*DIO2

It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5- ...

*Desiccated thyroid extract

By the 1960s, it was known that thyroxine was the essential hormone produced by the thyroid gland, and that most T3 was ... Desiccated thyroid has roughly a 4:1 ratio of thyroxine (T4) to triiodothyronine (T3). In humans, the ratio is 11:1. A ... Endocrinologists found that treatment with thyroxine alone worked as well or better than thyroid extract for the majority of ... Braverman LE, Ingbar SH, Sterling K. Conversion of thyroxine to triiodothyronine in athyreotic human subjects. J Clin Invest ...

*Thyroid

... albeit not thyroxine). Thyroxine is critical to the regulation of metabolism and growth throughout the animal kingdom. For ... administering thyroxine will trigger metamorphosis. In amphibian metamorphosis, thyroxine and iodine also exert a well-studied ... Thyroxine is given to replace the hormones lost and to suppress TSH production, as TSH may stimulate recurrence. With the ... Thyroxine itself was first isolated in 1914 and synthesized in 1927, and trirodothyroxine in 1952. The conversion of T4 to T3 ...

*Iodothyronine deiodinase

Thyroxine (T4), the precursor of 3,5,3'-triiodothyronine (T3) is transformed into T3 by deiodinase activity. T3, through ... D-propranolol inhibits thyroxine deiodinase, thereby blocking the conversion of T4 to T3, providing some though minimal ... Inactivation of thyroid hormones occurs by removal of an iodine atom on the inner ring, which converts thyroxine to the ... Hypothyroidism is a disease diagnosed by decreased levels of serum thyroxine (T4). Presentation in adults leads to decreased ...

*Antithyroid agent

A study has shown no difference in outcome for adding thyroxine to antithyroid medication and continuing thyroxine versus ... Glinoer D, de Nayer P, Bex M (2001). "Effects of l-thyroxine administration, TSH-receptor antibodies and smoking on the risk of ...

*Transthyretin

The reduced level of transthyretin in the CSF may indicate a lower thyroxine transport in brains of patients with schizophrenia ... Numerous other small molecules are known to bind in the thyroxine binding sites, including many natural products (such as ... Transthyretin (TTR) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4 ... This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes transthyretin into the blood, ...

*Thyroxine-binding globulin

... tests are sometimes used to find the cause of raised or lowered levels of thyroid hormone. This is ... Thyroxine-binding globulin (TBG) is a globulin that binds thyroid hormones in circulation. It is one of three transport ... 1991). "Complete thyroxine-binding globulin (TBG) deficiency caused by a single nucleotide deletion in the TBG gene". Metab. ... 1993). "Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its ...

*Thyroxine-binding proteins

Examples include: Thyroxine-binding globulin Transthyretin Serum albumin Thyroxine-binding proteins at the US National Library ... A thyroxine-binding protein is any of several transport proteins that bind thyroid hormone and carry it around the bloodstream ...

*Thyroxine 5-deiodinase

... also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is ... Thyroxine 5-deiodinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive ... L-thyroxine + AH2 The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. ...

*Reference ranges for blood tests

Substances with a molar mass around 1000g/mol (e.g. thyroxine) are almost vertically aligned in the mass and molar images. ... see Section 2. Pre-analytic factors Free T4; Thyroxine, Free; T4, Free UNC Health Care System Derived from molar values using ... "Euthyroid patient with elevated serum free thyroxine". Clinical Chemistry. 54 (7): 1239-41. doi:10.1373/clinchem.2007.101428. ...

*Thyroid function tests

Total thyroxine is rarely measured, having been largely superseded by free thyroxine tests. Total thyroxine (Total T4) is ... Reference ranges: Thyroid Hormone Binding Ratio(THBR) Thyroxine-binding index (TBI) The Free Thyroxine Index (FTI or T7) is ... Example values are: An increased thyroxine-binding globulin results in an increased total thyroxine and total triiodothyronine ... Total thyroxine; fT4: Free thyroxine; fT3: Free triiodothyronine; rT3: Reverse triiodothyronine Reference ranges for blood ...

*Organoiodine compound

The thyroxine hormones are organoiodine compounds that are required for health and the reason for government-mandated ... thyroxine (T4), a hormone. triiodothyronine (T3), another thyroid hormone. In terms of human health, the most important ... organoiodine compounds are the two thyroid hormones thyroxine ("T4") and triiodothyronine ("T3"). Marine natural products are ...

*Chan-Lam coupling

An Expedient Synthesis of Thyroxine. Evans, David; Katz, J.; West, T. Tetrahedron Lett. VOL 39 (1998) pp. 2937-2942 New Aryl/ ...

*Thiocyanate

Iodine is an essential component of thyroxine. Since thiocyanates will decrease iodide transport into the thyroid follicular ... cell, they will decrease the amount of thyroxine produced by the thyroid gland. As such, foodstuffs containing thiocyanate are ...

*Thyrotoxic myopathy

Since excess thyroxine leads to onset of TM, the overall goal of treatment is to reduce to overproduction of thyroxine from the ... For TM, blood tests reveal increased thyroxine levels. Increased thyroxine levels accompanied with decreased neuromuscular ... Thyroxine is a hormone produced in the thyroid gland that regulates the growth metabolism of the nervous system and regulates ... Overproduction of thyroxine is due to the enlargement of the thyroid gland. Graves' disease is an autoimmune condition where ...

*Bovidae

Mating in sheep is also affected by melatonin, that advances the onset of the breeding season; and thyroxine, that terminates ...

*Thyronine

... is a deiodinated form of thyroxine. Thyronine at the US National Library of Medicine Medical Subject Headings (MeSH) ...

*Polystyrene sulfonate

Common examples include lithium, thyroxine, and digitalis. In September 2017, the FDA recommended separating the dosing of ...

*George Barger

Harington, C. R.; Barger, G. (1927). "Chemistry of Thyroxine: Constitution and Synthesis of Thyroxine". The Biochemical Journal ... He also made significant contributions to the synthesis of thyroxine. and vitamin B1 In 1936 and 1937 he worked with Joseph ... permanent dead link] Britons discover synthetic thyroxin, T.R. Ybarra, New York Times, Sunday 12 December 1927. ...

*Once Upon a Time... Life

... those representing thyroxine are given life by iodine. These hormones are all female. Red blood cells - represented by red ...

*Sex hormone-binding globulin

High estrogen, and thyroxine cause it to increase. In an effort to explain obesity-related reductions in SHBG, recent evidence ...

*Iodine deficiency

A low amount of thyroxine (one of the two thyroid hormones) in the blood, due to lack of dietary iodine to make it, gives rise ... If goiter is untreated for around five years, however, iodine supplementation or thyroxine treatment may not reduce the size of ... Iodine is an essential dietary mineral; the thyroid hormones thyroxine and triiodothyronine contain iodine. In areas where ...

*Levothyroxine

... , also known as L-thyroxine, is a manufactured form of the thyroid hormone, thyroxine (T4). It is used to treat ... Greater than 99% of circulating thyroid hormones are bound to plasma proteins including thyroxine-binding globulin, thyroxine- ... DrugBank DB00451 Harington (1926). "Chemistry of Thyroxine: Constitution and Synthesis of Desiodo-Thyroxine". Biochem J. 20 (2 ... Thyroxine was first isolated in pure form in 1914 at the Mayo Clinic by Edward Calvin Kendall from extracts of hog thyroid ...

*Tyropanoic acid

". "Inhibition of hepatic binding of thyroxine by cholecystographic agents". J. Clin. Invest. 65 (5): 1032-40. May 1980. doi: ...

*Monolysocardiolipin acyltransferase

found that treatment with thyroxine, a thyroid hormone, can produce an almost two-fold increase in MLCL AT-1 activity. Schlame ... Mutter, Thomas; Dolinsky, Vernon W.; Ma, Brian J.; Taylor, William A.; Hatch, Grant M. (2000). "Thyroxine regulation of ...