A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T ... Cytotoxic T-lymphocytes have been implicated in the development of various diseases and disorders, for example in transplant ... Neumann H, Medana IM, Bauer J, Lassmann H (June 2002). "Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases". ... Bakshi RK, Cox MA, Zajac AJ (2014). "Cytotoxic T Lymphocytes". Encyclopedia of Medical Immunology. pp. 332-342. doi:10.1007/978 ...
... s, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical ... Pross HF, Jondal M (August 1975). "Cytotoxic lymphocytes from normal donors. A functional marker of human non-T lymphocytes". ... CD8+ cytotoxic T-lymphocytes also use NKG2D receptors to detect senescent cells, and promote killing similar to NK cells. For ... West WH, Cannon GB, Kay HD, Bonnard GD, Herberman RB (January 1977). "Natural cytotoxic reactivity of human lymphocytes against ...
Marker for cytotoxic T lymphocytes "CD8 alpha - Marker for cytotoxic T lymphocytes". Archived from the original on 2015-09-21 ... "CD8 alpha - Marker for cytotoxic T Lymphocytes". Archived from the original on 21 September 2015. Retrieved 11 January 2016. T- ... Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. The main recognition site is a flexible loop at the α3 ... In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ...
Walker, BD (July 1987). "HIV-specific cytotoxic T lymphocytes in seropositive individuals". Nature. 328 (6128): 345-348. ...
After gaining a PhD in 1978 and producing a doctoral thesis titled 'Analysis of clones of cytotoxic lymphocytes' at the ... Ching, Lai-Ming (1978). Analysis of clones of cytotoxic lymphocytes (Doctoral thesis). ResearchSpace@Auckland, University of ...
Lin and Hamann's group show all human cytotoxic lymphocytes, including CD56dull NK cells and CD27-CD45RA+ effector-type CD8+ T ... October 2011). "Specific expression of GPR56 by human cytotoxic lymphocytes". Journal of Leukocyte Biology. 90 (4): 735-40. doi ... More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells. GPR56 binds ... GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic ...
GPR56 has been shown to a marker for inflammatory NK cell subsets and to be expressed by cytotoxic lymphocytes. GPR126 is ... "Specific expression of GPR56 by human cytotoxic lymphocytes". Journal of Leukocyte Biology. 90 (4): 735-40. CiteSeerX 10.1. ...
Masson D, Zamai M, Tschopp J (Dec 1986). "Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of ... Granzyme A (GzmA, EC 3.4.21.78, CTLA3, HuTPS, T-cell associated protease 1, cytotoxic T lymphocyte serine protease, TSP-1, T- ... 1988). "Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate ... Baetz K, Isaaz S, Griffiths GM (1995). "Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a ...
Holm G, Björkholm M, Mellstedt H, Johansson B (1976). "Cytotoxic activity of lymphocytes from patients with Hodgkin's disease ...
Bowness, Paul (1993). Recognition of antigen and superantigen by cytotoxic lymphocytes (Thesis). Thesis DPhil--University of ... "The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides". ... McMichael, A. J.; Gotch, F. M.; Noble, G. R.; Beare, P. A. (7 July 1983). "Cytotoxic T-cell immunity to influenza". The New ... Klenerman, Paul (1995). Cytotoxic T cell antagonism in HIV infection (Thesis). Thesis DPhil--University of Oxford. "Professor ...
In this way, it governs the action of cytotoxic lymphocytes. The amount of IL-2 being produced by the T-helper cells is ... IL-2 activates T-helper lymphocytes and induces the production of other cytokines. ...
Cytotoxic CD8+ T lymphocytes are able to recognize malignant cells. Production of neoantigens by tumour cells can lead to ... CD8+ T lymphocytes destroy melanocytes in some parts of the skin what manifest like white spots on the skin. Multiple genes as ... Skin TRM: TRM cells in the skin express cutaneous lymphocyte antigen (CLA) and CCR8 which are skin homing antigens. They have ... There is also higher number of CD49a+ CD8+ CD103+ T cells with cytotoxic potential in epiderma and derma of the vitiligo ...
That signal binds to a receptor, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), on the CTL and turns off the cytotoxic ... Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, an inhibitory mechanism interrupts this ... These antigens are recognized by dendritic cells that present the antigens to cytotoxic T lymphocytes (CTLs) in the lymph nodes ... Robert C, Ghiringhelli F (August 2009). "What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients ...
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism (immune ... which is expressed on the surface of activated T lymphocytes and inhibits the killing of cancer cells. Tremelimumab blocks the ...
Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein. Proc Natl Acad Sci U S A. 1991 Apr 15 ... Malik, A.; Egan, J. E.; Houghten, R. A.; Sadoff, J. C.; Hoffman, S. L. (1991-04-15). "Human cytotoxic T lymphocytes against the ... Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science. 1998 Oct 16;282(5388):476-80 ... the first demonstration of human cytotoxic T lymphocytes against any parasite, and the complexity of protective immunity at ...
