological functions ...
Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... "Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator". J. Biol. Chem. 283 (14): 9031-9. doi:10.1074/ ... interacts with signal transducer and activator of transcription (STAT) 5a". Mol. Endocrinol. 13 (4): 555-65. doi:10.1210/mend. ...
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (October 1996). "Trans-activation by human immunodeficiency virus Tat ... Marcello A, Zoppé M, Giacca M (March 2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". ... "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular ...
"The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein ... Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat ...
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ... with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators ...
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator ... "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175-81. doi:10.1080/ ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection ... Marcello A, Zoppé M, Giacca M (2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and ... 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc ... Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans- ... Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB ...
1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367 ... "Positive and Negative TAFII Functions That Suggest a Dynamic TFIID Structure and Elicit Synergy with TRAPs in Activator-Induced ...
Chimeric transactivators GAL4QF and LexAQF allow to combine the use of all three binary expression systems. GAL4QF binds to UAS ... The genes were renamed to simplify their use as follows: transcriptional activator qa-1F as QF, repressor qa-1S as QS, and the ... The original transactivator QF appeared to be toxic when expressed broadly in Drosophila. To overcome this problem, two new ... The cluster contains a transcriptional activator qa-1F, a transcriptional repressor qa-1S, and five structural genes. The qa-1F ...
"The trans-activator gene of HTLV-III is essential for virus replication". Nature. 320 (6060): 367-371. Bibcode:1986Natur.320.. ... that at the time was presumed to be a transcriptional activator.[citation needed] Fisher's group showed that Ikaros proteins ... Fisher showed that the transactivator gene tat was essential for virus replication, that truncation of the 3' open reading ...