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*  Thromboregulation
Thromboxane A2 (TX2) has a positive feedback in platelet activation. It is produced by the oxygenation of arachidonic acid by ... cycloxygenase and thromboxane A2 synthase. TX2 effects are mediated by G protein-coupled receptors, subtypes TPα and TPβ. Both ... 5-triphosphate signaling and the mobilization of calcium inside the cell for thromboxane A2. PGI2, prostacyclin, binds to IP ... These signaling elements include thromboxane A2, receptor type α, phospholipase Cβ3, and IP3 receptors. Signalization in ...
*  Prostaglandin receptor
... thromboxane A2 (TXA2), and PGH2. They are named based on the prostanoid to which they preferentially bind and respond, e.g. the ... One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well. All ...
*  Prostaglandin
A thromboxane synthase (TxAS) has also been identified. Prostaglandin-F synthase (PGFS) catalyzes the formation of 9α,11β-PGF2α ... inhibit phospholipase A2 production) COX-2 selective inhibitors or coxibs Cyclopentenone prostaglandins may play a role in ... Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet aggregation. Their name ... The cyclooxygenase pathway produces thromboxane, prostacyclin and prostaglandin D, E and F. Alternatively, the lipoxygenase ...
*  Ramatroban
Endo S, Akiyama K (November 1996). "[Thromboxane A2 receptor antagonist in asthma therapy]". Nippon Rinsho (in Japanese). 54 ( ... Ramatroban (INN) is a thromboxane receptor antagonist. It is also a DP2 receptor antagonist. It is indicated for the treatment ... Fiedler VB, Seuter F, Perzborn E (December 1990). "Effects of the novel thromboxane antagonist Bay U 3405 on experimental ...
*  Thromboxane A2
... (TXA2) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties: it ... Thromboxane A2 is also a known vasoconstrictor and is especially important during tissue injury and inflammation. It is also ... "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization ... Receptors that mediate TXA2 actions are thromboxane A2 receptors. The human TXA2 receptor (TP) is a typical G protein-coupled ...
*  Prostaglandin DP2 receptor
... thromboxane A2. The Cyclopentenone prostaglandins, PGJ2, Δ12-PGJ2, and 15-d-Δ12,14-PGJ2 are spontaneously formed or protein- ... "11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule ...
*  Eicosanoid receptor
TXA2 (thromboxane): TP-(TXA2) (TBXA2R) - TBXA2R; TP is the receptor for thromboxane A2; relative potencies in binding to and ... implications of isoprostane-mediated thromboxane A2 receptor activation". British Journal of Pharmacology. 171 (13): 3115-31. ... Prostanoids and Prostaglandin receptors Prostanoids are prostaglandins (PG), thromboxanes (TX), and prostacyclins (PGI). Seven ... thromboxane A2 (http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=344). This receptor is the least ...
*  Jawahar L. Mehta
Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis. Proceedings of the National Academy of Sciences (USA ...
*  Testosterone
Ajayi AA, Mathur R, Halushka PV (Jun 1995). "Testosterone increases human platelet thromboxane A2 receptor density and ... Testosterone also regulates the population of thromboxane A2 receptors on megakaryocytes and platelets and hence platelet ... Ajayi AA, Halushka PV (May 2005). "Castration reduces platelet thromboxane A2 receptor density and aggregability". QJM. 98 (5 ...
*  12-Hydroxyheptadecatrienoic acid
Thromboxane synthase further metabolizes PGH2 to the 20 carbon product, Thromboxane A2, the 17 carbon product, 12-HHT, and the ... Hecker, M; Ullrich, V (1989). "On the mechanism of prostacyclin and thromboxane A2 biosynthesis". The Journal of Biological ... Campbell, P. B.; Tolson, T. A. (1988). "Modulation of human monocyte leukotactic responsiveness by thromboxane A2 and 12- ... trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity". British Journal of Haematology. 101 (1 ...
*  Thromboxane B2
Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in ... Thromboxane B2 is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine. It itself is ... "Definition: thromboxane b2 from Online Medical Dictionary". Retrieved 2008-11-02. Inhibition of platelet aggregation and ... not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. ...
*  Prostaglandin antagonist
Mechanism of action of aspirin Cheng Y et al., Role of prostacyclin in the cardiovascular response to thromboxane A2. "Science ... Corticosteroids inhibit phospholipase A2 production by boosting production of lipocortin, an inhibitor protein. Relatively new ... thromboxane) and PGI2 (prostacyclin) levels. An increased in the ratio of TxA2/PGI2 could lead to increased platelet ...
