*  PRDX5
The typical peroxiredoxin is composed of a thioredoxin domain and a C-terminal, whereas PRDX5 has an N-terminal domain and a ... Biochemically, PRDX5 is a peroxidase that can use cytosolic or mitochondrial thioredoxins to reduce alkyl hydroperoxides or ... "Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis". Biochemical and Biophysical Research ... "Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis". Biochemical and Biophysical Research ...
*  TMX1
Thioredoxin-related transmembrane protein 1 is a protein that in humans is encoded by the TMX1 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: TXNDC1 thioredoxin domain containing 1". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and ... "Identification of a novel thioredoxin-related transmembrane protein". J Biol Chem. 276 (13): 10032-8. doi:10.1074/jbc. ...
*  Thioredoxin reductase
Humans express three thioredoxin reductase isozymes: thioredoxin reductase 1 (TrxR1, cytosolic), thioredoxin reductase 2 (TrxR2 ... Thioredoxin reductase is the only enzyme known to catalyze the reduction of thioredoxin and hence is a central component in the ... Thioredoxin reductases (TR, TrxR) (EC 1.8.1.9) are the only known enzymes to reduce thioredoxin (Trx). Two classes of ... Each monomer can separately bind a molecule of thioredoxin. Structure of E. coli ThxR dimer bound thioredoxin Structure of E. ...
*  Thioredoxin
... proteins also have a characteristic tertiary structure termed the thioredoxin fold. The thioredoxins are kept in ... enzyme activity regulated by thioredoxin Peroxiredoxin - enzyme activity regulated by thioredoxin Thioredoxin fold GRCh38: ... In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin ... Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin is a 12-kD ...
*  Thioredoxin domain
... thioredoxin domains; all of them seem to be PDIs. 3D-structures have been determined for a number of thioredoxins. The molecule ... thioredoxin reductase (TR) catalyses reduction of oxidised thioredoxin (trx) by NADPH using FAD and its redox-active disulfide ... Thioredoxin serves as a general protein disulfide oxidoreductase. It interacts with a broad range of proteins by a redox ... Thioredoxins have a beta-alpha unit preceding the motif common to all these proteins. DNAJC10; ERP70; GLRX3; P4HB; P5[ ...
*  Thioredoxin fold
The thioredoxin fold is a protein fold common to enzymes that catalyze disulfide bond formation and isomerization. The fold is ... Different thioredoxin fold-containing proteins vary greatly in their reactivity and in the pKa of their free thiols, which ... Despite sequence variability in many regions of the fold, thioredoxin proteins share a common active site sequence with two ... Although the structure is fairly consistent among proteins containing the thioredoxin fold, the pKa is extremely sensitive to ...
*  Ferredoxin-thioredoxin reductase
... EC 1.8.7.2, systematic name ferredoxin:thioredoxin disulfide oxidoreductase, is a [4Fe-4S] ... This leaves Thioredoxin inactive and allows carbohydrate breakdown to dominate metabolism. Ferredoxin-Thioredoxin Reductase is ... Using FTR, reduced Ferredoxin then reduces Thioredoxin. Thioredoxin, through thiol/disulfide exchange, then activates ... plants use Ferredoxin-thioredoxin reductase for carbon fixation regulation. FTR, as part of a greater Ferredoxin-Thioredoxin ...
*  Phosphoadenylyl-sulfate reductase (thioredoxin)
... and thioredoxin disulfide, whereas its two products are 3'-phosphoadenylyl sulfate and thioredoxin. This enzyme belongs to the ... thioredoxin disulfide ⇌ {\displaystyle \rightleftharpoons } 3'-phosphoadenylyl sulfate + thioredoxin The 3 substrates of this ... thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase, 3'-phosphoadenylylsulfate reductase, thioredoxin:3'-phospho- ... In enzymology, a phosphoadenylyl-sulfate reductase (thioredoxin) (EC 1.8.4.8) is an enzyme that catalyzes the chemical reaction ...
*  Adenylyl-sulfate reductase (thioredoxin)
... and thioredoxin disulfide, whereas its two products are 5'-adenylyl sulfate and thioredoxin. This enzyme belongs to the family ... thioredoxin disulfide ⇌ {\displaystyle \rightleftharpoons } 5'-adenylyl sulfate + thioredoxin The 3 substrates of this enzyme ... Adenylyl-sulfate reductase (thioredoxin) (EC 1.8.4.10) is an enzyme that catalyzes the chemical reaction AMP + sulfite + ... The systematic name of this enzyme class is AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate- ...
