Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council (2007). Toxicity testing in the ... including more than 200 human tissue culture tests to replace toxicity and other testing on animals ... Today, AFAAR funds a ... but does not oblige the test performer to do so; "Article 25.1 - In order to avoid animal testing, testing on vertebrate ... Toxicity testing typically involves studying adverse health outcomes in animals subjected to high doses of toxicants with ...
Hill, Sharon (August 7, 2019). "Large Lake Erie algal bloom nearing Colchester tested for toxicity". Windsor Star. Archived ... Water testing was being conducted in August. The largest Lake Erie blooms to date occurred in 2015, exceeding the severity ... "UWindsor researchers test the waters for harmful algae bloom". University of Windsor. August 8, 2019. Archived from the ... One blamed the commercial fishing ban on a "test of wills" between commercial and recreational fishermen: "One side needed ...
Methods for measuring acute toxicity usually take between 24 and 96 hours to identify contaminants in water supplies. ... Water testing is a broad description for various procedures used to analyze water quality. Millions of water quality tests are ... The water test market is approximately two-thirds equipment and one-third consumables. Reagents are used with each test and ... The low-end test equipment is dominated by few large suppliers, notably Germany's Loviband and Merck, DelAgua Water Testing of ...
Toxicity of rotenone to fish in standardized laboratory tests. U. S. Dept. Interior, No. 72. 11 pp. Panov, A.; Dikalov, S; ... Its potent toxicity is used to control insects. While there may be some differences in the amounts of nutrients and anti- ... and organic legume-based cropping on a test farm at the Rodale Institute over 22 years. The study found that "the crop yields ... "Mechanism of toxicity in rotenone models of Parkinson's disease". The Journal of Neuroscience. 23 (34): 10756-64. doi:10.1523/ ...
A long-term exposure to a low concentration showed no toxicity. This was tested in rats. They were exposed to different ... During several tests in the late 1940s, it was found to be the most toxic of several chemicals to whiteflies on vegetables, two ... A mixture containing 5% sulfotep at the concentration of 0.5 grams of phosphate per 1000 cubic feet was found in tests in the ... There are two cases of acute toxicity known in man. The cholinesterase activity in these people was reduced. It took them 20 ...
Moreover, standard Draize tests were used to assess the dermal toxicity in humans, guinea pigs and rabbits. This resulted in ... In one experiment, the oral toxicity was tested in rats. The rats received oral doses of cinnamyl acetate and the LD50 was ... Moreover, the level of skin irritation in swines was tested via a 48-h patch test. In this study, 0.05 g of cinnamyl acetate ... Furthermore, studies on the dermal toxicity were performed. Experiments on rabbits resulted in an LD50 of more than 5.0 g/kg, ...
Sándor, G; Busch, A; Watzke, H; Reek, J; Ványi, A (1991). "Subacute toxicity testing of ochratoxin-A and citrinin in swine". ... There are different types of toxicity. The types of toxicity that have been studied for citrinin are acute toxicity, ... Citrinin H1 is produced out of two citrinin molecules and its toxicity is increased compared to the original toxicity of ... Hussein, HS; Brasel, JM (2001). "Toxicity, metabolism and impact of mycotoxins on humans and animals". Toxicity. 167 (2): 101- ...
Maddison was taking part in sarin nerve agent toxicity tests; sarin was dripped onto his arm and he died shortly afterwards. In ... animal tests with non-animal tests) are used as the basic code of practice. There has been a decrease in animal experimentation ... Tests were carried out on servicemen to determine the effects of nerve agents on human subjects, with one recorded death due to ... Testing showed that it still contained anthrax spores and in 1986 the Government felt obliged to take necessary steps to ...
ELS tests were adapted from full life-cycle toxicity tests, chronic tests that expose an organism to a contaminant for its ... Biological test method: toxicity tests using the early life stages of salmonid fish (rainbow trout). Report EPS 1/RM/28, 2nd ed ... FELS tests are part of a suite of sublethal toxicity tests for effluent used by Environment Canada in environmental effects ... An early life stage (ELS) test is a chronic toxicity test using sensitive early life stages like embryos or larvae to predict ...
