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*  Perlecan
... although no distinction between syndecan and perlecan has been made in these tissues. Another procedure that could be made ... 262 (1-2): 71-8. doi:10.1023/B:MCBI.0000038218.09259.1c. PMID 15532711. Lee RT, Yamamoto C, Feng Y, Potter-Perigo S, Briggs WH ... 6 (1): 10-7. doi:10.1007/BF03032652. PMID 10749582. Mathiak M, Yenisey C, Grant DS, Sharma B, Iozzo RV (June 1997). "A role for ... 1672 (1): 36-45. doi:10.1016/j.bbagen.2004.02.005. PMID 15056491. Tamsma JT, van den Born J, Bruijn JA, Assmann KJ, Weening JJ ...
*  Glypican
Therefore, unlike syndecans the heparan sulfate glycosaminoglycan chains attached to glypicans are located rather close to the ... with the other major family being syndecans. Six glypicans have been identified in mammals, and are referred to as GPC1 through ... In humans, glypican-1 is overexpressed in breast and brain cancers (gliomas), while glypican-3 is overexpressed in liver ... Matsuda K, Maruyama H, Guo F, Kleeff J, Itakura J, Matsumoto Y, Lander AD, Korc M (July 2001). "Glypican-1 is overexpressed in ...
*  Syndecan-3
... syndecan-3)". J. Biol. Chem. 269 (17): 12999-3004. PMID 8175719. Chernousov MA, Carey DJ (1993). "N-syndecan (syndecan 3) from ... Asundi VK, Carey DJ (1997). "Phosphorylation of recombinant N-syndecan (syndecan 3) core protein". Biochem. Biophys. Res. ... "Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein ... Syndecan-3 is a protein that in humans is encoded by the SDC3 gene. GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May ...
*  SULF1
Given several HSPGs (perlecan, syndecan 1/3, glypican) are upregulated and growth factor signaling through FGF-2, Wnt, BMP, and ... 126 (1): 231-48. doi:10.1053/j.gastro.2003.09.043. PMID 14699503. Dong G, Chen Z, Li ZY, Yeh NT, Bancroft CC, Van Waes C ( ... 254 Suppl 1: S138-43. doi:10.1007/BF02439745. PMID 9065649. Lai JP, Yu C, Moser CD, Aderca I, Han T, Garvey TD, Murphy LM, ... 126 (1): 231-48. doi:10.1053/j.gastro.2003.09.043. PMID 14699503. Li J, Kleeff J, Abiatari I, Kayed H, Giese NA, Felix K, Giese ...
*  Syndecan 1
The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for ... Asundi VK, Carey DJ (Nov 1995). "Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural ... cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. Three SDC1 elements ... Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein encoded by this gene is a transmembrane (type ...
*  Lacritin
Further analysis narrowed the site to syndecan-1's N-terminal 51 amino acids, and subsequently to the N-terminal sequence GAGAL ... cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. A G-protein-coupled ... binding was not shared with family members syndecan-2 or syndecan-4, indicating that the protein core (and not the negatively ... Syndecan-1 binds many growth factors through its long heparan sulfate side-chains. Yet, long heparan sulfate chains interfere ...
*  Plasma cell
The surface antigen CD138 (syndecan-1) is expressed at high levels. Another important surface antigen is CD319 (SLAMF7). This ... ISBN 1-4292-0211-4. Federico Caligaris-Cappio; Manlio Ferrarini (1997). Human B Cell Populations (Chemical Immunology) (v. 67 ... Differentiation of mature B cells into plasma cells is dependent upon the transcription factors Blimp-1/PRDM1 and IRF4. After ... ISBN 0-323-01639-1. Bona, Constantin; Francisco A. Bonilla (1996). "5". Textbook of Immunology. Martin Soohoo (2 ed.). CRC ...
*  Mir-10 microRNA precursor family
The cell-surface proteoglycan Syndecan-1 is a target of miR-10b. miR-10a binds to the five prime untranslated region (5'UTR) of ... "Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of ... 217 (1): 73-7. doi:10.1007/s00427-006-0116-1. PMID 17103184. Huang, Jian; Hao, Pei; Chen, Hui; Hu, Wei; Yan, Qing; Liu, Feng; ... Zebrafish have seven Hox gene clusters, genes encoding miR-10 (mir-10a, mir-10b-1, mir-10b-2 and mir-10c) are found in the Hox ...
*  CCL5
Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (October 2003). "Interaction of RANTES with syndecan-1 ... ISBN 1-57059-253-5. Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (January 1999). "RFLAT-1: a new zinc finger ... 1617 (1-2): 80-8. doi:10.1016/j.bbamem.2003.09.006. PMID 14637022. Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, ... Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (2004). "HIV-1 Vpr and anti-inflammatory ...
