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*  List of MeSH codes (D12.776.660)
... telomeric repeat binding protein 1 MeSH D12.776.660.235.700.875 -- telomeric repeat binding protein 2 MeSH D12.776.660.352. ... hmgb proteins MeSH D12.776.660.235.400.600.300 -- hmgb1 protein MeSH D12.776.660.235.400.600.600 -- hmgb2 protein MeSH D12.776. ... hmgn1 protein MeSH D12.776.660.235.400.400.300 -- hmgn2 protein MeSH D12.776.660.235.400.500 -- hmga proteins MeSH D12.776. ... hmga1b protein MeSH D12.776.660.235.400.500.400 -- hmga1c protein MeSH D12.776.660.235.400.500.600 -- hmga2 protein MeSH ...
*  TERF2IP
Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene. TERF2IP has ... 2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 ... "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein". O'Connor, Matthew S; Safari Amin; Liu Dan; Qin ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  TERF2
Telomeric repeat-binding factor 2 is a protein that is present at telomeres throughout the cell cycle. It is also known as ... There are 4 domain categories on the TERF2 protein that allow it to bind to both other proteins in the shelterin protein ... which is the binding site of TERF2 where it recruits client proteins. These client proteins also contain a TRFH binding motif, ... "Entrez Gene: TERF2 telomeric repeat binding factor 2". "Apollo Contributes to G Overhang Maintenance and Protects Leading-End ...
*  Telomere-binding protein
... function to bind telomeric DNA in various species. In particular, telomere-binding protein refers to TTAGGG repeat binding ... Telomere-binding proteins function to generate a T-loop, which is a specialized loop structure to cap the telomeric ends. ... There include: TRF1 TRF2 POT1 TIN2 RAP1 TPP1 Both TRF1 and TRF2 bind the telomeric repeat sequences in the duplex region of the ... It has homology to the Myb transcription factors as the protein-DNA complex requires both Myb repeats. TRF1 binds near the N- ...
*  TERF1
... the protein has a molecular function of binding telomeric DNA and the double-stranded telomeric DNA. The telomeric repeat- ... Telomeric Repeat Factor 1 (TRF1) is a protein that binds at telomere ends. This gene encodes a telomere specific protein which ... the telomeric repeat-binding factor 1 protein has most of its functions related to the binding of components and regulation of ... Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. The human TERF1 gene is located in ...
*  Shelterin
TRF1 (Telomere Repeat Factor 1): TRF1 is a homodimeric protein that binds to the double-stranded TTAGGG region of the telomere ... In mammals and other eukaryotes, telomeric DNA consists of double- and single-stranded TTAGGG repeats and a single-stranded, G- ... Flynn RL, Zou L (2010). "Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians". Critical ... RAP1 (Repressor / Activator Protein 1): RAP1 is a stabilizing protein associated with TRF2. POT1 (Protection of Telomere 1): ...
*  TNKS
... contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding ... "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance ... contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding ... "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance ...
*  FLNA
The edited adenosine is located in the 22 immunogloulin like repeat of the protein. This region is an integrin β binding domain ... "Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in ... "Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein". Mol. Immunol. 37 (10): ... Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. Actin-binding protein, or filamin, is a 280-kD ...
*  HMBOX1
... is a protein that in humans is encoded by the HMBOX1 gene. HMBOX1 directly binds to the double-stranded repeat sequence of ... binding to telomeric DNA was demonstrated through a co-crystal structure of the DNA-binding domain of HMBOX1 with telomeric DNA ... "HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment". The EMBO Journal. 32 (12): ... Homeobox containing 1, also known as homeobox telomere-binding protein 1 (HOT1), ...
*  Transposon silencing
piRNAs bound to PIWI proteins seem to use post-transcriptional transcript destruction to silence transposons (4). Transposon ... gene silencing proteins). Many piRNAs are derived from transposons and other repeated elements, and therefore lack specific ... This is referred to as the telomeric-silencing effect (TSE) (2). Just two P elements in the telomere are enough to suppress ... are between 26 and 31 nucleotides in length and function through interactions with piwi proteins from the Argonaute protein ...
*  ZBTB48
... also known as telomeric zinc-finger associated protein (TZAP), is a protein that directly binds to the double-stranded repeat ... "ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator". EMBO Reports. 18 (6): 929-946. doi: ... Beyond its telomeric function, ZBTB48 acts as a transcriptional activator on a small set of target genes, including ... complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein". ...
*  TNKS2
... contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding ... Chi, N W; Lodish H F (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts ... telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. England. 361 (Pt 3): 451-9. doi: ... telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3): 451-9. doi:10.1042/ ...
*  RAC3
The protein encoded by this gene is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this ... 2000). "The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted ... 2004). "Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators". J. ... Haataja L, Kaartinen V, Groffen J, Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB ...
*  H2AFB3
H2A histone family, member B3 is a protein that in humans is encoded by the H2AFB3 gene. Histones are basic nuclear proteins ... This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer ... This record represents the most telomeric copy. [provided by RefSeq, Jul 2008]. GRCh38: Ensembl release 89: ENSG00000277745 - ... "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones ...
*  Human herpesvirus 6
This phenomenon is possible as a result of the telomeric repeats found within the direct repeat termini of HHV-6's genome. The ... binds P53 and incorporates it into virions. Another gene product, the ORF-1 protein, can also bind and inactivate P53. Cells ... possess a repeated TTAGGG sequence, identical to that of human telomeres. Variability in the number of telomeric repeats is ... Another product of HHV-6, the immediate early protein U95, has been shown to bind nuclear factor-kappa B. Deregulation of this ...
