Staal FJ, Clevers H (February 2000). "Tcf/Lef transcription factors during T-cell development: unique and overlapping functions ... T-cell factor/lymphoid enhancing factor) transcription factors. β-catenin recruits other transcriptional coactivators, such as ... eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF ... β-catenin binds to transcription factors such as the protein TCF4 and in combination the molecules activate the necessary genes ...

Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related ... dependent activation of tissue-specific gene transcription". J. Cell Sci. 113 (12): 2221-31. doi:10.1242/jcs.113.12.2221. PMID ... implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. 337 (1): 13-7. doi:10.1042/0264 ...

It is a member of the TCF family that can form a bipartite transcription factor (β-catenin/TCF) alongside β-catenin. Bipartite ... Brantjes H, Roose J, van De Wetering M, Clevers H (April 2001). "All Tcf HMG box transcription factors interact with Groucho- ... As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence several biological pathways, ... Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription ...

Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related ... down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 ... Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel ... "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)". van de Wetering M, Oosterwegel M, Holstege F, et al. ( ...

Eastman Q, Grosschedl R (Apr 1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Current Opinion ... "Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho- ... "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription". Molecular and ... Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (Mar 2002). "The transcription co-repressor TLE1 interacted with the ...

Castrop J, van Norren K, Clevers H (Feb 1992). "A gene family of HMG-box transcription factors with homology to TCF-1". Nucleic ... This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription ... Brantjes H, Roose J, van De Wetering M, Clevers H (Apr 2001). "All Tcf HMG box transcription factors interact with Groucho- ... "TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]". Retrieved 2021-05-29. "Salmonella infection data for Tcf7l1". ...

Eastman Q, Grosschedl R (April 1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Current Opinion ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... "Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in ... The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the ...

Brantjes H, Roose J, van De Wetering M, Clevers H (April 2001). "All Tcf HMG box transcription factors interact with Groucho- ... It's a member of T cell factor/lymphoid enhancer factor (TCF/LEF) family. Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD ... Skokowa J, Welte K (June 2007). "LEF-1 is a decisive transcription factor in neutrophil granulopoiesis". Annals of the New York ... Waterman ML (2004). "Lymphoid enhancer factor/T cell factor expression in colorectal cancer". Cancer and Metastasis Reviews. 23 ...

"Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells". The Journal of Biological ... Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009). "Zinc finger transcription factor INSM1 interrupts cyclin D1 ... Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. Independent of CDK, cyclin ...

This protein activates two transcription factors: T-cell factor (TCF) and lymphoid enhancer factor (LEF). These factors cause ... One of the most important factors in classifying a tumor as benign or malignant is its invasive potential. If a tumor lacks the ... Pituitary adenomas can cause elevated levels of hormones such as growth hormone and insulin-like growth factor-1, which cause ...

"Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". The EMBO ... September 2010). "Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells ... protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ...

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of ... "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 ( ... Janknecht R, Hunter T (1997). "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen- ... Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 ( ...

"Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 ( ... Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by ... Roberts EC, Deed RW, Inoue T, Norton JD, Sharrocks AD (2001). "Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor ... Hara E, Hall M, Peters G (1997). "Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors ...

"Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 ( ... "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". ... Asp J, Thornemo M, Inerot S, Lindahl A (1998). "The helix-loop-helix transcription factors Id1 and Id3 have a functional role ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ...

... a T cell-specific transcription factor containing a sequence-specific HMG box". The EMBO Journal. 10 (1): 123-132. doi:10.1002/ ... His group identified the TCF1 protein, a member of the TCF gene family and a crucial downstream component of the Wnt signaling ... Collaborating with Bert Vogelstein, he found that in colon cancer where the APC gene is doubly mutated, TCF family members ... His interest in the gastrointestinal tract began with the discovery that another TCF family member, the TCF4 protein, is ...

SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong ... Sox genes are related to the Tcf/Lef1 group of genes which also contain a sequence-specific high mobility group and have a ... Sox 2 is also a transcription factor in the maintenance of pluripotency in both Early Embryos and ES Cells. Granule cells then ... transcription factors". Int. J. Biochem. Cell Biol. 39 (12): 2195-214. doi:10.1016/j.biocel.2007.05.019. PMC 2080623. PMID ...

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) ... 2008). "Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with ...

... is stabilized in the presence of Wnt and regulates gene transcription through interaction with TCF/LEF transcription factors. ... Fibroblast growth factor 8 (FGF8) transcription factors are essential for regulating the addition of secondary heart field ... A variety of growth factors and transcription factors in the extracellular matrix signal cells and direct them toward a ... GATA transcription factors, which are complex molecules that bind to the DNA sequence GATA, play a critical role in cell ...

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF ... Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 ( ... 1994). "Net, a new ets transcription factor that is activated by Ras". Genes Dev. 8 (13): 1502-13. doi:10.1101/gad.8.13.1502. ... Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. ...

Valenta T, Lukas J, Korinek V (May 2003). "HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression ... transcription factor. Global transcript analysis of human pluripotent stem cell (hPSC)-derived 3D retinal organoids ... "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". ... van Vliet J, Turner J, Crossley M (2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP ...

Tcf) of transcription factors. In colon cancer cell nuclei, α-catenin was found to accumulate and repress Tcf-dependent ... 30 In parallel, choi et al., found a different mechanism by which α-catenin binds beta-catenin to TCF/LEF family DNA-binding ... alpha-Catenin is an inhibitor of transcription. Proc Natl Acad Sci U S A. 2014;111(14):5260-5. 31. Choi SH, Estaras C, Moresco ... alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex. J Biol Chem ...

In the nucleus β-catenin associates with Lef/Tcf transcription factor, which is already working on DNA as a repressor, ... Binding of β-catenin to Lef/Tcf works as a transcription activator, activating the transcription of the Wnt-responsive genes. ... Growth and differentiation factors (GDFs) Growth factor and clotting factors are paracrine signaling agents. The local action ... Ligands that bind to RTKs include fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and ...

... of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. ... a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs". Genomics. 27 (3): ... Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene ... "A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse ...

Genomatix's MatInspector program predicted 418 transcription factor binding sites within the BEND2 promoter, including for SRY ... neurogenin, interferon regulatory factor-3 (IRF-3), Ikaros2, and TCF/LEF-1. The BEND2 protein has no known paralogs within the ... the transcription factors found in its promoter region, and the nature of the proteins it interacts with. Though the precise ... It regulates transcription of all five transcriptional variants of BEND2. ...

... a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription ... Upon engaging the transcription factors LEF1, TCF1, TCF2 or TCF3, β-catenin forces them to disengage their previous partners: ... Kennell JA, O'Leary EE, Gummow BM, Hammer GD, MacDougald OA (August 2003). "T-cell factor 4N (TCF-4N), ... June 2006). "The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress- ...

... a holding company TCF Bank TCF-1 or HNF1A, a gene TCF4 or TCF7L2, a protein transcription factor TCF/LEF family of ... Look up tcf in Wiktionary, the free dictionary. TCF can mean: TCF Center, Detroit, Michigan, USA; a convention center TCF ... "tcf" on Wikipedia. All pages with titles containing TCF or TCFs All pages with titles beginning with TCF This disambiguation ... low-cost schools in Pakistan TCF, short for Twentieth Century Fox TCF Hungary Film Rights Exploitation Limited Liability ...

While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a ... regulator of the NF-κB transcription factor. Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in ...

This prevents it from translocating into the nucleus, where it acts as a transcription factor for proliferation genes. APC is ... TCF, and Pygo.[citation needed] The ability of APC to bind β-catenin has been classically considered to be an integral part of ... APC I1307K has also been implicated as a risk factor for certain other cancers. The (Adenomatous Polyposis Coli) APC protein ... "Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor ...

Brachyury is an essential transcription factor required for mesoderm formation. Without MACF1, insufficient brachyury is ... Also, MACF1 is required for sufficient β-catenin to travel to the nucleus, where subsequently TCF/β-catenin-dependent ... Chen HJ, Lin CM, Lin CS, Perez-Olle R, Leung CL, Liem RK (Jul 2006). "The role of microtubule actin cross-linking factor 1 ( ... Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 is a protein that in humans is encoded by the MACF1 gene. MACF1 ...

Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is ... May 2022). "Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron ... October 2008). "Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development". ... TCF4 proteins act as transcription factors which will bind to the immunoglobulin enhancer mu-E5/kappa-E2 motif. TCF4 activates ...