*  Farnesoid X receptor
Anisfeld AM, Kast-Woelbern HR, Meyer ME, Jones SA, Zhang Y, Williams KJ, Willson T, Edwards PA (May 2003). "Syndecan-1 ... 36 (1): 44-50. doi:10.1038/aps.2014.116. PMC 4571315 . PMID 25500875. Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, ... 9 (1): 72-85. doi:10.1210/mend.9.1.7760852. PMID 7760852. Zavacki AM, Lehmann JM, Seol W, Willson TM, Kliewer SA, Moore DD (Jul ... 290 (1-2): 35-43. doi:10.1016/S0378-1119(02)00557-7. PMID 12062799. Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, ...
*  Heparanase
Lacritin binds the cell surface heparan sulfate proteoglycan syndecan-1 only in the presence of active heparanase. Heparanase ... "Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin". The ... 35 (1-2): 116-27. doi:10.1159/000093553. PMID 16855356. van den Hoven MJ, Rops AL, Vlodavsky I, Levidiotis V, Berden JH, van ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Vlodavsky I, Friedmann Y, Elkin M, Aingorn H, Atzmon R, ...
*  Douglas Scherr
Syndecan-1 expression in prostate cancer and the role of p27 in primary prostate epithelial cell transformation. T32 Research ... 97 (1): 33-6. doi:10.1111/j.1464-410X.2005.05880.x. PMID 16336324. Barocas, DA; Rohan, SM; Kao, J; Gurevich, RD; Del Pizzo, JJ ... 11 (24 Pt 1): 8570-6. doi:10.1158/1078-0432.CCR-05-1047. PMID 16361539. Raman, JD; Ng, CK; Boorjian, SA; Vaughan Ed, ED; Sosa, ... 171 (2 Pt 1): 615-20. doi:10.1097/01.ju.0000106955.19813.f6. PMID 14713772. Boorjian, S; Tickoo, SK; Mongan, NP; Yu, H; Bok, D ...
*  Indatuximab ravtansine
CD138 (Syndecan-1) is highly overexpressed on various solid tumors and in hematological malignancies, and represents one of the ... ImmunoGen, more on DM1/DM4 and the linker used in Indatuximab ravtansine Syndecan 1, the protein encoded by SDC1. Indatuximab ...
*  Midkine
1997). "Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine ... and syndecans is considered to be its receptor. MK appears to enhance the angiogenic and proliferative activities of cancer ... 179 (1): 572-8. doi:10.1016/0006-291X(91)91409-6. PMID 1883381. Tsutsui J, Uehara K, Kadomatsu K, et al. (1991). "A new family ... 69 (1-2): 40-3. doi:10.1159/000133934. PMID 7835084. Fairhurst JL, Kretschmer PJ, Kovacs E, et al. (1993). "Structure of the ...
*  CCR5
Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (Oct 2003). "Interaction of RANTES with syndecan-1 and ... The HIV-1 epidemic is therefore far too young to be the source of positive selection that drove the frequency of CCR5 Δ32 from ... 51: 1-33. PMID 9891584. Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G (Dec 1999). "Use of ... The HIV-1 envelope glycoprotein structure is essential in enabling the viral entry of HIV-1 into a target host cell. The ...
*  Joshua Sonett
Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with ... The course of neurofibromatiosis Type 1 on immunosuppression after lung transplantation: Report of 2 cases. Merlo, C.A., Studer ... kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 ...
*  Fascin
doi:10.1007/s00534-009-0046-1. ISSN 0944-1166. PMID 19259612. Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, ... 162 (1): 69-80. doi:10.1016/S0002-9440(10)63799-6. ISSN 0002-9440. PMC 1851132 . PMID 12507891. Vignjevic D, Schoumacher M, ... 32 (1): 1-9. doi:10.1002/cm.970320102. ISSN 0886-1544. PMID 8674129. Yamashiro-Matsumura S, Matsumura F (April 1985). " ... Roh YH, Kim YH, Choi HJ, Lee KE, Roh MS (March 2009). "Fascin overexpression correlates with positive thrombospondin-1 and ...
*  Syndecan
The syndecan numbers reflect the order in which the cDNAs for each family member were cloned. All syndecans have an N-terminal ... The syndecans are known to form homologous oligomers that may be important for their functions. Functions of syndecan can be ... Syndecan-4 is upregulated in osteoarthritis and inhibition of syndecan-4 reduces cartilage destruction in mouse models of OA. ... All members of the syndecan family have 5 exons. The difference in size of the syndecans is credited to the variable length of ...
