... 1 is the most studied of all the syndecans in cancer research. Many studies have shown that syndecan 1 plays an ... The syndecan protein family has four members. Syndecans 1 and 3 and syndecans 2 and 4, making up separate subfamilies, arose by ... The syndecan numbers reflect the order in which the cDNAs for each family member were cloned. All syndecans have an N-terminal ... The syndecans are known to form homologous oligomers that may be important for their functions. Functions of syndecan can be ...

... can be a marker for plasma cells. The syndecan-1 core protein consists of an extracellular domain which can be ... "Entrez Gene: SDC1 syndecan 1". Averbeck M, Kuhn S, Bühligen J, Götte M, Simon JC, Polte T (November 2017). "Syndecan-1 ... Altered syndecan-1 expression has been detected in several different tumor types. In breast cancer, syndecan-1 is up regulated ... Syndecan-1 is a sponge for growth factors and chemokines, with binding largely via heparan sulfate chains. The syndecans ...

The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for ... Syndecan-2 is a protein that in humans is encoded by the SDC2 gene. The protein encoded by this gene is a transmembrane (type I ... Altered syndecan-2 expression has been detected in several different tumor types. SDC2 has been shown to interact with: CASK, ... "Entrez Gene: SDC2 syndecan 2". Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)- ...

Chernousov MA, Carey DJ (1993). "N-syndecan (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor". J. Biol ... Asundi VK, Carey DJ (1997). "Phosphorylation of recombinant N-syndecan (syndecan 3) core protein". Biochem. Biophys. Res. ... Identification as N-syndecan (syndecan-3)". J. Biol. Chem. 269 (17): 12999-3004. doi:10.1016/S0021-9258(18)99975-8. PMID ... "Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein ...

... is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has ... Syndecan-4 has more widespread distribution than other syndecans and it is the only syndecan that has been found consistently ... Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. It has more widespread distribution ... Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. Syndecan-4 binds to FGF and mediates ...

... syndecan 4; SLC34A2; solute carrier family 34 (sodium phosphate), member 2; TPM3; tropomyosin 3 Several drugs target ROS1 ...

Asundi VK, Carey DJ (1995). "Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif ... Identification as N-syndecan (syndecan-3)". J. Biol. Chem. 269 (17): 12999-3004. doi:10.1016/S0021-9258(18)99975-8. PMID ...

Grootjans JJ, Reekmans G, Ceulemans H, David G (2000). "Syntenin-syndecan binding requires syndecan-synteny and the co- ... "Entrez Gene: SDCBP syndecan binding protein (syntenin)". Lin D, Gish GD, Songyang Z, Pawson T (February 1999). "The carboxyl ... The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton ... Bass MD, Humphries MJ (2002). "Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor ...

Granés F, Urena JM, Rocamora N, Vilaró S (April 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell Sci. 113 (7): 1267 ...

"Entrez Gene: SDCBP2 syndecan binding protein (syntenin) 2". Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double ...

The most prominent was syndecan-1 (SDC1). In confirmatory pull-down assays, binding was not shared with family members syndecan ... Syndecan-1 binds many growth factors through its long heparan sulfate side-chains. Yet, long heparan sulfate chains interfere ... Syndecan-1 likely serves as a co-receptor. Binding lacritin may improve its GPCR affinity. Lacritin survival signaling is ... Since syndecans are always decorated with heparan sulfate, this means that heparanase must be available to partially or ...

Syndecan-syntenin-ALIX exosome biogenesis pathway are one of the ESCRT-independent or non-canonical pathways for exosome ... June 2012). "Syndecan-syntenin-ALIX regulates the biogenesis of exosomes". Nature Cell Biology. 14 (7): 677-85. doi:10.1038/ ...

PKCε binds RACK2 at Z-lines with an EC50 of 86 nM; PKCε also binds at costameres to syndecan-4. PKCε has been shown to bind F- ... "Localization of the transmembrane proteoglycan syndecan-4 and its regulatory kinases in costameres of rat cardiomyocytes: a ...

Fiore VF, Ju L, Chen Y, Zhu C, Barker TH (September 2014). "Dynamic catch of a Thy-1-α5β1+ syndecan-4 trimolecular complex". ...

The surface antigen CD138 (syndecan-1) is expressed at high levels. Another important surface antigen is CD319 (SLAMF7). This ...

Gao Y, Li M, Chen W, Simons M (2000). "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration". J ... SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be ...

"Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis". Nature Medicine. 15 (9): 1072-6. doi: ...

The major cell membrane HSPGs are the transmembrane syndecans and the glycosylphosphatidylinositol (GPI) anchored glypicans. ...

"Evolution of serum hyaluronan and syndecan levels in prognosis of sepsis patients". Clinical Biochemistry. 49 (10-11): 768-776 ...

de Witte L, Bobardt M, Chatterji U, Degeest G, David G, Geijtenbeek TB, Gallay P (December 2007). "Syndecan-3 is a dendritic ...

2000). "Synbindin, a Novel Syndecan-2-Binding Protein in Neuronal Dendritic Spines". J. Cell Biol. 151 (1): 53-68. doi:10.1083/ ...

The cell-surface proteoglycan Syndecan-1 is a target of miR-10b. miR-10a binds to the five prime untranslated region (5'UTR) of ... Ibrahim, Sherif (15 September 2012). "Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and ... "Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of ...

"Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds". ...

Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan ...

"Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". J. Biol. Chem. 273 (17): 10702-8 ...

"Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". The Journal of Biological ...

Steigemann P, Molitor A, Fellert S, Jäckle H, Vorbrüggen G (February 2004). "Heparan sulfate proteoglycan syndecan promotes ...

"Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". The Journal of Biological ...

Where examined, syndecan-4 has been identified as the HSPG critical for CCN1 functions. The CYR61 binding sites for some of ...

1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". J. Biol. Chem. 273 (17 ...