It was discovered via a lengthy trial-and-error search for a more stable version of the natural product thienamycin, which is ... Thienamycin has antibacterial activity, but is unstable in aqueous solution, so impractical to administer to patients. Imipenem ... Kahan FM, Kropp H, Sundelof JG, Birnbaum J (December 1983). "Thienamycin: development of imipenen-cilastatin". The Journal of ... Kesado T, Hashizume T, Asahi Y (June 1980). "Antibacterial activities of a new stabilized thienamycin, N-formimidoyl ...
1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". J. Antibiot. 32 ... Streptomyces cattleya is a Gram-positive bacterium which makes cephamycin, penicillin and thienamycin. The bacterium expresses ... "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". The Journal of ...
doi:10.1016/0076-6879(70)19059-8. Kropp H, Sundelof JG, Hajdu R, Kahan FM (July 1982). "Metabolism of thienamycin and related ...
This screen enabled the discovery of fosfomycin, cephamycin C, thienamycin and several carbapenems. Specially prepared giant ...
from the carbapenem thienamycin, a naturally derived product of Streptomyces cattleya. Concern has arisen in recent years over ... Lenapenem Tomopenem Thienamycin (thienpenem) the first discovered carbapenem Enterobacteriaceae are common pathogens ...
... an aroma compound with a white bread-like smell Thienamycin, a beta-lactam antibiotic MTSL, a chemical used for certain NMR ...
Biapenem Doripenem Ertapenem Faropenem Imipenem Meropenem Panipenem Razupenem Tebipenem Thienamycin Aztreonam Tigemonam ...
... thienamycin remains antimicrobially active. Thienamycin displayed high activity against bacteria that were resistant to other β ... allowing for the structural elucidation of thienamycin in 1979 (Figure 1). Thienamycin was the first among the naturally ... Thienamycin (also known as thienpenem) is one of the most potent naturally produced antibiotics known thus far, discovered in ... Thienamycin has excellent activity against both Gram-positive and Gram-negative bacteria and is resistant to bacterial β- ...