*  Thromboxane
The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing feature of thromboxanes is a 6-membered ... including thromboxane A2 that stimulate vasoconstriction, reducing blood flow at the site. Thromboxane A2 (TXA2), produced by ... Thromboxane synthase inhibitors inhibit the final enzyme (thromboxane synthase) in the synthesis of thromboxane. Ifetroban is a ... converts the arachidonic acid derivative prostaglandin H2 to thromboxane. Thromboxane acts by binding to any of the thromboxane ...
*  Nonsteroidal anti-inflammatory drug
Aspirin inhibits platelet aggregation by inhibiting the action of thromboxane A2. NSAIDs are useful in the management of post- ... COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular ... and thereby the synthesis of thromboxanes and prostaglandins. It is thought that inhibiting COX-2 leads to the anti- ... phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of ...
*  Epoxyeicosatrienoic acid
... thromboxane A2, certain leukotrienes, and the EETs. In portal hypertension, portal vein endothelium appears to be dysfunctional ... causes arachidonic acid to be released from the sn-2 position of cellular phospholipids through the action of Phospholipase A2- ...
*  Thromboxane receptor
TBXA2R thromboxane A2 receptor (Homo sapiens) Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K (1995). "Rat kidney ... Park MK, Choi JK, Kim HJ, Nakahata N, Lim KM, Kim SY, Lee CH (2014). "Novel inhibitory effects of cardamonin on thromboxane A2- ... Funk CD, Furci L, Moran N, Fitzgerald GA (1994). "Point mutation in the seventh hydrophobic domain of the human thromboxane A2 ... Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). "G proteins of the G12 family are activated via thromboxane A2 and ...
*  Krebs-Henseleit solution
"5-hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure". J. Soc. Gynecol. Investig. ...
*  PTGS1
Thromboxane A2, the major product of COX-1 in platelets, induces platelet aggregation. The inhibition of COX-1 is sufficient to ... released from membrane phospholipids at the sn-2 ester binding site by the enzymatic activity of phospholipase A2, to ...
*  Hemostasis
Platelets release cytoplasmic granules which contain serotonin, ADP and thromboxane A2, all of which increase the effect of ... Adenosine diphosphate (ADP) attracts more platelets to the affected area, serotonin is a vasoconstrictor and thromboxane A2 ... Platelets release cytoplasmic granules such as adenosine diphosphate (ADP), serotonin and thromboxane A2. ...
*  Umbilical cord
The vasoconstrictive occlusion appears to be mainly mediated by serotonin and thromboxane A2. The artery in cords of preterm ... Quan A, Leung SW, Lao TT, Man RY (December 2003). "5-hydroxytryptamine and thromboxane A2 as physiologic mediators of human ...
*  Ozagrel
Loo MH, Egan D, Vaughan ED, Marion D, Felsen D, Weisman S (March 1987). "The effect of the thromboxane A2 synthesis inhibitor ... Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. ...
*  Low-density lipoprotein receptor-related protein 8
This causes the phosphorylation of a p38MAPkinase, resulting in the production of thromboxane A2. Thromboxane A2 functions to ...
*  Vasospasm
... and thromboxane A2. However the serotonin and the thromboxane A2 cause more contraction of the smooth muscle cells and as a ... However, aggregating platelets also stimulate thromboxane A2 and serotonin which can induce contraction of the smooth muscle ...
*  11-Dehydrothromboxane B2
... (or 11-dehydro-TXB2) is produced from the breakdown of thromboxane A2. It is released by activated ... Catella F, Healy D, Lawson JA, FitzGerald GA (1986). "11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 ...
*  U46619
Missing or empty ,url= (help) Liel, N.; Mais, D.E.; Halushka, P.V (1987). "Binding of a thromboxane A2/prostaglandin H2 agonist ... U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH2 first prepared in 1975, and acts as a thromboxane A2 ... and exhibits many properties similar to thromboxane A2, including shape change and aggregation of platelets and smooth muscle ...
*  Prostaglandin-endoperoxide synthase 2
The synthesized PGH2 is converted to prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), or thromboxane A2 by tissue- ... from forming a prostaglandin called thromboxane A2. It sticks platelets together and promotes clotting; inhibiting this helps ...
*  GNA13
Becker KP, Garnovskaya M, Gettys T, Halushka PV (Jul 1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects ... "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the ...