*  FUS (gene)
FUS/TLS is a member of the TET protein family that also includes the EWS protein, the TATA-binding protein (TBP)-associated ... FUS/TLS has also been proposed to bind human telomeric RNA (UUAGGG)4 and single-stranded human telomeric DNA in vitro. Beyond ... multiple RGG repeats, which are extensively dimethylated at arginine residues and a C-terminal zinc finger motif. FUS/TLS was ... RNA-binding protein FUS/TLS (Fused in Sarcoma/Translocated in Sarcoma) is a protein that in humans is encoded by the FUS gene. ...
*  Titia de Lange
In 1995, she identified and purified the Telomeric-repeat binding factor protein 1 (TRF1). With the assistance of Bas van ... In 2005, de Lange came to the crucial realization that six telomeric proteins form a dynamic protein complex, that she named ... Shelterin subunits are not the only proteins that associate with telomeres but they differ from other proteins by meeting the ... A human telomeric protein. Science 270: 1663-1667. Retrieved from doi: 10.1126/science.270.5242.1663 B. van Steensel and T. de ...
*  G-quadruplex
These RNA transcripts containing G4C2 repeats were shown to bind and separate a wide variety of proteins, including nucleolin. ... The human telomeric repeat (which is the same for all vertebrates) consists of many repeats of the sequenced (GGTTAG), and the ... These telomeric regions are characterized by long regions of double-stranded CCCTAA:TTAGGG repeats. The repeats end with a 3' ... "The Werner Syndrome Protein is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA ...
*  Piet Borst
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res. 2007;35: ... Crozatier M, Van der Ploeg LH, Johnson PJ, Gommers-Ampt J, Borst P. Structure of a telomeric expression site for variant ... Ouellette M, Hettema E, Wust D, Fase-Fowler F, Borst P. Direct and inverted DNA repeats associated with P-glycoprotein gene ... Proc Natl Acad Sci U S A. 2015;112(21):6601-6. Jansen RS, Mahakena S, de Haas M, Borst P, van de Wetering K. ATP-binding ...
*  Chromosome 5 (human)
... encoding protein Ankyrin repeat domain 31 APBB3: encoding protein Amyloid beta A4 precursor protein-binding family B member 3 ... telomeric SMN2: survival motor neuron 2, centromeric SNCAIP: synuclein, alpha interacting protein (synphilin) SPEF2: Sperm ... Purine-rich element-binding protein A PWWP2A: encoding protein PWWP domain containing 2A RANBP3L: encoding protein RAN binding ... Protein Red IRX1: Iroquois-class homeodomain protein (human) LARP1: La-related protein 1 LMAN2: Lectin mannose binding 2 LNCR3 ...
*  Sirtuin 1
SIRT1 mediated HR requires the WRN protein. WRN protein functions in double-strand break repair by HR. WRN protein is a RecQ ... The silencing activity of Sir2 is most prominent at telomeric sequences, the hidden MAT loci (HM loci), and the ribosomal DNA ( ... Resveratrol also enhances the binding between Sirtuin 1 and Lamin A. In addition to resveratrol, a range of other plant-derived ... Chromatin silencing, as a result of Sir2 activity, reduces homologous recombination between rDNA repeats, which is the process ...
*  FAM203B
The FAM203B protein is also predicted to locate to the cytoplasm. There are many possible transcription factor binding sites in ... "LOC377711 HEAT repeat-containing protein 7A-like [Homo sapiens (human)]". NCBI Gene. Retrieved 10 May 2013. "FAM203A family ... FAM203A and FAM203B are located in the telomeric region of chromosome 8, an area of chromosomes that frequently experiences ... "Predicted: brain protein 16-like [Danio rerio]". NCBI Protein. Retrieved 5 February 2013. "Predicted: brain protein 16-like [ ...
*  Mega-telomere
Mega-telomeric DNA also binds to various proteins to form complex structures on the ends of chromosomes. Telomeres are ... More specifically, telomere-peptide nucleic acid fluorescein probes are frequently used to identify telomeric sequence repeats ... Telomeric regions of DNA were first identified in the late 1970s (See: Discovery of Telomeric DNA). However, extremely long ... In 1994, extremely long telomeric regions were identified in chickens. Telomeric sequences ranging from 20 kilobases to several ...
*  RRM3
The binding of these two proteins appears to be linked to inappropriate replication timing and genome integrity. Rrm3p ... Rrm3p is also commonly associated with telomeric and subtelomeric DNA replication, in which its effects are thought to be ... including sites at ribosomal DNA repeats, tRNA genes, centromeres, telomeres, G4 DNA and the silent mating-type loci. At these ... Rrm3p is part of a network of DNA replication and helicase proteins. Related proteins include Srs2 and Sgs1, both of which are ...
*  Non-coding RNA
Telomerase is an RNP enzyme that adds specific DNA sequence repeats ("TTAGGG" in vertebrates) to telomeric regions, which are ... are bound by iron response proteins (IRP). The IRE is found in UTRs of various mRNAs whose products are involved in iron ... For example, a riboswitch can directly bind a small target molecule; the binding of the target affects the gene's activity.[ ... Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) are repeats found in the DNA of many bacteria and archaea. ...
*  Telomerase
These TTAGGG repeats (with their various protein binding partners) are called telomeres. The template region of TERC is 3'- ... Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol. 2010 Apr ... TERT proteins from many eukaryotes have been sequenced. By using TERC, TERT can add a six-nucleotide repeating sequence, 5'- ... The protein consists of four conserved domains (RNA-Binding Domain (TRBD), fingers, palm and thumb), organized into a ring ...