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*  Factor X
Each molecule of Factor Xa can generate 1000 molecules of thrombin. This large burst of thrombin is responsible for fibrin ... amplification of the procoagulant signal by thrombin generated on the TF-bearing cell and 3) propagation of thrombin generation ... In stage 3, thrombin generation, Factor XIa activates free Factor IX on the surface of activated platelets. The activated ... It acts by cleaving prothrombin in two places (an arg-thr and then an arg-ile bond), which yields the active thrombin. This ...
*  Heparin cofactor II
2004). "Molecular mapping of the thrombin-heparin cofactor II complex". J. Biol. Chem. 279 (41): 43237-44. doi:10.1074/jbc. ... Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state. GRCh38: Ensembl release ... 2003). "Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular ... 2002). "Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism". Proc ...
*  Thromboregulation
Brass, Lawrence (September 2003). "Thrombin and Platelet activation". Chest: Journal of the College of Chest Physicians. USA. ...
*  Discovery and development of direct thrombin inhibitors
Thrombin also has two exosites (1 and 2). Thrombin is a little different from other serine proteases as exosite 1 is anion- ... Thrombin is in the serine protease family. It has 3 binding domains in which thrombin-inhibition drugs bind to. Those proteases ... But heparin can also form a bridge between thrombin and fibrin which binds to exosite 1 which protects the thrombin from ... DTIs aren't dependent to cofactors like antithrombin to inhibit thrombin so they can both inhibit free/soluble thrombin as well ...
*  Discovery and development of direct Xa inhibitors
Unlike older drugs, e.g. heparin, DX-9065a is selective for FXa compared to thrombin even though FXa and thrombin are similar ... In addition, a salt bridge between Glu-97 of thrombin and the amidine group fixed in the pyrrolidine ring of DX-9065a reduces ... That's why the IC50 value for thrombin is >1000µM while the IC50 value for FXa is 0,16µM. Rivaroxaban binding to FXa is ... While FXa has a glutamine residue in that position, thrombin has a glutamic acid that causes electrostatic repulsion with the ...
*  Thrombin
E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. ... Thrombin is sold under the brand name Fibrimex for use as a binding agent for meat. The thrombin in Fibrimex derives from ... Thrombin interacts with thrombomodulin. As part of its activity in the coagulation cascade, thrombin also promotes platelet ... Due to its high proteolytic specificity, thrombin is a valuable biochemical tool. The thrombin cleavage site (Leu-Val-Pro-Arg- ...
*  Vorapaxar
2012). "Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes". New England Journal of Medicine. 366 (1): 20-33. ... It functions by inhibiting thrombin-related platelet aggregation. This mechanism works by a different pathway than other anti- ... Vorapaxar (brand name Zontivity, formerly known as SCH 530348) is a thrombin receptor (protease-activated receptor, PAR-1) ... Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity. Journal of Medicinal ...
*  Protein C
... the protein may be said to be activated not by thrombin but the thrombin-thrombomodulin (or even thrombin-thrombomodulin-EPCR) ... Thrombin itself may also have an effect on the levels of EPCR. In addition, proteins released from cells can impede protein C ... Activation of the enzyme occurs when a thrombin molecule cleaves away the activation peptide from the N-terminus of the heavy ... Factor Va binds to prothrombin and Factor Xa, increasing the rate at which thrombin is produced by four orders of magnitude ( ...
*  Fondaparinux
In contrast to heparin, fondaparinux does not inhibit thrombin. Fondaparinux is given subcutaneously daily. Clinically, it is ...
*  Argatroban
This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared). Argatroban is used as an ... Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food ... Direct thrombin inhibitors. N Engl J Med 2005;353:1028-40. PMID 16148288 http://www.pharmatimes.com/Article/12-07-03/UK_launch_ ...
*  Thrombin time
Batroxobin has a similar action to thrombin but unlike thrombin it is not inhibited by heparin. Normal values for thrombin time ... The thrombin time (TT), also known as the thrombin clotting time (TCT) is a blood test that measures the time it takes for a ... The thrombin time compares the rate of clot formation to that of a sample of normal pooled plasma. Thrombin is added to the ... The time between the addition of the thrombin and the clot formation is recorded as the thrombin clotting time. Whole blood is ...
*  Thrombin receptor
Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand ... "Thrombin receptors and their antagonists: an update on the patent literature". Expert Opin Ther Pat. 20 (7): 875-84. Jul 2010. ... There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). These receptors are ...