*  L-methionine:oxidized-thioredoxin S-oxidoreductase
... may refer to: Methionine-S-oxide reductase L-methionine (S)-S-oxide ...
*  TXN2
Thioredoxin, mitochondrial also known as thioredoxin-2 is a protein that in humans is encoded by the TXN2 gene on chromosome 22 ... Zhou J, Damdimopoulos AE, Spyrou G, Brüne B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on ... Zhou J, Damdimopoulos AE, Spyrou G, Brüne B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on ... As a thioredoxin, TXN2 is a 12-kDa protein characterized by the redox active site Trp-Cys-Gly-Pro-Cys. In its oxidized ( ...
*  NAD+ kinase
Lu J, Holmgren A (Jan 2014). "The thioredoxin antioxidant system". Free Radical Biology & Medicine. 66: 75-87. doi:10.1016/j. ... Furthermore, NADPH is required for the antioxidant activities of thioredoxin reductase and glutaredoxin. Thionicotinamide and ...
*  Auranofin
Assays of thioredoxin reductase and transcriptional profiling suggest that the effect of auranofin on the enzyme enhances the ... Role of thioredoxin reductase". Free Radic Res. 39 (7): 687-95. doi:10.1080/10715760500135391. PMID 16036347. Suarez-Almazor ME ... The drug acts in a similar manner in bacteria as in parasites by inhibiting thioredoxin reductase (TrxR). Studies in humans are ...
*  TXNL4B
Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene. TXNL4B has been shown to interact with ... "Entrez Gene: TXNL4B thioredoxin-like 4B". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ... "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily" (PDF). Physiol. Genomics ...
*  Arsenate reductase (glutaredoxin)
Martin JL (1995). "Thioredoxin--a fold for all reasons". Structure. 3 (3): 245-50. doi:10.1016/S0969-2126(01)00154-X. PMID ...
*  TXNL1
Thioredoxin-like protein 1 is a protein that in humans is encoded by the TXNL1 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: TXNL1 thioredoxin-like 1". Miranda-Vizuete A, Spyrou G (2000). "Genomic structure and chromosomal localization of ... 2002). "Crystal structure of the catalytic domain of a human thioredoxin-like protein". Eur. J. Biochem. 269 (8): 2060-2068. ... 2006). "Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2)". Int. J. Cancer. 118 (7): 1670-1679. ...
*  TXNIP
"Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin ... "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin ... up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin". Proceedings of the National Academy of Sciences of ... "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein". The ...
*  Disulfide oxidoreductase D
... thioredoxin reductase (TrxB; present in the cytoplasm), thioredoxin (TrxA; also in the cytoplasm), DsbD (the integral membrane ... This dithiol then donates electrons to the periplasmic C-terminal thioredoxin motif (CXXC) of DsbD, thereby reducing C461 and ...
*  GLRX3
"Entrez Gene: TXNL2 thioredoxin-like 2". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ... a novel protein kinase C-interacting protein with a thioredoxin homology domain". J Biol Chem. 275 (3): 1902-9. doi:10.1074/jbc ...
*  TRPC5
Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin. This channel ... "TRPC channel activation by extracellular thioredoxin". Nature. 451 (7174): 69-72. doi:10.1038/nature06414. PMC 2645077 . PMID ...
*  TXNRD1
Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodes a member of ... This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against ... "Entrez Gene: TXNRD1 thioredoxin reductase 1". This article incorporates text from the United States National Library of ... Thioredoxin reductase GRCh38: Ensembl release 89: ENSG00000198431 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
*  TXNL4A
Thioredoxin-like protein 4A is a protein that is encoded by the TXNL4A gene in humans. TXNL4A has been shown to interact with ... "Entrez Gene: TXNL4A thioredoxin-like 4A". Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). " ... "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics. 1 (3 ...
*  TXNDC5
Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene. This gene encodes a protein ... Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing ... TXNDC5 thioredoxin domain containing 5". Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene ... new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics. 2 (10): 1104-19. doi ...
*  Protein tag
These include thioredoxin (TRX) and poly(NANP). Some affinity tags have a dual role as a solubilization agent, such as MBP, and ... Maltose binding protein-tag, a protein which binds to amylose agarose Nus-tag Thioredoxin-tag Fc-tag, derived from ...
*  Amino acid
Gromer S, Urig S, Becker K (January 2004). "The thioredoxin system-from science to clinic". Medicinal Research Reviews. 24 (1 ...