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*  Thrombin
... bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... Thrombin interacts with thrombomodulin. As part of its activity in the coagulation cascade, thrombin also promotes platelet ... Esmon CT (July 1995). "Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the ... However, binding of the active fragment of thrombomodulin appears to allosterically promote the active conformation of thrombin ...
*  Thrombomodulin
... is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. In humans, thrombomodulin is ... Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves ... Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming ... Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin- ...
*  Protein C
Another is necessary for interacting with thrombomodulin. The activation of protein C is strongly promoted by thrombomodulin ... the protein may be said to be activated not by thrombin but the thrombin-thrombomodulin (or even thrombin-thrombomodulin-EPCR) ... The activity of protein C may be down-regulated by reducing the amount either of available thrombomodulin or of EPCR. This may ... The presence of thrombomodulin accelerates activation by several orders of magnitude, and EPCR speeds up activation by a factor ...
*  CD93
... and thrombomodulin, a well characterized anticoagulant. All of them contain a C-type lectin domain, a series of epidermal ... CD93 has been suggested to have arisen from the thrombomodulin gene through a duplication event. CD93 was originally identified ...
*  Ex-Rad
Thrombomodulin. Activated protein C. Chelation therapy a countermeasure for treating internal radio-isotope contamination. DPTA ... "Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity". Nature Medicine. 18 ...
*  Thrombosis
When this occurs, endothelial cells downregulate substances such as thrombomodulin, which is a key modulator of thrombin ... ISBN 978-1-4557-2613-4. Ito, Takashi; Kakihana, Yasuyuki; Maruyama, Ikuro (2016-01-01). "Thrombomodulin as an intravascular ...
*  Endothelial protein C receptor
Van de Wouwer M, Collen D, Conway EM (2005). "Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and ...
*  Rhomboid protease
They have also been implicated in ephrin signalling, the cleavage of the anticoagulant protein thrombomodulin and wound healing ... "Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing". The Journal of Investigative Dermatology. ...
*  Rhomboid, veinlet-like 2 (drosophila)
"Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing". Journal of Investigative Dermatology. 131 ( ...
*  CPN1
2003). "Modulation of procarboxypeptidase R (ProCPR) activation by complementary peptides to thrombomodulin". Microbiol. ...
*  Howel-Evans syndrome
RHBDL2 cleaves thrombomodulin at the transmembrane domain and causes the release of soluble thrombomodulin. RHBDF2 may also ... Thrombomodulin - a membrane glycoprotein - is upregulated in neoepidermis during cutaneous wound healing. ...
*  EGF-like domain
Other proteins contain only cEGF such as thrombomodulin and the LDL-receptor. In mixed EGF-proteins the hEGF- and cEGF-like ... "beta-Hydroxyaspartic acid or beta-hydroxyasparagine in bovine low density lipoprotein receptor and in bovine thrombomodulin". ...
*  CD248
This family comprise two other members, CD93 and Thrombomodulin which are better characterized. The function of endosialin ...
*  Factor V
In the presence of thrombomodulin, thrombin acts to decrease clotting by activating Protein C; therefore, the concentration and ...
*  Protein C deficiency
Defects in interaction with thrombomodulin, phospholipids, factors V/VIII and others have been described. The majority of ...
*  Carboxypeptidase B2
Mosnier LO, Elisen MG, Bouma BN, Meijers JC (2002). "Protein C inhibitor regulates the thrombin-thrombomodulin complex in the ... When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase ... do not determine the thrombomodulin dependence of TAFI activation". J. Biol. Chem. 277 (12): 9944-51. doi:10.1074/jbc. ... couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex". J. Biol. Chem. 271 (28): 16603- ...
*  Coagulation
Thrombomodulin binds these proteins in such a way that it activates Protein C. The activated form, along with protein S and a ... Protein C is activated in a sequence that starts with Protein C and thrombin binding to a cell surface protein thrombomodulin. ... in the presence of thrombomodulin), and it activates Factor XIII, which forms covalent bonds that crosslink the fibrin polymers ...
*  Septic shock
... including reduced synthesis of anticoagulation factors such as tissue factor pathway inhibitor and thrombomodulin. The effects ...
*  Hemostasis
The endothelial cells of intact vessels prevent blood clotting with a heparin-like molecule and thrombomodulin and prevent ...
*  Index of biochemistry articles
... thrombomodulin - thromboxane receptor - thylakoid - thyroid hormone receptor - thyrotropin - thyrotropin receptor - thyrotropin ...
*  List of diseases (T)
... autoimmune Thrombocytosis Thrombomodulin anomalies, familial Thrombotic microangiopathy, familial Thrush Thumb absence ...
*  RHTM
Recombinant human thrombomodulin (rhTM). ...
*  Atypical hemolytic uremic syndrome
... and thrombomodulin). This results in platelet activation, damage to endothelial cells (cells that line the blood vessels), and ...
*  KLF2
... thrombomodulin) and NOS3 (endothelial nitric oxide synthase) expression, having an anti-thrombotic effect Through the ...
*  List of drugs: Tf-Th
Thrombostat thrombomodulin alfa (INN) thymalfasin (INN) thymocartin (INN) thymoctonan (INN) thymopentin (INN) thymostimulin ( ...