*  Co-receptor
Syndecans 1 and 4 have been implicated in a variety of cancer types including cervical, breast, lung, and colon cancer, and ... HIV-1 and HIV-2 can both use the CCR8 co-receptor. The crossover of co-receptor targets for different strains and the ability ... 9 (1): S2. doi:10.1186/1479-5876-9-S1-S2. PMID 21284901. Evans, M.J., von Hahn, T., Tscherne, D.M., Syder, A.J., Panis, M., ... 9 (1): S8. doi:10.1186/1479-5876-9-S1-S8. PMID 21284907. Cicala, C., Arthos, J., Fauci, A.S. (2011). "HIV-1 envelope, integrins ...
*  Deepak Shukla
His laboratory was first to implicate heparanase in HSV-1 release and syndecans in HSV-1 entry and cell-to-cell fusion. He has ... He contributed to the discovery of HSV-1 entry receptors and establishing a link between the receptors and HSV-1 induced ocular ... "A novel role for 3-O-sulfated heparan Sulfate in herpes simplex virus 1 entry" (1999) "A novel role for phagocytosis-like ... Shukla has been directly associated with the discoveries of HSV-1 entry receptors, 3-O. Besides 3-O sulfated heparan sulfate, ...
*  ALOX15
15-LOX-1's metabolic action is thought to be one mechanism by which dietary ω-3 polyunsaturated fatty acids, particularly fish ... These results, as well as a 15-LOX-1 transgene study on colon cancer in mice suggests but do not prove that 15-LOX-1 is a tumor ... 91 (1): 64-74. PMID 9414270. Kelavkar U, Wang S, Montero A, Murtagh J, Shah K, Badr K (July 1998). "Human 15-lipoxygenase gene ... 15-LOX-1 and its 5-oxo-15-hydroxy-ETE and eoxin metabolites have been suggested as potential contributors to, and therefore ...
*  Envelope glycoprotein GP120
de Witte L, Bobardt M, Chatterji U, Degeest G, David G, Geijtenbeek TB, Gallay P (December 2007). "Syndecan-3 is a dendritic ... 1] However, most antibodies that bind the CDbs region of gp120 do not neutralize HIV, and rare ones that do such as IgG1-b12 ... The diversity of env has been shown to increase by 1-2% per year in HIV-1 group M and the variable units are notable for rapid ... 383 (1): 47-59. doi:10.1016/j.virol.2008.09.017. PMC 2642736 . PMID 18973914. Wood N, Bhattacharya T, Keele BF, Giorgi E, Liu M ...
*  Syndecan-2
The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for ... syndecan-2) during mouse embryonic development". Development. 119 (3): 841-54. PMID 8187643. "Entrez Gene: SDC2 syndecan 2". ... Syndecan-2 is a protein that in humans is encoded by the SDC2 gene. The protein encoded by this gene is a transmembrane (type I ... Altered syndecan-2 expression has been detected in several different tumor types. SDC2 has been shown to interact with: CASK, ...
*  Syndecan-4
... is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has ... Syndecan-4 has more widespread distribution than other syndecans and it is the only syndecan that has been found consistently ... Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. It has more widespread distribution ... Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. Syndecan-4 binds to FGF and mediates ...
*  Fibronectin
... syndecans). Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide ... heparin-binding and syndecan-binding (III12-14). Fibronectin has numerous functions that ensure the normal functioning of ... doi:10.1007/s12105-015-0678-1. PMID 26759148. Lee JC, Jeng YM, Su SY, Wu CT, Tsai KS, Lee CH, Lin CY, Carter JM, Huang JW, Chen ... 309 (1): 48-55. doi:10.1016/j.yexcr.2005.05.024. PMID 15992798. George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, ...
*  CUTL1
Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan ... 46 (1): 33-8. doi:10.1038/ng.2846. PMC 3874239 . PMID 24316979. Sohda M, Misumi Y, Yamamoto A, Nakamura N, Ogata S, Sakisaka S ... 1 (1): 50-5. doi:10.1038/ng0492-50. PMID 1301999. Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the ... 197 (1-2): 73-81. doi:10.1016/s0378-1119(97)00243-6. PMID 9332351. Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled ...
*  MMP17
... type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan- ... 87 (1-2): 97-8. doi:10.1159/000015402. PMID 10640822. English WR, Puente XS, Freije JM, et al. (2000). "Membrane type 4 matrix ... J. 398 (1): 15-22. doi:10.1042/BJ20060243. PMC 1525013 . PMID 16686598. The MEROPS online database for peptidases and their ... 2004). "ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol- ...