Latouche JB, Sadelain M (April 2000). "Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells". ... MHC class I are found on all cells and stimulate cytotoxic T cells (CD8 cells), and MHC class II are found on APCs and ... these antigens can be loaded to aAPCs to successfully stimulate and expand tumor-specific cytotoxic T cells. These T cells can ...
The doctors generated cytotoxic T lymphocytes from the bone marrow donors. Their therapeutic approach to Epstein-Barr virus ... With Cliona Rooney, Heslop was the first to demonstrate that antigen-specific cytotoxic T cells could be used to eradicate an ... Heslop also studies the use of third-party cytotoxic T cells to treat viral infections after transplant. Together with other ...
"Platelets mediate cytotoxic T lymphocyte-induced liver damage". Nat. Med. 11 (11): 1167-9. doi:10.1038/nm1317. PMC 2908083. ... in particular virus-specific cytotoxic T lymphocytes(CTLs), contributes to most of the liver injury associated with HBV ... Immunosuppressive drugs favor increased HBV replication while inhibiting cytotoxic T cell function in the liver. The risk of ...
"Platelets mediate cytotoxic T lymphocyte-induced liver damage". Nature Medicine. 11 (11): 1167-1169. doi:10.1038/nm1317. PMC ... activates macrophages and activates cytotoxic response in T and B lymphocytes. Recently, the belief that mammalian platelets ... Diacovo TG, Puri KD, Warnock RA, Springer TA, von Andrian UH (July 1996). "Platelet-mediated lymphocyte delivery to high ... Instead of platelets, non-mammalian vertebrates have nucleated thrombocytes, which resemble B lymphocytes in morphology. They ...
... specific cytotoxic T-lymphocyte responses utilizing B-lymphoblastoid cell lines transduced with the CD4 gene and infected with ... "HIV-1 Induces Cytotoxic T Lymphocytes in the Cervix of Infected Women". The Journal of Experimental Medicine. 185 (2): 293-303 ... "Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes". ... Musey, Luwy; Hughes, James; Schacker, Timothy; Shea, Theresa; Corey, Lawrence; McElrath, M. Juliana (1997). "Cytotoxic-T-Cell ...
Effector lymphocytes function to eliminate the antigen, either by releasing antibodies (in the case of B cells), cytotoxic ... The two main types of lymphocytes are B lymphocytes and T lymphocytes. B lymphocytes make antibodies, and T lymphocytes help ... Lymphocytes include T cells (for cell-mediated, cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive ... A lymphocyte count is usually part of a peripheral complete blood cell count and is expressed as the percentage of lymphocytes ...
"The immunogenic properties of melanoma-associated antigens recognized by cytotoxic T lymphocytes". Experimental and Clinical ... gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. ...
Acute rejection is caused by antigen-specific Th1 and cytotoxic T-lymphocytes. They recognize transplanted tissue because of ... Activation of T-lymphocytes T-lymphocytes are fully activated under two conditions: T-lymphocytes must recognize complex MHC- ... B-lymphocytes, NK cells and cytokines also play a role in it. Cellular rejection - CD4+ and CD8+ T-lymphocytes, NK cells ... of CD8+ T-lymphocytes recognize these peptides when form the complex with MHC class I molecules and TCR of CD4+ T-lymphocytes ...
Furthermore, the Fas receptor also mediates tumor-specific cytotoxic T lymphocyte (CTL) anti-tumor cytotoxicity. In addition to ... Fleischer B (August 1986). "Lysis of bystander target cells after triggering of human cytotoxic T lymphocytes". European ... "Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes". Journal of ... Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL ...
... human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability". Journal of Immunology. ...
Tetramer stains usually analyze cytotoxic T lymphocyte (CTL) populations. CTLs are also called CD8+ T-cells, because they have ... "Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA". Science. 279 (5359): 2103-6. Bibcode: ... This was compared to results of cytotoxic assays and plasma RNA viral load to characterize the function of CTLs in HIV ... "The Adaptive Immune Response: T lymphocytes and Their Functional Types". Anatomy and Physiology II. Lumen Learning. Retrieved ...
July 1993). "Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA". European Journal of ...
In vivo application of RNA leads to the induction of specific cytotoxic T lymphocytes and antibodies. In: Eur.J.Immunol, 30, ... "In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine". Nature. Springer Science and ... PhD thesis Ingmar Hoerr was the first to develop an RNA vaccine for the induction of specific cytotoxic T-lymphocytes (CTL) and ... "Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells". Nature. Springer Science and ...
July 1993). "Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA". European Journal of ... "In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies". European Journal of ... Then, the PD-1 targeted sd-rxRNA helped increasing the anti-tumor activity of tumor-infiltrating lymphocytes (TIL) against ... Genes associated with immune defense were significantly up-regulated, along with increased CD8+ T lymphocytes, NK cells, and ...
"On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of ... Integrin receptors are involved in the attachment of adherent cells to the extracellular matrix and of lymphocytes to other ... Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, ... specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes". ...