... of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue". Applied ... "Differential expression of mitochondrial DNA replication factors in mammalian tissues". The Journal of Biological Chemistry. ...
... kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria". ...
Treatment for MELAS currently is 1. support the good mitochondria that is left with a mito cocktail and 2. avoid known mito ... They continue to investigate the effects of mitochondrial gene mutations in different tissues, particularly in the brain. This ... They impair the ability of mitochondria to make proteins, use oxygen, and produce energy. Researchers have not determined how ... Because egg cells, but not sperm cells, contribute mitochondria to the developing embryo, only females pass mitochondrial ...
... in cell or tissue culture); subcellular components (e.g. mitochondria or ribosomes); cellular or subcellular extracts (e.g. ... Viruses, which only replicate in living cells, are studied in the laboratory in cell or tissue culture, and many animal ... Solutions include: Increasing the complexity of in vitro systems to reproduce tissues and interactions between them (as in " ... in vivo tissue and organ sensitivities can be completely different or even inverse of those observed on cells cultured and ...
Ethanol is metabolised to acetaldehyde by alcohol dehydrogenase (ADH), which is found in many tissues, including the gastric ... which is found predominantly in liver mitochondria. Acetate is used by the muscle cells to produce acetyl-CoA using the enzyme ...
This results in an uneven distribution of dysfunctional mitochondria within each cell, and among different tissues of the body ... In muscle fibers containing high ratios of the mutated mitochondria, there is a higher concentration of mitochondria. This ... The distribution of mutated mtDNA in each cell, tissue, and organ, is dependent on when and where the mutation occurs. This may ... Mitochondria replicate during each cell division during gestation and throughout life. Because the mutation in mitochondrial ...
It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. It may be found ... which causes rapid relaxation of smooth muscle tissue and facilitates engorgement of tissue necessary for normal sexual ... synthase in smooth muscle tissue, such as the muscle in the genitals of both men and women. The contraction and relaxation of ...
In human cells, it has been shown that PRDX5 can be localized to mitochondria, peroxisomes, the cytosol, and the nucleus. Human ... In addition, expressing human PRDX5 in other organisms or tissues such as yeast, mouse brain, and Xenopus embryos also leads to ... Leyens G, Donnay I, Knoops B (December 2003). "Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino ... Leyens G, Donnay I, Knoops B (December 2003). "Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino ...
Intracellular tTG is abundant in the cytosol but smaller amounts can also be found in the nucleus and the mitochondria. ... Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein- ... Hasegawa G, Suwa M, Ichikawa Y, Ohtsuka T, Kumagai S, Kikuchi M, Sato Y, Saito Y (August 2003). "A novel function of tissue- ... Wilhelmus MM, Verhaar R, Andringa G, Bol JG, Cras P, Shan L, Hoozemans JJ, Drukarch B (March 2011). "Presence of tissue ...
The Nematopsis spores were found to occur in mollusc tissue (Lauckner 1983). The life cycle of Nematopsis was described by H. ... mitochondria and secretory granules (Tuntuwaranuruk et al. 2015). The oocyst of Nematopsis contains a single uni-nucleated ... 2010) Different species of Nematopsis have preferences for different host species and tissue type (Sprague and Orr 1952). The ... The study suggested that infection led to lesions and tissue destruction in the oysters (Brito et al. 2010). How Nematopsis can ...
... s induce insulin resistance in many tissues by inhibition of Akt/PKB signaling. Aggregation of LDL cholesterol by ... Ceramides cause endothelial dysfunction by activating protein phosphatase 2 (PP2A). In mitochondria, ceramide suppresses the ... Mitochondrion. 6 (3): 118-25. doi:10.1016/j.mito.2006.03.002. PMC 2246045. PMID 16713754. Wehbe, Zeinab; Behringer, Sidney; ... "Aging up-regulates expression of inflammatory mediators in mouse adipose tissue". The Journal of Immunology. 179 (7): 4829-39. ...
This is larger than adipose tissue (fat) at 18.8 kJ/kg (4.5 kcal/kg), and bone at 9.6 kJ/kg (2.3 kcal/kg). The efficiency of ... Well exercised muscles can not only add more size but can also develop more mitochondria, myoglobin, glycogen and a higher ... The muscle tissue of a skeletal muscle is striated - having a striped appearance due to the arrangement of the sarcomeres. ... Connective tissue is present in all muscles as deep fascia. Deep fascia specialises within muscles to enclose each muscle fiber ...
It is reported to have high levels of expression in tissues pertaining to the circulatory system and the immune system. It is ... Data on localization of PRR29 within cells shows that it is primarily found in the nucleus, followed by the mitochondria and ... Experiments have been performed on tissue and cell samples in order to observe any potential changes in expression of the ... Its expression is concentrated in related tissues including the spleen, lungs, white blood cells, and heart. In situ ...
CPS III is found in the mitochondria of some elasmobranch and in a few teleosts liver and/or extrahepatic tissues. It ... 2017-08-23). "Multi-tissue RNA-seq and transcriptome characterisation of the spiny dogfish shark (Squalus acanthias) provides a ... "Expression and Activity of Carbamoyl Phosphate Synthetase III and Ornithine Urea Cycle Enzymes in Various Tissues of Four Fish ... carbamoyl phosphate synthetase III activity and related urea cycle enzymes in muscle and liver tissues of juvenile rainbow ...
... and various female reproductive tissues. All of these tissues with the exception of the thyroid and female reproductive tissues ... PSORTII also predicted a 13% probability of localization to the nucleus and 13% to the mitochondria. Nuclear localization is ... "NCBI GEO profile of CXorf38 across various tissues". www.ncbi.nlm.nih.gov. Retrieved 2019-05-07. Anantharaman V, Makarova KS, ... CXorf38 has moderate expression across nearly all tissues. The highest expression occurs in the lymph node, thyroid, spleen, ...
The pathologic changes of sarcopenia include a reduction in muscle tissue quality as reflected in the replacement of muscle ... Increased exercise can produce greater numbers of cellular mitochondria, increase capillary density, and increase the mass and ... buildup of damaged mitochondria. Deficiency of BNIP3 leads to muscle inflammation and atrophy. Multiple diagnostic criteria ... strength of connective tissue. There are currently no approved medications for the treatment of sarcopenia. Testosterone or ...
Thus, if light was to get to those layers, many free radicals would form and cause damage to nearby tissues. The deepest layer ... ARMS2 protein may localize to the mitochondria and participate in energy metabolism, though much remains to be discovered about ... The mutation in CFH (Y402H) results in reduced ability of the protein to localise to and protect tissues such as the retina ... Other gene markers of progression risk includes tissue inhibitor of metalloproteinase 3 (TIMP3), suggesting a role for ...
Doxorubicin has been shown to be selectively toxic to cardiac tissue, although some toxicity has been seen in other tissues as ... is an uncoupling agent in that it inhibits proper functioning of complex I of the electron transport chain in mitochondria. It ... A very common mechanism is covalent binding of either the drug or its metabolites to specific enzymes or receptor in tissue- ...
As this gene is mostly inactive, save for in testis tissue, a methylation mechanism is in place that inactivates this gene in ... As such, the absolute amounts of site-specific kinases and phosphates expressed in the mitochondria directly affect PDH ... The activity of the PDH complex in mammalian tissues is largely determined by the phosphorylation of certain subunits within ... Some affected individuals have abnormal brain structures, such as underdevelopment of the tissue connecting the left and right ...
... and other tissues enriched in mitochondria. FASTKD5 also localizes to RNA granules, membraneless bodies containing mRNAs and ... This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress. ... As a member of the FASTKD family, FASTKD5 localizes to the mitochondria to modulate their energy balance, especially under ... Though ubiquitously expressed in all tissues, FASTKD5 appears more abundantly in skeletal muscle, heart muscle, ...
This causes oxidative damage to the inner compartment of the mitochondria and destruction of the mitochondria. Clk1 gene - the ... Mite Adactylidium - The initial food source of Adactylidium mite larvae is the body tissues of their mother resulting in her ... The concept of programmed cell death was used before, by Lockshin & Williams in 1964 in relation to insect tissue development, ... However, if there is increased stress after breeding they undergo phenoptosis, like in yeast, induced by the mitochondria. ...
... and other tissues enriched in mitochondria. TBRG4 also localizes to the bone marrow (BM), where it functions in hematopoiesis ... As a member of the FASTKD family, TBRG4 localizes to the mitochondria to modulate their energy balance, especially under ... Though ubiquitously expressed in all tissues, TBRG4 appears more abundantly in skeletal muscle, heart muscle, ... which is known for regulating the energy balance of mitochondria under stress and cell cycle progression. TBRG4 is involved in ...
