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*  Calcineurin
Thus tacrolimus contributes to the frequent development of new diabetes following renal transplantation. Calcineurin/NFAT ... "Pharmacology and side effects of cyclosporine and tacrolimus". UpToDate. 2014-04-10. Bannai H, Lévi S, Schweizer C, Inoue T, ... pimecrolimus and tacrolimus. Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a ...
*  Pimecrolimus
... has a similar mode of action to that of tacrolimus but is more selective, with no effect on dendritic (Langerhans ... It has lower permeation through the skin than topical steroids or topical tacrolimus although they have not been compared with ... Tacrolimus and pimecrolimus are both calcineurin inhibitors and function as immunosuppressants. See also: Immunosuppressants in ... Importantly, although the FDA has approved updated black-box warning for tacrolimus and pimecrolimus, the recent report of the ...
*  Tacrolimus
... is predominantly eliminated via the faeces in form of its metabolites. When applied locally on eczema, tacrolimus ... The name tacrolimus is derived from "Tsukuba macrolide immunosuppressant". Tacrolimus was first approved by the Food and Drug ... Tacrolimus prevents the dephosphorylation of NF-AT. In detail, tacrolimus reduces peptidylprolyl isomerase activity by binding ... increase tacrolimus levels by competing for cytochrome enzymes. Tacrolimus is a macrolide calcineurin inhibitor. In T-cells, ...
*  Mycophenolic acid
... ciclosporin or tacrolimus) and prednisolone. Mycophenolate mofetil is the morpholino‌ethyl ester of mycophenolic acid; the ...
*  Liver transplantation
Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. If the patient ... Most liver transplant recipients receive corticosteroids plus a calcineurin inhibitor such as tacrolimus or ciclosporin, (also ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: T: Tacrolimus
Official pharmaceutical site from Astellas. Includes consumer, prescribing and eczema information. ...
*  Pyoderma gangrenosum
Topical application of clobetasol, mupirocin, and gentamicin alternated with tacrolimus can be effective. Pyoderma gangrenosum ... tacrolimus; thalidomide; infliximab; or plasmapheresis. There is currently a phase III trial for the use of the IL-1B ...
*  Khellin
Plettenberg, Heidi; Assmann, Till; Ruzicka, Thomas (2003). "Childhood vitiligo and tacrolimus". Arch Dermatol. 139: 651-654. ...
*  Streptomyces tacrolimicus
... produces tacrolimus. Martínez-Castro, M; Barreiro, C; Romero, F; Fernández-Chimeno, RI; Martín, JF ( ... nov., a low producer of the immunosuppressant tacrolimus (FK506)". International Journal of Systematic and Evolutionary ... nov., a low producer of the immunosuppressant tacrolimus (FK506)". International Journal of Systematic and Evolutionary ...
*  Mark G. Lebwohl
Tacrolimus ointment is effective for facial and intertriginous psoriasis. J Am Acad Dermatol. 2004;51(5):731-8. Lebwohl M, ... 2004). "Tacrolimus ointment is effective for facial and intertriginous psoriasis". J Am Acad Dermatol. 51 (5): 723-30. doi: ... J Invest Dermatol 2003;121(3): 594-5. Lebwohl M, Freeman AK, Chapman MS, Feldman SR, Hartle JE, Henning A; Tacrolimus Ointment ...
*  Ascomycin
Tacrolimus, Pimecrolimus Griffiths CE. Ascomycin: an advance in the management of atopic dermatitis. Br J Dermatol. 2001. Apr; ... Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant ...
*  Streptomyces tsukubaensis
It produces the immunosuppressive drug tacrolimus. Pritchard D (2005). "Sourcing a chemical succession for cyclosporin from ...
*  FK1012
... is a dimer of tacrolimus; the two tacrolimus units are linked at their vinyl groups. Fegan, A; White, B; Carlson, JC; ... FK1012, a derivative of tacrolimus, is used as a research tool in chemically induced dimerization applications. The protein ...
