Both of these thymocytes types are known as single positive thymocytes. Success in positive selection allows the thymocyte to ... Thymocytes that have a T cell receptor incapable of binding MHC class I or class II undergo apoptosis. Some thymocytes are able ... A thymocyte is an immune cell present in the thymus, before it undergoes transformation into a T cell. Thymocytes are produced ... At this stage thymocytes upregulate both CD4 and CD8, becoming double positive cells. Double positive thymocytes that have a T ...

... (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors ( ... thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic ...

Thymocytes positively select thymocytes in human system. Hum Immunol. 54:15-20,1997 Choi EY, Park WS, Jung KC, Kim SH, Kim YY, ... Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity. 23:387-96, 2005 Lee ... 54:15-20, 1997). Since then, he has tried to demonstrate that thymocyte-thymocyte (or, T cell-T cell, so called T-T) ... Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in ...

These mutations affect thymocytes developing within the thymus. Regulated by Foxp3, it's these thymocytes that during ... Autoimmune regulator (AIRE) Autoimmunity Central tolerance Immunity IPEX syndrome Lymphocytes Thymocyte GRCh38: Ensembl release ...

Bonasio R, Scimone ML, Schaerli P, Grabie N, Lichtman AH, von Andrian UH (October 2006). "Clonal deletion of thymocytes by ... Klein L (August 2009). "Dead man walking: how thymocytes scan the medulla". Nature Immunology. 10 (8): 809-11. doi:10.1038/ ... what thymocytes see (and don't see)". Nature Reviews. Immunology. 14 (6): 377-91. doi:10.1038/nri3667. PMC 4757912. PMID ... How thymic antigen presenting cells coordinate thymocyte selection". Seminars in Cell & Developmental Biology. 84: 2-10. doi: ...

Klein L (August 2009). "Dead man walking: how thymocytes scan the medulla". Nature Immunology. 10 (8): 809-11. doi:10.1038/ ... what thymocytes see (and don't see)". Nature Reviews. Immunology. 14 (6): 377-91. doi:10.1038/nri3667. PMC 4757912. PMID ... "CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance". ...

Tanuma S, Shiokawa D (September 1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes". Biochemical and ...

"Characterization of connexin 30.3 and 43 in thymocytes". Immunol. Lett. 94 (1-2): 65-75. doi:10.1016/j.imlet.2004.03.019. PMID ...

It is expressed on all leukocytes but highest on thymocytes and is believed to augment T-cell adhesion and apoptosis of double ... "Apoptosis of immature thymocytes mediated by E2/CD99". Journal of Immunology. 158 (6): 2543-50. PMID 9058785. Oh KI, Kim BK, ... "Engagement of CD99 induces up-regulation of TCR and MHC class I and II molecules on the surface of human thymocytes". Journal ... "Engagement of CD99 induces up-regulation of TCR and MHC class I and II molecules on the surface of human thymocytes". J. ...

Similar results were shown in rat and human thymocytes when TPEN was used. TPEN is also shown to induce apoptosis in K562 cells ... "Chelation of intracellular zinc triggers apoptosis in mature thymocytes". Laboratory Investigation. 69 (1): 101-10. PMID ...

"The relationship between glucocorticoid structure and effects upon thymocytes". Molecular Pharmacology. 13 (5): 948-955. PMID ...

It is chemotactic for thymocytes, macrophages, and dendritic cells. CCL25 elicits its effects by binding to the chemokine ...

Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX ... "Entrez Gene: thymocyte selection-associated high mobility group box gene TOX". Bordon Y (August 2019). "TOX for tired T cells ... TOX is necessary for positive selection in developing thymocytes. Knock out TOX mice shows a requirement of TOX for the CD4 T ... January 2021). "Role, function and regulation of the thymocyte selection-associated high mobility group box protein in CD8+ T ...

... "p53 is required for radiation-induced apoptosis in mouse thymocytes". Nature. 362 (6423): 847-849. Bibcode:1993Natur.362..847L ...

It may also mediate adhesion between thymocytes and thymic stroma. CD44 (PGP1) is an adhesion molecule that has pleiotropic ...

"Expression of GTP-binding protein alpha subunits in human thymocytes". Mol. Cell. Biochem. 144 (1): 45-51. doi:10.1007/ ...

This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B- ...

"Expression of GTP-binding protein alpha subunits in human thymocytes". Molecular and Cellular Biochemistry. 144 (1): 45-51. doi ...

Thymocytes uptake The thymic cortical cells take up early thymocytes migrating from the bone marrow to the thymus and form the ... They inhibit thymocytes/TEC interaction and affect the movement of thymocytes in and out of TNC, in particular by increasing ... Thymocytes within TNC Incubation of TNC at 37 °C in tissue culture releases thymocytes (TNC-T) present within it. Incubation of ... If the internalized thymocytes are selected for negative selection, vacuoles containing the thymocytes move closer to the area ...

Thymocyte nuclear protein 1 is a protein that in humans is encoded by the THYN1 gene. This gene encodes a protein that is ... "Entrez Gene: THYN1 thymocyte nuclear protein 1". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two ... 2004). "Modulation of mThy28 nuclear protein expression during thymocyte development". Tissue & Cell. 35 (6): 471-8. doi: ... "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1-2): 189-96. doi:10.1016/S0378-1119(02 ...

The cortex is mainly made up of thymocytes and epithelial cells. The thymocytes, immature T cells, are supported by a network ... This process is error-prone, and some thymocytes fail to make functional T-cell receptors, whereas other thymocytes make T-cell ... Thymocytes that react strongly to self antigens do not survive, and die by apoptosis. Some CD4 positive T cells exposed to self ... Here the thymocytes and epithelium meet and join with connective tissue. The pharyngeal opening of each diverticulum is soon ...

... what thymocytes see (and don't see)". Nature Reviews Immunology. 14 (6): 377-391. doi:10.1038/nri3667. ISSN 1474-1733. PMC ... thymocytes". European Journal of Immunology. 39 (4): 956-964. doi:10.1002/eji.200839175. ISSN 0014-2980. PMID 19283781. ... "CCR7 Signals Are Essential for Cortex-Medulla Migration of Developing Thymocytes". Journal of Experimental Medicine. 200 (4): ... "CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance". ...

"Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. ...

As the developing thymocyte progresses through to the DN3 stage (CD44−CD25+), the thymocyte expresses an invariant α-chain ... Negative selection removes thymocytes that are capable of strongly binding with "self" MHC molecules. Thymocytes that survive ... The vast majority of developing thymocytes will not pass positive selection, and die during this process. A thymocyte's fate is ... whereas thymocytes that interact well with MHC class I molecules mature into CD8+ "killer" cells. A thymocyte becomes a CD4+ ...

PGE2 affect T-lymphocyte formation by regulating apoptosis of immature thymocytes. In addition, it can suppress an immune ...

"Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. ...

"Identification of mRNAs associated with programmed cell death in immature thymocytes". Mol. Cell. Biol. 11 (8): 4177-88. doi: ...

Patients with immature thymocytes in the thymus begins T-ALL development. Furthermore, hereditary conditions such as Down ... resulting in disruption of developmental pathways controlling thymocyte development, tumor suppressor development, and ... appetite Swollen lymph nodes Unexplained skin itch Originating from epigenetic and genetic alterations in immature thymocytes, ...

Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB (2000). "CCR8 on human thymocytes functions as a human ... human thymocytes". J. Exp. Med. 196 (3): 379-87. doi:10.1084/jem.20020110. PMC 2193942. PMID 12163566. Spinetti G, Bernardini G ...

"Rethymic- allogenic thymocyte-depleted thymus tissue-agdc implant". DailyMed. Retrieved 20 December 2021. "Rethymic". U.S. Food ...