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*  Peroxisome proliferator-activated receptor gamma
Many insulin sensitizing drugs (namely, the thiazolidinediones) used in the treatment of diabetes activate PPARG as a means to ... Different classes of compounds which activate PPARgamma weaker than thiazolidinediones (the so-called "partial agonists of ...
*  Sitagliptin
... such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2. Side effects are as common with ...
*  Thiazolidinedione
Thiazolidinediones reduce bone mineral density and increase the risk of fractures in women, possibly as a result of biasing the ... The thiazolidinediones /θaɪ.əˌzoʊlɪdiːnˈdaɪ.oʊn/, abbreviated as TZD, also known as glitazones after the prototypical drug ... Replacing one oxygen atom in a thiazolidinedione with an atom of sulfur gives a rhodanine. The only approved use of the ... Because of this, the FDA recommends two to three month checks of liver enzymes for the first year of thiazolidinedione therapy ...
*  Rosiglitazone
... is a member of the thiazolidinedione class of drugs. Thiazolidinediones act as insulin sensitizers. They reduce ... Thiazolidinediones bind to PPARγ. PPARs are expressed in fat cells, cells of the liver, muscle, heart, and inner wall ( ... Thiazolidinediones enter the cell, bind to the nuclear receptors, and alter the expression of genes. The several PPARs include ... Loke, Y. K.; Singh, S.; Furberg, C. D. (6 January 2009). "Long-term use of thiazolidinediones and fractures in type 2 diabetes ...
*  Osteoporosis
Thiazolidinediones (used for diabetes) - rosiglitazone and possibly pioglitazone, inhibitors of PPARγ, have been linked with an ... Murphy CE, Rodgers PT (2007). "Effects of thiazolidinediones on bone loss and fracture". Annals of Pharmacotherapy. 41 (12): ...
*  Lipotoxicity
This is accomplished with thiazolidinediones, a group of medications that activate nuclear receptor proteins responsible for ... Smith, U; Hammarstedt (March 2010). "Antagonistic effects of thiazolidinediones and cytokines in lipotoxicity". Biochimica et ...
*  Peroxisome proliferator-activated receptor
Thiazolidinedione Anti-diabetic drug Diabetes mellitus Insulin resistance Metabolic syndrome Michalik L, Auwerx J, Berger JP, ... The best-known PPAR ligands are the thiazolidinediones; see below for more details. After PPARδ (delta) was identified in ... For instance the hypolipidemic fibrates activate PPARα, and the anti diabetic thiazolidinediones activate PPARγ. The synthetic ...
*  Ciglitazone
Imoto H, Imamiya E, Momose Y, Sugiyama Y, Kimura H, Sohda T (October 2002). "Studies on non-thiazolidinedione antidiabetic ... Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues ... Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the ... Shah DK, Menon KM, Cabrera LM, Vahratian A, Kavoussi SK, Lebovic DI (April 2010). "Thiazolidinediones decrease vascular ...
*  Polycystic ovary syndrome
Check date values in: ,date= (help) Grover, Anjali; Yialamas, Maria A. (2011-03). "Metformin or thiazolidinedione therapy in ... A newer insulin resistance drug class, the thiazolidinediones (glitazones), have shown equivalent efficacy to metformin, but ... "Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome ...
*  Obesogen
Thiazolidinediones (TZD), rosiglitazone, and pioglitazone are all used to treat diabetes. These drugs act as agonists of the ... Goldberg RB (August 2007). "The new clinical trials with thiazolidinediones--DREAM, ADOPT, and CHICAGO: promises fulfilled?". ... and thiazolidinedione and as a result of unintentional exposure to environmental obesogens such as tributyltin, bisphenol A, ...
*  Faisal Masud
Review: Breaking insulin resistance with thiazolidinediones, Esculapio, Vol.1, No. 1. April-June 2005 16. Can vascular ...
*  Management of obesity
The thiazolidinediones, on the other hand, may cause weight gain, but decrease central obesity. Diabetics also achieve modest ... Fonseca V (2003). "Effect of thiazolidinediones on body weight in patients with diabetes mellitus". Am. J. Med. 115 Suppl 8A (8 ...
*  Abdominal obesity
Thiazolidinedione has been associated with heart failure and increased cardiovascular risk; so it has been withdrawn from the ... Thiazolidinediones may cause slight weight gain but decrease "pathologic" abdominal fat (visceral fat), and therefore may be ... Fonseca V (2003). "Effect of thiazolidinediones on body weight in patients with diabetes mellitus". Am. J. Med. 115 Suppl 8A (8 ... In the presence of diabetes mellitus type 2, the physician might instead prescribe metformin and thiazolidinediones ( ...
*  Barraquer-Simons syndrome
Thiazolidinediones have been used in the management of various types of lipodystrophies. They bind to peroxisome proliferator- ...
*  Englitazone
... is a hypoglycemic agent of thiazolidinedione (glitazone) class. Ciglitazone Darglitazone Netoglitazone Troglitazone ...
*  Frederick Masoudi
Metformin and thiazolidinedione use in Medicare patients with heart failure. JAMA 2003;290:81-85. PMID 12837715 Masoudi FA, ...
*  Metabolic syndrome
Use of drugs that decrease insulin resistance, e.g., metformin and thiazolidinediones, is controversial; this treatment is not ...
*  PDK4
... a thiazolidinedione known to activate the glycerol biogenesis pathway, increases PDK4 mRNA transcription in white adipose ... regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue". Diabetes. 57 (9): 2272-9. doi:10.2337 ...
*  Anti-vascular endothelial growth factor therapy
VEGF is also inhibited by thiazolidinediones (used for diabetes mellitus type 2 and related disease), and this effect on ... "Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro ... granulosa cells gives the potential of thiazolidinediones to be used in ovarian hyperstimulation syndrome. A Cochrane Review ...
*  Non-alcoholic fatty liver disease
Insulin sensitizers (metformin and thiazolidinediones) are commonly used for insulin resistance in those with NAFLD. ... and thiazolidinediones. Up to 80% of obese people have the disease. NASH is regarded as a major cause of cirrhosis of the liver ...
*  Troglitazone
Initially the metabolic toxicity was largely associated with reactive metabolite formation from the thiazolidinedione and ... Troglitazone, like the other thiazolidinediones (pioglitazone and rosiglitazone), works by activating peroxisome proliferator- ... Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission†". ... and a member of the drug class of the thiazolidinediones. It was prescribed for patients with diabetes mellitus type 2. It was ...
*  Glyceroneogenesis
Thiazolidinedione (Figure 8) is a substance which only affects glyceroneogenesis in adipose tissue. Thiazolidinedione will ...
*  Free fatty acid receptor 1
"A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs". Biochem. Biophys. Res. Commun. 301 (2 ...
*  Andrej Janež
Hevener, A. L.; Reichart, D.; Janez, A.; Olefsky, J. (2001). "Thiazolidinedione Treatment Prevents Free Fatty Acid-Induced ...
*  Macular edema
... timolol and thiazolidinediones among others. A few congenital diseases are known to be associated with macular edema for ...