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*  Thymidine kinase
ATP ---> + ADP Thymidine reacts with ATP to give thymidine monophosphate and ADP. Thymidine monophosphate, the product of the ... thymidine, ATP is adenosine triphosphate, TMP is (deoxy)thymidine monophosphate and ADP is adenosine diphosphate. Thymidine ... As analogs of thymidine, this type of drugs are readily phosphorylated to 5'-monophosphates. The monophosphate is further ... The unfused cells from the thymidine kinase-deficient cell line die because they have no source of thymidine monophosphate. The ...
*  Thymidine monophosphate
... (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP ... Unlike the other deoxyribonucleotides, thymidine monophosphate often does not contain the "deoxy" prefix in its name; ... It is an ester of phosphoric acid with the nucleoside thymidine. dTMP consists of a phosphate group, the pentose sugar ... Dorland's Illustrated Medical Dictionary provides an explanation of the nomenclature variation at its entry for thymidine. As a ...
*  Kinase
It phosphorylates thymidine to create thymidine monophosphate (dTMP). This kinase uses an ATP molecule to supply the phosphate ... Because of this, thymidine kinase activity is closely correlated with the cell cycle and used as a tumor marker in clinical ... Thymidine kinase is one of the many nucleoside kinases that are responsible for nucleoside phosphorylation. ... This transfer of a phosphate from one nucleotide to another by thymidine kinase, as well as other nucleoside and nucleotide ...
*  DTMP kinase
Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, ... thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase ... Nelson DJ, Carter CE (1969). "Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B". J ... Kielley RK (1970). "Purification and properties of thymidine monophosphate kinase from mouse hepatoma". J. Biol. Chem. 245 (16 ...
*  Thymidine kinase in clinical chemistry
ATP ---> + ADP Thymidine reacts with ATP to give thymidine monophosphate and ADP. Thymidine monophosphate, the product of the ... Thymidine kinase 1 is such a salvage enzyme, whereas thymidine kinase 2 is not cell cycle-dependent. Thymidine kinase is a ... Thymidine kinase Thymidylate kinase Nucleoside diphosphate kinase Thymidylate synthase Thymidine Kit S (1985). "Thymidine ... Thymidine monophosphate is produced by the cell in two different reactions - either by phosphorylation of thymidine as ...
*  Fluorouracil
Thymidylate synthase methylates deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). Administration of 5- ... Interrupting the action of this enzyme blocks synthesis of the pyrimidine thymidine, which is a nucleoside required for DNA ...
*  Arsenic poisoning
"Antigen binding characteristics of antibodies against hydroxyl radical modified thymidine monophosphate". Immunology Letters. ...
*  HAT medium
... which creates thymidine monophosphate (TMP) from deoxyuridine monophosphate (dUMP). By additional phosphorylation reactions, ... The alternative source is the thymidine present in the HAT medium that can be absorbed by the cells and phosphorylated by ... HAT Medium (hypoxanthine-aminopterin-thymidine medium) is a selection medium for mammalian cell culture, which relies on the ... and thymidine (a deoxynucleoside) which are intermediates in DNA synthesis. The trick is that aminopterin blocks DNA de novo ...
*  TS
... the enzyme used to generate thymidine monophosphate Tourette syndrome, a neurological condition involving involuntary tics ...
*  Capecitabine
... hence inhibiting the synthesis of thymidine monophosphate (ThMP), the active form of thymidine which is required for the de ...
*  TMP
... can refer to any of the following: Thymidine monophosphate, a nucleotide Trimethyl phosphate, a solvent Trimethylolpropane ... an antibiotic Threo-methylphenidate Thymolphalein monophosphate Template metaprogramming Tab Mix Plus, a Mozilla Firefox ...
*  Nucleoside
... such as the thymidine monophosphate) into nucleosides (such as thymidine) and phosphate. The nucleosides, in turn, are ... Examples of nucleosides include cytidine, uridine, adenosine, guanosine, thymidine and inosine. While a nucleoside is a ...
*  List of MeSH codes (D13)
... thymidine monophosphate MeSH D13.695.462.200 --- cyclic amp MeSH D13.695.462.200.225 --- 8-bromo cyclic adenosine monophosphate ... thymidine monophosphate MeSH D13.695.740.850 --- uracil nucleotides MeSH D13.695.740.850.210 --- deoxyuracil nucleotides MeSH ... cytidine monophosphate MeSH D13.695.740.246.370.250 --- cytidine monophosphate n-acetylneuraminic acid MeSH D13.695.740.246.400 ... cytidine monophosphate MeSH D13.695.827.232.370.250 --- cytidine monophosphate n-acetylneuraminic acid MeSH D13.695.827.232.400 ...
*  Nucleoside-diphosphate kinase
Nucleoside Nucleotide Nucleoside monophosphate Nucleoside triphosphate Thymidine kinase Thymidylate kinase Thymidine kinase in ...
*  5,10-Methylenetetrahydrofolate
... to 2-deoxy-thymidine-5-monophosphate (dTMP). The coenzyme is necessary for the biosynthesis of thymidine and is the C1-donor in ... enzyme for methylation of 2-deoxy-uridine-5-monophosphate (dUMP) ...
*  Valganciclovir
Ganciclovir is first phosphorylated to ganciclovir monophosphate by a viral thymidine kinase encoded by the cytomegalovirus ( ...
*  Thymidylate kinase
... monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium: ATP + thymidine 5'-phosphate ... Predicted thymidylate kinase, TKRP1 InterPro: IPR014505 DTYMK; Thymidine kinase Thymidylate synthase Thymidine kinase in ... Thymidylate kinase (EC 2.7.4.9; dTMP kinase) catalyzes the phosphorylation of thymidine 5'- ... displaystyle \rightleftharpoons } ADP + thymidine 5'-diphosphate Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and ...
*  Nucleotide salvage
... forming thymidine. Thymidine kinase can then phosphorylate this compound into thymidine monophosphate (TMP). Thymidylate kinase ... Alternatively, uridine-cytidine kinase can phosphorylate them into cytidine monophosphate (CMP) or deoxycytidine monophosphate ... Thymidine phosphorylase or pyrimidine-nucleoside phosphorylase adds 2-deoxy-alpha-D-ribose 1-phosphate to thymine, ... Uridine kinase (aka uridine-cytidine kinase) can then phosphorylate this nucleoside into uridine monophosphate (UMP). UMP/CMP ...
*  Stampidine
... and stavudine is poorly phosphorylated to its monophosphate form in thymidine kinase-deficient cells. Stampidine exhibited: ... This is governed by the supply of thymidine kinase that is available, ... and has been designed to avoid dependence on the rate limiting step of phosphorylation of stavudine to stavudine monophosphate ...
*  Glycosidic bond
... thymidine diphosphate (TDP), or cytidine monophosphate (CMP). These activated biochemical intermediates are known as sugar ...
*  Thymidylate synthase
... to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of ... Pyrimidine analogues Thymidylate synthase inhibitor Thymidine kinase Thymidine kinase in clinical chemistry Thymidylate kinase ... Thymidylate synthetase (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) ... deoxyuridine monophosphate (dUMP) and N5,N10-methylene tetrahydrofolate are together used to form dTMP, yielding dihydrofolate ...
*  Uridine monophosphate synthetase
... thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer". Prostate Cancer and Prostatic Diseases. 8 ... monophosphate, which derivates into barbiturate ribonucleoside-5'-monophosphate, xantosine-5'-monophosphate. P. falciparum ... These two sites catalyze the last two steps of the de novo uridine monophosphate (UMP) biosynthetic pathway. After addition of ... Uridine monophosphate synthase (UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) is the enzyme that ...
*  Thymidine
... deoxythymidine monophosphate), dTDP, or dTTP (for the di- and tri- phosphates, respectively). It exists in solid form as small ... Radiolabeled thymidine (TdR), such as tritiated thymidine (3H-TdR), is commonly used in cell proliferation assays. The ... Before the boom in thymidine use caused by the need for thymidine in the production of the antiretroviral drug azidothymidine ( ... AZT), much of the world's thymidine production came from herring sperm. Thymidine occurs almost exclusively in DNA but it also ...
*  Thymine
Thymidine can be phosphorylated with up to three phosphoric acid groups, producing dTMP (deoxythymidine monophosphate), dTDP, ... Thymine combined with deoxyribose creates the nucleoside deoxythymidine, which is synonymous with the term thymidine. ...
*  Orotidine 5'-phosphate decarboxylase
It catalyzes the decarboxylation of orotidine monophosphate (OMP) to form uridine monophosphate (UMP). The function of this ... and thymidine triphosphate. OMP decarboxylase has been a frequent target for scientific investigation because of its ... Many studies investigated the binding of a potent inhibitor of OMP decarboxylase, 6-hydroxy uridine monophosphate (BMP, a ... Lee JK, Houk KN (May 1997). "A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase ...
*  DNA
Vainio S, Genest PA, ter Riet B, van Luenen H, Borst P (April 2009). "Evidence that J-binding protein 2 is a thymidine ... as shown for adenosine monophosphate. Adenine pairs with thymine and guanine pairs with cytosine. It was represented by A-T ... Biosynthesis of J occurs in two steps: in the first step, a specific thymidine in DNA is converted into ... 5-hydroxymethyldeoxyuracil (hm5dU) is also known to replace thymidine in several genomes including the Bacillus phages SPO1, ϕe ...