Wu H (2007). TNF Receptor Associated Factors (TRAFs). Vol. 1. Springer Science & Business Media. pp. 1-206. ISBN 978-0397507597 ... Due to its regulation of TNF, TAK1 has become a novel target for the treatment of TNF mediated diseases such as auto immune ... "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner". Nat. Cell Biol. 10 (10): ... Following TNF stimulation, TAK1 forms a ternary structure with TAB1 and TAB2/3 to form a fully activated TAK1 kinase. Following ...

"The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. ... "Entrez Gene: TRAF6 TNF receptor-associated factor 6". Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K ... "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor ... The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are ...

TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". ... So T, Salek-Ardakani S, Nakano H, Ware CF, Croft M (April 2004). "TNF receptor-associated factor 5 limits the induction of Th2 ... Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR- ... "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- ...

TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". Mol ... "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. ... mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF". Mol. Cell. Biol. 21 (12 ... TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is ...

... bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". ... "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cellular ... TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene. The scaffold protein encoded by this ... "Entrez Gene: TRAF5 TNF receptor-associated factor 5". Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K ...

IKK2 RELA Toll-like receptor TNF receptor superfamily Imd pathway In other words, c-Fos repression allows ΔFosB to accumulate ... "Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) ... Sheikh MS, Huang Y (2003). "Death receptor activation complexes: it takes two to activate TNF receptor 1". Cell Cycle. 2 (6): ... Many NF-κB target genes that may be important for plasticity and learning include growth factors (BDNF, NGF) cytokines (TNF- ...

TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". The Journal ... specific TNF receptor blockade may be advantageous to anti-TNF treatments". Cytokine & Growth Factor Reviews. 13 (4-5): 315-321 ... is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor ... c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 ...

Both appear to compete with TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited ... Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR (October 1999). "Mediation of TNF receptor-associated factor effector functions ... Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR (October 1999). "Mediation of TNF receptor-associated factor effector functions ... November 2005). "Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating ...

Liu H, Su YC, Becker E, Treisman J, Skolnik EY (1999). "A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 ... TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase". The ... TNF-α specifically attenuates the signaling pathway initiated by insulin receptors, reducing the amount of glucose transport ... Skolnik EY, Marcusohn J (1996). "Inhibition of insulin receptor signaling by TNF: potential role in obesity and non-insulin- ...

TNFR1 binding protein TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which ... First, extrinsic stimulus through the TNF receptor by TNFα signals the recruitment of the TNF receptor-associated death domain ... The Tumor Necrosis Factor Receptor can signal for both apoptosis and necroptosis. The RIPK1 protein can also signal for both ... Toll-like receptors (TLRs) can also signal to the necrosome, leading to necroptosis. TLRs are a class of receptors that ...

An example of this is the binding of tumour necrosis factor-alpha (TNF-alpha) to TNF-alpha receptor. An example of a TNF ... Altieri DC (February 1994). "Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the ... Altieri DC (1994). "Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease ... receptor is Fas (CD95), which recruits activator caspases like caspase-8 upon binding TNF at the cell surface. The activation ...

TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and ... The sequential and functional homology of TNF and LT led to the renaming of TNF as TNFα and LT as TNFβ. In 1985, Bruce A. ... The binding of TNF to its receptor and its displacement by LT confirmed the functional homology between the two factors. ...

"Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS ... "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS ... TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered ... "Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI". Current Biology. 10 (13): 785 ...

1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and ... 2000). "TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated ... TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. UNITED STATES. 163 (6): ... activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2)". J. Biol. Chem. 278 (17): 15429 ...

Kelly ML, Wang M, Crisostomo PR, Abarbanell AM, Herrmann JL, Weil BR, Meldrum DR (June 2010). "TNF receptor 2, not TNF receptor ... 2009). "Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based ... Cells that have the capacity to release soluble factors such as cytokines, chemokines, and growth factors which act in a ... These factors facilitate self-healing of the organ or region by inducing local (stem) cells or attracting cells to migrate ...

This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of ... Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/ ... Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/ ... Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor ...

... bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". ... "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cellular ... TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this ... "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell ...

TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor ... It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF ... Hu WH, Johnson H, Shu HB (1999). "Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK ... Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM (2001). "The ectodermal dysplasia receptor activates the nuclear factor-kappaB ...