... to limit toxicity. Routine monitoring of the complete blood count, liver function tests, and creatinine are recommended. ... Nitrous oxide potentiating the haematological toxicity of methotrexate has also been documented. Proton-pump inhibitors such as ... Probenecid inhibits methotrexate excretion, which increases the risk of methotrexate toxicity. Likewise, retinoids and ... so increase the risk of toxicity. While they may be used together, increased monitoring is recommended. The aminoglycosides ...
Eiden C, Mathieu O, Cathala P, Debruyne D, Baccino E, Petit P, Peyriere H (November 2013). "Toxicity and death following ... Drug Testing and Analysis. 3 (9): 569-75. doi:10.1002/dta.204. PMID 21960541. ...
Less kidney toxicity has been reported with liposomal formulations (such as AmBisome) and it has become preferred in patients ... European Committee on Antimicrobial Susceptibility Testing (2015-11-16). "Antifungal Agents, Breakpoint tables for ... In order to improve the tolerability of amphotericin and reduce toxicity, several lipid formulations have been developed. ... Liposomal formulations have been found to have less renal toxicity than deoxycholate, and fewer infusion-related reactions. ...
A blood test may reveal increases in blood urea nitrogen (BUN), creatinine, phosphorus, and calcium. Emesis (induction of ... Their toxicity to dogs can cause the animal to develop acute kidney injury (the sudden development of kidney failure) with ... Vomiting and diarrhea are often the first clinical signs of grape or raisin toxicity. They often develop within a few hours of ... "Grape and Raisin Toxicity in Dogs , VCA Animal Hospitals". Retrieved 11 December 2015. McKnight, Katrina (February 2005). " ...
In case of pregnancy, there are more severe toxic effects as tested in rats. At a dose of 2100 mg/kg, there were cases of fetal ... Glybuzole is a drug with low toxicity, it causes no irritation. Sometimes it results in dyspnoea, or shortness of breath, and ...
Seger D, Welch L (August 1994). "Carbon monoxide controversies: neuropsychologic testing, mechanism of toxicity, and hyperbaric ... The mechanism for toxicity was first suggested by James Watt in 1793, followed by Adrien Chenot in 1854 and finally ... Carbon monoxide is not toxic to all forms of life, and the toxicity is a classical dose-dependent example of hormesis. Small ... Apart from the toxicity of carbon monoxide, indigenous Native Americans may have experienced the neuroactive properties of ...
... tested negative for mutagen effects, organ toxicity, and reproductive effects. Imazaquin is a non-volatile chemical ... It has a toxicity classification of III, which corresponds to only a slight toxicity. It is a relatively low toxicity pesticide ... Chronic toxicity studies were also conducted upon rabbits, rats, and beagle dogs. Chronic dermal exposure to imazaquin in ...
A specific blood test to verify toxicity is not typically available. An electrocardiogram (ECG) should be included in the ... There is no role for physostigmine in the treatment of tricyclic toxicity as it may increase cardiac toxicity and cause ... Factors that increase the risk of toxicity include advancing age, cardiac status, and concomitant use of other drugs. However, ... Preskorn S, Irwin H (1982). "Toxicity of tricyclic antidepressants--kinetics, mechanism, intervention: a review". J Clin ...
Based on acute toxicity, pesticides are assigned to a Toxicity Class. Pesticides are the most thoroughly tested chemicals after ... Many case studies testing the effectiveness of the push-pull approach have been done across the world. The most successful push ... Their toxicities vary greatly, but they have been phased out because of their persistence and potential to bioaccumulate.: 239- ... Toxicity also depends on the rate of absorption, distribution within the body, metabolism, and elimination of compounds from ...
These toxicity tests typically result in a no-observed-effect concentration (NOEC, also called a no-observed-effect level, or ... Current practice consists of the use of standard tests. In the standard tests groups of animals are exposed to different ... Chen C.W. and Selleck R.E. (1969) - A kinetic model of fish toxicity threshold. Res. J. Water Pollut. Control Feder. 41: 294 - ... The shape of the effect patterns over time depends on properties of the test compound, properties of the organism, the endpoint ...
