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*  Fibrinolysis
Tissue plasminogen activator (t-PA) and urokinase are the agents that convert plasminogen to the active plasmin, thus allowing ... t-PA and urokinase are themselves inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2 (PAI-1 ... plasmin further stimulates plasmin generation by producing more active forms of both tissue plasminogen activator (tPA) and ... Plasmin is produced in an inactive form, plasminogen, in the liver. Although plasminogen cannot cleave fibrin, it still has an ...
*  Urokinase
However, urokinase is not very selective for clot-bound plasminogen, unlike tissue plasminogen activator (TPA) which ... The most important inhibitors of urokinase are the serpins plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator ... Urokinase is marketed as Abbokinase or Kinlytic and competes with recombinant tissue plasminogen activator (e.g., alteplase) as ... It is believed that the tissue degradation following plasminogen activation facilitates tissue invasion and, thus, contributes ...
*  Plasminogen activator inhibitor-1
... that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of ... Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein ... Alessi MC, Poggi M, Juhan-Vague I (June 2007). "Plasminogen activator inhibitor-1, adipose tissue and insulin resistance". ... Plasminogen activator inhibitor-1 has been shown to interact with ORM1. GRCh38: Ensembl release 89: ENSG00000106366 - Ensembl, ...
*  Tissue plasminogen activator
The Tissue-Type Plasminogen Activator Story, Collen, D., Lijnen, H.R. Genentech Press Release 1982 Tissue Plasminogen Activator ... "Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized ... Tissue plasminogen activator also plays a role in cell migration and tissue remodeling.[citation needed] Once in the body, tPA ... Tissue-type plasminogen activators were initially identified and isolated from mammalian tissues after which a cDNA library was ...
*  Alteplase
It is a tissue plasminogen activator. It is approved by the US Food and Drug Administration for the treatment of myocardial ...
*  Proteases (medical and related uses)
Nattokinase See Tissue plasminogen activator and Maggot therapy. Examples are reported by M. Mecikoglu et al., "The Effect of ... Tissue plasminogen activator (TPA) is a serine protease occurring in animals including humans. Human-identical TPA (produced ... Bromelain is a protease usually obtained from pineapple stem tissue, which has been medically used for its anti-inflammatory ... 19 (7). Klasen HJ (May 2000). "A review on the nonoperative removal of necrotic tissue from burn wounds". Burns. 26 (3): 207-22 ...
*  Myocardial infarction
These medications include tissue plasminogen activator, reteplase, streptokinase, and tenecteplase. Thrombolysis is not ... Blockage of an artery can lead to tissue death in tissue being supplied by that artery. Atherosclerotic plaques are often ... Tissue death and myocardial scarring alter the normal conduction pathways of the heart, and weaken affected areas. The size and ... The dead tissue is surrounded by a zone of potentially reversible ischemia that progresses to become a full-thickness ...
*  HMGB1
"Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen ... Antibodies that neutralize HMGB1 confer protection against damage and tissue injury during arthritis, colitis, ischemia, sepsis ... Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation". J. Biol. ... is a unique activator of p53". Genes Dev. 12 (4): 462-72. doi:10.1101/gad.12.4.462. PMC 316524 . PMID 9472015. Milev P, Chiba A ...
*  Thromboelastography
A single, modified TEG assay with exogenous tissue plasminogen activator (tPA) demonstrated remarkable efficiency in unmasking ... "Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes". Journal of the American ... A RapidTEG uses tissue factor in addition to kaolin thereby further speeding up the reaction. In this assay, the R-value is ...
*  Streptokinase
Further thrombotic events could be treated with Tissue plasminogen activator (tPA). Overdose of streptokinase or tPA can be ... Rabijns A, De Bondt HL, De Ranter C (May 1997). "Three-dimensional structure of staphylokinase, a plasminogen activator with ... Each domain binds plasminogen, although none can activate plasminogen independently. Plasmin is produced in the blood to break ... and complexes of streptokinase with human plasminogen can hydrolytically activate other unbound plasminogen by activating ...
*  Deoxyribonuclease
Intrapleural tissue plasminogen activator (tPA) combined with deoxyribonuclease has been shown to increase pleural drainage, ... Rahman, Najib (August 11, 2011). "Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection". The New ...
*  Désiré Collen
... tissue-type) plasminogen activator. Lancet. 1981; 2: 1018-20. Van de Werf F et al. Coronary thrombolysis with tissue-type ... characteristic of human tissue-type plasminogen activator (t-PA), whereas most other malignant cells produced a plasminogen ... Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA ... The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and ...
*  Plasminogen activator
There are two main plasminogen activators: urokinase (uPA) and tissue plasminogen activator (tPA). Tissue plasminogen ... The main inhibitor of tissue plasminogen activator and urokinase is plasminogen activator inhibitor-1 (PAI-1). Plasminogen ... Plasminogen activators are inhibited by plasminogen activator inhibitor-1, plasminogen activator inhibitor-2, and protein C ... that specifically inhibits tissue plasminogen activator (tPA) and urokinase (uPA). Tissue plasminogen activator and urokinase ...
*  LRP1
"Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized ... Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G (Jan 2000). "Role of tissue plasminogen activator receptor LRP in ... Notably, LRP1 functions in clearing proteases such as plasmin, urokinase-type plasminogen activator, and metalloproteinases, ... "Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells". Oncotarget. 6 ...
*  Fibrinogen alpha chain
Ichinose A, Takio K, Fujikawa K (Jul 1986). "Localization of the binding site of tissue-type plasminogen activator to fibrin". ... Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator. Fibrinogen Fibrinogen gamma chain GRCh38: ... fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator". The ... and plasminogen-binding sites within fibrin(ogen) alpha C-domains". Biochemistry. 40 (3): 801-808. doi:10.1021/bi001789t. PMID ...
*  Cerebral infarction
In increasing numbers of primary stroke centers, pharmacologic thrombolysis with the drug tissue plasminogen activator (tPA), ... Smith WS (June 1, 2006). "Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic ... 70 to 80% reduction in diameter). In tissue losses that are not immediately fatal, the best course of action is to make every ... A cerebral infarction is an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries ...
*  SERPINI1
2005). "Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system". Thromb. Haemost ... Yepes M; Lawrence DA (2004). "Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous ... Barker-Carlson K; Lawrence DA; Schwartz BS (2003). "Acyl-enzyme complexes between tissue-type plasminogen activator and ... 1998). "Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. ...
*  Björn Dirk Krapohl
Effect of tissue-plasminogen activator on leukocyte-endothelial interactions at the microcirculatory level. Plast Reconstr Surg ...
*  Intracameral injection
Wu, T-T; Wang, H-H (2007). "Intracameral recombinant tissue plasminogen activator for the treatment of severe fibrin reaction ... Intracameral injection of recombinant tissue plasminogen activator (r-TPA) has been found to be effective in treating the ...
*  MERCI Retriever
The treatment process itself is termed the r-tPA method (Recombinant Tissue Plasminogen Activator). The success of the r-tPA is ...
*  Dysfunctional uterine bleeding
... increased levels of tissue plasminogen activator (TPA) (a fibrinolytic enzyme) lead to more fibrinolysis. Diagnosis must be ... When this happens, the corpus luteum, which is a mound of tissue that produces progesterone, does not form. As a result, ...
*  Reperfusion therapy
"Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and ... 1997). "A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial ... recombinant tissue plasminogen activator, rtPA). More recently, thrombolytic agents similar in structure to rtPA such as ... "Coronary thrombolysis with recombinant single-chain urokinase-type plasminogen activator in patients with acute myocardial ...
*  Neurointensive care
Tissue plasminogen activator: Monitor patient who receive TPA for 24 hours for brain bleeds. Korbakis, Georgia; Bleck, Thomas ( ...
*  Glymphatic system
Interestingly, injection of tissue plasminogen activator (a fibrinolytic drug) in the CSF improved glymphatic functioning. In a ... a rate that is not compatible with the intense metabolic demands of brain tissue. A clearance system based on simple diffusion ... proteins and metabolic waste products from the systemic tissues back into the blood. The efficient removal of soluble proteins ... flow was initially believed to be the complete answer to the long-standing question of how the sensitive neural tissue of the ...
*  PDGFC
"Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator". J. Biol. ... Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide- ... "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines". Exp. Cell Res. 312 (6): 782- ... of the PDGFR-α signaling pathway and has a specific role in palatogenesis and the morphogenesis of the integumentary tissue. ...
*  AP-1 transcription factor
... and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth ... Weber JR, Skene JH (July 1998). "The activity of a highly promiscuous AP-1 element can be confined to neurons by a tissue- ... Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, ... May 2004). "HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth ...
*  Joanna Wardlaw
"Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis". The ... "The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic ...