... may be of interest in the context of therapeutic approaches in human lung cancers in general and bronchoalveolar adenocarcinoma ... Expression of the JSRV Envelope protein activates signalling cascades that promote cellular proliferation and malignant ... Enzootic nasal tumor virus Ovine pulmonary adenocarcinoma Enzootic nasal adenocarcinoma York DF, Querat G (2003). "A history of ... JSRV is the virus that is the cause of the contagious lung tumors in sheep called ovine pulmonary adenocarcinoma (OPA). The ...
If the malignant tumors metastasize and spread throughout the body then they could potentially be fatal. Clear-cell tumors have ... Some suggested therapeutic targets include the PI3K/AKT/mTOR, VEGF, Il-6/STAT3, MET, and HNF-1beta pathways. Better insight ... Ovarian clear-cell carcinoma, or clear-cell carcinoma of the ovary, also called ovarian clear-cell adenocarcinoma, is one of ... Therefore, surgical removal of the ovary or partial removal of the ovary is sufficient for treatment for malignant tumors. When ...
... hCG was discovered to be expressed in certain kinds of malignant neoplasms, including breast cancer, adenocarcinoma of the ... 22: 1-5. Fick, J; RH Lindberg; J Parkkonen; B Arvidsson; M Tysklind; DGJ Larsson (2010). "Therapeutic levels of levonorgestrel ... Sheaff MT, Martin JE, Badenoch DF, Baithun SI (April 1996). "beta hCG as a prognostic marker in adenocarcinoma of the prostate ... direct therapeutic effect by preventing establishment, inhibiting the growth, and causing the necrosis of tumors. This has led ...
... indicating that PDK2/CNNM3 signalling pathway may be a potential therapeutic target for Cisplatin-resistant lung adenocarcinoma ... Lung cancer is one of the most common malignant tumours and a leading cause of mortality in humans. Lung cancer is the most ... Moreover, it has been prove that CNNM3 is one of the most correlated genes to PDK2 in lung adenocarcinoma. PDK2 regulates the ... These evidences could be opening a path towards new innovative therapeutic routes and of wide application. To recap, the ...
... after mucoepidermoid carcinoma and polymorphous adenocarcinoma). It represents 28% of malignant submandibular gland tumors, ... Thus, the MYB oncogene is a potential diagnostic and therapeutic target in ACC. ACC has a relatively quiet genome with few ... It is the third-most common malignant salivary gland tumor overall ( ... making it the single most common malignant salivary gland tumor in this region. Patients may survive for years with metastases ...
MUC4 is often overexpressed in pancreatic adenocarcinomas and has been shown to promote tumor growth and metastasis, though the ... Such efforts have been successful at reducing EGF receptor expression, its downstream signaling, and consequently malignant ... presenting MUC-4 as a good therapeutic target for the treatment of esophageal cancer. Unlike pancreatic and esophageal cancers ... Bile acids have been found to stimulate carcinogenesis in pancreatic ductal adenocarcinoma cells through increased expression ...
... are associated with malignant parotid tumours. Facial pain and paraesthesia are also very often associated with malignant ... Targeted Therapy - Due to the poor results with chemotherapy, it's urgent to explore novel therapeutic interventions for this ... not otherwise specified Adenocarcinoma, not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma ... Sublingual gland tumours are very rare but if present, they are most likely to be malignant. Saku et al. in 1997 and Venturi in ...
... while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not. P63 is also helpful in distinguishing ... The defective epithelial commitment could be partially rescued by a small therapeutic compound. Transcription factor p63 is a ... of ductal adenocarcinoma and Gleason pattern 4 cribriform and noncribriform acinar adenocarcinomas of the prostate". The ... P63 should be strongly stained in poorly differentiated squamous cell, but negative in small cell or adenocarcinoma. TP63 has ...
Malignant tumors make up 80 to 96 percent of mammary tumors in cats, almost all adenocarcinomas. Male cats may also develop ... in the carcinogenesis of this canine tumor has potential to complement and refine the current diagnostic and therapeutic ... Dogs with noninvasive adenocarcinomas have an average survival time of two years, while dogs with invasive adenocarcinomas have ... They are the most malignant type of canine mammary tumor. Malignant tumors are also subdivided histopathologically into those ...
Katsetos CD, Dráber P (2012). "Tubulins as therapeutic targets in cancer: from bench to bedside". Current Pharmaceutical Design ... "Loss of class III beta-tubulin induced by histone deacetylation is associated with chemosensitivity to paclitaxel in malignant ... of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma". Clinical ... Expert Opinion on Therapeutic Targets. 17 (4): 461-72. doi:10.1517/14728222.2013.766170. PMID 23379899. S2CID 26229777. Aoki D ...
"MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma". JAMA. 299 (4): 425-436 ... as a target for 13q31-q32 amplification in malignant Lymphoma". Cancer Res. 64 (9): 3087-3095. doi:10.1158/0008-5472.CAN-03- ... "Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant ... "MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis". JAMA. ...
February 2008). "Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer". Molecular Cancer ... immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions". Diagnostic ... October 2010). "Mesothelin as a potential therapeutic target in human cholangiocarcinoma". Journal of Cancer. 1: 141-149. doi: ... December 2008). "Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression ...
1999). "Florid cutaneous papillomatosis, malignant acanthosis nigrica, palmoplantar keratoderma, and gastric adenocarcinoma" ( ... Comprehensive Therapeutic Strategies. Elsevier Health Sciences. p. 88. ISBN 978-0-7020-4328-4. Judith Collier; Murray Longmore ... Florid cutaneous papillomatosis, malignant acanthosis nigricans, and the sign of Leser-Trélat may be highlighted as part of a ... Malignant acanthosis nigricans may also become evident, many times with the sudden eruption of multiple seborrheic keratoses, ...
... pancreatic ductal adenocarcinoma, acute myeloid leukemia, prostate adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, ... This will lead to the discovery of new therapeutic targets, more precise disease definitions and improved strategies to prevent ... Medulloblastoma and pediatric pilocytic astrocytoma and malignant lymphoma and prostate cancer India: Oral cancer - ... Ductal adenocarcinoma and prostate cancer - adenocarcinoma China: Gastric cancer - Intestinal- and diffuse-type European Union/ ...
These findings can be precursor lesions of a primary bladder adenocarcinoma. No history of a different primary adenocarcinoma ... Sheldon, C. A.; Clayman, R. V.; Gonzalez, R.; Williams, R. D.; Fraley, E. E. (1984-01-01). "Malignant urachal lesions". The ... and therapeutic aspects of urachal carcinoma-A comprehensive review with meta-analysis of 1,010 cases". Urologic Oncology. 34 ( ... "Urachal Adenocarcinoma". AUAnet.org. Humphrey, Peter A.; Moch, Holger; Cubilla, Antonio L.; Ulbright, Thomas M.; Reuter, Victor ...
June 2008). "Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests ... In these instances, a minimum of 10% of the viable malignant cells present must be identified as LCLC before the tumor is ... given the differences between standard therapeutic regimens for SCLC and NSCLC.[citation needed] C-SCLC also occurs quite ... As a result, it is recommended that all multiphasic malignant lung tumors (i.e. those with more than one histological pattern) ...
Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. It ... "Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer". Oncology (Williston Park). 31 (3): 159-66, 168. PMID ... and soft compared to pancreatic adenocarcinoma, lacking its dense stroma. They can arise in any part of the pancreas. ...
Certain non-malignant diseases also give rise to dramatic elevation of TK values in cells and tissue: in peripheral lymphocytes ... Experimental and Therapeutic Medicine. 2 (6): 1177-1181. doi:10.3892/etm.2011.338. PMC 3440839. PMID 22977640. Liu Y, Ling Y, ... "Deoxythymidine kinase in the staging of prostatic adenocarcinoma". The Prostate. 29 (1): 15-9. doi:10.1002/(SICI)1097-0045( ... As TK1 is present in cells during cell division, it is reasonable to assume that the TK activity in malignant tissue should be ...
For example, autocrine Wnt signaling could provide a novel target for therapeutic intervention by means of Wnt antagonists or ... Their research showed that autocrine IL-6 signaling induced malignant features in Notch-3 expressing mammospheres. A study ... of lung adenocarcinomas, and IL-6. Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway ... In breast cancer, the acquisition of tamoxifen resistance is another major therapeutic problem. It has been shown that ...
Buryk MA, Simons JP, Picarsic J, Monaco SE, Ozolek JA, Joyce J, Gurtunca N, Nikiforov YE, Feldman Witchel S. Can malignant ... RET rearrangements in lung adenocarcinoma and radiation. J Thorac Oncol. 2014 Jan;9(1):118-20. Dettmer MS, Perren A, Moch H, ... Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer ...
Kim I, Xu W, Reed JC (December 2008). "Cell death and endoplasmic reticulum stress: disease relevance and therapeutic ... and DERL1 discriminates malignant from benign canine mammary tumors". Veterinary Pathology. 47 (3): 446-54. doi:10.1177/ ... "Increased Derlin-1 expression in metastases of canine mammary adenocarcinomas". Journal of Comparative Pathology. 142 (1): 79- ... "Derlin-1 and stanniocalcin-1 are differentially regulated in metastasizing canine mammary adenocarcinomas". Journal of ...
... are poorly differentiated adenocarcinoma. The term adenocarcinoma refers to cancer that begins in the cells in glandular ... Clinical guideline 104: Metastatic malignant disease of unknown primary origin. London, 2010. López-Lázaro (1 May 2015). "The ... current perspectives and future therapeutic strategies". Journal of Translational Medicine. 10: 12. doi:10.1186/1479-5876-10-12 ... The majority of cancers of unknown primary, about 90%, are adenocarcinomas, with 60% appearing as moderately to well- ...
The GPER-selective agonist G-1 shows therapeutic efficacy in mouse models of obesity and diabetes. Immunohistochemical and ... Estradiol produces cell proliferation in both normal and malignant breast epithelial tissue. However, GPER knockout mice show ... has been shown to attenuate the growth of patient-derived xenografts of pancreatic ductal adenocarcinoma. A contrary argument ... "GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast". ...
This type of malignant neoplasm mimics pancreatic development at 7 weeks of gestation and tends to affect, most commonly, young ... Mortality during the first few years after diagnosis is around 15%, although current therapeutic approaches have reached cure ... fetal adenocarcinoma and pleuropulmonary blastoma. Pleuropulmonary blastomas are characterized by the proliferation of ... About 0.5% to 1% of all primary malignant lung tumors are childhood tumors of the lung, making it a rare form of neoplasm. ...
... and DERL1 discriminates malignant from benign canine mammary tumors". Veterinary Pathology. 47 (3): 446-54. doi:10.1177/ ... "Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34". Cancer Research. 70 (14): 5923-30. doi: ... "DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma". Oncogene. 19 (23): 2791-5. doi ... "Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas". Veterinary Pathology. 46 ( ...
During Cd-induced malignant transformation, the promoter regions of ERCC1, as well as of hMSH2, XRCC1, and hOGG1, were heavily ... Nucleotide excision repair (NER) is the primary DNA repair mechanism that removes the therapeutic platinum-DNA adducts from the ... of the crypts within 10 cm on each side of colonic adenocarcinomas (within the early field defects from which the cancers ... Zhou ZH, Lei YX, Wang CX (February 2012). "Analysis of aberrant methylation in DNA repair genes during malignant transformation ...
It was reported that IL-1β secretion was elevated in the lung adenocarcinoma cell line A549. It has also been shown in another ... The role of IL-1β has been investigated for potential therapeutic target for treatment of diabetic retinopathy. However, ... study that IL-1β, together with IL-8, plays an important role in chemoresistance of malignant pleural mesothelioma by inducing ...
The combination of nivolumab with ipilimumab is used for the first-line treatment of adults with malignant pleural mesothelioma ... Sundar R, Cho BC, Brahmer JR, Soo RA (March 2015). "Nivolumab in NSCLC: latest evidence and clinical potential". Therapeutic ... and Esophageal Adenocarcinoma Nivolumab is used as a first-line treatment for inoperable or metastatic melanoma in combination ... Johnson DB, Peng C, Sosman JA (March 2015). "Nivolumab in melanoma: latest evidence and clinical potential". Therapeutic ...
... subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas ... Additionally, evidence is accumulating that the UPS plays an essential role in malignant transformation. UPS proteolysis plays ... Drews O, Taegtmeyer H (Dec 2014). "Targeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic ... Notably, findings illustrate that lung adenocarcinomas can be divided into two main groups; those with and without general ...
Therapeutic vaccines are currently undergoing clinical trials. The lifetime recurrence rate of CIN is about 20%,[citation ... Endocervical brush sampling at the time of Pap smear to detect adenocarcinoma and its precursors is necessary along with doctor ... 40 are known to affect the epithelial tissue of the anogenital area and have different probabilities of causing malignant ...