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*  Breast cancer classification
Carcinoma in situ is proliferation of cancer cells within the epithelial tissue without invasion of the surrounding tissue. In ... Geyer, F. C.; Marchiò, C.; Reis-Filho, J. S. (2009). "The role of molecular analysis in breast cancer". Pathology. 41 (1): 77- ... 2010). "Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and ... The test is run on formalin fixed, paraffin-embedded tissue. MammaPrint traditionally used rapidly frozen tissue but a room ...
*  Gene expression profiling in cancer
Survival analyses are often shown as Kaplan-Meier survival plots, an example of which is shown to the right. In addition to ... In a particular type of cell or tissue, only a small subset of an organism's genomic DNA will be expressed as mRNAs at any ... Current cancer research makes use primarily of DNA microarrays in which an arrayed series of microscopic spots of pre-defined ... The unique pattern of gene expression for a given cell or tissue is referred to as its molecular signature. For example, the ...
*  Antibody microarray
2003). Detection of multiple cytokines by protein arrays from cell lysate and tissue lysate. Clin Chem Lab Med. 41:139-145 ... of any array format; their reproducibility also enables quantitative analysis to be performed. Due to the difficulty of ... of antibody arrays is comparable to that of ELISA and antibody arrays are regularly used for profiling experiments on tissue ... Currently the largest commercially available sandwich-based antibody array detects 1000 different proteins. Antibody arrays are ...
*  Gene expression profiling
Therefore, gene set analysis is considered a knowledge based analysis approach. Commonly used gene sets include those derived ... First, different cells and tissues express a subset of genes as a direct consequence of cellular differentiation so many genes ... 2007). "A verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in ... Different from the analysis on differentially expressed individual genes, another type of analysis focuses on differential ...
*  RGS12
2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue". Ann. N. Y. ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... 1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770-7. doi: ... 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation ...
*  Uri Alon
... patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays ...
*  Frozen tissue array
Consequently frozen tissue array should be the best tool for high throughput analysis on this purpose. Frozen tissue cores with ... Frozen tissue array consists of fresh frozen tissues in which up to 50 separate tissue cores are assembled in array fashion to ... Tissue microarrays from frozen tissues-OCT technique. Methods Mol Biol. 2010, 664:73-80. "Frozen Tissue Array". BioChain ... Paraffin tissue array was developed during late years in the 1980s; this array can help scientists high throughput analyze gene ...
*  List of MeSH codes (E05)
... oligonucleotide array sequence analysis MeSH E05.588.570.700 --- protein array analysis MeSH E05.588.570.850 --- tissue array ... protein array analysis MeSH E05.196.630.570.850 --- tissue array analysis MeSH E05.196.680.100 --- blotting, northern MeSH ... oligonucleotide array sequence analysis MeSH E05.393.525.680 --- protein array analysis MeSH E05.393.525.700 --- random ... oligonucleotide array sequence analysis MeSH E05.393.760.640 --- oligonucleotide array sequence analysis MeSH E05.393.760.700 ...
*  Tissue microarray
... s are particularly useful in analysis of cancer samples. One variation is a Frozen tissue array. The use of ... Tissue microarrays (also TMAs) consist of paraffin blocks in which up to 1000 separate tissue cores are assembled in array ... These tissue cores are then inserted in a recipient paraffin block in a precisely spaced, array pattern. Sections from this ... In the tissue microarray technique, a hollow needle is used to remove tissue cores as small as 0.6 mm in diameter from regions ...
*  Ribose-5-phosphate isomerase
... significant increase in RpiA expression was detected both in tumor biopsies of HCC patients and in a liver cancer tissue array ... Importantly, the clinicopathological analysis indicated that RpiA mRNA levels were highly correlated with clinical stage, grade ... Dickensen F.; Williamson D. H. (1956). "Pentose phosphate isomerase and epimerase from animal tissues". Biochem. J. 64 (3): 567 ...
*  Biomarker discovery
Antibody Array Tissue Microarray The term metabolomic has been recently introduced to address the global analysis of all ... March 2007). "Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification ... not possible if tissues and biofluids were considered separately). By conceptualizing tissue biofluids as information channels ... Biofluids contain proteins from tissues and serve as effective hormonal communicators. The tissue acts as a transmitter of ...
*  Automated tissue image analysis
Once the sample image has been acquired and resident in the computer's random access memory as a large array of 0's and 1's, a ... Automated tissue image analysis is a process by which computer-controlled automatic test equipment is used to evaluate tissue ... In a typical application, automated tissue image analysis could be used to measure the aggregate activity of cancer cells in a ... In breast cancer patients, for example, automated tissue image analysis may be used to test for high levels of proteins known ...
*  Unresolved complex mixture
Recent analysis by GC×GC-ToF-MS of UCMs extracted from the mussel tissues, has shown that they contain a vast array of both ... The comparative analysis of UCMs extracted from mussels known to possess high, moderate and low Scope for Growth (SfG), a ... Analysis of the hydrocarbon fraction of crude oils by gas chromatography (GC) reveals a complex mixture containing many ...
*  Multielectrode array
Heuschkel MO, Wirth C, Steidl EM, Buisson B. Development of 3-D Multi-Electrode Arrays for Use with Acute Tissue Slices. In: ... means of predicting cell-electrode behavior is by modeling the system using a geometry-based finite element analysis in an ... The first implantable arrays were microwire arrays developed in the 1950s. The first experiment involving the use of an array ... Silicon-based microelectrode arrays include two specific models: the Michigan and Utah arrays. Michigan arrays allow a higher ...
*  Microarray
... for detailed analyses or optimization of protein-protein interactions Tissue microarrays Cellular microarrays (also called ... It is a 2D array on a solid substrate (usually a glass slide or silicon thin-film cell) that assays large amounts of biological ... Microarray databases Microarray analysis techniques Tse-Wen Chang, TW (1983). "Binding of cells to matrixes of distinct ... transfection microarrays) Chemical compound microarrays Antibody microarrays Glycan arrays (carbohydrate arrays) Phenotype ...
*  Degradomics
In addition, proteases recruited from remote sources like nearby tissues are ignored by these DNA based arrays, reiterating the ... Biol.622:175-93 (2010). Kappelhoff R., Overall C.M. The CLIP-CHIP oligonucleotide microarray: dedicated array for analysis of ... A drawback that separates it from microarray analysis is its limited scope: a microarray can handle parallel analysis of ... Yeast two-hybrid analyses have been adapted for protease-substrate discovery. As protease exosites play roles in protein- ...
*  Alternative splicing
... arrays from ExonHit or Jivan) have been used. The array is then probed with labeled cDNA from tissues of interest. The probe ... In microarray analysis, arrays of DNA fragments representing individual exons (e.g. Affymetrix exon microarray) or exon/exon ... Most EST libraries come from a very limited number of tissues, so tissue-specific splice variants are likely to be missed in ... In this mode, a particular exon may be included in mRNAs under some conditions or in particular tissues, and omitted from the ...
*  PSL Research University
Tissue level: the behavior of a cell is not an intrinsic property ; in a tissue, it strongly depends on its interactions with ... SGA: Synthetic Genetic Array platform. A powerful tool which analyzes the interactions between genes to allow for a greater ... Microscopy: The DEEP laboratory depends greatly on optical imaging and image analysis to measure the dynamics of cellular ... The work on tissues is strongly motivated by its applications to the understanding of the mechanisms of tumor growth and ...
*  Chronic electrode implant
Analysis of the images prompted the division of tissue damage into 4 categories: 1) fluid displacement, 2) vessel rupture, 3) ... Cheung, K.C., et al., Flexible polyimide microelectrode array for in vivo recordings and current source density analysis. ... Freire, M.A.M., et al., Comprehensive analysis of tissue preservation and recording quality from chronic multielectrode ... Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Experimental ...
*  Bio-MEMS
... cells and tissues have been used in the development of cell-based arrays, microarrays, microfabrication based tissue ... For cell analysis, cells can be studied intact or after lysis. A lytic buffer stream can be introduced alongside a stream ... Micromachined surgical tools such as tiny forceps, microneedle arrays and tissue debriders have been made possible by metal and ... Reverse-phase protein arrays test replicates of cell lysates and serum samples with different antibodies to study the changes ...
*  CombiMatrix
... paraffin-embedded cancer tissues for somatic copy number variations and copy-neutral LOH using Illumina's CytoSNP 850K array. ... Their focus is cytogenomic miscarriage analysis, prenatal analysis and postnatal/pediatric analysis. History In the mid-1990's ... This array contains more than 845,000 SNP markers covering both coding and non-coding human genome sequences. The median ... 2011) Inversion and deletion of 16q22 defined by array CGH, FISH and RT-PCR in a patient with AML. Dawson AJ, Bal S, McTavish B ...
*  Gap junction
Biochemical analysis of gap junction rich isolates from various tissues demonstrated a family of connexins. Ultrastructure and ... It has been noted that the organisation of proteins into arrays with a gap junction plaque may be significant. It is likely ... Tissues in this section have well known functions observed to be coordinated by gap junctions with inter-cellular signaling ... Gap junctions appear to be in all animal organs and tissues and it will be interesting to find exceptions to this other than ...
*  Housekeeping gene
"RT2 Profiler PCR Array (96-Well Format and 384-Well Format". Qiagen catalog no. 330231 PAHS-00ZA. Caradec J, Sirab N, Keumeugni ... For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis ... Dec 21, 2001). "A compendium of gene expression in normal human tissues". Physiol Genomics. 7 (2): 97-104. doi:10.1152/ ... "Analyses of Human Transcriptomes". Nat Genet. 23 (4): 387-388. doi:10.1038/70487. PMID 10581018. Hsiao LL, Dangond F, Yoshida T ...
*  MMP27
"Expression analysis of the entire MMP and TIMP gene families during mouse tissue development". FEBS Lett. 563 (1-3): 129-34. ... Sparse information about MMP-27 expression was found in studies of gene expression profiling (micro-array) or in expression ... Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR, Yong VW (2003). "Analyses of ... MMP-27 transcript is detected in almost every tissue, except the brain, with the highest expression found in the liver during ...
*  Myosin
The now diverse array of myosins likely evolved from an ancestral precursor (see picture). Analysis of the amino acid sequences ... The term was originally used to describe a group of similar ATPases found in the cells of both striated muscle tissue and ... ISBN 3-527-30594-7. Reddy, Anireddy S. N.; Day, Irene S. (2001). "Analysis of the myosins encoded in the recently completed ... These new myosins were collectively termed "unconventional myosins" and have been found in many tissues other than muscle. ...
*  Phage display
While pVI has been useful for the analysis of cDNA libraries, pIII and pVIII remain the most utilized coat proteins for phage ... Burton DR, Barbas CF, Persson MA, Koenig S, Chanock RM, Lerner RA (November 1991). "A large array of human monoclonal ... tissue or organism) so that the function or the mechanism of the function of that protein may be determined. Phage display is ... detection and analysis of phage T4 terminase (gp17) and late sigma factor (gp55) interaction". J Mol Biol. 319 (2): 289-304. ...
*  National Center for Functional Glycomics
... on various glycan arrays (CFG glycan array, Microbial glycan array, NCFG-derived arrays) Structural analysis of glycans ... Such techniques developed by the NCFG and other glycomics groups can further be applied to tissues to generate an overall ... The NCFG has developed GlycoPattern, a web-based bioinformatics resource to assist in analysis of glycan array data. The ... Agravat, S. B.; Saltz, J. H.; Cummings, R. D.; Smith, D. F. (20 August 2014). "GlycoPattern: a web platform for glycan array ...