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*  Death receptor 5
Abe K, Kurakin A, Mohseni-Maybodi M, Kay B, Khosravi-Far R (2001). "The complexity of TNF-related apoptosis-inducing ligand". ... This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and ... Kuang AA, Diehl GE, Zhang J, Winoto A (Aug 2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced ... and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity. 7 (6): 821-30. doi:10.1016/s1074-7613(00 ...
*  CFLAR
2001). "The complexity of TNF-related apoptosis-inducing ligand". Ann. N. Y. Acad. Sci. 926 (1): 52-63. doi:10.1111/j.1749- ... and caspase-related inducer of apoptosis". Immunity. 6 (6): 751-63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847. Irmler M, ... CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE- ...
*  Decoy receptor 1
TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL". J. Immunol. 160 (1 ... 2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678- ... 2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. ... 2002). "Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells". Graefes Arch. Clin. Exp. ...
*  Decoy receptor 2
2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678- ... 2000). "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL ... 2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. ... syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand". J ...
*  Adenovirus early region 1A
"Adenovirus E1A Oncogene Expression in Tumor Cells Enhances Killing by TNF-Related Apoptosis-Inducing Ligand (TRAIL)". 2000. " ...
*  Tumor necrosis factor superfamily
TNF-related apoptosis inducing ligand (TRAIL), a cytokine that induces apoptosis. All these cytokines seem to form homotrimeric ... TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has ... All members of the TNF family, with the exception of the secreted lymphotoxin and a proliferation-inducing ligand (APRIL), are ... "Identification and characterization of a new member of the TNF family that induces apoptosis". Immunity. 3 (6): 673-82. doi: ...
*  Tumor microenvironment
Myelomonocytic cell products that cause apoptosis include FasL, TNF-α, and TNF-related apoptosis-inducing ligand (TRAIL). ... Cancer cells induce apoptosis of activated T cells (a class of lymphocyte) by secreting exosomes containing death ligands such ... Another T cell inhibitor appears to be the apoptosis inducer Fas ligand (FasL) that is found in the tumor vasculature of tumor ... Both IDO and PD-L1 may induce T cell apoptosis. ... TAMs have been induced in vitro by exposing macrophage ...
*  Mir-25 microRNA precursor family
"MiR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in ... Kwok, H. H.; Yue, P. Y. K.; Mak, N. K.; Wong, R. N. S. (2012). "Ginsenoside Rb1 induces type I collagen expression through ... Zhu, Z.; Zuo, Z.; Lu, X.; Wang, L.; Wang, H.; Zhu, Z. (2011). "MiR-25 regulates apoptosis by targeting Bim in human ovarian ... Xie, T.; Liang, J.; Guo, R.; Liu, N.; Noble, P. W.; Jiang, D. (2011). "Comprehensive microRNA analysis in bleomycin-induced ...
*  CD4+ T cells and antitumor immunity
Th1 and NK cells both contribute to killing of tumor cells via the TNF-related apoptosis-inducing ligand (TRAIL) pathway. NK ... For example, it was recently shown that CD4+ T cells primarily produce TNF after recognition of tumor-antigens in melanoma. TNF ... Th17 differentiation is induced by TGF-β and IL-6, and signature cytokines of Th17 cells include IL-17A and IL17-F. The ... In conjuncture with TNF (Tumor Necrosis Factors), IFN-γ can have direct cytotoxic effects on tumor cells (Franzen et al., 1986 ...
*  Newcastle disease
The results also indicate the extrinsic pathway is activated by TNF-related, apoptosis-inducing ligand-induced, NDV-mediated ... NDV triggers apoptosis in a wide range of cancer cell types via the mitochondrial/intrinsic pathway, through loss of membrane ... In addition, an increase of CD4+ and CD8+ T-cells occurs within the tumor cells when inducing NDV/F3aa recombined with the ... Kuruppu & Tanabe 2005) The precise way in which the presence of NDV induces tumor cell death remains to be clarified and may ...
*  IFN1@
2004). "IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/ ... 2007). "Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin ... 2005). "Cross-regulation of TNF and IFN-α in autoimmune diseases". Proc. Natl. Acad. Sci. U.S.A. 102 (9): 3372-7. doi:10.1073/ ... 2006). "Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of ...
