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*  Thermolysin
However thermolysin is also widely used for peptide bond formation through the reverse reaction of hydrolysis. Thermolysin is ... Like all bacterial extracellular proteases thermolysin is first synthesised by the bacterium as a pre-proenzyme. Thermolysin is ... Thermolysin has a T50 value of 86.9 °C, making it the most thermo stable member of the TLP family. Studies on the contribution ... Thermolysin has a molecular weight of 34,600 Da. Its overall structure consists of two roughly spherical domains with a deep ...
*  Brian Matthews (biochemist)
Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (2009). "Structural Studies of Thermolysin: the Work of Brian W. Matthews". ... Matthews BW, Colman PM, Jansonius JN, Titani K, Walsh KA, Neurath H (1972). "Structure of thermolysin". Nature New Biology. 238 ... He also solved early structures of the thermophilic bacterial enzyme thermolysin, the helix-turn-helix DNA-binding ...
*  TLN
Thermolysin, an enzyme. ...
*  NLN (gene)
The catalytic site is contained within a thermolysin-like region found in many metallopeptidases and located in the domain near ... Matthews BW, Weaver LH, Kester WR (December 1974). "The conformation of thermolysin". The Journal of Biological Chemistry. 249 ...
*  Phosphoramidon
It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme ... "Binding between thermolysin and its specific inhibitor, phosphoramidon". Journal of Biochemistry. 95 (2): 529-34. PMID 6715312 ...
*  Fast parallel proteolysis
The protease thermolysin can be fully inactivated by EDTA. This feature of thermolysin makes FASTpp compatible with subsequent ... in a thermal gradient PCR cycler to different maximal temperatures in presence of the thermostable protease thermolysin (see ...
*  Microbial collagenase
"Circular dichroism comparative studies of two bacterial collagenases and thermolysin". Biochim. Biophys. Acta. 624: 51-59. doi: ...
*  Talopeptin
It is a known reversible inhibitor of thermolysin and is expected to inhibit other metalloproteinases. Chemically, talopeptin ... Kitagishi, Keiko; Hiromi, Keitaro (1984). "Inhibitory spectrum of talopeptin (MKI), a specific inhibitor of thermolysin". ... "Equilibrium study on the binding between thermolysin and Streptomyces metalloprotease inhibitor, talopeptin (MKI)". Journal of ...
*  MMP3
Alternatively, it has been shown for thermolysin (another metalloproteinase) that the amide product can be released in its ... Hangauer DG, Monzingo AF, Matthews BW (Nov 1984). "An interactive computer graphics study of thermolysin-catalyzed peptide ... "A theoretical study of the mechanism for peptide hydrolysis by thermolysin". Journal of Biological Inorganic Chemistry. 7 (3): ...
*  Silanol
Some silanediols and silanetriols inhibit hydrolytic enzymes such as thermolysin, acetycholinesterase. Literally, silanol ...
*  Ecadotril
Thermolysin complexed with the inhibitor (S)-thiorphan are isomeric thiol-containing inhibitors of endopeptidase EC 24-11 (also ... The peptidase domain for members of this family also contains a bacterial member and resembles that of thermolysin the ... "Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin". Biochemistry. 28 (4): ... predicted active site residues for members of this family and thermolysin occur in the motif HEXXH. ...
*  Thermostability
"Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond". The Journal of Biological Chemistry. 272 ...
*  Dispase
2006). "A quenched fluorescent dipeptide for assaying dispase- and thermolysin-like proteases". Analytical Biochemistry. 352: ...
*  Endopeptidase
Thermolysin - cuts before Ile, Met, Phe, Trp, Tyr, or Val, unless preceded by Pro. Sometimes cuts after Ala, Asp, His or Thr. ...
*  Astacin
The overall topology of this domain is shared by the archetypal zinc-endopeptidase thermolysin. Astacin protease domains also ... the type example for clan MA and the predicted active site residues for members of this family and thermolysin occur in the ... molecular structure and comparison with thermolysin". J. Mol. Biol. 229 (4): 945-68. doi:10.1006/jmbi.1993.1098. PMID 8445658. ... The protein fold of the peptidase domain for members of this family resembles that of thermolysin, ...
*  Peptide deformylase
"Substrate recognition and selectivity of peptide deformylase Similarities and differences with metzincins and thermolysin". J. ...
*  Ilomastat
Grobelny D, Poncz L, Galardy RE (August 1992). "Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas ... Examples of enzymes that ilomastat inhibit include thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase ( ...
*  Decellularization
Lipases, thermolysin, galactosidase, nucleases, and trypsin have all been used in the removal of cells. After a cell is lysed ...
*  Matrix metalloproteinase
Kester WR, Matthews BW (1977). "Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for ...
*  Bacillolysin
This enzyme catalyses the following chemical reaction Similar, but not identical, to that of thermolysin This enzyme is present ... Å resolution and comparison with the homologous but more thermostable enzyme thermolysin". J. Mol. Biol. 199: 525-537. doi: ... "The primary structure of Bacillus cereus neutral proteinase and comparison with thermolysin and Bacillus subtilis neutral ...
*  Dactylysin
Joudiou, C.; Carvalho, K.M.; Camarao, G.; Boussetta, H. & Cohen, P. (1993). "Characterization of the thermolysin-like cleavage ...
*  Transition state analog
Thermolysin is an enzyme produced by Bacillus thermoproteolyticus that catalyses the hydrolysis of peptides containing ... Holden, Hazel; Tronrud, D. E.; Monzingo, A. F.; Weaver, L. H. (1987). "Slow-and fast-binding inhibitors of thermolysin display ... mechanism starts form the small peptide molecule and replaces the zinc binding water molecule towards Glu143 of thermolysin. ...
*  Thermal shift assay
However, commercially available thermolysin is dependent on calcium ions for activity and denatures itself just above 85 ... In fast parallel proteolysis the researcher adds a thermostable protease (thermolysin) and takes out samples in parallel upon ... FastPP exploits that proteins become increasingly susceptible to proteolysis when unfolded and that thermolysin cleaves at ... showed that stabilization by ligand binding could impart resistance to proteolytic digestion with thermolysin. Protection ...
*  Aureolysin
... autocatalytic activation of the M4 metalloprotease aureolysin is controlled by a conserved N-terminal fungalysin-thermolysin- ...
*  Candoxatril
Holland, D.R.; Barclay, P.L.; Danilewicz, J.C.; Matthews, B.W.; James, K. (January 1994). "Inhibition of thermolysin and ... the gluzincins a faint but significant structural relationship of the metzincins to the thermolysin-like enzymes, Zincin is the ... neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor ...