... itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. Terfenadine, in addition ... Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst ... "Status of Terfenadine-Containing Drugs in Canada". Health Canada. 23 April 2004. Archived from the original on 13 July 2006. " ... In the United States, terfenadine as Seldane was brought to market in 1985 as the first non-sedating antihistamine for the ...

... terfenadine (trade name Seldane), and, therefore, put loratadine on a lower priority. However, terfenadine had to be removed ... Thompson D, Oster G (May 1996). "Use of terfenadine and contraindicated drugs". JAMA. American Medical Association. 275 (17): ... terfenadine > loratadine. However, the onset of action varies significantly and clinical efficacy is not always directly ...

Wood SF (January 1986). "Astemizole and terfenadine compared in hay fever". The Practitioner. 230 (1411): 41-4. doi:10.1161/ ...

Terfenadine produces azacyclonol as a major active metabolite. It is made by the organometallic addition of 4-bromopyridine to ... Martens J (April 1996). "Determination of the terfenadine metabolite azacyclonol in human serum using gas chromatography-mass ... is also known as diphenylmethanolpiperidine and is the parent structure of the antihistamines fexofenadine and terfenadine. ...

Kintz, P; Mangin, P (December 1992). "Toxicological Findings in a Death Involving Dextromethorphan and Terfenadine". The ...

Pinney, SP; Koller, BS; Franz, MR; Woosley, Raymond L.; Ph (1995). "Terfenadine increases the QT interval in isolated guinea ...

Benzyl salicylate and terfenadine have been shown to bind to CD81. Cluster of differentiation GRCh38: Ensembl release 89: ... "Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: synthesis and structure optimization ...

Contraindications include the coadministration of terfenadine, astemizole, cisapride, pimozide, or carbamazepine. Nefazodone is ...

Small P, Barrett D, Biskin N (February 1990). "Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal ...

... are taking terfenadine, if 400 mg per day multidose of fluconazole is administered; concomitant administration of fluconazole ...

The first non-sedating antihistamine was terfenadine (Seldane) and was developed in 1973. Subsequently, other non-sedating ... The United States government removed two second generation antihistamines, terfenadine and astemizole, from the market based on ...

Yasuda SU, Yasuda RP (April 1999). "Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human ... "Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole". FEBS ...

Yasuda SU, Yasuda RP (1999). "Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic ...

The older antihistaminic agent terfenadine was found to metabolize into the related carboxylic acid, fexofenadine. Fexofenadine ... so terfenadine was replaced in the market by its metabolite. Fexofenadine was originally synthesized in 1993 by Massachusetts- ...

"Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole". FEBS ...

In some cases, this can lead to a fatal interaction with drugs like astemizole or terfenadine. The effect of grapefruit juice ... Often this allows prodrugs to be activated and absorbed, as in the case of the histamine H1-receptor antagonist terfenadine. ... of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine". British ...

"Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine- ...

... of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine". British ...

A series of drugs derived from Terfenadine have been shown to inhibit CYP2J2 and to suppress the proliferation and cause the ... "Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo". ...

... or norephedrine Dexfenfluramine Dinitrophenol Strychnine Etretinate Fenfluramine Lindane Terfenadine ANVISA. "Portaria n.o 344 ...

... and terfenadine; neither did it affect metabolism of the CYP1A2 substrate clozapine. Sertraline had no effect on the actions of ...

Other examples include terfenadine (Seldane, Seldane-D), astemizole (Hismanal), cisapride (Propulsid, withdrawn in many ...

Terfenadine, the first non-sedating antihistamine, had to be withdrawn from the market because of the small risk of a serious ... However, terfenadine was discovered to be the prodrug of the active molecule, fexofenadine, which does not carry the same risks ... However, in this case the parent compound does not have the side effects associated with terfenadine, and so both loratadine ...

... terfenadine (Seldane)), may have arrhythmogenic effects. Woosley's invention, fexofenadine (Allegra), resulted from this ...

Drugs that prolong the QT interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, ...

... or antihistamines such as terfenadine. Other drugs which prolong the QT interval include some antipsychotics such as ...

Some examples of chiral drug to metabolite switches, (those in the market and others under investigation) include terfenadine ...

... terfenadine, amiodarone, flecainide, quinidine, fluorouracil, and benzodiazepines. Cimetidine may decrease the effects of ...

Acyclic: pridinol Pyrolidino: diphenylprolinol 2-Piperidine: pipradrol 4-Piperidine: terfenadine, fexofenadine Benzilic ester: ...

... terfenadine, ergotamine, ticagrelor, ranolazine or dihydroergotamine is not recommended. It should not be used with colchicine ...