Loading...
*  TLR 1
... is a member of the toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TLR1 ... Toll-Like Receptor 1 at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Lien E, Ingalls RR (January 2002). "Toll-like receptors". Crit. Care Med. 30 (1 Suppl): S1-11. doi:10.1097/00003246-200201001- ... TLR1 recognises peptidoglycan and (triacyl) lipoproteins in concert with TLR2 (as a heterodimer). Toll-like receptors, ...
*  TLR5
"Toll-like receptors". Critical Care Medicine. 30 (1 Suppl): S1-11. doi:10.1097/00003246-200201001-00001. PMID 11782555. Toll- ... Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll- ... "Entrez Gene: TLR5 toll-like receptor 5". Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, ... Smith MF, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB (Aug 2003). "Toll-like receptor (TLR) 2 and ...
*  Flagellin
There exists a specific innate immune receptor that recognizes flagellin, Toll-like receptor 5 (TLR5). In addition, a 22-amino ... Theodore S. Steiner (21 November 2006). "How Flagellin and Toll-Like Receptor 5 Contribute to Enteric Infection" (PDF). ... Flagellin perception in Arabidopsis thaliana functions via the receptor-like-kinase FLS2 (flagellin-sensitive-2)). Upon flg22 ... 2007 A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence, Nature 448, 497-500. doi:10.1038/ ...
*  Profilin
... derived profilin triggers human toll-like receptor 5-dependent cytokine production". Journal of Innate Immunity. 6 (5): 685-694 ... Profilin binds some variants of membrane phospholipids (Phosphatidylinositol (4,5)-bisphosphate and Inositol triphosphate). The ...
*  Pathogen-associated molecular pattern
They are recognized by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals. A ... Lessons from flagellin and Toll-like receptor 5". FEBS Letters. 580 (12): 2976-84. doi:10.1016/j.febslet.2006.04.036. PMID ... A virulence signal capable of binding to a pathogen receptor, in combination with a MAMP, has been proposed as one way to ... Although the term "PAMP" is relatively new, the concept that molecules derived from microbes must be detected by receptors from ...
*  Entolimod
Cai, Z.; Sanchez, A.; Shi, Z.; Zhang, T.; Liu, M.; Zhang, D. (2011). "Activation of Toll-like Receptor 5 on Breast Cancer Cells ... Entolimod is a recombinant protein that acts as an agonist of toll-like receptor 5 (TLR5), an innate immunity receptor. ... "Toll-like Receptor 5 Agonist Protects Mice from Dermatitis and Oral Mucositis Caused by Local Radiation: Implications for Head- ... "An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models". Science. 320 (5873): 226-30. doi: ...
*  Cleveland BioLabs
Entolimod acts through activation of Toll-like Receptor 5 to mobilize antitumor immune response and reduce radiation effects on ... CBLB612 is a proprietary compound based upon a natural activator of TLR2/TLR6 heterodimeric receptor. It structurally mimics ...
*  Toll-like receptor
Toll-like receptors and ligands database at University of Munich The Toll-Like Receptor Family of Innate Immune Receptors (pdf ... NOD-like receptor Immunologic adjuvant Toll (gene family) Toll-Like Receptors at the US National Library of Medicine Medical ... toll-like receptor superfamily"; all members of this family have in common a so-called TIR (toll-IL-1 receptor) domain. Three ... This difference might reflect a function of these receptors as cytokine receptors rather than PRRs. Toll pathway is activated ...
*  Richard Bonneau
Andersen-Nissen E, Smith KD, Bonneau R, Strong RK, Aderem A. A conserved surface on Toll-like receptor 5 recognizes bacterial ... 5(8):R52-68 Mike Boxem, Zoltan Maliga, Niels J. Klitgord, Na Li, Irma Lemmens, Miyeko Mana, Lorenzo De Lichtervelde, Joram Mul ... 7(5):R36. David J Reiss, Nitin S Baliga, Bonneau R. (2006) Integrated biclustering of heterogeneous genome-wide datasets. BMC ...
*  FAM185A
... expression is greatly decreased in ROR1-alpha knockout mice and toll-like receptor 5 knockout mice. Mice also show a ...
*  Toll-like receptor 11
TLR11 belongs to the toll-like receptor (TLR) family and the interleukin-1 receptor/toll-like receptor superfamily. In mice, ... Toll-like receptor 11 (TLR11) is a protein that in mice is encoded by the gene TLR11, whereas in humans it is represented by a ... Zhang, D.; Zhang, G; Hayden, MS; Greenblatt, MB; Bussey, C; Flavell, RA; Ghosh, S (2004). "A Toll-like Receptor That Prevents ... Its job is to initiate a signal that will activate the Toll pathway in the cell. The ultimate end of the Toll pathway is the ...
*  Toll-Interleukin receptor
... the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (TLRs) and IL-1R is not restricted to ... interleukin-1 receptor, Toll receptor and many plant R proteins. It contains three highly conserved regions, and mediates ... The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, ... Anderson KV (2000). "Toll signaling pathways in the innate immune response". Curr. Opin. Immunol. 12 (1): 13-19. doi:10.1016/ ...
*  IRF5
2005). "The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling". J. Biol. Chem. 280 ( ... Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. IRF5 is a member of the interferon ... 38 (5): 550-5. doi:10.1038/ng1782. PMID 16642019. IRF5 protein, human at the US National Library of Medicine Medical Subject ... Barnes BJ, Moore PA, Pitha PM (2001). "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the ...
*  Hermann Wagner
In Munich, he subsequently contributed to our understanding of Toll-like-Receptors(TLR), through which innate immune cells ... "Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8". Science. 303 (5663): 1526-1529. doi: ... F., Heil; Hemmi, H.; Hochrein, H.; Ampenberger, F.; Kirschning, C.; Akira, S.; Lipford, G.; Wagner, H.; Bauer, S. (5 March 2004 ...
*  MYD88
"Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". Journal of Immunology. 170 (7): 3565 ... "Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". Journal of Immunology. 170 (7): 3565 ... "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in ... Arancibia SA, Beltrán CJ, Aguirre IM, Silva P, Peralta AL, Malinarich F, Hermoso MA (2007). "Toll-like receptors are key ...
*  TLR9
It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including ... Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster ... "Entrez Gene: TLR9 toll-like receptor 9". Dias AA, Silva CO, Santos JP, Batista-Silva LR, Acosta CC, Fontes AN, Pinheiro RO, ... Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, Shah AM, Nishida K, Otsu K (December 2016). "Toll-like receptor 9 ...
*  TLR2
... is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is ... Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated ... The following ligands have been reported to be agonists of the toll-like receptor 2: TLR 2 has been shown to interact with TLR ... The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen ...
*  Luke A. J. O'Neill
"ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance". Nature ... O'Neill, Luke A. J.; Bowie, Andrew G. (2007). "The family of five: TIR-domain-containing adaptors in Toll-like receptor ... Liew, Foo Y.; Xu, Damo; Brint, Elizabeth K.; O'Neill, Luke A. J. (2005). "Negative regulation of Toll-like receptor-mediated ... Palsson-McDermott, Eva M.; O'Neill, Luke A. J. (2004). "Signal transduction by the lipopolysaccharide receptor, Toll-like ...
*  Akiko Iwasaki
"Toll-like receptor control of the adaptive immune response" (PDF). Nature Immunology. Nature Publishing Group. Retrieved 4 May ... According to Google Scholar, one of her publications, Toll-like receptor control of the adaptive immune response, has been ... Iwasaki, A.; Medzhitov, R. (2004). "Toll-like receptor control of the adaptive immune responses". Nature Immunology. 5 (4): 987 ... 14 (5): 315-328. doi:10.1038/nri3665. Iwasaki, A.; Medzhitov, R. (2010). "Regulation of adaptive immunity by the innate immune ...
*  MiR-146
... dysregulates a number of targets which are mostly involved in toll-like receptor pathways that bring about a cytokine ... Quinn SR, O'Neill LA (Jul 2011). "A trio of microRNAs that control Toll-like receptor signalling". International Immunology. 23 ... 105 (5): 625-30. PMID 21141085. Bellingham SA, Coleman BM, Hill AF (Nov 2012). "Small RNA deep sequencing reveals a distinct ... 67 Suppl 3: iii50-5. doi:10.1136/ard.2008.100289. PMID 19022814. Ma X, Becker Buscaglia LE, Barker JR, Li Y (Jun 2011). " ...
*  TLR3
... is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 is a ... Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the ... "Entrez Gene: toll-like receptor 3". Norval M (2012). "Virus-Cell Interactions". In Greenwood D, Slack RC, Barer MR, et al. ... Pan LN, Zhu W, Li Y, Xu XL, Guo LJ, Lu Q, Wang J (2014). "Astrocytic Toll-like receptor 3 is associated with ischemic ...
*  Alloimmunity
"Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity". J. Immunol. 179 (3): 1700-10. ... Receptors of KIR (Killer-cell immunoglobulin-like receptor) family bind concrete MHC class I molecules. If the graft has these ... Specific T-cell receptors (TCR) of CD8+ T-lymphocytes recognize these peptides when form the complex with MHC class I molecules ... In contrast, there are also such receptors on T-lymphocytes that cause inhibition of T-cell activation (for instance CD152/CTLA ...
*  MAP3K3
"Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3". Nature Immunology. 5 (1): 98-103 ... "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149-56. doi: ... 272 (5): 2668-74. doi:10.1074/jbc.272.5.2668. PMID 9006902. MAP3K3 in GeneCards - The Human Gene Compendium. http://www. ...
*  Sjögren syndrome
Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors" Annu. Rev. Immunol 2003; 21, 335-376 Pflugfelder S. C.; et al. (1993 ... could prompt epithelial cells to activate the HLA-independent innate immune system through toll-like receptors. Although a ... Perrier, S; Coussediere, C; Dubost, JJ; Albuisson, E; Sauvezie, B (1998). "IL-1 receptor antagonist (IL-1RA) gene polymorphism ... Tolls DB, Toda I (1999). "Androgens and dry eye in Sjögren's syndrome". Ann N Y Acad Sci. 876: 312-24. doi:10.1111/j.1749- ...
*  Interferon alpha-1
... master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors". Nature Reviews. Immunology ... Honda K, Taniguchi T. "Toll-like receptor signaling and IRF transcription factors". IUBMB Life. 58 (5-6): 290-5. doi:10.1080/ ... The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits, IFNAR1 (α-subunit) and IFNAR2 (β ... Uzé, G; Schreiber, G; Piehler, J; Pellegrini, S (2007). "The receptor of the type I interferon family". Current topics in ...
*  Interferon
... such as membrane bound Toll like receptors or the cytoplasmic receptors RIG-I or MDA5, can trigger release of IFNs. Toll Like ... Interferon type I: All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α/β receptor (IFNAR) that ... In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and ... the ligand for this receptor is double-stranded RNA (dsRNA). After binding dsRNA, this receptor activates the transcription ...
*  TLR4
"Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". Journal of Immunology. 170 (7): 3565 ... TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor ( ... Pålsson-McDermott EM, O'Neill LA (2004). "Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4". ... Toll-like receptor 4 has been shown to be important for the long-term side-effects of opioid analgesic drugs. Various μ-opioid ...