The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially ... At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, ...
The surfactant is responsible for lung elasticity, that is for lung tissue's ability to contract and expand. For example, ... CTL2s occur especially in the mitochondria in the tongue, kidneys, muscles and heart. They are associated with the ... Choline is in high demand during pregnancy as a substrate for building cellular membranes (rapid fetal and mother tissue ... CTL1s have moderate affinity for choline and transport it in almost all tissues, including the intestines, liver, kidneys, ...
... and other tissues enriched in mitochondria. Nonetheless, FASTKD2 has been observed to mediate apoptosis independent of import ... Though ubiquitously expressed in all tissues, FASTKD2 appears more abundantly in skeletal muscle, heart muscle, ... and then this term was replaced by apoptosis to emphasize its role opposite mitosis in tissue kinetics. In later stages of ... The mitochondrial targeting domain directs FASTKD2 to be imported into the mitochondria. Though the functions of the C-terminal ...
... II is also located at the mitochondria outer membrane so it can have direct access to ATP. The relative specific ... Hexokinase I/A is found in all mammalian tissues, and is considered a "housekeeping enzyme," unaffected by most physiological, ... Hexokinases I and II can associate physically to the outer surface of the external membrane of mitochondria through specific ... This association confers hexokinase direct access to ATP generated by mitochondria, which is one of the two substrates of ...
The activity of the PDH complex in mammalian tissues is largely determined by the phosphorylation of certain subunits within ... As such, the absolute amounts of site-specific kinases and phosphates expressed in the mitochondria directly affect PDH ... Some affected individuals have abnormal brain structures, such as underdevelopment of the tissue connecting the left and right ... Mitochondrion. 6 (3): 155-9. doi:10.1016/j.mito.2006.03.001. PMID 16713755. Dahl HH, Brown GK, Brown RM, Hansen LL, Kerr DS, ...
Degeneration of nerve tissue in the spinal cord causes the ataxia; particularly affected are the sensory neurons essential for ... It also regulates iron transfer in the mitochondria by providing a proper amount of reactive oxygen species (ROS) to maintain ... Degeneration of nerve tissue in the spinal cord causes ataxia. The sensory neurons essential for directing muscle movement of ... Without frataxin, the energy in the mitochondria falls, and excess iron creates extra ROS, leading to further cell damage. Low ...
Basophilic chromidia and mitochondria in normal and in tumor tissue. The Journal of Histochemistry and Cytochemistry, 3(3), 212 ...
... and other tissues enriched in mitochondria. FASTKD1 has been validated as an RNA-binding protein. FASTKD1 is an important ... As a member of the FASTKD family, FASTKD1 localizes to the mitochondria to modulate their energy balance, especially under ... Kerr JF, Wyllie AH, Currie AR (Aug 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue ... Though ubiquitously expressed in all tissues, FASTKD1 appears more abundantly in skeletal muscle, heart muscle, ...
"The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating ... found that in addition to producing more heat than typical of other tissues, brown adipose tissue seemed to short circuit, or ... UCP2 localizes to a wide variety of tissues, and is thought to be involved in regulating reactive oxygen species (ROS). In the ... UCP1 is restricted to brown adipose tissue, where it provides a mechanism for the enormous heat-generating capacity of the ...
... without causing damage to the mitochondrion since there are multiple copies of mtDNA per mitochondrion). The standard genetic ... "Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues". Science. 336 (6077): 82-6. Bibcode:2012Sci...336 ... Mitochondria present in eukaryotic cells contain multiple copies of mitochondrial DNA (mtDNA) in the mitochondrial matrix. In ... For example, muscle and liver cells contain more copies of mtDNA per mitochondrion than blood and skin cells do. Due to the ...
Due to the tissue specific expression, only transcription factors with brain tissue specificity increase c2orf80 transcription ... Within the cell, it is possible that c2orf80 is expressed in the nucleus, or the mitochondria. An analysis via PSORT II ... C2orf80 is tissue specific, and expressed only in the brain. A tumor specific RNA assessment via The Cancer Genome Atlas showed ... probability it is located in the mitochondria. The c2orf80 protein has two nuclear localization signals that may play a role in ...
... connective tissue, kidney, lungs, parathyroid, pharynx, placenta, testis and trachea. In mouse, the gene expression of C6orf165 ... Less likely possibilities are in the mitochondria (21%) or in the nucleus (17%) or in vacuoles (4%). From the EST file of ...