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*  RHEB
AMP-activated protein kinase (AMPK) RAF proto-oncogene serine/threonine-protein kinase (C-Raf) mammalian Target of Rapamycin ... RHEB is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. ... Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a serine/threonine kinase whose activation leads to phosphorylation ... Yee WM, Worley PF (Feb 1997). "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase ...
*  Atg1
AuTophaGy related 1 (Atg1) is a 101.7kDa serine/threonine kinase in S.cerevisiae, encoded by the gene ATG1. It is essential for ... In a non-kinase role it is - through complex formation with Atg13 and Atg17 - directly controlled by the TOR kinase, a sensor ... Tomoda T, Bhatt RS, Kuroyanagi H, Shirasawa T, Hatten ME (December 1999). "A mouse serine/threonine kinase homologous to C. ... October 1994). "Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase". ...
*  Mechanistic target of rapamycin
... and protein kinase C α (PKCα). mTORC2 also phosphorylates the serine/threonine protein kinase Akt/PKB on serine residue Ser473 ... TOR was originally discovered at the Biozentrum and Sandoz Pharmaceuticals in 1991 in Basel, Switzerland, and the name TOR pays ... In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell ... mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins ...
*  AMPA receptor
GluA1 has four known phosphorylation sites at serine 818 (S818), S831, threonine 840, and S845 (other subunits have similar ... This is determined by post-transcriptional modification - RNA editing - of the Q-to-R editing site of the GluA2 mRNA. Here, A→I ... Derkach V, Barria A, Soderling TR (March 1999). "Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3- ... Mauceri D, Cattabeni F, Di Luca M, Gardoni F (May 2004). "Calcium/calmodulin-dependent protein kinase II phosphorylation drives ...
*  RTKN
1996). "Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho- ... 2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. 6 (11): 1122-8. ...
*  P70-S6 Kinase 1
It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway ... binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif". The Journal of Biological ... This gene encodes a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic ... Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein ...
*  MTOR inhibitors
... protein tyrosine kinases and protein serine/threonine kinases. Dual-specificity kinases are subclass of the tyrosine kinases. ... Structure, Function and Regulation of TOR complexes from Yeasts to Mammals. The Enzymes. 27. pp. 329-66. doi:10.1016/S1874-6047 ... mTOR is a kinase within the family of phosphatidylinositol-3 kinase-related kinases (PIKKs), which is a family of serine/ ... which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related ...
*  MTORC1
Ultimately, Akt phosphorylates TSC2 on serine residue 939, serine residue 981, and threonine residue 1462. These phosphorylated ... since the mTOR and the PI3K proteins are both in the same phosphatidylinositol 3-kinase-related kinase (PIKK) family of kinases ... Russell RC, Fang C, Guan KL (Aug 2011). "An emerging role for TOR signaling in mammalian tissue and stem cell physiology". ... IKK beta can phosphorylate TSC1 at serine residue 487 and TSC1 at serine residue 511. This causes the heterodimer TSC complex ...
*  MTORC2
... phosphorylates the serine/threonine protein kinase Akt/PKB at a serine residue S473 as well as serine residue S450. ... TOR complex 2 at the US National Library of Medicine Medical Subject Headings (MeSH)} Molecular and Cellular Biology portal. ... "Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B". ... Phosphorylation of the serine stimulates Akt phosphorylation at a threonine T308 residue by PDK1 and leads to full Akt ...