... also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use. In mice, swainsonine ... Gardner, DR; Cook, D (2016). "Analysis of Swainsonine and Swainsonine N-Oxide as Trimethylsilyl Derivatives by Liquid ... they are host of endophytic fungi which produces swainsonine. The biosynthesis of swainsonine has been investigated in the ... Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a ...

The toxin is called swainsonine. Research suggests that the plant itself may not be toxic, but becomes toxic when inhabited by ... 2002). Distribution of locoweed toxin swainsonine in populations of Oxytropis lambertii. J Chem Ecol 28:4 701-7. McLain-Romero ... endophytic fungi of the genus Embellisia, which produce swainsonine. Locoweed USDA, NRCS. (2023). "Oxytropis lambertii Pursh". ...

The polyhydroxy alkaloids include compounds like castanospermine and swainsonine. (+)-Castanospermine (-)-Swainsonine The ... Ipalbidine Swainsonine-type compounds are currently under investigation for their potential as active agents against AIDS. ... Swainsonine and castanospermine function as inhibitors of sugar-splitting enzymes. Castanospermine also exhibits anti-cancer ... For instance, Slaframine and swainsonine were identified in the fungus Rhizoctonia leguminicola, while Castanospermine was ...

Some species, including a few that produce swainsonine, accumulate selenium. This has led to confusion between swainsonine ... swainsonine disease, swainsonine toxicosis in North America) and pea struck in Australia. Locoism is reported most often in ... Worldwide, swainsonine is produced by a small number of species, most of them in three genera of the flowering plant family ... Swainsonine is produced by a small number of species, including species in several genera of plants and two genera of fungi. ...

Cattle tend to prefer the flowers and fruits of the plants, which contain higher levels of swainsonine than the leaves. One to ... 1998). Tissue swainsonine clearance in sheep chronically poisoned with locoweed (Oxytropis sericea). Journal of Animal Science ... The toxic agent in the plant is swainsonine, an alkaloid. Animals affected include cattle, sheep, horses, goats, and wildlife ...

Biosynthesis shown in figure: Swainsonine Merck Index, 11th Edition, 1902. Castanospermine at Fermentek Hohenschutz, Liza D.; ...

... and is attributed in part to the alkaloid toxins slaframine and swainsonine. "Bloat in Camelids". Croom WJ, Hagler WM, ... Froetschel MA, Johnson AD (May 1995). "The involvement of slaframine and swainsonine in slobbers syndrome: a review". Journal ...

Stegelmeier BL, Molyneux RJ, Elbein AD, James LF (May 1995). "The lesions of locoweed (Astragalus mollissimus), swainsonine, ...

A few species are known to produce swainsonine, a phytotoxin harmful to livestock (see Locoweed). In Australia, animals ... intoxicated with swainsonine are said to be pea struck. The following is a list of species of Swainsona accepted by Plants of ...

In livestock alpha-mannosidosis is caused by chronic poisoning with swainsonine from locoweed. Alpha-mannosidosis is a lifelong ...

This is caused by an alkaloid it contains called swainsonine, formerly known as locoine. The plant is toxic both fresh and ...

Swainsonine inhibits the metabolism of glycoproteins, which leads to starvation despite ample food consumption. However, in an ... Krakauer also speculated that McCandless might have been poisoned by a toxic alkaloid called swainsonine, after eating sweet- ...

The plant contains the alkaloid swainsonine causing alpha-mannosidosis, a risk to grazing livestock. In 2014, thousands of ...

The saturated analogs are indolizidine, which are found in a variety of alkaloids such as swainsonine. International Union of ...

Nitrogen-containing, 'sugar-shaped' heterocycles have been found in nature, including deoxynojirimycin, swainsonine, australine ...

It is a key enzyme of N-linked Glycan processing and is inhibited by small molecule swainsonine. Harpaz N, Schachter H (May ...

... swainsonine". J. Org. Chem. 71 (18): 7097-9. doi:10.1021/jo0610661. PMID 16930074. Pyne, S.G.; Au, C. W. G.; Davis, A. S.; ...

... is a heterocyclic chemical compound that forms the central core of the indolizidine alkaloids such as swainsonine ...

Anti-cancer and anti-viral activity was subsequently observed for swainsonine-a mannose analogue-and castanospermine-a glucose ...

... swainsonine: a possible animal model for celiac disease". Gastroenterology. 95 (1): 100-6. doi:10.1016/0016-5085(88)90296-x. ...

Some astragalus species can be toxic, such as those found in the United States containing the neurotoxin swainsonine, which ...

... and those that make swainsonine (a poisonous alkaloid). Samples of A. drummondii in New Mexico were tested and found to be ... negative for the production of swainsonine, suggesting that this species may be safe for cattle to eat. Hooker, William Jackson ...

"Analysis of Swainsonine and Swainsonine N-Oxide as Trimethylsilyl Derivatives by Liquid Chromatography-Mass Spectrometry and ... These seeds are toxic and it can be hazardous to cattle; the toxicity is related to the swainsonine produced by its endophytes ...

Swainsonine Mannosidosis at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (All stub articles, ...

... which Krakauer thought might contain swainsonine. This theory was later debunked by experts in the field of botany. Krakauer ...

... and low concentrations of the toxin swainsonine gives it potential for development as a forage crop. "Swainsona colutoides F. ...

"The involvement of slaframine and swainsonine in slobbers syndrome: a review" Journal of Animal Science, Journal of Animal ...

The involvement of slaframine and swainsonine in slobbers syndrome: a review[permanent dead link], Journal of Animal Science, ( ...

... possibly swainsonine (the toxic chemical in locoweed) or something similar. In addition to neurological symptoms, such as ...

The molecular formula C8H15NO3 (molar mass: 173.21 g/mol, exact mass: 173.1052 u) may refer to: Acetylleucine Swainsonine SCH- ...