... and toxicity tests such as LD50, where a substance's toxicity is tested by determining the concentration at which it will kill ... Animal tests performed include the Draize eye irritancy test, where test chemicals are applied to rabbits' eyes and left on for ... Animal testing data for cosmetics can be used if the data for the ingredient used in the cosmetic originated from testing for ... Rowan, Andrew N. (October 2015). "Ending the Use of Animals in Toxicity Testing and Risk Evaluation". Cambridge Quarterly of ...
The toxicity of cynaropicrin was investigated in vitro and in vivo. In mice, doses of 25 mg/kg/day increased the mortality and ... SK-OV-3, SK-MEL-2, A549, HCT-15 and XF498 (CNS) cell lines have been tested and resulted in a range between 0.29 and 1.37 μg/ml ... At a dose of 400 mg/kg, mice died due to its toxicity. It has been shown that cynaropicrin has a dose-related effect on cell ... Removal of this group led to a loss of toxicity towards T. brucei rhodesiense and a tenfold loss of activity against T brucei. ...
These tests include: acute toxicity test (short-term toxicity test) and chronic toxicity test (long-term toxicity test). These ... These tests include: acute toxicity test (short-term toxicity test) and chronic toxicity test (long-term toxicity test). These ... IBT was the nation's largest independent laboratory that conducted toxicity tests. The EPA and the Canadian Department of ... Based on acute toxicity, pesticides are assigned to a Toxicity Class. Some pesticides are considered too hazardous for sale to ...
Tsunoda, H.; Tsuruta, O. (1958). "Toxicity of P. Rugulosum and P. Tardum, Animal Test of Pericle". The Japanese Journal of ...
In 2007, tests on a number of FEMA trailers by the Sierra Club showed 83% had levels of formaldehyde in the indoor air at ... Hsu, Spencer S. (2008-07-03). "Toxicity in FEMA Trailers Blamed on Cheap Materials, Low Construction Standards". Washington ... Congressmen Henry Waxman and Charlie Melancon requested that FEMA test the trailers and address the issue. The United States ... Brunker, Mike (July 25, 2006). "Are FEMA trailers 'toxic tin cans'? Private testing finds high levels of formaldehyde; ...
Weitz HJ, Campbell CD, Killham K (2002). "Development of a novel, bioluminescence-based, fungal bioassay for toxicity testing ... this sensitivity is being investigated as a means to develop bioluminescence-based biosensors to test the toxicity of polluted ... After intercontinental compatibility tests, Petersen and Bermudes suggested that bioluminescence and compatibility were ...
Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council (2007). Toxicity Testing in the ... He contributed mostly to the fields of bioequivalence testing, health risk assessment, population pharmacokinetics and Bayesian ...
National Academies Press (US). "Omics technologies in chemical testing - OECD". www.oecd.org. Retrieved 2023-04-11. Toxicity, ... In vitro tests can also be combined with in vivo testing to make a in vitro in vivo test battery, for example for ... Within developmental neurotoxicity and reproductive toxicity there are hopes for test batteries to become easy screening ... Alternatives to animal testing, Animal test conditions, Laboratory techniques). ...
Toxicity Testing in the 21st Century, has also been an impetus for EBT. EBT provides new tools for assessing test method ... National Research Council (2007). Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC: The National ... EBT can also help scientists integrate new toxicological test methods into test strategies being implemented across the globe. ... Research in the 1970s and 1980s showed that different physicians regularly recommended different treatments and tests for ...
... gastrointestinal toxicity, or other more marked toxicity associated with such agents. In contrast to most other cytostatic ... Adverse liver function tests are commonly seen with EMP, but severe liver dysfunction is rare with the medication. Central ... EMP produces cardiovascular toxicity similarly to diethylstilbestrol, but to a lesser extent in comparison at low doses (e.g., ... Due to its relatively severe side effects and toxicity, EMP has rarely been used in the treatment of prostate cancer. This is ...
HLA-DQ typing has a practical advantage in that it is the only diagnostic test that allows to exclude CD when a person is ... Its toxicity depends on the cultivar consumed. Furthermore, oats are frequently cross-contaminated with gluten-containing ... Diagnostic tests (antibodies and duodenum biopsies) lose their usefulness if the person is already eating a gluten-free diet. ... For diagnosis of wheat allergy, allergy tests are available. For people with celiac disease, a lifelong strict gluten-free diet ...