*  Medical animation
Mechanism of Action: Protopic (tacrolimus). Archived 2011-12-04 at the Wayback Machine. Astellas Pharma US, Inc. 2008. Choa, ...
*  Inhaled ciclosporin
"Systemic ciclosporin and tacrolimus in dermatology. Dermatol Ther. 2007 Jul-Aug;20(4):239-50. Kitahara K, Kawai S. " ... "Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2007 May;19(3):238-45. Review. ...
*  Streptomyces tsukubensis
... produses the immunosuppressant tacrolimus. Chen, D.; Zhang, Q.; Zhang, Q.; Cen, P.; Xu, Z.; Liu, W. ( ... the producer of the clinically important immunosuppressant tacrolimus (FK506)". Journal of Bacteriology. 194 (14): 3756-7. doi: ...
*  Kimura's disease
A patient with refractory Kimura's disease after surgery and treatment with prednisone was treated with tacrolimus. Tacrolimus ... Tacrolimus may be an effective treatment for patients with Kimura's disease, but more research is needed to determine its long- ... Da-Long, S; Wei, R; Bing, G; Yun-Yan, Z; Xiang-Zhen, L; Xin, L (2014). "Tacrolimus on Kimura's disease: A case report". Oral ... FK-506 blood concentration was controlled within 5 to 15 μg/l. After 6 months, the dosage of tacrolimus was reduced to 0.5 mg ...
*  Graft-versus-host disease
Cyclosporin binds to the cytosolic protein Peptidyl-prolyl cis-trans isomerase A (known as cyclophilin), while tacrolimus binds ... cyclosporin and tacrolimus are common drugs used for GVHD prophylaxis.[citation needed] Graft-versus-host-disease can largely ... Cyclosporine and tacrolimus are inhibitors of calcineurin. Both substances are structurally different but have the same ...
*  Pityriasis alba
Tacrolimus has been reported as speeding resolution. In exceptionally severe cases PUVA therapy may be considered. The patches ... Rigopoulos D, Gregoriou S, Charissi C, Kontochristopoulos G, Kalogeromitros D, Georgala S (2006). "Tacrolimus ointment 0.1% in ...
*  Eosinophilic folliculitis
Other therapies include PUVA, topical tacrolimus, and isotretinoin. Eosinophilic folliculitis associated with HIV infection ...
*  Thygeson's superficial punctate keratopathy
Tacrolimus (Protopic 0.03% ointment) is also an experimental treatment. Laser eye treatment. Amniotic membrane (Case Study) ...
*  Efonidipine
Tacrolimus: Efonidipine inhibits metabolic enzymes involved in Tacrolimus metabolism and reduces its clearance. So, increase in ... blood concentration of Tacrolimus can occur. The common side effects are hot flushes, facial flushing and headache. In addition ...
*  C12orf40
In the fibroblasts of hypertrophic scars, exposure to the immunosuppressant Tacrolimus causes C12orf40 up-regulation. In pigs, ... Wong, Victor W.; You, Fanglei; Januszyk, Michael; Kuang, Anna A. (September 2013). "Tacrolimus fails to regulate collagen ...
*  Streptomyces isolates
Sirolimus (Rapamycin), ascomycin, and tacrolimus were isolated from Streptomyces. Pimecrolimus is a derivative of ascomycin. ...
*  Kidney transplantation
Tacrolimus, which is a similar drug, also causes nephrotoxicity. Blood levels of both must be monitored closely and if the ... The most common medication regimen today is a mixture of tacrolimus, mycophenolate, and prednisolone. Some recipients may ... These food products are known to interact with the transplant medications, specifically tacrolimus, cyclosporin and sirolimus; ... The routine immunosuppressives are tacrolimus (Prograf), mycophenolate (Cellcept), and prednisolone; these drugs cost US$1,500 ...