*  Death receptor 4
Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric ... 2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. ... This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell ... and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts". J. Biol. Chem. 275 ...
*  Fractional kill
TNF-related apoptosis inducing ligand). TRAIL is a ligand native to the human body that is currently being developed as a ... Surprisingly, the authors found that each of the agents was able to induce apoptosis in all phases of the cell cycle, ... suggesting that the mechanism through which the drugs induce apoptosis may be independent of the drugs' biochemical targets. In ... Very little direct information is available on whether cells undergo apoptosis from a certain point in the cell cycle. One ...
*  TRAIL
In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces ... Bucur O, Ray S, Bucur MC, Almasan A (2006). "APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate ... "Identification and characterization of a new member of the TNF family that induces apoptosis". Immunity. 3 (6): 673-82. doi: ... Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A (May 1996). "Induction of apoptosis by Apo-2 ligand, a new ...
*  Follicular atresia
TNF alpha) and receptors Fas ligand and receptors TNF-related apoptosis-inducing ligand (TRAIL; also called APO-2) and ... TNF-related apoptosis-inducing ligand TRAIL activates Caspase 3 (CASP3), which in turn interacts with caspases 6, 7, 8, 9, and ... "Roles of tumor necrosis factor-related apoptosis-inducing ligand signaling pathway in granulosa cell apoptosis during atresia ... mediates signals that induce apoptosis by binding Fas ligand and therefore plays an important role in follicular atresia. Lack ...
*  Anaplastic thyroid cancer
New drugs, such as fosbretabulin (a type of combretastatin), bortezomib and TNF-Related Apoptosis Induced Ligand (TRAIL), are ...
*  Anticancer gene
TRAIL (TNF related apoptosis-inducing ligand) is a member of the TNF family of apoptosis-inducing ligands TP53 is another anti- ... Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc. Natl. Acad. Sci. U S A 94, ... Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science. 277, 818-21. (1997).. ... The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in ...
*  Development of analogs of thalidomide
... increasing sensitivity to FAS mediated cell death and enhancement of TNF-related apoptosis inducing ligand. They have also been ... This effect is not related to TNF-α inhibition since potent TNF-α inhibitors such as rolipram and pentoxifylline did not ... Inhibition of TNF-α is not the mechanism of thalidomide's inhibition of angiogenesis since numerous other TNF-α inhibitors do ... Thalidomide was discovered to inhibit tumour necrosis factor-alpha (TNF-α) in 1991. TNF-α is a cytokine produced by macrophages ...
*  Immunoediting
TNF-related apoptosis-inducing ligands (TRAILs), and reactive oxygen species. Most of the tumor cells are destroyed in this ... In the second phase, newly synthesized IFN-gamma induces tumor death (to a limited amount) as well as promoting the production ... Tumor infiltration by lymphocytes is seen as a reflection of a tumor-related immune response. There is increasing evidence that ... This again promotes more tumor killing by these cells via apoptosis and the production of reactive oxygen and nitrogen ...
*  Caspase 14
... and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this ... "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase". Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; ... 2004). "Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ...
*  Actinic keratosis
... the CD95 ligand, TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors, and loss of heterozygosity. Recent research ... Because they are related to sun-damage on the skin, most people who have an AK have more than one. Often, large areas of sun- ... It works in two ways, first by disrupting cell membranes and mitochondria resulting cell death, and then by inducing antibody- ... It is thought that UV radiation induces mutations in the keratinocytes of the epidermis, promoting the survival proliferation ...
*  Trail (disambiguation)
"TNF-related apoptosis-inducing ligand" Technical Report Archive & Image Library, also known as TRAIL Trail, Scottish clan aka ...
*  TNFRSF18
2007). "Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell ... "A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis". Proc ... "Glucocorticoid-induced TNF receptor, a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated ... 2006). "Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis". Acta Derm. ...
*  TNFSF12
Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein ... a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis". The Journal of Biological Chemistry. ... TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to ... The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ...
*  RANKL
TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), ... RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls ... RANKL is identified as a part of the TNF family; RANKL is specifically categorized under the TNFSF11, the TNF ligand ... Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 ( ...
*  Caspase 10
Shu HB, Halpin DR, Goeddel DV (1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751-63. ... 1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem. 272 (30 ... Micheau, Olivier; Tschopp Jürg (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling ... "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer ...