1998). "A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and ... Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene. The ... 2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long- ... Tan I, Ng CH, Lim L, Leung T (2001). "Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a ...

... two inherited connective tissue disorders causing aortic dissection. In humans, genome-wide association studies have linked ... Phosphatase and actin regulator 1 (PHACTR1) is a protein that in humans is encoded by the PHACTR1 gene on chromosome 6. It is ... PHACTR1 is a member of the phosphatase and actin regulator family and contains 4 RPEL repeats, three of which reside at the C- ... "Entrez Gene: Phosphatase and actin regulator 1". Retrieved 2013-09-10. "BioGPS - your Gene Portal System". biogps.org. ...

... alkaline phosphatase and aldolase isozymes in tissue sections". Histochemistry. 48 (2): 101-9. doi:10.1007/BF00494548. PMID ... Structural organization and tissue-specific expression by multiple promoters and alternate mRNA processing". Eur. J. Biochem. ... ALDOA is ubiquitously expressed in most tissues, though it is predominantly expressed in developing embryo and adult muscle. In ... kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been ...

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene. This gene encodes a ... These variants exhibit tissue-specific expression. GRCh38: Ensembl release 89: ENSG00000151490 - Ensembl, May 2017 GRCm38: ... 2004). "Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human ... 2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor ...

2004). "TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting ...

X-rays can confirm the presence of bone changes and soft tissue swelling. Biopsy of the affected areas can confirm the presence ... No specific blood tests exist, but tests such as erythrocyte sedimentation rate (ESR) and alkaline phosphatase levels are often ... He described a group of infants with tender swelling in the soft tissues and cortical thickenings in the skeleton, with onset ... Infantile cortical hyperostosis (ICH) is a self-limited inflammatory disorder of infants that causes bone changes, soft tissue ...

... tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of ... In order to mineralise the bone, the osteoblasts secrete vesicles containing alkaline phosphatase. This cleaves the phosphate ... Bone tissue is mineralized tissue of two types, cortical bone and cancellous bone. Other types of tissue found in bones include ... Bone marrow, also known as myeloid tissue in red bone marrow, can be found in almost any bone that holds cancellous tissue. In ...

This protein is also called "PEST-domain Enriched Phosphatase" ("PEP") or "Lymphoid phosphatase" ("LYP"). The name LYP is used ... Tissue Antigens. 76 (2): 144-148. doi:10.1111/j.1399-0039.2010.01480.x. PMID 20331840. Begovich AB, Carlton VE, Honigberg LA, ... Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of ... Hill RJ, Zozulya S, Lu YL, Ward K, Gishizky M, Jallal B (March 2002). "The lymphoid protein tyrosine phosphatase Lyp interacts ...

... subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate ... Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene. The ADF (actin-depolymerizing ... a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233-46. doi:10.1016/S0092-8674(01)00638-9. PMID ... "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): ...

The unique role of ACP during the formation of mineralized tissues makes it a promising candidate material for tissue repair ... Moreover, it can increase alkaline phosphatase activities of mesoblasts, enhance cell proliferation and promote cell adhesion. ... Holt, Carl (June 2013). "Unfolded phosphopolypeptides enable soft and hard tissues to coexist in the same organism with ... preventing deposition of insoluble calcium phosphates and calcification of soft tissue. In the laboratory, stored samples of ...

The glands are surrounded by tissue that swells with blood during sexual arousal, and secrete a fluid from openings near the ... In addition to PSA and acid phosphatase, Skene's gland fluid contains high concentrations of glucose and fructose. In an amount ... Toivanen R, Shen MM (2017). "Prostate organogenesis: tissue induction, hormonal regulation and cell type specification". ... and of prostate-specific acid phosphatase, some authors refer to the Skene's glands as the "female prostate". They are ...

Calcified Tissue International. 85 (3): 228-34. doi:10.1007/s00223-009-9272-4. PMID 19641839. S2CID 21508194. Makita N, Suzuki ... "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with ... and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus". Annals of the New York Academy of ... "Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis ...

Canonically, inhibitory receptors recruit phosphatases through their ITIM motifs, inhibiting the function of cells in which ... wide tissue distribution can be observed. Paired receptors transduce extracellular signals through opposing intracellular ...

... subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate ... Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene. The ADF (actin-depolymerizing ... Overview of all the structural information available in the PDB for UniProt: Q76I76 (Protein phosphatase Slingshot homolog 2) ... 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". EMBO J. 24 (3): ...

... subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate ... For the SSH-1 protocol, see Secure Shell#Version 1 Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is ... 2003). "Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells". J. Biol. ... 2004). "A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia". J. Cell Biol ...

... is greatly expressed in the liver of rats, although the protein is found in small amounts in other tissues and cells ... Regucalcin has an inhibitory effect on protein kinase and protein phosphatase activity dependent on Ca signaling. Regucalcin ... Regucalcin is expressed in the neuron of brain tissues, and the decrease of brain regucalcin causes accumulation of calcium in ... Notably, it has been shown that epigenetic modifications of survivin and regucalcin in non-small cell lung cancer tissues ...

Evidence exists showing the presence of GnRH and its receptor in extrapituitary tissues as well as a role in progression of ... Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. ...

However, they often form persistent stages (stages in which the larvae persist in the tissue) in the tissue, which are ... The acid phosphatase reaction can be used for diagnosis. Acanthocheilonema reconditum (syn. Dipetalonema reconditum) occurs in ... The parasites cause small nodules in the area of the bifurcation of the trachea or in the lung tissue; dead worms can also ... Capsule formation in muscle tissue begins about 15 days after infection and is complete after four to eight weeks - the host's ...

This causes severe truncation and loss of function in the gene's protein product, tyrosine phosphatase SHP-2. SHP-2 plays an ... These tumors can become painful if they pressure sensitive tissue or nerves. Metachondromatosis is differentiated from ... "OMIM Entry * 176876 - PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 11; PTPN11". omim.org. Retrieved 23 March 2022. Yang, ... Gonzalez-Quevedo, Rosa (31 January 2005). "Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog- ...

These two enzymes have different tissue distribution. SK1 is highly expressed in spleen, lung and leukocytes, while SK2 is ... S1P can be dephosphorylated to sphingosine by sphingosine phosphatases and can be irreversibly degraded by an enzyme, ... S1P has protected ovarian tissue xenografts in SCID mouse models from radiation induced atresia. In animal models these ... It is less abundant in tissue fluids. This is referred to as the S1P gradient, which seems to have biological significance in ...

The presence of genistein or genistin in the tissue culture caused a significant increase in alkaline phosphatase activity, ... "Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: the genistein ... study have shown that both genistin and genistein are capable of enhancing bone metabolism in the femoral-metaphyseal tissues ...

"Expression of human red cell acid phosphatase activity in placenta and other tissues". Jinrui Idengaku Zasshi. The Japanese ... It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein ... "Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase". Protein Science. 1 (6): 710-721. doi: ... and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase". The Journal of ...

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein ( ... and lung tissues. In Her-2-positive breast cancer cells, t-Darpp overexpression imparts resistance to Trastuzumab (Herceptin), ... Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1". The Journal of Biological Chemistry. ... "Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, ...

The selective protection of non-malignant tissues is believed to be due to higher alkaline phosphatase activity, higher pH, and ... Amifostine is an organic thiophosphate prodrug which is hydrolysed in vivo by alkaline phosphatase to the active cytoprotective ... Amifostine is believed to radioprotect normal tissue via Warburg-type effects. Common side effects of amifostine include ... "Normal tissue radioprotection by amifostine via Warburg-type effects". Scientific Reports. 6: 30986. Bibcode:2016NatSR... ...

The role of matrix metalloproteinases (MMPs) in osteoclast biology is ill-defined, but in other tissue they have been linked ... This permits characterization of osteoclasts by their staining for high expression of tartrate resistant acid phosphatase (TRAP ... Basle MF, Mazaud P, Malkani K, Chretien MF, Moreau MF, Rebel A (1988). "Isolation of osteoclasts from Pagetic bone tissue: ... Three theories were dominant: from 1949 to 1970 the connective tissue origin was popular, which stated that osteoclasts and ...

This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its ... "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase ... Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and receptor functions". Cell Tissue Res. 290 (2): 423-8. doi: ... 1998). "Alternative splicing of human NrCAM in neural and nonneural tissues". Mol. Cell. Neurosci. 10 (5-6): 287-95. doi: ...

It is also associated with endometriosis, a disorder of abnormal tissue growth outside of the uterus. The tumor cells emerge in ... Mutations in ARID1A commonly contain phosphatase and tensin homolog (PTEN) that are hypothesized to contribute to clear-cell ...

Rarely ALP (alkaline phosphatase - an enzyme active at sites of bone formation) may be elevated. Treatment is normalization of ... Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, ... Cutting through the excised calcium deposition reveals semifluid calcium suspension in albumin encapsulated by fibrous tissue ...

Chk1 in turn phosphorylates a phosphatase involved in cell cycle control. It mediates the cellular response to DNA replication ... Inhibition of cell proliferation by the miR-15a/16-1 cluster occurs in both lymphoid and non-lymphoid tissue. The miR-15a/16-1 ...

... which is broken down throughout the body by tissue-nonspecific alkaline phosphatase (TNAP). Without pyrophosphate, calcium ... In experiments at the molecular level, treatment with adenosine or a phosphatase inhibitor reversed and prevented calcification ...