*  Anti-thrombin aptamers
Thrombin shows similar influence as potassium ion. In the ion-deficient condition, thrombin helps TBA form into a stable G- ... A second thrombin-binding aptamer, HD22, recognizes thrombin exosite II and was discovered in 1997 by NeXstar (now Gilead ... Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first ... High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in ...
*  Thrombin-antithrombin complex
... (TAT) is a protein complex of thrombin and antithrombin. Lippi G, Cervellin G, Franchini M, ...
*  Direct thrombin inhibitor
Discovery and development of direct thrombin inhibitors Di Nisio M, Middeldorp S, Büller H (2005). "Direct thrombin inhibitors ... This SbO4L shows allosteric inhibition of thrombin for fibrinogen, while providing a competitive inhibition of thrombin ... Dabigatran Thrombin demonstrates a high level of allosteric regulation. Allosterism in thrombin is regulated by the exosites 1 ... Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly ...
*  Anti-thrombin antibodies
... can react with both types of thrombin in the antithrombin-thrombin complex. Antibodies (IgG) against ... Autoimmune anti-thrombin was also found to inhibit the binding of antithrombin III to thrombin. Such activities are more often ... Anti-thrombin antibodies are autoantibodies directed against thrombin that may constitute a fraction of lupus anticoagulant and ... Other than antibodies to thrombin, antibodies to vascular heparin sulfate appear to interfere with antithrombin-thrombin ...
*  Thrombin-activatable fibrinolysis inhibitor
Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the ...
*  Jones Pharma
"Thrombin-Jmi". thrombin-jmi.com. Retrieved 2014-12-14. "Levoxyl® (levothyroxine sodium tablets, USP) , Safety Info". levoxyl. ... The primary therapeutic compounds marketed by the company include Thrombin-JMI and Levoxyl On May 30, 2000 the company became a ...
*  Anticoagulant
An oral direct thrombin inhibitor, ximelagatran (Exanta) was denied approval by the Food and Drug Administration (FDA) in ... It works by activating antithrombin III, which blocks thrombin from clotting blood. Heparin can be used in vivo (by injection ... thrombin) inhibitor, and the factor Xa inhibitors rivaroxaban and apixaban. Clinical trials have shown them therapeutically ... "Direct thrombin inhibitors". N. Engl. J. Med. 353 (10): 1028-40. doi:10.1056/NEJMra044440. PMID 16148288. Costantinides, Fulvia ...
*  Hypercoagulability in pregnancy
Thrombin levels increase. Protein S, an anticoagulant, decreases. However, the other major anticoagulants, protein C and ... September/October 2002 Volume 8, Issue 5 de Boer K, ten Cate JW, Sturk A, Borm JJ, Treffers PE (1989). "Enhanced thrombin ...
*  G protein-coupled receptor
Brass LF (September 2003). "Thrombin and platelet activation". Chest. 124 (3 Suppl): 18S-25S. doi:10.1378/chest.124.3_suppl.18S ...
*  Ximelagatran
It acts solely by inhibiting the actions of thrombin. It is taken orally twice daily, and rapidly absorbed by the small ... Ho SJ, Brighton TA (2006). "Ximelagatran: direct thrombin inhibitor". Vasc Health Risk Manag. 2 (1): 49-58. doi:10.2147/vhrm. ... a direct thrombin inhibitor, was the first member of this class that can be taken orally. ... dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute ...
*  Coagulation factor II receptor
"Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding ... Tellez C, Bar-Eli M (May 2003). "Role and regulation of the thrombin receptor (PAR-1) in human melanoma". Oncogene. 22 (20): ... Ogino Y, Tanaka K, Shimizu N (Nov 1996). "Direct evidence for two distinct G proteins coupling with thrombin receptors in human ... Vu TK, Hung DT, Wheaton VI, Coughlin SR (Mar 1991). "Molecular cloning of a functional thrombin receptor reveals a novel ...
*  Protein C inhibitor
... s have ability to inhibit protein C, thrombin and other enzymes that are stimulated by heparin. The heparin ... Protein C inhibitor is activated by heparin against thrombin. Protein C inhibitor (PCI) is serine protease inhibitor of serpin ... "Thrombin inhibition by the serpins". Journal of Thrombosis and Haemostasis. 11 Suppl 1: 254-64. doi:10.1111/jth.12252. PMID ... inhibiting several blood coagulation enzymes counting thrombin and factor Xa. In the beginning, protein C inhibitor(PCI) was ...