"Transforming Growth Factor-β1 overexpression in Tumor Necrosis Factor-α receptor knockout mice induces fibroproliferative lung ... Liu J.-Y.; Brass D. M.; Hoyle G. W.; Brody A. R. (1998). "TNF-α receptor knockout mice are protected from the ... The cytokines, transforming growth factor beta and tumor necrosis factor alpha, appear to play major roles in the development ... The amount and length of an individual's exposure to asbestos are the primary factors that determine the level of risk. The ...

... cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R ... "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ... 1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine- ... the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, ...

... specific TNF receptor blockade may be advantageous to anti-TNF treatments". Cytokine Growth Factor Rev. 13 (4-5): 315-21. doi: ... Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and ... Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor ... This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ...

Tumor necrosis factor-alpha (TNF-alpha) and its receptor are the molecules that seem to be responsible for the sensitization of ... TNF-alpha then binds to the TNF receptors expressed on nociceptors, activating the MAPK/NF-kappa B pathways. This leads to the ... TNF-alpha might also increase the number of AMPA receptors, and decrease the numbers of GABA receptors on the membrane of ... In any case, CCL21 binds to C-C chemokine receptor type 7 and chemokine receptor CXCR3 receptors on microglia in the thalamus. ...

... a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an ... "A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis". ... GITR was identified as a new member of the TNF receptor superfamily, by comparing gene expression in untreated and DEX-treated ... Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced TNFR-related protein ( ...

TRAF2, tumor necrosis factor (TNF) receptor associated factor 2, is part of some E3 ubiquitin ligase complexes and is involved ... In this study, CCDC130 is categorized as a known splicing factor and its homolog in yeast is Yju2. This yeast protein is a ... EEF1A1 is a eukaryotic elongation factor that is involved in the binding of aminoacyl-tRNA to the A-site of ribosomes during ... GATA5 is a transcription factor that helps activate the promoter for lactase-phlorizin hydrolase. Interactions with CDA, DERA, ...

... tumor necrosis factor alpha (TNF alpha) and receptors Fas ligand and receptors TNF-related apoptosis-inducing ligand (TRAIL; ... receptors APO-3 ligand and receptors PFG-5 ligand and receptors Granulosa cell apoptosis is promoted by tumor necrosis factor- ... Other risk factors include traditional cardiovascular disease risk factors such as dyslipidemia and hypertension. Non- ... alpha (TNFα), although the mechanism of how it occurs is unclear. Fas antigen, a cell surface receptor protein, that is ...

Through tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2, TNFα mediates the differentiation of ... These cells, including macrophages, release inflammatory mediators such as cytokines (tumor necrosis factor alpha (TNFα), ... Stromal cell-derived factor 1 (SDF-1) and CXCR4 mediate recruitment of mesenchymal stem cells. IL-1 and IL-6 are the most ... Mechanical factors such as the bone not being aligned, and too much or too little movement. Excess mobility can disrupt the ...

Genome polyprotein Tyrosine-protein kinase Fyn Pre-mRNA-processing factor 39 (PRP39) TNF receptor-associated factor 4 (TRAF4) ... A number of other interactions have been indicated such as: Vimentin Growth factor receptor-bound protein 2 (GRB2) ... Llorian M, Beullens M, Andrés I, Ortiz JM, Bollen M (February 2004). "SIPP1, a novel pre-mRNA splicing factor and interactor of ... WW domain binding protein 11 (WBP11) Npw38-binding protein (NpwBP) Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1) ...

... tumor necrosis factor) model and the Fas-Fas ligand-mediated model, both involving receptors of the TNF receptor (TNFR) family ... The TNF-alpha receptor superfamily also includes death receptors (DRs), such as DR4 and DR5. These receptors bind to the ... Most cells in the human body have two receptors for TNF-alpha: TNFR1 and TNFR2. The binding of TNF-alpha to TNFR1 has been ... For example, the M-T2 protein of myxoma viruses can bind TNF preventing it from binding the TNF receptor and inducing a ...

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors ... bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc ... TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is ... "Entrez Gene: TRAF1 TNF receptor-associated factor 1". Abdul-Sater, Ali A; Edilova, Maria I; Clouthier, Derek L; Mbanwi, Achire ...

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein ... 1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science. 268 (5210): ... "Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)". Wolf FW, Marks RM, Sarma V, et al. (1992 ... "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific ...